Thymoma complicated with polymyositis and myasthenia gravis: A case report_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

YAN Dongqing , YIN Yin , WANG Peijie ,  LI Yun

Department of Thoracic Surgery, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518107, Guangdong, P. R. China;

Corresponding author：

LI Yun, Email: liyun28@mail.sysu.edu.cn

Keywords：

Thymoma; polymyositis; myasthenia gravis; electromyography; muscle enzymes; case report

DOI：

10.7507/1007-4848.202210026

Video：

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Abstract Full text Figures/Tables Video References Cited by

Thymoma complicated with polymyositis and myasthenia gravis is a rare case, which can be clearly diagnosed and given symptomatic treatment according to its own diagnostic criteria, imaging and laboratory examinations. This paper reports the clinical data of a thymoma patient with polymyositis and myasthenia gravis admitted to the Seventh Affiliated Hospital of Sun Yat-Sen University, and discusses the possible pathogenesis and treatment methods.

Citation： YAN Dongqing, YIN Yin, WANG Peijie, LI Yun. Thymoma complicated with polymyositis and myasthenia gravis: A case report. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2023, 30(6): 924-926. doi: 10.7507/1007-4848.202210026 Copy

1.	李明明, 郭健, 张卫东. 胸腺瘤合并单纯红细胞再生障碍性贫血一例. 天津医药, 2009, 37(1): 42.
2.	魏建新, 朱海文, 姚化建. 胸腺瘤合并单纯红细胞再生障碍性贫血临床特点 (附3例报告). 河南外科学杂志, 2009, 15(1): 2-4.
3.	曹丽, 肖毅, 周剑峰, 等. 胸腺瘤合并T淋巴母细胞淋巴瘤1例报告. 肿瘤防治研究, 2010, 37(11): 1334.
4.	陶学濂, 张乃峥. 胸腺瘤与自身免疫病 (附1例报告). 北京医学, 1986, (6): 330-368.
5.	Lin J, Lu J, Zhao C, et al. Giant cell polymyositis associated with myasthenia gravis and thymoma. J Clin Neurosci, 2014, 21(12): 2252-2254.
6.	Finsterer J, Stöllberger C, Ho CY. Respiratory insufficiency from myasthenia gravis and polymyositis due to malignant thymoma triggering Takotsubo syndrome. Int J Neurosci, 2018, 128(12): 1207-1210.
7.	赵玉月, 彭琳一, 费允云, 等. 多发性肌炎合并重症肌无力三例报告并文献复习. 中华全科医师杂志, 2016, 15(5): 387-390.
8.	Shelton GD, Calcutt NA, Garrett RS, et al. Necrotizing myopathy induced by overexpression of interferon-gamma in transgenic mice. Muscle Nerve, 1999, 22(2): 156-165.
9.	Gilhus NE, Aarli JA, Matre R. Myasthenia gravis. Antibodies to skeletal muscle cell surface antigens. J Neuroimmunol, 1983, 5(3): 239-249.
10.	Skeie GO, Romi F, Aarli JA, et al. Pathogenesis of myositis and myasthenia associated with titin and ryanodine receptor antibodies. Ann N Y Acad Sci, 2003, 998: 343-350.
11.	操亚云, 桂梦翠, 季苏琼, 等. 重症肌无力合并多发性肌炎两例临床分析并文献复习. 中国神经免疫学和神经病学杂志, 2017, 24(3): 193-196.
12.	宇佳利, 王磊, 冯枫, 等. 多发性肌炎合并重症肌无力1例报告. 中华医学会第十八次全国神经病学学术会议论文汇编 (下), 2015: 2.
13.	National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: Thymomas and thymic carcinomas version 1.2020. URL: https://www.nccn.org.
14.	中华医学会神经病学分会神经免疫学组, 中国免疫学会神经免疫学分会. 中国重症肌无力诊断和治疗指南2015. 中华神经科杂志, 2015, 48(11): 934-940.

1. 李明明, 郭健, 张卫东. 胸腺瘤合并单纯红细胞再生障碍性贫血一例. 天津医药, 2009, 37(1): 42.
2. 魏建新, 朱海文, 姚化建. 胸腺瘤合并单纯红细胞再生障碍性贫血临床特点 (附3例报告). 河南外科学杂志, 2009, 15(1): 2-4.
3. 曹丽, 肖毅, 周剑峰, 等. 胸腺瘤合并T淋巴母细胞淋巴瘤1例报告. 肿瘤防治研究, 2010, 37(11): 1334.
4. 陶学濂, 张乃峥. 胸腺瘤与自身免疫病 (附1例报告). 北京医学, 1986, (6): 330-368.
5. Lin J, Lu J, Zhao C, et al. Giant cell polymyositis associated with myasthenia gravis and thymoma. J Clin Neurosci, 2014, 21(12): 2252-2254.
6. Finsterer J, Stöllberger C, Ho CY. Respiratory insufficiency from myasthenia gravis and polymyositis due to malignant thymoma triggering Takotsubo syndrome. Int J Neurosci, 2018, 128(12): 1207-1210.
7. 赵玉月, 彭琳一, 费允云, 等. 多发性肌炎合并重症肌无力三例报告并文献复习. 中华全科医师杂志, 2016, 15(5): 387-390.
8. Shelton GD, Calcutt NA, Garrett RS, et al. Necrotizing myopathy induced by overexpression of interferon-gamma in transgenic mice. Muscle Nerve, 1999, 22(2): 156-165.
9. Gilhus NE, Aarli JA, Matre R. Myasthenia gravis. Antibodies to skeletal muscle cell surface antigens. J Neuroimmunol, 1983, 5(3): 239-249.
10. Skeie GO, Romi F, Aarli JA, et al. Pathogenesis of myositis and myasthenia associated with titin and ryanodine receptor antibodies. Ann N Y Acad Sci, 2003, 998: 343-350.
11. 操亚云, 桂梦翠, 季苏琼, 等. 重症肌无力合并多发性肌炎两例临床分析并文献复习. 中国神经免疫学和神经病学杂志, 2017, 24(3): 193-196.
12. 宇佳利, 王磊, 冯枫, 等. 多发性肌炎合并重症肌无力1例报告. 中华医学会第十八次全国神经病学学术会议论文汇编 (下), 2015: 2.
13. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: Thymomas and thymic carcinomas version 1.2020. URL: https://www.nccn.org.
14. 中华医学会神经病学分会神经免疫学组, 中国免疫学会神经免疫学分会. 中国重症肌无力诊断和治疗指南2015. 中华神经科杂志, 2015, 48(11): 934-940.

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