Ultrasonography Features of Primary Thyroid Non-Hodgkin Lymphoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 YANGPan ¹ , SUNYing-he ² ,  MABu-yun ¹ , JINYa ¹ , ZHOUJie-hong ¹ , PENGYu-lan ¹

1. Department of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;
2. Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding author：

MABu-yun, Email: ws_mby@126.com

Keywords：

Thyroid non-hodgkin lymphoma; Primary neoplasm; Ultrasonography

DOI：

10.7507/1007-9424.20140263

Video：

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Objective To investigate ultrasonography features of primary thyroid non-Hodgkin lymphoma (PT-NHL). Methods Ultrasonographic data of patients with PT-NHL(PT-NHL group) and non-Hodgkin lymphoma (control group) who were treated in our hospital from May. 2002 to Jul. 2014 were collected and analyzed. Results Compared with control group, enhancement of posterior echoes was more common in PT-NHL group (P=0.000), and difference values of transverse diameters, anteroposterior diameters, and sagittal diameters of more involved lobe to another lobe were bigger(P < 0.05), but echo pattern of gland, ultrasonographic classification of lesions, classification of vascularity, and condition of cervical lymph nodes were found no statistical difference(P > 0.05). In patients with nodular-type lesions(37 patients in PT-NHL group and 12 patients in control group), length of nodule lesions was larger in PT-NHL group (P=0.000), but there was no statistical difference in shape, boundary, orientation, and echoes of nodules between 2 groups(P > 0.05). In Pulsed-Wave(PW) Doppler between 2 groups(17 patients in PT-NHL group and 4 patients in control group), vascular resistance index(RI) was higher in PT-NHL group than those of control group (P=0.024). Conclusion The enhancement of posterior echoes was a feature in ultrasonography images of PT-NHL. Asymmetrical volume, high value of RI, and big nodule might link to PT-NHL, but diffuse heterogeneous echo with hypoechoic lesions might result in wrong diagnosis as PT-NHL.

Citation： YANGPan, SUNYing-he, MABu-yun, JINYa, ZHOUJie-hong, PENGYu-lan. Ultrasonography Features of Primary Thyroid Non-Hodgkin Lymphoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(9): 1092-1096. doi: 10.7507/1007-9424.20140263 Copy

1.	岑溪南, 马明信, 郭辉, 等.原发结外淋巴瘤139例临床及误诊分析[J]. 北京大学学报:医学版, 2003, 35(2):143-145.
2.	Al Diab AR, Aleem A, Qayum A, et al.Clinico-pathological pattern of extranodal non-Hodgkin's lymphoma in Saudi Arabia[J]. Asian Pac J Cancer Prev, 2011, 12(12):3277-3282.
3.	徐义全, 青晓艳, 樊晋川, 等.四川省肿瘤医院2002至2011年全身麻醉甲状腺恶性肿瘤患者临床病理学分析[J/CD]. 中华临床医师杂志:电子版, 2013, 7(7):2842-2846.
4.	崔俊生, 陈桂秋, 倪劲松, 等.不同年代甲状腺恶性肿瘤构成分析(附1011例病理报告)[J]. 中国实用外科杂志, 2004, 24(10):600-602.
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11.	张廷令.原发性甲状腺淋巴瘤:Mayo临床中心到1978年的经验复习[J]. 国外医学外科学分册, 1981, (4):225-226.
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14.	李昌幼, 罗佐杰.原发性甲状腺淋巴瘤的发病机制及诊治现状[J]. 实用医学杂志, 2013, 29(3):341-342.
15.	Ben-Ezra J, Wu A, Sheibani K.Hashimoto's thyroiditis lacks detectable clonal immunoglobulin and T cell receptor gene rearrangements[J]. Hum Pathol, 1988, 19(12):1444-1448.
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18.	Green LD, Mack L, Pasieka JL.Anaplastic thyroid cancer and primary thyroid lymphoma:a review of these rare thyroid malignancies[J]. J Surg Oncol, 2006, 94(8):725-736.
19.	Meusers P, Elo B, Wittig A, et al.Diagnosis and treatment of primary malignant lymphoma of the thyroid gland[J].Chinese-German J Clin Oncol,2003,2(4):219-223.
20.	Sun TQ, Zhu XL, Wang ZY, et al.Characteristics and prognosis of primary thyroid non-Hodgkin's lymphoma in Chinese patients[J]. J Surg Oncol, 2010, 101(7):545-550.
21.	朱坚, 费健.原发性甲状腺淋巴瘤的诊断和治疗分析[J]. 外科理论与实践, 2013, 18(2):156-158.
22.	孙治君, 姚榛祥, 管小琴.甲状腺原发性恶性淋巴瘤的诊断与治疗(附7例报告)[J]. 中国普外基础与临床杂志, 2003, 10(4):393-394.
23.	章美武, 陈赛君.原发性甲状腺淋巴瘤的超声表现[J]. 现代实用医学, 2012, 24(12):1377-1378.
24.	杨丽娟, 母义明, 胡翠宁, 等.11例原发性甲状腺淋巴瘤的超声表现[J]. 中国病案, 2013, 14(11):74-75.
25.	骆惊涛, 魏玺, 张仑.原发性甲状腺淋巴瘤的超声表现病理及其他影像学特征分析[J]. 中国肿瘤临床, 2014, 41(2):123-126.
26.	彭晓琼, 苏新良, 蒲大容, 等.原发性甲状腺恶性淋巴瘤的常规超声及超声造影表现[J]. 临床超声医学杂志, 2013, 15(7):488-490.
27.	宋琳琳, 詹维伟, 周建桥, 等.浅表器官结外淋巴瘤的超声表现[J]. 诊断学理论与实践, 2012, 11(5):471-475.
28.	李鹏, 张惠.高频超声诊断原发性甲状腺淋巴瘤[J]. 中国医学影像技术, 2012, 28(12):2269-2270.

1. 岑溪南, 马明信, 郭辉, 等.原发结外淋巴瘤139例临床及误诊分析[J]. 北京大学学报:医学版, 2003, 35(2):143-145.
2. Al Diab AR, Aleem A, Qayum A, et al.Clinico-pathological pattern of extranodal non-Hodgkin's lymphoma in Saudi Arabia[J]. Asian Pac J Cancer Prev, 2011, 12(12):3277-3282.
3. 徐义全, 青晓艳, 樊晋川, 等.四川省肿瘤医院2002至2011年全身麻醉甲状腺恶性肿瘤患者临床病理学分析[J/CD]. 中华临床医师杂志:电子版, 2013, 7(7):2842-2846.
4. 崔俊生, 陈桂秋, 倪劲松, 等.不同年代甲状腺恶性肿瘤构成分析(附1011例病理报告)[J]. 中国实用外科杂志, 2004, 24(10):600-602.
5. Dayan CM, Daniels GH.Chronic autoimmune thyroiditis[J]. N Eng J Med, 1996, 335(2):99-107.
6. 喻建军, 曾亮, 周晓, 等.原发性甲状腺淋巴瘤误诊分析[J]. 中国耳鼻咽喉头颈外科, 2008, 15(1):25-27.
7. Campo E, Swerdlow SH, Harris NL, et al.The 2008 WHO classification of lymphoid neoplasms and beyond:evolving concepts and practical applications[J]. Blood, 2011, 117(19):5019-5032.
8. Ota H, Ito Y, Matsuzuka F, et al.Usefulness of ultrasonography for diagnosis of malignant lymphoma of the thyroid[J]. Thyroid, 2006, 16(10):983-987.
9. Ma B, Jia Y, Wang Q, et al.Ultrasound of primary thyroid non-Hodgkin's lymphoma[J]. Clin Imaging, 2014, 38(5):621-626.
10. Walsh S, Lowery AJ, Evoy D, et al.Thyroid lymphoma:recent advances in diagnosis and optimal management strategies[J]. Oncologist, 2013, 18(9):994-1003.
11. 张廷令.原发性甲状腺淋巴瘤:Mayo临床中心到1978年的经验复习[J]. 国外医学外科学分册, 1981, (4):225-226.
12. Sarinah B, Hisham AN.Primary lymphoma of the thyroid:diagnostic and therapeutic considerations[J]. Asian J Surg, 2010, 33(1):20-24.
13. Ahmed R, Al-Shaikh S, Akhtar M.Hashimoto thyroiditis:a century later[J]. Adv Anat Pathol, 2012, 19(3):181-186.
14. 李昌幼, 罗佐杰.原发性甲状腺淋巴瘤的发病机制及诊治现状[J]. 实用医学杂志, 2013, 29(3):341-342.
15. Ben-Ezra J, Wu A, Sheibani K.Hashimoto's thyroiditis lacks detectable clonal immunoglobulin and T cell receptor gene rearrangements[J]. Hum Pathol, 1988, 19(12):1444-1448.
16. Stein SA, Wartofsky L.Primary thyroid lymphoma:a clinical review[J]. J Clin Endocrinol Metab, 2013, 98(8):3131-3138.
17. Watanabe N, Noh JY, Narimatsu H, et al.Clinicopathological features of 171 cases of primary thyroid lymphoma:a long-term study involving 24553 patients with Hashimoto's disease[J]. Br J Haematol, 2011, 153(2):236-243.
18. Green LD, Mack L, Pasieka JL.Anaplastic thyroid cancer and primary thyroid lymphoma:a review of these rare thyroid malignancies[J]. J Surg Oncol, 2006, 94(8):725-736.
19. Meusers P, Elo B, Wittig A, et al.Diagnosis and treatment of primary malignant lymphoma of the thyroid gland[J].Chinese-German J Clin Oncol,2003,2(4):219-223.
20. Sun TQ, Zhu XL, Wang ZY, et al.Characteristics and prognosis of primary thyroid non-Hodgkin's lymphoma in Chinese patients[J]. J Surg Oncol, 2010, 101(7):545-550.
21. 朱坚, 费健.原发性甲状腺淋巴瘤的诊断和治疗分析[J]. 外科理论与实践, 2013, 18(2):156-158.
22. 孙治君, 姚榛祥, 管小琴.甲状腺原发性恶性淋巴瘤的诊断与治疗(附7例报告)[J]. 中国普外基础与临床杂志, 2003, 10(4):393-394.
23. 章美武, 陈赛君.原发性甲状腺淋巴瘤的超声表现[J]. 现代实用医学, 2012, 24(12):1377-1378.
24. 杨丽娟, 母义明, 胡翠宁, 等.11例原发性甲状腺淋巴瘤的超声表现[J]. 中国病案, 2013, 14(11):74-75.
25. 骆惊涛, 魏玺, 张仑.原发性甲状腺淋巴瘤的超声表现病理及其他影像学特征分析[J]. 中国肿瘤临床, 2014, 41(2):123-126.
26. 彭晓琼, 苏新良, 蒲大容, 等.原发性甲状腺恶性淋巴瘤的常规超声及超声造影表现[J]. 临床超声医学杂志, 2013, 15(7):488-490.
27. 宋琳琳, 詹维伟, 周建桥, 等.浅表器官结外淋巴瘤的超声表现[J]. 诊断学理论与实践, 2012, 11(5):471-475.
28. 李鹏, 张惠.高频超声诊断原发性甲状腺淋巴瘤[J]. 中国医学影像技术, 2012, 28(12):2269-2270.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Ultrasonography Features of Primary Thyroid Non-Hodgkin Lymphoma

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