• 1. Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China;
  • 2. West China School of Medicine, Sichuan University, Chengdu, 610041, P. R. China;
  • 3. West China School of Stomatology, Sichuan University, Chengdu, 610041, P. R. China;
QIAN Yongjun, Email: qianyongjun@scu.edu.cn
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Reactive oxygen species (ROS) play an important role in the pathogenesis of various cardiovascular diseases, by leading to cell apoptosis and thus causing organic injuries. Anti-ROS therapy is highly anticipated, but currently, there is still no appropriate prevention method. Studies have shown that thioredoxin (Trx), being a kind of significant endogenous antioxidant system, has excellent antioxidant capacity. Promotion of Trx can reduce key biomolecules to eliminate ROS or regulate many signaling pathways, thus resisting ROS injuries, which may be a new anti-ROS strategy. Therefore, we reviewed the research progress of Trx in cardiac antioxidant therapy to discuss its potential and possibility to be a target for prevention of heart-related ROS injury.

Citation: SUN Yiren, YANG Ziqi, WANG Xinran, QIAN Yongjun. Thioredoxin-1: A potential target for prevention of heart-related reactive oxygen species injury. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2023, 30(12): 1779-1783. doi: 10.7507/1007-4848.202203025 Copy

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