Clinical Analysis of 16 Patients with Rectal Neuroendocrine Neoplasm_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 陈伟伟 ^1,2 ,  谷云飞 ¹ , 陈邑岐 ¹

1. ;
2. ;

Corresponding author：

谷云飞, Email: Guyunfei127@126.com

Keywords：

直肠神经内分泌肿瘤; 诊断; 治疗

DOI：

10.7507/1007-9424.20140375

Video：

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Abstract Full text Figures/Tables Video References Cited by

目的总结直肠神经内分泌肿瘤（RNEN）的临床诊断和治疗方法。方法回顾性分析2009年1月至2013年12月期间南京中医药大学附属医院（江苏省中医院）收治的16例RNEN患者的临床资料。结果 16例患者均顺利完成手术，手术时间30～120 min，平均50 min；术中出血量10～80 mL，平均55 mL；均无手术死亡，术中均未见严重并发症发生。术后住院时间10～35 d，平均17 d。手术创面均一期愈合，均顺利出院。术后所有患者均获访，随访时间为2个月～5年，中位随访时间为20个月。随访期间所有患者均未见复发或转移，无死亡病例。结论 RNEN发病隐匿，具有恶性潜能，且常无特异性临床表现，故应加深对该病的认识，及时对就诊患者进行全面检查，做到早发现、早诊断及早治疗，且治疗后应对患者进行严密随访。

Citation： 陈伟伟, 谷云飞, 陈邑岐. Clinical Analysis of 16 Patients with Rectal Neuroendocrine Neoplasm. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(12): 1576-1578. doi: 10.7507/1007-9424.20140375 Copy

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2.	Modlin IM, Kidd M, Latich I, et al.Current status of gastrointe-stinal carcinoids[J].Gastroenterology, 2005, 128(6):1717-1751.
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6.	Modlin IM, Oberg K, Chung DC, et al.Gastroenteropancreatic neuroendocrine tumours[J].Lancet Oncol, 2008, 9(1):61-72.
7.	周鑫, 谢海艇, 谢凌铎, 等.直肠神经内分泌肿瘤的诊疗进展[J/CD].中华临床医师杂志:电子版, 2013, 7(13):6049-6050.
8.	孟曼, 令狐恩强.直肠神经内分泌肿瘤的病理及临床进展[J].解放军医学院学报, 2013, 34(10):1098-1100.
9.	Ishii N, Horiki N, Itoh T, et al.Endoscopic submucosal dissection and preoperative assessment with endoscopic ultrasonography for the treatment of rectal carcinoid tumors[J].Surg Endosc, 2010, 24(6):1413-1419.
10.	Shields CJ, Tiret E, Winter DC, et al.Carcinoid tumors of the rectum:a multi-institutional international collaboration[J].Ann Surg, 2010, 252(5):750-755.
11.	Ramage JK, Ahmed A, Ardill J, et al.Guidelines for the mana-gement of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs)[J].Gut, 2012, 61(1):6-32.
12.	Siperstein AE, Berber E.Cryoablation, percutaneous alcohol injection, and radiofrequency ablation for treatment of neuroendocrine liver metastases[J].World J Surg, 2001, 25(6):693-696.
13.	杜丰, 依荷芭丽·迟, 孙永琨, 等.直肠神经内分泌肿瘤的临床病理特征及治疗模式分析[J].中国肿瘤临床与康复, 2013, 20(6):599-602.
14.	Pavel M, Baudin E, Couvelard A, et al.ENETS consensus guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown primary[J].Neuroendocrinology, 2012, 95(2):157-176.
15.	De Jong M, Breeman WA, Bernard HF, et al.Therapy of neuro-endocrine tumors with radiolabeled somatostatin-analogues[J].Q J Nucl Med, 1999, 43(4):356-366.

1. Beck DE, Roberts PL, Saclarides TJ, et al著.马东旺, 姜军, 王西墨译.结直肠外科学[M].北京:北京大学医学出版社, 2013:764-766.
2. Modlin IM, Kidd M, Latich I, et al.Current status of gastrointe-stinal carcinoids[J].Gastroenterology, 2005, 128(6):1717-1751.
3. Modlin IM, Lye KD, Kidd M.A 5-decade analysis of 13715 carcinoid tumors[J].Cancer, 2003, 97(4):934-959.
4. Yao JC, Hassan M, Phan A, et al.One hundred years after "carcinoid":epidemiology of and prognostic factors for neuroendocrine tumors in 35825 cases in the United States[J].J Clin Oncol, 2008, 26(18):3063-3072.
5. 何东, 陈兴灿, 王金泉.胰腺无功能性神经内分泌瘤1例并文献复习[J].中华实用诊断与治疗杂志, 2011, 25(2):164-165.
6. Modlin IM, Oberg K, Chung DC, et al.Gastroenteropancreatic neuroendocrine tumours[J].Lancet Oncol, 2008, 9(1):61-72.
7. 周鑫, 谢海艇, 谢凌铎, 等.直肠神经内分泌肿瘤的诊疗进展[J/CD].中华临床医师杂志:电子版, 2013, 7(13):6049-6050.
8. 孟曼, 令狐恩强.直肠神经内分泌肿瘤的病理及临床进展[J].解放军医学院学报, 2013, 34(10):1098-1100.
9. Ishii N, Horiki N, Itoh T, et al.Endoscopic submucosal dissection and preoperative assessment with endoscopic ultrasonography for the treatment of rectal carcinoid tumors[J].Surg Endosc, 2010, 24(6):1413-1419.
10. Shields CJ, Tiret E, Winter DC, et al.Carcinoid tumors of the rectum:a multi-institutional international collaboration[J].Ann Surg, 2010, 252(5):750-755.
11. Ramage JK, Ahmed A, Ardill J, et al.Guidelines for the mana-gement of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs)[J].Gut, 2012, 61(1):6-32.
12. Siperstein AE, Berber E.Cryoablation, percutaneous alcohol injection, and radiofrequency ablation for treatment of neuroendocrine liver metastases[J].World J Surg, 2001, 25(6):693-696.
13. 杜丰, 依荷芭丽·迟, 孙永琨, 等.直肠神经内分泌肿瘤的临床病理特征及治疗模式分析[J].中国肿瘤临床与康复, 2013, 20(6):599-602.
14. Pavel M, Baudin E, Couvelard A, et al.ENETS consensus guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown primary[J].Neuroendocrinology, 2012, 95(2):157-176.
15. De Jong M, Breeman WA, Bernard HF, et al.Therapy of neuro-endocrine tumors with radiolabeled somatostatin-analogues[J].Q J Nucl Med, 1999, 43(4):356-366.

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Clinical Analysis of 16 Patients with Rectal Neuroendocrine Neoplasm

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