Vasoactive Intestinal Peptide Secreting Tumors: Report of 1 Case and Retrospective Analysis of Data in Literatures_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 岳鹏举 , 苏安平 , 张懿 , 杨敏 , 王力 ,  田伯乐

四川大学华西医院胰腺外科（四川成都 610041）;

Corresponding author：

田伯乐, Email: bo-le@medmail.com.cn

Keywords：

胰腺神经内分泌肿瘤; 血管活性肠肽; 血管活性肠肽瘤

DOI：

10.7507/1007-9424.20140118

Video：

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Abstract Full text Figures/Tables Video References Cited by

目的探讨胰腺血管活性肠肽瘤（VIPoma）的临床、实验室和影像学特点，以及诊断方法和治疗手段。方法报道1例胰腺VIPoma，同时检索国内文献得到49例胰腺VIPoma患者临床资料，并对此50例病例进行分析。结果分泌性腹泻、低血钾和代谢性酸中毒是胰腺VIPoma的主要临床表现，血浆血管活性肠肽（VIP）水平增高具有诊断价值。经手术治疗，腹泻症状可减轻或消失；对于远处转移患者，生长抑素、化疗、干扰素等治疗均有效。结论 VIPoma早期诊断困难，确诊依赖于典型临床症状、血浆VIP水平、影像学检查以及免疫组化检查。手术切除可改善预后，生长抑素等治疗可缓解症状，发生转移者也应积极治疗。

Citation： 岳鹏举, 苏安平, 张懿, 杨敏, 王力, 田伯乐. Vasoactive Intestinal Peptide Secreting Tumors: Report of 1 Case and Retrospective Analysis of Data in Literatures. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(4): 488-491. doi: 10.7507/1007-9424.20140118 Copy

1.	Amir A, Ghaferi KA, Chojnacki WD, et al. Pancreatic VIPomas:subject review and one institutional experience[J]. J Gastrointest Surg, 2008, 12(2):382-393.
2.	Verner JV, Morrison AB. Islet cell tumor and a syndrome of refractory diarrhoea and hypokalemia[J]. Am J Med, 1958, 25(3):374-380.
3.	陈家伟, 何戎华, 薛婉芬.胰性霍乱[J].中华内科杂志, 1977, 2(6):387-388.
4.	王祖森, 吴力群, 赫建帅, 等.胰腺血管活性肠肽瘤1例报告暨国内文献复习[J].中国普通外科杂志, 2010, 19(3):330-332.
5.	Kane MG, O'Dorisio TM, Krejs GJ. Production of secretory diarrhea by intravenous infusion of vasoactive intestinal polypeptide[J]. N Engl J Med, 1983, 309(24):1482-1485.
6.	Cynthia Ro, Wanxing Chai, Victoria E. Yu, et al. Pancreatic neuroendocrine tumors:biology, diagnosis, and treatment[J]. Chin J Cancer, 2013, 32(6):312-324.
7.	Adam N, Lim SS, Ananda V, et al. VIPoma syndrome:challen-ges in management[J]. Singapore Med J, 2010, 51(7):e129-e132.
8.	Brunt LM, Mazoujian G, O'Dorisio TM, et al. Stimulation of vasoactive intestinal peptide and neurotensin secretion by pentagastrin in a patient with VIPoma syndrome[J]. Surgery, 1994, 115(3):362-369.
9.	Legmann P, Vignaux O'Dousset B, et al. Pancreatic tumors:comparison of dual-phase helical CT and endoscopic sonography[J]. Am J Roentgenol, 1998, 170(5):1315-1322.
10.	Sofka CM, Semelka RC, Marcos HB, et al. MR imaging of metastatic pancreatic VIPoma[J]. Magn Reson Imaging, 1997, 15(10):1205-1208.
11.	Thomason JW, Martin RS, Fincher ME. Somatostatin receptor scintigraphy:the definitive technique for characterizing vasoactive intestinal peptide-secreting tumors[J]. Clin Nucl Med, 2000, 25(9):661-664.
12.	Nikou GC, Toubanakis C, Nikolaou P, et al. VIPomas:an update in diagnosis and management in a series of 11 patients[J]. Hepatogastroenterology, 2005, 52(64):1259-1265.
13.	Remme CA, de Groot GH, Schrijver G. Diagnosis and treatment of VIPoma in a female patient[J]. Eur J Gastroenterol Hepatol, 2006, 18(1):93-99.
14.	Kulke MH, Anthony LB, Bushnell DL, et al. NANETS treatment guidelines:well-differentiated neuroendocrine tumors of the stomach and pancreas[J]. Pancreas, 2010, 39(6):735-752.
15.	Shaib W, Mitchell K, Saif MW. Amelioration of symptoms and reduction of VIP levels after hepatic artery chemoembolization in a patient with sandostatin resistant VIPoma[J]. Yale J Biol Med, 2010, 83(1):27-33.
16.	Johnston PC, Ardill JE, Johnston BT, et al. Vasoactive intestinal polypeptide secreting pancreatic tumour with hepatic metastases:long term survival after orthotopic liver transplantation[J]. Ir J Med Sci, 2010, 179(3):439-441.
17.	Soga J, Yakuwa Y. VIPoma/diarrheogenic syndrome:a statistical evaluation of 241 reported cases[J]. J Exp Clin Cancer Res, 1998, 17(4):389-400.

1. Amir A, Ghaferi KA, Chojnacki WD, et al. Pancreatic VIPomas:subject review and one institutional experience[J]. J Gastrointest Surg, 2008, 12(2):382-393.
2. Verner JV, Morrison AB. Islet cell tumor and a syndrome of refractory diarrhoea and hypokalemia[J]. Am J Med, 1958, 25(3):374-380.
3. 陈家伟, 何戎华, 薛婉芬.胰性霍乱[J].中华内科杂志, 1977, 2(6):387-388.
4. 王祖森, 吴力群, 赫建帅, 等.胰腺血管活性肠肽瘤1例报告暨国内文献复习[J].中国普通外科杂志, 2010, 19(3):330-332.
5. Kane MG, O'Dorisio TM, Krejs GJ. Production of secretory diarrhea by intravenous infusion of vasoactive intestinal polypeptide[J]. N Engl J Med, 1983, 309(24):1482-1485.
6. Cynthia Ro, Wanxing Chai, Victoria E. Yu, et al. Pancreatic neuroendocrine tumors:biology, diagnosis, and treatment[J]. Chin J Cancer, 2013, 32(6):312-324.
7. Adam N, Lim SS, Ananda V, et al. VIPoma syndrome:challen-ges in management[J]. Singapore Med J, 2010, 51(7):e129-e132.
8. Brunt LM, Mazoujian G, O'Dorisio TM, et al. Stimulation of vasoactive intestinal peptide and neurotensin secretion by pentagastrin in a patient with VIPoma syndrome[J]. Surgery, 1994, 115(3):362-369.
9. Legmann P, Vignaux O'Dousset B, et al. Pancreatic tumors:comparison of dual-phase helical CT and endoscopic sonography[J]. Am J Roentgenol, 1998, 170(5):1315-1322.
10. Sofka CM, Semelka RC, Marcos HB, et al. MR imaging of metastatic pancreatic VIPoma[J]. Magn Reson Imaging, 1997, 15(10):1205-1208.
11. Thomason JW, Martin RS, Fincher ME. Somatostatin receptor scintigraphy:the definitive technique for characterizing vasoactive intestinal peptide-secreting tumors[J]. Clin Nucl Med, 2000, 25(9):661-664.
12. Nikou GC, Toubanakis C, Nikolaou P, et al. VIPomas:an update in diagnosis and management in a series of 11 patients[J]. Hepatogastroenterology, 2005, 52(64):1259-1265.
13. Remme CA, de Groot GH, Schrijver G. Diagnosis and treatment of VIPoma in a female patient[J]. Eur J Gastroenterol Hepatol, 2006, 18(1):93-99.
14. Kulke MH, Anthony LB, Bushnell DL, et al. NANETS treatment guidelines:well-differentiated neuroendocrine tumors of the stomach and pancreas[J]. Pancreas, 2010, 39(6):735-752.
15. Shaib W, Mitchell K, Saif MW. Amelioration of symptoms and reduction of VIP levels after hepatic artery chemoembolization in a patient with sandostatin resistant VIPoma[J]. Yale J Biol Med, 2010, 83(1):27-33.
16. Johnston PC, Ardill JE, Johnston BT, et al. Vasoactive intestinal polypeptide secreting pancreatic tumour with hepatic metastases:long term survival after orthotopic liver transplantation[J]. Ir J Med Sci, 2010, 179(3):439-441.
17. Soga J, Yakuwa Y. VIPoma/diarrheogenic syndrome:a statistical evaluation of 241 reported cases[J]. J Exp Clin Cancer Res, 1998, 17(4):389-400.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Vasoactive Intestinal Peptide Secreting Tumors: Report of 1 Case and Retrospective Analysis of Data in Literatures

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