Localization of small pulmonary nodules with magnetic beads: An animal experiment_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LV Lu ^1,2 , SHI Aihua ³ , YAN Xiaopeng ^3,4 , ZHANG Zhixuan ^1,5 , ZHOU Guxiang ⁵ , FU Junke ¹ , MA Feng ³ , WANG Haohua ^3,4 , LV Yi ^3,4 ,  ZHANG Yong ^1,3

1. Department of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, P.R.China;
2. Zonglian College, Xi’an Jiaotong University, Xi’an, 710061, P.R.China;
3. National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, P.R.China;
4. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, P.R.China;
5. Qide College, Xi’an Jiaotong University, Xi’an, 710061, P.R.China;

Corresponding author：

ZHANG Yong, Email: zhangyongyang05@163.com

Keywords：

Magnetic beads; small pulmonary nodules; rabbit; magnetic tracer technique; animal experiment

DOI：

10.7507/1007-4848.202009014

Video：

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Objective To investigate the feasibility of using magnetic beads to locate small pulmonary nodules.Methods Twelve rabbits were randomly divided into two groups, 6 in each group. One group underwent thoracotomy after anesthesia and the other group underwent percutaneous puncture under the guidance of X-ray. One and two cylindrical tracer magnets (magnetic beads) with a diameter of 1 mm and a height of 3 mm were injected adjacent to the imaginary pulmonary nodules in left lung in each group. The magnetic beads beside the imaginary nodules were attracted by a pursuit magnet with a diameter of 9 mm and a height of 19 mm. The effectiveness of localization by magnetic beads were determined by attraction between tracer and pursuit magnets.Results All processes were uneven in 12 rabbits. There was micro hemorrhage and no hematoma in the lung tissue at the injection site of the magnetic beads. When tracked with the pursuit magnets, there was one bead divorce in cases that one bead was injected, but no migration or divorce of the magnetic beads in cases that two magnetic beads were simultaneously injected to localize the small pulmonary nodules.Conclusion The feasibility of using magnetic beads to locate small pulmonary nodules has been preliminarily verified.

Citation： LV Lu, SHI Aihua, YAN Xiaopeng, ZHANG Zhixuan, ZHOU Guxiang, FU Junke, MA Feng, WANG Haohua, LV Yi, ZHANG Yong. Localization of small pulmonary nodules with magnetic beads: An animal experiment. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2021, 28(11): 1360-1364. doi: 10.7507/1007-4848.202009014 Copy

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13.	Tsutsui H, Kinouchi Y, Sasaki H, et al. Studies on the Sm-Co magnet as a dental material. J Dent Res, 1979, 58(6): 1597-1606.
14.	刘豪, 付珊, 付琴琴. 医用钕铁硼体内植入表面改性研究现状. 现代生物医学进展, 2019, 19(1): 175-179.
15.	Klima U, MacVaugh H 3rd, Bagaev E, et al. Magnetic vascular port in minimally invasive direct coronary artery bypass grafting. Circulation, 2004, 110(11 Suppl 1): Ⅱ55-Ⅱ60.
16.	Graves CE, Co C, Hsi RS, et al. Magnetic compression anastomosis (magnamosis): First-in-human trial. J Am Coll Surg, 2017, 225(5): 676-681.
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1. 中华医学会呼吸病学分会肺癌学组, 中国肺癌防治联盟专家组. 肺结节诊治中国专家共识(2018 年版). 中华结核和呼吸杂志, 2018, 41(10): 763-771.
2. Liu Q, Huang Y, Chen H, et al. Computed tomography-based radiomic features for diagnosis of indeterminate small pulmonary nodules. J Comput Assist Tomogr, 2020, 44(1): 90-94.
3. 吕璐, 严小鹏, 张至轩, 等. 肺小结节定位研究进展. 国际外科学杂志, 2020, 47(3): 197-201, 封四.
4. Iacovacci V, Lucarini G, Innocenti C, et al. Polydimethylsiloxane films doped with NdFeB powder: Magnetic characterization and potential applications in biomedical engineering and microrobotics. Biomed Microdevices, 2015, 17(6): 112.
5. 黄涛, 王向东, 石晓宁, 等. 钕铁硼稀土永磁材料腐蚀防护技术的研究进展. 中国稀土学报, 2018, 36(4): 394-405.
6. 严小鹏, 商澎, 史爱华, 等. 磁外科学体系的探索与建立. 科学通报, 2019, 64(8): 815-826.
7. 中华医学会放射学分会心胸学组. 低剂量螺旋 CT 肺癌筛查专家共识. 中华放射学杂志, 2015, 49(5): 328-335.
8. Mao Y, Yang D, He J, et al. Epidemiology of lung cancer. Surg Oncol Clin N Am, 2016, 25(3): 439-445.
9. 中华医学会, 中华医学会肿瘤学分会, 中华医学会杂志社. 中华医学会肺癌临床诊疗指南(2019 版). 中华肿瘤杂志, 2020, 42(4): 257-287.
10. Zheng RS, Sun KX, Zhang SW, et al. Report of cancer epidemiology in China, 2015. Zhonghua Zhong Liu Za Zhi, 2019, 41(1): 19-28.
11. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin, 2018, 68(1): 7-30.
12. Thistlethwaite PA, Gower JR, Hernandez M, et al. Needle localization of small pulmonary nodules: Lessons learned. J Thorac Cardiovasc Surg, 2018, 155(5): 2140-2147.
13. Tsutsui H, Kinouchi Y, Sasaki H, et al. Studies on the Sm-Co magnet as a dental material. J Dent Res, 1979, 58(6): 1597-1606.
14. 刘豪, 付珊, 付琴琴. 医用钕铁硼体内植入表面改性研究现状. 现代生物医学进展, 2019, 19(1): 175-179.
15. Klima U, MacVaugh H 3rd, Bagaev E, et al. Magnetic vascular port in minimally invasive direct coronary artery bypass grafting. Circulation, 2004, 110(11 Suppl 1): Ⅱ55-Ⅱ60.
16. Graves CE, Co C, Hsi RS, et al. Magnetic compression anastomosis (magnamosis): First-in-human trial. J Am Coll Surg, 2017, 225(5): 676-681.
17. Matsuzaki I, Hattori M, Hirose K, et al. Magnetic anchor-guided endoscopic submucosal dissection for gastric lesions (with video). Gastrointest Endosc, 2018, 87(6): 1576-1580.
18. Chen CK, Chang HT, Chen YC, et al. Utilization and safety of percutaneous lung biopsy: A 10-year nationwide population-based study. Int J Environ Res Public Health, 2019, 16(8): 1316.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Localization of small pulmonary nodules with magnetic beads: An animal experiment

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