Research progress of miR-139-5p_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

FANG Shaohan ¹ , ZHU Xiaolei ¹ , ZHANG Xiaowen ² , FENG Yihui ³ , LI Ning ¹ ,  GENG Guojun ¹

1. Department of Thoracic Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, 360000, Fujian, P. R. China;
2. Xiamen University, Xiamen, 361003, Fujian, P. R. China;
3. Fujian Medical University, Fuzhou, 350122, P. R. China;

Corresponding author：

GENG Guojun, Email: ggj622@126.com

Keywords：

MiR-139-5p; cancer; chemoradiotherapy; inflammation; review

DOI：

10.7507/1007-4848.202101103

Video：

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MicroRNAs (miRNAs) are a class of short, highly conserved, non-coding RNA molecules that regulate gene expression by specific binding to the messenger RNAs (mRNAs). At present, the researches on miRNAs have caused immense global concern, and expression of miR-139-5p plays a significant role in tumorigenesis, metastasis and recurrence, through regulating proliferation, migration, and invasion of cancer cells in lung cancer, esophageal cancer, breast cancer, tongue squamous cell carcinoma, hepatocellular carcinoma, etc. MiR-139-5p has a positive impact on the prognosis of cancer, and it can combine with some chemotherapeutic drugs to reverse resistance and enhance the sensitivity of radiotherapy. It also works in the cells and tissues of other diseases, including nerve cells, and inflammation. This article reviewed the progress of miR-139-5p.

Citation： FANG Shaohan, ZHU Xiaolei, ZHANG Xiaowen, FENG Yihui, LI Ning, GENG Guojun. Research progress of miR-139-5p. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2023, 30(1): 149-153. doi: 10.7507/1007-4848.202101103 Copy

1.	Zhang HD, Jiang LH, Sun DW, et al. MiR-139-5p: Promising biomarker for cancer. Tumour Biol, 2015, 36(3): 1355-1365.
2.	Murray MJ, Coleman N. MicroRNA dysregulation in malignant germ cell tumors: More than a biomarker? J Clin Oncol, 2019, 37(16): 1432-1435.
3.	Buchan JR, Parker R. Molecular biology. The two faces of miRNA. Science, 2007, 318(5858): 1877-1878.
4.	Svoronos AA, Engelman DM, Slack FJ. OncomiR or tumor suppressor? The duplicity of microRNAs in cancer. Cancer Res, 2016, 76(13): 3666-3670.
5.	Aghaei M, Khodadadian A, Elham KN, et al. Major miRNA involved in insulin secretion and production in beta-cells. Int J Gen Med, 2020, 13: 89-97.
6.	Heydarzadeh S, Ranjbar M, Karimi F, et al. Overview of host miRNA properties and their association with epigenetics, long non-coding RNAs, and Xeno-infectious factors. Cell Biosci, 2021, 11(1): 43.
7.	Du S, Ling H, Guo Z, et al. Roles of exosomal miRNA in vascular aging. Pharmacol Res, 2021, 165: 105278.
8.	Gizak A, Duda P, Pielka E, et al. GSK3 and miRNA in neural tissue: From brain development to neurodegenerative diseases. Biochim Biophys Acta Mol Cell Res, 2020, 1867(7): 118696.
9.	Zhao Y, Xu J, Le VM, et al. EpCAM aptamer-functionalized cationic liposome-based nanoparticles loaded with miR-139-5p for targeted therapy in colorectal cancer. Mol Pharm, 2019, 16(11): 4696-4710.
10.	Ji X, Guo H, Yin S, et al. MiR-139-5p functions as a tumor suppressor in cervical cancer by targeting TCF4 and inhibiting Wnt/β-catenin signaling. Onco Targets Ther, 2019, 12: 7739-7748.
11.	Katsumi T, Ninomiya M, Nishina T, et al. MiR-139-5p is associated with inflammatory regulation through c-FOS suppression, and contributes to the progression of primary biliary cholangitis. Lab Invest, 2016, 96(11): 1165-1177.
12.	Wei H, Huang L, Wei F, et al. Up-regulation of miR-139-5p protects diabetic mice from liver tissue damage and oxidative stress through inhibiting Notch signaling pathway. Acta Biochim Biophys Sin (Shanghai), 2020, 52(4): 390-400.
13.	Rekker K, Tasa T, Saare M, et al. Differentially-expressed miRNAs in ectopic stromal cells contribute to endometriosis development: The plausible role of miR-139-5p and miR-375. Int J Mol Sci, 2018, 19(12): 3789.
14.	张业霞, 房振亚, 李睿, 等. miR-139-5 p 和 miR-210 联合检测对子痫前期早期诊断的价值. 辽宁医学院学报, 2016, 37(6): 22-26.
15.	Huang J, Zheng L, Kong H, et al. MiR-139-5p promotes the proliferation and invasion of trophoblast cells by targeting sFlt-1 in preeclampsia. Placenta, 2020, 92: 37-43.
16.	Huang Y, Jiang J, Zheng G, et al. MiR-139-5p modulates cortical neuronal migration by targeting Lis1 in a rat model of focal cortical dysplasia. Int J Mol Med, 2014, 33(6): 1407-1414.
17.	Ming S, Shui-Yun W, Wei Q, et al. MiR-139-5p inhibits isoproterenol-induced cardiac hypertrophy by targetting c-Jun. Biosci Rep, 2018, 38(2): BSR20171430.
18.	Zhang H, Sun Z, Yu L, et al. MiR-139-5p inhibits proliferation and promoted apoptosis of human airway smooth muscle cells by downregulating the Brg1 gene. Respir Physiol Neurobiol, 2017, 246: 9-16.
19.	Long H, Sun B, Cheng L, et al. MiR-139-5p represses BMSC osteogenesis via targeting Wnt/β-catenin signaling pathway. DNA Cell Biol, 2017, 36(8): 715-724.
20.	Puyol M, Seoane J, Aguilar E, et al. World Cancer Research Day: A call to action for a coordinated international research effort to prevent, diagnose, and treat cancer. Clin Cancer Res, 2021, 27(4): 963-966.
21.	Chen J, Yu Y, Chen X, et al. MiR-139-5p is associated with poor prognosis and regulates glycolysis by repressing PKM2 in gallbladder carcinoma. Cell Prolif, 2018, 51(6): e12510.
22.	Sun C, Sang M, Li S, et al. Hsa-miR-139-5p inhibits proliferation and causes apoptosis associated with down-regulation of c-Met. Oncotarget, 2015, 6(37): 39756-39792.
23.	Hua S, Lei L, Deng L, et al. MiR-139-5p inhibits aerobic glycolysis, cell proliferation, migration, and invasion in hepatocellular carcinoma via a reciprocal regulatory interaction with ETS1. Oncogene, 2018, 37(12): 1624-1636.
24.	Yue S, Wang L, Zhang H, et al. MiR-139-5p suppresses cancer cell migration and invasion through targeting ZEB1 and ZEB2 in GBM. Tumour Biol, 2015, 36(9): 6741-6749.
25.	Wang K, Jin J, Ma T, et al. MiR-139-5p inhibits the tumorigenesis and progression of oral squamous carcinoma cells by targeting HOXA9. J Cell Mol Med, 2017, 21(12): 3730-3740.
26.	Yonemori M, Seki N, Yoshino H, et al. Dual tumor-suppressors miR-139-5p and miR-139-3p targeting matrix metalloprotease 11 in bladder cancer. Cancer Sci, 2016, 107(9): 1233-1242.
27.	Hou J, Zhuo H, Chen X, et al. MiR-139-5p negatively regulates PMP22 to repress cell proliferation by targeting the NF-κB signaling pathway in gastric cancer. Int J Biol Sci, 2020, 16(7): 1218-1229.
28.	Jiao W, Zhang J, Wei Y, et al. MiR-139-5p regulates VEGFR and downstream signaling pathways to inhibit the development of esophageal cancer. Dig Liver Dis, 2019, 51(1): 149-156.
29.	Song M, Yin Y, Zhang J, et al. MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1. Protein Cell, 2014, 5(11): 851-861.
30.	于卫芳, 韩双双, 杨雅静, 等. MicroRNA-139-5p 在结直肠癌血浆中的表达及意义. 广东医学, 2014, 35(7): 1042-1044.
31.	唐志金, 于海文, 沈华. 血清 miR-139-5p、miR-146b-5p 水平在乳腺癌诊断中的临床价值. 检验医学与临床, 2020, 17(21): 3080-3083, 3088.
32.	Fang J, Huang C, Ke J, et al. LncRNA TTN-AS1 facilitates proliferation, invasion, and epithelial-mesenchymal transition of breast cancer cells by regulating miR-139-5p/ZEB1 axis. J Cell Biochem, 2020, 121(12): 4772-4784.
33.	Pang C, Liu M, Fang W, et al. MiR-139-5p is increased in the peripheral blood of patients with prostate cancer. Cell Physiol Biochem, 2016, 39(3): 1111-1117.
34.	Liu H, Yin Y, Hu Y, et al. MiR-139-5p sensitizes colorectal cancer cells to 5-fluorouracil by targeting NOTCH-1. Pathol Res Pract, 2016, 212(7): 643-649.
35.	Giacomini I, Ragazzi E, Pasut G, et al. The pentose phosphate pathway and its involvement in cisplatin resistance. Int J Mol Sci, 2020, 21(3): 937.
36.	Jiang Y, Jiang J, Jia H, et al. Recovery of miR-139-5p in ovarian cancer reverses cisplatin resistance by targeting C-Jun. Cell Physiol Biochem, 2018, 51(1): 129-141.
37.	Huang N, Guo W, Ren K, et al. LncRNA AFAP1-AS1 supresses miR-139-5p and promotes cell proliferation and chemotherapy resistance of non-small cell lung cancer by competitively upregulating RRM2. Front Oncol, 2019, 9: 1103.
38.	Xiu D, Liu L, Cheng M, et al. Knockdown of lncRNA TUG1 enhances radiosensitivity of prostate cancer via the TUG1/miR-139-5p/SMC1A axis. Onco Targets Ther, 2020, 13: 2319-2331.
39.	Pajic M, Froio D, Daly S, et al. MiR-139-5p modulates radiotherapy resistance in breast cancer by repressing multiple gene networks of DNA repair and ROS defense. Cancer Res, 2018, 78(2): 501-515.
40.	Branco ACCC, Yoshikawa FSY, Pietrobon AJ, et al. Role of histamine in modulating the immune response and inflammation. Mediators Inflamm, 2018, 2018: 9524075.
41.	Zou F, Mao R, Yang L, et al. Targeted deletion of miR-139-5p activates MAPK, NF-κB and STAT3 signaling and promotes intestinal inflammation and colorectal cancer. FEBS J, 2016, 283(8): 1438-1452.
42.	Yao L, Xu B, Li X. Neisseria gonorrhoeae-induced salpingitis is targeted by circular RNA EIF3K via miR-139-5p and regulating MAPK/NF-κB signaling pathway to promotes apoptosis and autophagy bacterial cells. Microb Pathog, 2020, 142: 104051.
43.	Petersmann A, Nauck M, Müller-Wieland D, et al. Definition, classification and diagnosis of diabetes mellitus. Exp Clin Endocrinol Diabetes, 2018, 126(7): 406-410.
44.	Li J, Su L, Gong YY, et al. Downregulation of miR-139-5p contributes to the antiapoptotic effect of liraglutide on the diabetic rat pancreas and INS-1 cells by targeting IRS1. PLoS One, 2017, 12(3): e0173576.
45.	Wang Y, Sun H, Song J, et al. MiR-139-5p protect against myocardial ischemia and reperfusion (I/R) injury by targeting autophagy-related 4D and inhibiting AMPK/mTOR/ULK1 pathway. Int J Clin Exp Pathol, 2017, 10(9): 10140-10151.
46.	Qu Y, Wu J, Chen D, et al. MiR-139-5p inhibits HGTD-P and regulates neuronal apoptosis induced by hypoxia-ischemia in neonatal rats. Neurobiol Dis, 2014, 63: 184-193.
47.	Wei ZX, Xie GJ, Mao X, et al. Exosomes from patients with major depression cause depressive-like behaviors in mice with involvement of miR-139-5p-regulated neurogenesis. Neuro-psychopharmacology, 2020, 45(6): 1050-1058.

1. Zhang HD, Jiang LH, Sun DW, et al. MiR-139-5p: Promising biomarker for cancer. Tumour Biol, 2015, 36(3): 1355-1365.
2. Murray MJ, Coleman N. MicroRNA dysregulation in malignant germ cell tumors: More than a biomarker? J Clin Oncol, 2019, 37(16): 1432-1435.
3. Buchan JR, Parker R. Molecular biology. The two faces of miRNA. Science, 2007, 318(5858): 1877-1878.
4. Svoronos AA, Engelman DM, Slack FJ. OncomiR or tumor suppressor? The duplicity of microRNAs in cancer. Cancer Res, 2016, 76(13): 3666-3670.
5. Aghaei M, Khodadadian A, Elham KN, et al. Major miRNA involved in insulin secretion and production in beta-cells. Int J Gen Med, 2020, 13: 89-97.
6. Heydarzadeh S, Ranjbar M, Karimi F, et al. Overview of host miRNA properties and their association with epigenetics, long non-coding RNAs, and Xeno-infectious factors. Cell Biosci, 2021, 11(1): 43.
7. Du S, Ling H, Guo Z, et al. Roles of exosomal miRNA in vascular aging. Pharmacol Res, 2021, 165: 105278.
8. Gizak A, Duda P, Pielka E, et al. GSK3 and miRNA in neural tissue: From brain development to neurodegenerative diseases. Biochim Biophys Acta Mol Cell Res, 2020, 1867(7): 118696.
9. Zhao Y, Xu J, Le VM, et al. EpCAM aptamer-functionalized cationic liposome-based nanoparticles loaded with miR-139-5p for targeted therapy in colorectal cancer. Mol Pharm, 2019, 16(11): 4696-4710.
10. Ji X, Guo H, Yin S, et al. MiR-139-5p functions as a tumor suppressor in cervical cancer by targeting TCF4 and inhibiting Wnt/β-catenin signaling. Onco Targets Ther, 2019, 12: 7739-7748.
11. Katsumi T, Ninomiya M, Nishina T, et al. MiR-139-5p is associated with inflammatory regulation through c-FOS suppression, and contributes to the progression of primary biliary cholangitis. Lab Invest, 2016, 96(11): 1165-1177.
12. Wei H, Huang L, Wei F, et al. Up-regulation of miR-139-5p protects diabetic mice from liver tissue damage and oxidative stress through inhibiting Notch signaling pathway. Acta Biochim Biophys Sin (Shanghai), 2020, 52(4): 390-400.
13. Rekker K, Tasa T, Saare M, et al. Differentially-expressed miRNAs in ectopic stromal cells contribute to endometriosis development: The plausible role of miR-139-5p and miR-375. Int J Mol Sci, 2018, 19(12): 3789.
14. 张业霞, 房振亚, 李睿, 等. miR-139-5 p 和 miR-210 联合检测对子痫前期早期诊断的价值. 辽宁医学院学报, 2016, 37(6): 22-26.
15. Huang J, Zheng L, Kong H, et al. MiR-139-5p promotes the proliferation and invasion of trophoblast cells by targeting sFlt-1 in preeclampsia. Placenta, 2020, 92: 37-43.
16. Huang Y, Jiang J, Zheng G, et al. MiR-139-5p modulates cortical neuronal migration by targeting Lis1 in a rat model of focal cortical dysplasia. Int J Mol Med, 2014, 33(6): 1407-1414.
17. Ming S, Shui-Yun W, Wei Q, et al. MiR-139-5p inhibits isoproterenol-induced cardiac hypertrophy by targetting c-Jun. Biosci Rep, 2018, 38(2): BSR20171430.
18. Zhang H, Sun Z, Yu L, et al. MiR-139-5p inhibits proliferation and promoted apoptosis of human airway smooth muscle cells by downregulating the Brg1 gene. Respir Physiol Neurobiol, 2017, 246: 9-16.
19. Long H, Sun B, Cheng L, et al. MiR-139-5p represses BMSC osteogenesis via targeting Wnt/β-catenin signaling pathway. DNA Cell Biol, 2017, 36(8): 715-724.
20. Puyol M, Seoane J, Aguilar E, et al. World Cancer Research Day: A call to action for a coordinated international research effort to prevent, diagnose, and treat cancer. Clin Cancer Res, 2021, 27(4): 963-966.
21. Chen J, Yu Y, Chen X, et al. MiR-139-5p is associated with poor prognosis and regulates glycolysis by repressing PKM2 in gallbladder carcinoma. Cell Prolif, 2018, 51(6): e12510.
22. Sun C, Sang M, Li S, et al. Hsa-miR-139-5p inhibits proliferation and causes apoptosis associated with down-regulation of c-Met. Oncotarget, 2015, 6(37): 39756-39792.
23. Hua S, Lei L, Deng L, et al. MiR-139-5p inhibits aerobic glycolysis, cell proliferation, migration, and invasion in hepatocellular carcinoma via a reciprocal regulatory interaction with ETS1. Oncogene, 2018, 37(12): 1624-1636.
24. Yue S, Wang L, Zhang H, et al. MiR-139-5p suppresses cancer cell migration and invasion through targeting ZEB1 and ZEB2 in GBM. Tumour Biol, 2015, 36(9): 6741-6749.
25. Wang K, Jin J, Ma T, et al. MiR-139-5p inhibits the tumorigenesis and progression of oral squamous carcinoma cells by targeting HOXA9. J Cell Mol Med, 2017, 21(12): 3730-3740.
26. Yonemori M, Seki N, Yoshino H, et al. Dual tumor-suppressors miR-139-5p and miR-139-3p targeting matrix metalloprotease 11 in bladder cancer. Cancer Sci, 2016, 107(9): 1233-1242.
27. Hou J, Zhuo H, Chen X, et al. MiR-139-5p negatively regulates PMP22 to repress cell proliferation by targeting the NF-κB signaling pathway in gastric cancer. Int J Biol Sci, 2020, 16(7): 1218-1229.
28. Jiao W, Zhang J, Wei Y, et al. MiR-139-5p regulates VEGFR and downstream signaling pathways to inhibit the development of esophageal cancer. Dig Liver Dis, 2019, 51(1): 149-156.
29. Song M, Yin Y, Zhang J, et al. MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1. Protein Cell, 2014, 5(11): 851-861.
30. 于卫芳, 韩双双, 杨雅静, 等. MicroRNA-139-5p 在结直肠癌血浆中的表达及意义. 广东医学, 2014, 35(7): 1042-1044.
31. 唐志金, 于海文, 沈华. 血清 miR-139-5p、miR-146b-5p 水平在乳腺癌诊断中的临床价值. 检验医学与临床, 2020, 17(21): 3080-3083, 3088.
32. Fang J, Huang C, Ke J, et al. LncRNA TTN-AS1 facilitates proliferation, invasion, and epithelial-mesenchymal transition of breast cancer cells by regulating miR-139-5p/ZEB1 axis. J Cell Biochem, 2020, 121(12): 4772-4784.
33. Pang C, Liu M, Fang W, et al. MiR-139-5p is increased in the peripheral blood of patients with prostate cancer. Cell Physiol Biochem, 2016, 39(3): 1111-1117.
34. Liu H, Yin Y, Hu Y, et al. MiR-139-5p sensitizes colorectal cancer cells to 5-fluorouracil by targeting NOTCH-1. Pathol Res Pract, 2016, 212(7): 643-649.
35. Giacomini I, Ragazzi E, Pasut G, et al. The pentose phosphate pathway and its involvement in cisplatin resistance. Int J Mol Sci, 2020, 21(3): 937.
36. Jiang Y, Jiang J, Jia H, et al. Recovery of miR-139-5p in ovarian cancer reverses cisplatin resistance by targeting C-Jun. Cell Physiol Biochem, 2018, 51(1): 129-141.
37. Huang N, Guo W, Ren K, et al. LncRNA AFAP1-AS1 supresses miR-139-5p and promotes cell proliferation and chemotherapy resistance of non-small cell lung cancer by competitively upregulating RRM2. Front Oncol, 2019, 9: 1103.
38. Xiu D, Liu L, Cheng M, et al. Knockdown of lncRNA TUG1 enhances radiosensitivity of prostate cancer via the TUG1/miR-139-5p/SMC1A axis. Onco Targets Ther, 2020, 13: 2319-2331.
39. Pajic M, Froio D, Daly S, et al. MiR-139-5p modulates radiotherapy resistance in breast cancer by repressing multiple gene networks of DNA repair and ROS defense. Cancer Res, 2018, 78(2): 501-515.
40. Branco ACCC, Yoshikawa FSY, Pietrobon AJ, et al. Role of histamine in modulating the immune response and inflammation. Mediators Inflamm, 2018, 2018: 9524075.
41. Zou F, Mao R, Yang L, et al. Targeted deletion of miR-139-5p activates MAPK, NF-κB and STAT3 signaling and promotes intestinal inflammation and colorectal cancer. FEBS J, 2016, 283(8): 1438-1452.
42. Yao L, Xu B, Li X. Neisseria gonorrhoeae-induced salpingitis is targeted by circular RNA EIF3K via miR-139-5p and regulating MAPK/NF-κB signaling pathway to promotes apoptosis and autophagy bacterial cells. Microb Pathog, 2020, 142: 104051.
43. Petersmann A, Nauck M, Müller-Wieland D, et al. Definition, classification and diagnosis of diabetes mellitus. Exp Clin Endocrinol Diabetes, 2018, 126(7): 406-410.
44. Li J, Su L, Gong YY, et al. Downregulation of miR-139-5p contributes to the antiapoptotic effect of liraglutide on the diabetic rat pancreas and INS-1 cells by targeting IRS1. PLoS One, 2017, 12(3): e0173576.
45. Wang Y, Sun H, Song J, et al. MiR-139-5p protect against myocardial ischemia and reperfusion (I/R) injury by targeting autophagy-related 4D and inhibiting AMPK/mTOR/ULK1 pathway. Int J Clin Exp Pathol, 2017, 10(9): 10140-10151.
46. Qu Y, Wu J, Chen D, et al. MiR-139-5p inhibits HGTD-P and regulates neuronal apoptosis induced by hypoxia-ischemia in neonatal rats. Neurobiol Dis, 2014, 63: 184-193.
47. Wei ZX, Xie GJ, Mao X, et al. Exosomes from patients with major depression cause depressive-like behaviors in mice with involvement of miR-139-5p-regulated neurogenesis. Neuro-psychopharmacology, 2020, 45(6): 1050-1058.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Research progress of miR-139-5p

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