Research progress on deep hypothermic circulatory arrest in rat model_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

YAN Weidong ,  JI Bingyang

Department of Cardiopulmonary Bypass, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, P. R. China;

Corresponding author：

JI Bingyang, Email: jibingyang@fuwai.com

Keywords：

Deep hypothermic circulatory arrest; rat model; review

DOI：

10.7507/1007-4848.202101078

Video：

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Deep hypothermic circulatory arrest (DHCA) technology is the basic means of organ protection in complex aortic arch surgeries, congenital heart disease surgeries, pulmonary endarterectomy and other operations. The establishment of DHCA in rat model is helpful to explore the influence of DHCA and its pathophysiological pathways. However, there are some problems in this process, such as imperfect monitoring, inaccurate management and non-standard heparinization during the experimental period. It is necessary to review relevant literatures on DHCA rat model, in order to establish a DHCA rat model with standardized operation, clear standards and mature technology.

Citation： YAN Weidong, JI Bingyang. Research progress on deep hypothermic circulatory arrest in rat model. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2022, 29(12): 1678-1685. doi: 10.7507/1007-4848.202101078 Copy

1.	Sade RM, Castaneda AR. Recent advances in cardiac surgery in the young infant. Surg Clin North Am, 1976, 56(2): 451-465.
2.	Waterbury T, Clark TJ, Niles S, et al. Rat model of cardiopulmonary bypass for deep hypothermic circulatory arrest. J Thorac Cardiovasc Surg, 2011, 141(6): 1549-1551.
3.	Rein JG, Freed MD, Norwood WI, et al. Early and late results of closure of ventricular septal defect in infancy. Ann Thorac Surg, 1977, 24(1): 19-27.
4.	Zhu X, Ji B, Liu J, et al. Establishment of a novel rat model without blood priming during normothermic cardiopulmonary bypass. Perfusion, 2014, 29(1): 63-69.
5.	Jiang X, Gu T, Liu Y, et al. A novel augmented venous-drainage model of cardiopulmonary bypass for deep hypothermic circulatory arrest without blood priming. Perfusion, 2018, 33(4): 297-302.
6.	Shim JK, Ma Q, Zhang Z, et al. Effect of pregabalin on cerebral outcome after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats. J Thorac Cardiovasc Surg, 2014, 148(1): 298-303.
7.	Liu M, Zeng Q, Li Y, et al. Neurologic recovery after deep hypothermic circulatory arrest in rats: A description of a long-term survival model without blood priming. Artif Organs, 2019, 43(6): 551-560.
8.	Jungwirth B, Mackensen GB, Blobner M, et al. Neurologic outcome after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats: Description of a new model. J Thorac Cardiovasc Surg, 2006, 131(4): 805-812.
9.	Engels M, Bilgic E, Pinto A, et al. A cardiopulmonary bypass with deep hypothermic circulatory arrest rat model for the investigation of the systemic inflammation response and induced organ damage. J Inflamm (Lond), 2014, 11: 26.
10.	Modine T, Azzaoui R, Fayad G, et al. A recovery model of minimally invasive cardiopulmonary bypass in the rat. Perfusion, 2006, 21(2): 87-92.
11.	Gourlay T, Ballaux PK, Draper ER, et al. Early experience with a new technique and technology designed for the study of pulsatile cardiopulmonary bypass in the rat. Perfusion, 2002, 17(3): 191-198.
12.	Gao S, Gu T, Shi E, et al. Inhibition of long noncoding RNA growth arrest-specific 5 attenuates cerebral injury induced by deep hypothermic circulatory arrest in rats. J Thorac Cardiovasc Surg, 2019.
13.	杨波, 苏肇伉, 陈惠文. 大鼠深低温停循环模型的建立. 临床儿科杂志, 2003, 6: 368-370.
14.	田鑫, 江基尧, 邱永明, 等. 大鼠深低温停循环复苏模型的建立. 中华神经外科杂志, 2004, 20(5): 417-420.
15.	You XM, Nasrallah F, Darling E, et al. Rat cardiopulmonary bypass model: Application of a miniature extracorporeal circuit composed of asanguinous prime. J Extra Corpor Technol, 2005, 37(1): 60-65.
16.	Shen L, Wang J, Liu K, et al. Hydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest. Neurochem Res, 2011, 36(8): 1501-1511.
17.	Gu Q, Gu H, Lu X, et al. The influence of deep hypothermic global brain ischemia on EEG in a new rat model. J Card Surg, 2012, 27(5): 612-617.
18.	朱贤, 陆龙, 赵向东, 等. 不同温度大鼠无血预充深低温停循环模型的建立. 中国体外循环杂志, 2013, 11(2): 107-110, 115.
19.	Bartels K, Ma Q, Venkatraman TN, et al. Effects of deep hypothermic circulatory arrest on the blood brain barrier in a cardiopulmonary bypass model—A pilot study. Heart Lung Circ, 2014, 23(10): 981-984.
20.	李斌, 朱耀斌, 刘爱军, 等. 大鼠深低温停循环模型的建立. 中华实用诊断与治疗杂志, 2015, 29(7): 634-636.
21.	郦安琪, 徐嗣卫, 陈文超, 等. 40分钟深低温停循环大鼠长期存活模型的建立. 中华急诊医学杂志, 2019, 28(4): 484-488.
22.	张帅, 刘杨, 蒋璇, 等. 新型无血预充体外循环深低温停循环模型. 中国心血管病研究, 2020, 18(7): 647-651.
23.	王立烽, 韦冬冬, 朱贤, 等. 闭式少预充量大鼠深低温停循环模型的建立. 浙江医学, 2020, 42(8): 770-774.
24.	马晓洁, 罗璇, 张莉, 等. 延长创伤环境中暴露时间对雌雄大鼠行为差异及HPT轴的影响. 中华行为医学与脑科学杂志, 2020, 29(7): 584-588.
25.	Ballaux PK, Gourlay T, Ratnatunga CP, et al. A literature review of cardiopulmonary bypass models for rats. Perfusion, 1999, 14(6): 411-417.
26.	Ordodi VL, Paunescu V, Ionac M, et al. Artificial device for extracorporeal blood oxygenation in rats. Artif Organs, 2008, 32(1): 66-70.
27.	Wang Y, Gu T, Shi E, et al. Inhibition of microRNA-29c protects the brain in a rat model of prolonged hypothermic circulatory arrest. J Thorac Cardiovasc Surg, 2015, 150(3): 675-684.
28.	Li YA, Liu ZG, Zhang YP, et al. Differential expression profiles of circular RNAs in the rat hippocampus after deep hypothermic circulatory arrest. Artif Organs, 2021, 45(8): 866-880.
29.	Chen Q, Lei YQ, Liu JF, et al. Triptolide improves neurobehavioral functions, inflammation, and oxidative stress in rats under deep hypothermic circulatory arrest. Aging (Albany NY), 2021, 13(2): 3031-3044.
30.	Chen Q, Sun KP, Huang JS, et al. Resveratrol attenuates neuroinflammation after deep hypothermia with circulatory arrest in rats. Brain Res Bull, 2020, 155: 145-154.
31.	Jenke A, Yazdanyar M, Miyahara S, et al. AdipoRon attenuates inflammation and impairment of cardiac function associated with cardiopulmonary bypass-induced systemic inflammatory response syndrome. J Am Heart Assoc, 2021, 10(6): e018097.
32.	Shi J, Jiang X, Gao S, et al. Gene-modified exosomes protect the brain against prolonged deep hypothermic circulatory arrest. Ann Thorac Surg, 2021, 111(2): 576-585.
33.	Liu M, Li Y, Gao S, et al. A novel target to reduce microglial inflammation and neuronal damage after deep hypothermic circulatory arrest. J Thorac Cardiovasc Surg, 2020, 159(6): 2431-2444.
34.	Li Y, Liu M, Gao S, et al. Cold-inducible RNA-binding protein maintains intestinal barrier during deep hypothermic circulatory arrest. Interact Cardiovasc Thorac Surg, 2019, 29(4): 583-591.
35.	Weber C, Jenke A, Chobanova V, et al. Targeting of cell-free DNA by DNaseⅠ diminishes endothelial dysfunction and inflammation in a rat model of cardiopulmonary bypass. Sci Rep, 2019, 9(1): 19249.
36.	Jiang X, Gu T, Liu Y, et al. Protection of the rat brain from hypothermic circulatory arrest injury by a chipmunk protein. J Thorac Cardiovasc Surg, 2018, 156(2): 525-536.

1. Sade RM, Castaneda AR. Recent advances in cardiac surgery in the young infant. Surg Clin North Am, 1976, 56(2): 451-465.
2. Waterbury T, Clark TJ, Niles S, et al. Rat model of cardiopulmonary bypass for deep hypothermic circulatory arrest. J Thorac Cardiovasc Surg, 2011, 141(6): 1549-1551.
3. Rein JG, Freed MD, Norwood WI, et al. Early and late results of closure of ventricular septal defect in infancy. Ann Thorac Surg, 1977, 24(1): 19-27.
4. Zhu X, Ji B, Liu J, et al. Establishment of a novel rat model without blood priming during normothermic cardiopulmonary bypass. Perfusion, 2014, 29(1): 63-69.
5. Jiang X, Gu T, Liu Y, et al. A novel augmented venous-drainage model of cardiopulmonary bypass for deep hypothermic circulatory arrest without blood priming. Perfusion, 2018, 33(4): 297-302.
6. Shim JK, Ma Q, Zhang Z, et al. Effect of pregabalin on cerebral outcome after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats. J Thorac Cardiovasc Surg, 2014, 148(1): 298-303.
7. Liu M, Zeng Q, Li Y, et al. Neurologic recovery after deep hypothermic circulatory arrest in rats: A description of a long-term survival model without blood priming. Artif Organs, 2019, 43(6): 551-560.
8. Jungwirth B, Mackensen GB, Blobner M, et al. Neurologic outcome after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats: Description of a new model. J Thorac Cardiovasc Surg, 2006, 131(4): 805-812.
9. Engels M, Bilgic E, Pinto A, et al. A cardiopulmonary bypass with deep hypothermic circulatory arrest rat model for the investigation of the systemic inflammation response and induced organ damage. J Inflamm (Lond), 2014, 11: 26.
10. Modine T, Azzaoui R, Fayad G, et al. A recovery model of minimally invasive cardiopulmonary bypass in the rat. Perfusion, 2006, 21(2): 87-92.
11. Gourlay T, Ballaux PK, Draper ER, et al. Early experience with a new technique and technology designed for the study of pulsatile cardiopulmonary bypass in the rat. Perfusion, 2002, 17(3): 191-198.
12. Gao S, Gu T, Shi E, et al. Inhibition of long noncoding RNA growth arrest-specific 5 attenuates cerebral injury induced by deep hypothermic circulatory arrest in rats. J Thorac Cardiovasc Surg, 2019.
13. 杨波, 苏肇伉, 陈惠文. 大鼠深低温停循环模型的建立. 临床儿科杂志, 2003, 6: 368-370.
14. 田鑫, 江基尧, 邱永明, 等. 大鼠深低温停循环复苏模型的建立. 中华神经外科杂志, 2004, 20(5): 417-420.
15. You XM, Nasrallah F, Darling E, et al. Rat cardiopulmonary bypass model: Application of a miniature extracorporeal circuit composed of asanguinous prime. J Extra Corpor Technol, 2005, 37(1): 60-65.
16. Shen L, Wang J, Liu K, et al. Hydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest. Neurochem Res, 2011, 36(8): 1501-1511.
17. Gu Q, Gu H, Lu X, et al. The influence of deep hypothermic global brain ischemia on EEG in a new rat model. J Card Surg, 2012, 27(5): 612-617.
18. 朱贤, 陆龙, 赵向东, 等. 不同温度大鼠无血预充深低温停循环模型的建立. 中国体外循环杂志, 2013, 11(2): 107-110, 115.
19. Bartels K, Ma Q, Venkatraman TN, et al. Effects of deep hypothermic circulatory arrest on the blood brain barrier in a cardiopulmonary bypass model—A pilot study. Heart Lung Circ, 2014, 23(10): 981-984.
20. 李斌, 朱耀斌, 刘爱军, 等. 大鼠深低温停循环模型的建立. 中华实用诊断与治疗杂志, 2015, 29(7): 634-636.
21. 郦安琪, 徐嗣卫, 陈文超, 等. 40分钟深低温停循环大鼠长期存活模型的建立. 中华急诊医学杂志, 2019, 28(4): 484-488.
22. 张帅, 刘杨, 蒋璇, 等. 新型无血预充体外循环深低温停循环模型. 中国心血管病研究, 2020, 18(7): 647-651.
23. 王立烽, 韦冬冬, 朱贤, 等. 闭式少预充量大鼠深低温停循环模型的建立. 浙江医学, 2020, 42(8): 770-774.
24. 马晓洁, 罗璇, 张莉, 等. 延长创伤环境中暴露时间对雌雄大鼠行为差异及HPT轴的影响. 中华行为医学与脑科学杂志, 2020, 29(7): 584-588.
25. Ballaux PK, Gourlay T, Ratnatunga CP, et al. A literature review of cardiopulmonary bypass models for rats. Perfusion, 1999, 14(6): 411-417.
26. Ordodi VL, Paunescu V, Ionac M, et al. Artificial device for extracorporeal blood oxygenation in rats. Artif Organs, 2008, 32(1): 66-70.
27. Wang Y, Gu T, Shi E, et al. Inhibition of microRNA-29c protects the brain in a rat model of prolonged hypothermic circulatory arrest. J Thorac Cardiovasc Surg, 2015, 150(3): 675-684.
28. Li YA, Liu ZG, Zhang YP, et al. Differential expression profiles of circular RNAs in the rat hippocampus after deep hypothermic circulatory arrest. Artif Organs, 2021, 45(8): 866-880.
29. Chen Q, Lei YQ, Liu JF, et al. Triptolide improves neurobehavioral functions, inflammation, and oxidative stress in rats under deep hypothermic circulatory arrest. Aging (Albany NY), 2021, 13(2): 3031-3044.
30. Chen Q, Sun KP, Huang JS, et al. Resveratrol attenuates neuroinflammation after deep hypothermia with circulatory arrest in rats. Brain Res Bull, 2020, 155: 145-154.
31. Jenke A, Yazdanyar M, Miyahara S, et al. AdipoRon attenuates inflammation and impairment of cardiac function associated with cardiopulmonary bypass-induced systemic inflammatory response syndrome. J Am Heart Assoc, 2021, 10(6): e018097.
32. Shi J, Jiang X, Gao S, et al. Gene-modified exosomes protect the brain against prolonged deep hypothermic circulatory arrest. Ann Thorac Surg, 2021, 111(2): 576-585.
33. Liu M, Li Y, Gao S, et al. A novel target to reduce microglial inflammation and neuronal damage after deep hypothermic circulatory arrest. J Thorac Cardiovasc Surg, 2020, 159(6): 2431-2444.
34. Li Y, Liu M, Gao S, et al. Cold-inducible RNA-binding protein maintains intestinal barrier during deep hypothermic circulatory arrest. Interact Cardiovasc Thorac Surg, 2019, 29(4): 583-591.
35. Weber C, Jenke A, Chobanova V, et al. Targeting of cell-free DNA by DNaseⅠ diminishes endothelial dysfunction and inflammation in a rat model of cardiopulmonary bypass. Sci Rep, 2019, 9(1): 19249.
36. Jiang X, Gu T, Liu Y, et al. Protection of the rat brain from hypothermic circulatory arrest injury by a chipmunk protein. J Thorac Cardiovasc Surg, 2018, 156(2): 525-536.

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