Diagnosis and Treatment of Intrahepatic Biliary Cystadenoma: Report of 12 Cases_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 WANGKe-wei ,  DONGMing , KONGFan-min , ZHOUJian-ping

Department of Gastrointestinal Surgery, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China;

Corresponding author：

DONGMing, Email: cmudongming@sohu.com

Keywords：

Cystadenoma; Bile duct; Treatment; Recurrence

DOI：

10.7507/1007-9424.20150021

Video：

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Objective To evaluate the clinical manifestation, diagnosis, and treatment of intrahepatic biliary cystadenoma (IBCA). Methods The clinical date of 12 patients with IBCA from January 2004 to December 2013 in our hospital were retrospectively analyzed. Results Of the total 10 patients were female and 2 were male. The average age was 49.0 years old (16-77 49.0 years old). The course of disease were 1 month-3years (average:7 months). The clinical symptoms were right upper abdominal fullness with a sense of pain in 6 patients, right upper abdominal mass in 1 case, jaundice in 1 case, and no symptoms in 4 cases. Enhanced CT examination showed that the tumor complete capsule and there were internal septations in 11 cases, the density of internal septations was different. There was mild enhancement of cyst wall and internal septations in 9 cases. All of 12 cases received surgical resection. Only 1 case showed recurrence in 2 years after operation, the remaining 11 patients had no recurrence. Conclusions IBCA often occurs in middle-aged women. The main clinical symptoms are abdominal fullness with a sense of pain, right upper abdominal mass or jaundice. Enhanced CT is the main method of diagnosis before operation. Radical resection of IBCA is the best treatment, and can prevent recurrence effectively.

Citation： WANGKe-wei, DONGMing, KONGFan-min, ZHOUJian-ping. Diagnosis and Treatment of Intrahepatic Biliary Cystadenoma: Report of 12 Cases. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(1): 88-90. doi: 10.7507/1007-9424.20150021 Copy

1.	Kazama S, Hiramatsu T, Kuriyama S, et al.Giant intrahepatic biliary cystadenoma in a male:a case report, immunohistopathological analysis, and review of the literature.Dig Dis Sci, 2005, 50(7):1384-1389.
2.	Teoh AY, Ng SS, Lee KF, et al.Biliary cystadenoma and other complicated cystic lesions of the liver:diagnostic and therapeutic challenges.World J Surg, 2006, 30(8):1560-1566.
3.	Flormann SS, Slakey DP.Giant biliary cystadenoma:case report and literature review.Am Surg, 2001, 67(8):727-732.
4.	Rooney TB, Schofer JM, Stanley MD, et al.Biliary cystadenoma of the gallbladder.Am J Roentgendol, 2005, 185(6):1571-1572.
5.	Pojchamarnwiputh S, Na Chiangmai W, Chotirosniramit A, et al.Computed tomography of biliary cystadenoma and biliary cystadenocarcinoma.Singapore Med J, 2008, 49(5):392-396.
6.	Del Poggio P, Buonocore M.Cystic tumors of the liver:a practical approach.World J Gastroenterol, 2008, 14(23):3616-3620.
7.	Senyüz OF, Numan F, Eroğlu E, et al.Hepatobiliary mucinous cystadenoma in a child.J Pediatr Surg, 2004, 39(1):E6-E8.
8.	Vogt DP, Henderson JM, Chmielewski E.Cystadenoma and cystadenocarcinoma of the liver:a single center experience.J Am Coll Surg, 2005, 200(5):727-733.
9.	孙国锋, 赵瑞霞, 张秀良.肝内胆管囊腺瘤1例报告.中国实用外科杂志, 2004, 24(11):687.
10.	Preetha M, Chung AY, Lim-Tan SK, et al.Intrahepatic biliary cystadenoma presenting with obstructive jaundice.Asian J Surg, 2004, 27(3):243-245.
11.	Ohtsubo K, Ohta H, Sakai J, et al.Mucin-producing biliary papillomatosis associated with gastrobiliary fistula.J Gastroenterol, 1999, 34(1):141-144.
12.	Koffron A, Ferrario M, Rao S, et al.Intrahepatic biliary cystadenoma (IBC):role of cyst fluid analysis and surgical management in the laparoscopic era.Surgery, 2004, 136(4):926-936.
13.	Choi HK, Lee JK, Lee KH, et al.Differential diagnosis for intrahepatic biliary cystadenoma and hepatic simple cyst significance of cystic fluid analysis and radiologic findings.J Clin Gastroenterol, 2010, 44(4):289-293.
14.	Choi BI, Lim JH, Han MC, et al.Biliary cystadenoma and cystadenocarcinoma:CT and sonographic findings.Radiology, 1989, 171(1):57-61.
15.	Buelow PC, Buck JL, Pantongrag-Brown L, et al.Biliary cystadenoma and cystadenocarcinoma:clinical-imaging-pathologic correlation with emphasis on the importance of ovarian stroma.Radiology, 1995, 196(3):805-810.
16.	Mortele KJ, Ros PR.Cystic focal liver lesions in the adult:differential CT and MR imaging features.Radiographics, 2001, 21(4):895-910.
17.	Thomas KT, Welch D, Trueblood A, et al.Effective treatment of biliary cystadenoma.Ann Surg, 2005, 241(5):769-775.
18.	Zhou JP, Dong M, Zhang Y, et al.Giant mucinous biliary cystadenoma:a case report.Hepatobiliary Pancreat Dis Int, 2007, 6(1):101-103.
19.	Gonzalez M, Majno P, Terraz S, et al.Biliary cystadenoma revealed by obstructive jaundice.Dig Liver Dis, 2009, 41(7):11-13.
20.	徐建, 李敬东, 李强, 等.肝脏良性肿瘤的临床诊治分析.中国普外基础与临床杂志, 2013, 20(3):316-318.
21.	Veroux M, Fiamingo P, Cillo U, et al.Cystadenoma and laparoscopic surgery for hepatic cystic disease:a need for laparotomy? Surg Endosc, 2005, 19(8):1077-1081.
22.	周宁新, 陈军周, 刘全达, 等."达芬奇"机器人普通外科手术180例:中国单中心报道.中国普外基础与临床杂志, 2011, 18(7):698-704.

1. Kazama S, Hiramatsu T, Kuriyama S, et al.Giant intrahepatic biliary cystadenoma in a male:a case report, immunohistopathological analysis, and review of the literature.Dig Dis Sci, 2005, 50(7):1384-1389.
2. Teoh AY, Ng SS, Lee KF, et al.Biliary cystadenoma and other complicated cystic lesions of the liver:diagnostic and therapeutic challenges.World J Surg, 2006, 30(8):1560-1566.
3. Flormann SS, Slakey DP.Giant biliary cystadenoma:case report and literature review.Am Surg, 2001, 67(8):727-732.
4. Rooney TB, Schofer JM, Stanley MD, et al.Biliary cystadenoma of the gallbladder.Am J Roentgendol, 2005, 185(6):1571-1572.
5. Pojchamarnwiputh S, Na Chiangmai W, Chotirosniramit A, et al.Computed tomography of biliary cystadenoma and biliary cystadenocarcinoma.Singapore Med J, 2008, 49(5):392-396.
6. Del Poggio P, Buonocore M.Cystic tumors of the liver:a practical approach.World J Gastroenterol, 2008, 14(23):3616-3620.
7. Senyüz OF, Numan F, Eroğlu E, et al.Hepatobiliary mucinous cystadenoma in a child.J Pediatr Surg, 2004, 39(1):E6-E8.
8. Vogt DP, Henderson JM, Chmielewski E.Cystadenoma and cystadenocarcinoma of the liver:a single center experience.J Am Coll Surg, 2005, 200(5):727-733.
9. 孙国锋, 赵瑞霞, 张秀良.肝内胆管囊腺瘤1例报告.中国实用外科杂志, 2004, 24(11):687.
10. Preetha M, Chung AY, Lim-Tan SK, et al.Intrahepatic biliary cystadenoma presenting with obstructive jaundice.Asian J Surg, 2004, 27(3):243-245.
11. Ohtsubo K, Ohta H, Sakai J, et al.Mucin-producing biliary papillomatosis associated with gastrobiliary fistula.J Gastroenterol, 1999, 34(1):141-144.
12. Koffron A, Ferrario M, Rao S, et al.Intrahepatic biliary cystadenoma (IBC):role of cyst fluid analysis and surgical management in the laparoscopic era.Surgery, 2004, 136(4):926-936.
13. Choi HK, Lee JK, Lee KH, et al.Differential diagnosis for intrahepatic biliary cystadenoma and hepatic simple cyst significance of cystic fluid analysis and radiologic findings.J Clin Gastroenterol, 2010, 44(4):289-293.
14. Choi BI, Lim JH, Han MC, et al.Biliary cystadenoma and cystadenocarcinoma:CT and sonographic findings.Radiology, 1989, 171(1):57-61.
15. Buelow PC, Buck JL, Pantongrag-Brown L, et al.Biliary cystadenoma and cystadenocarcinoma:clinical-imaging-pathologic correlation with emphasis on the importance of ovarian stroma.Radiology, 1995, 196(3):805-810.
16. Mortele KJ, Ros PR.Cystic focal liver lesions in the adult:differential CT and MR imaging features.Radiographics, 2001, 21(4):895-910.
17. Thomas KT, Welch D, Trueblood A, et al.Effective treatment of biliary cystadenoma.Ann Surg, 2005, 241(5):769-775.
18. Zhou JP, Dong M, Zhang Y, et al.Giant mucinous biliary cystadenoma:a case report.Hepatobiliary Pancreat Dis Int, 2007, 6(1):101-103.
19. Gonzalez M, Majno P, Terraz S, et al.Biliary cystadenoma revealed by obstructive jaundice.Dig Liver Dis, 2009, 41(7):11-13.
20. 徐建, 李敬东, 李强, 等.肝脏良性肿瘤的临床诊治分析.中国普外基础与临床杂志, 2013, 20(3):316-318.
21. Veroux M, Fiamingo P, Cillo U, et al.Cystadenoma and laparoscopic surgery for hepatic cystic disease:a need for laparotomy? Surg Endosc, 2005, 19(8):1077-1081.
22. 周宁新, 陈军周, 刘全达, 等."达芬奇"机器人普通外科手术180例:中国单中心报道.中国普外基础与临床杂志, 2011, 18(7):698-704.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Diagnosis and Treatment of Intrahepatic Biliary Cystadenoma: Report of 12 Cases

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