• Department of General Surgery, Tai'an First People's Hospital of Shandong Province, Tai'an 271000, Shandong Province, China;
SUNXiao-guo, Email: xiaoguosun@163.com
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Objective To explore the mechanism of postoperative recurrence of hepatocellular carcinoma(HCC) and predicting the candidate drug. Methods The differently expressed genes of the human gene expression profiles with 35 postoperative recurrence of HCC tissues and 41 no recurrence of HCC tissues were identified. Then enriched these genes with gene ontology(GO) terms and KEGG pathway, and predicting the candidate drugs for suppress the postoperative recurrence using Connectivity Map(cmap) database. Results Several pathways such as Focal adhesion and MAPK signaling pathway were found involve in postoperative recurrence of HCC. Moreover, two candidate small molecule drugs(bambuterol and lovastatin) were found may suppress and postoperative recurrence of HCC. Conclusion Focal adhesion and MAPK signaling pathway may involve in the postoperative recurrence of HCC, bambuterol and lovastatin may candidate drugs for treat postoperative recurrence of HCC.

Citation: SUNXiao-guo, LILi, WANGJin-hua. Exploring The Mechanism of Postoperative Recurrence of Hepatocellular Carcinoma and Predicting The Candidate Drugs. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(10): 1245-1249. doi: 10.7507/1007-9424.20140298 Copy

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