Research Progress of The Relationship Between The Insulin Resistance, IGF-Ⅰ, IGF-Ⅱ, and Colorectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 CAILin-gang , LIQi-ju

Department of General Surgery, Central Hospital of Huangpu District, Shanghai 200002, China;

Corresponding author：

CAILin-gang, Email: clg1980628@aliyun.com

Keywords：

Colorectal cancer; Insulin resistance; Insulin-like growth factor-Ⅰ; Insulin-like growth factor-Ⅱ

DOI：

10.7507/1007-9424.20150135

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To review the research progress of the relationship between the insulin resistance, insulin-like growth factor-Ⅰ(IGF-Ⅰ), insulin-like growth factor-Ⅱ(IGF-Ⅱ), and colorectal cancer, and to explore the future research trends. Methods The related literatures in recent 5 years from abroad databases (PubMed, Web of Science, and EMBASE)and domestic databases (CNKI, WANFANG, and WEIPU)were collected and reviewed. Results The research on the correlation between the changes and colorectal cancer with insulin resistance and IGF-Ⅰand IGF-Ⅱlevels, epidemiological studies and the mechanism research, indicates that there are complex and close relationship between them. Conclusions The research about the relationship between the insulin resistance, IGF-Ⅰ, IGF-Ⅱ, and colorectal cancer is promising.However, many issues need to be further investigated.

Citation： CAILin-gang, LIQi-ju. Research Progress of The Relationship Between The Insulin Resistance, IGF-Ⅰ, IGF-Ⅱ, and Colorectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(4): 509-512. doi: 10.7507/1007-9424.20150135 Copy

1.	Ali AT, Crowther NJ.Body fat distribution and insulin resistance.S Afr Med J, 2005, 95(11):878-880.
2.	Takahari D, Yamada Y, Okita NT, et al.Relationships of insulin like growth factor-1 receptor and epidermal growth factor receptor expression to clinical outcomes in patients with colorectal cancer.Oncology, 2009, 76(1):42-48.
3.	Sekharam M, Zhao H, Sun M, et al.Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway.Cancer Res, 2003, 63(22):7708-7716.
4.	李连第, 赵平, 孔灵芝.中国部分市、县恶性肿瘤的发病与死亡(第3卷).北京:人民卫生出版社, 2007:250-251.
5.	Larsson SC, Giovannucci E, Wolk A.Diabetes and colorectal cancer incidence in the cohort of Swedish men.Diabetes Care, 2005, 28 (7):1805-1807.
6.	曾春平, 陈幼萍, 杨清水, 等.胰岛素抵抗与结直肠癌患病关系的研究.南昌大学学报, 2014, 54(4):31-33.
7.	Chi F, Wu R, Zeng YC, et al.Circulation insulin-like growth factor peptides and colorectal cancer risk:an updated systematic review and meta-analysis.Mol Biol Rep, 2013, 40(5):3583-3590.
8.	文国容, 庹必光, 李娟, 等.胰岛素和IGF-Ⅱ水平的变化与结直肠癌的关系.遵义医学院学报, 2010, 33(3):205-207.
9.	Shiratsuchi I, Akagi Y, Kawahara A, et al.Expression of IGF-1 and IGF-1R and their relation to clinicopathological factors in colorectal cancer.Anticancer Res, 2011, 31(7):2541-2545.
10.	Kuklińsk A, Kamocki Z, Cepowicz D, et al.Relationships between insulin-like growth factor i and selected clinico-morphological parameters in colorectal cancer patients.Pol Przegl Chir, 2011, 83(5):250-257.
11.	黄桂林, 吴毅平, 雷娜.胰岛素样生长因子-1在原发性结直肠癌中表达的研究.中国普外基础与临床杂志, 2009, 16(9):693-697.
12.	胡永泽, 乌新林.IGF-I和IGF-IR在结直肠癌组织中的表达及临床意义.内蒙古医科大学学报, 2013, 35(1):27-31.
13.	Carden CP, Molife LR, de Bono JS.predictive biomarkers for targeting insulin-like growth factor-1 (IGF-1) receptor.Mol Cancer Ther, 2009, 8(8):2077-2078.
14.	Hewish M, Chau I, Cunningham D.Insulin-like growth factor 1 receptor targeted therapeutics:novel compounds and novel treatment strategies for cancer medicine.Recent Pat Anticancer Drug Discov, 2009, 4(1):54-72.
15.	Ewing GP, Goff LW.The insulin-like growth factor signaling pathway as a target for treatment of colorectal carcinoma.Clin Colorectal Cancer, 2010, 9(4):219-223.
16.	鞠昕丽, 初蕾蕾, 杨阅楼, 等.IGF-Ⅱ和IGF-ⅠR及IGFBP-3在结直肠癌组织中的表达及其临床意义.中国现代普通外科进展, 2013, 16(7):562-565.
17.	戚红霞, 李晓虹, 胡海强.血清IGF-1、IGFBP-3、VEGF及多项白介素在结直肠癌转移监测中的意义.海南医学院学报, 2013, 19(2):176-179.
18.	胡倚玲, 王爱红.结直肠癌患者血清中IGF-Ⅰ和IGF-BP3的水平及临床意义.中国高等医学教育, 2013, 9:132-133.
19.	陈权, 刘莉, 刘丽, 等.GHR、IGF-I在结直肠癌中的表达及其临床意义.华中科技大学学报, 2012, 41(5):597-602.
20.	郝敬鹏.血清IGF-Ⅱ和TGF-α水平变化在结直肠癌中的临床意义.中国现代医学杂志, 2013, 23(1):48-51.
21.	Giovannucci E.Insulin and colon cancer.Cancer Causes Control, 1995, 6(2):164-179.
22.	吴青眉, 吴秋云, 张爱群.结直肠癌代谢紊乱与胰岛素抵抗的研究.中华胃肠外科杂志, 2011, 14(4):261-263.
23.	黄云, 王治国, 王强.腹腔镜与开放直肠乙状结肠癌切除术术后胰岛素抵抗的差异及其临床意义.中国现代普通外科进展, 2011, 14(12):933-936.
24.	魏晓萍, 惠起源, 刘小芸.糖尿病与恶性肿瘤.新医学, 2009, 40 (1):56-58.
25.	Playford MP, Bicknell D, Bodmer W F, et al.Insulin like growth factor I regulates the location, stability, and transcriptional activity ofβ-catenin.Proc Natl Acid Sci USA, 2000, 97(22):12103-12108.
26.	Zha J, O'Brien C, Savage H, et al.Molecular predictors of response to a humanized anti-insulin like growth factor-I receptor monoclonal antibody in breast and colorectal cancer.Mol Cancer Ther, 2009, 8(8):2110-2121.
27.	Guo ST, Jiang CC, Wang GP, et al.MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer.Oncogene, 2013, 32(15):1910-1920.
28.	Lim do Y, Cho HJ, Kim J, et al.Luteolin decreases IGF-Ⅱproduc-tion and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells.BMC Gastroenterol, 2012, 12:9.
29.	Flanigan SA, Pitts TM, Eckhardt SG, et al.The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models.Clin Cancer Res, 2010, 16(22):5436-5446.
30.	李晴, 孔宪国, 郝杰民, 等.结直肠癌IGF-I mRNA表达与浸润转移的关系.癌症, 2000, 9(2):153-155.
31.	Pechlivanis S, Wagner K, Chang-claude J, et al.Polymorphisms in the insulin like growth factor 1 and IGF bindingprotein 3 genes and risk of colorectal cancer.Cancer Detect Prev, 2007, 31(5):408-416.
32.	胡水清, 汤哲, 张玫.糖尿病与结直肠癌患病危险关系的调查分析.世界华人消化杂志, 2007, 15(1):88-91.
33.	Kasprzak A, Szaflarski W, Szmeja J, et al.Expression of various insulin-like growth factor-1 mRNA isoforms in colorectal cancer.Contemp Oncol (Pozn), 2012, 16(2):147-153.
34.	Cho YY, Kim JG, Chae YS, et al.No association of insulin-like growth factor gene polymorphisms with survival in patients with colorectal cancer.Cancer Res Treat, 2011, 43(3):189-194.
35.	甘德芳, 高天翼, 王书奎, 等.结直肠癌患者中IGF2 LOI以及表达的研究.现代生物医学进展, 2013, (11):2090-2092.

1. Ali AT, Crowther NJ.Body fat distribution and insulin resistance.S Afr Med J, 2005, 95(11):878-880.
2. Takahari D, Yamada Y, Okita NT, et al.Relationships of insulin like growth factor-1 receptor and epidermal growth factor receptor expression to clinical outcomes in patients with colorectal cancer.Oncology, 2009, 76(1):42-48.
3. Sekharam M, Zhao H, Sun M, et al.Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway.Cancer Res, 2003, 63(22):7708-7716.
4. 李连第, 赵平, 孔灵芝.中国部分市、县恶性肿瘤的发病与死亡(第3卷).北京:人民卫生出版社, 2007:250-251.
5. Larsson SC, Giovannucci E, Wolk A.Diabetes and colorectal cancer incidence in the cohort of Swedish men.Diabetes Care, 2005, 28 (7):1805-1807.
6. 曾春平, 陈幼萍, 杨清水, 等.胰岛素抵抗与结直肠癌患病关系的研究.南昌大学学报, 2014, 54(4):31-33.
7. Chi F, Wu R, Zeng YC, et al.Circulation insulin-like growth factor peptides and colorectal cancer risk:an updated systematic review and meta-analysis.Mol Biol Rep, 2013, 40(5):3583-3590.
8. 文国容, 庹必光, 李娟, 等.胰岛素和IGF-Ⅱ水平的变化与结直肠癌的关系.遵义医学院学报, 2010, 33(3):205-207.
9. Shiratsuchi I, Akagi Y, Kawahara A, et al.Expression of IGF-1 and IGF-1R and their relation to clinicopathological factors in colorectal cancer.Anticancer Res, 2011, 31(7):2541-2545.
10. Kuklińsk A, Kamocki Z, Cepowicz D, et al.Relationships between insulin-like growth factor i and selected clinico-morphological parameters in colorectal cancer patients.Pol Przegl Chir, 2011, 83(5):250-257.
11. 黄桂林, 吴毅平, 雷娜.胰岛素样生长因子-1在原发性结直肠癌中表达的研究.中国普外基础与临床杂志, 2009, 16(9):693-697.
12. 胡永泽, 乌新林.IGF-I和IGF-IR在结直肠癌组织中的表达及临床意义.内蒙古医科大学学报, 2013, 35(1):27-31.
13. Carden CP, Molife LR, de Bono JS.predictive biomarkers for targeting insulin-like growth factor-1 (IGF-1) receptor.Mol Cancer Ther, 2009, 8(8):2077-2078.
14. Hewish M, Chau I, Cunningham D.Insulin-like growth factor 1 receptor targeted therapeutics:novel compounds and novel treatment strategies for cancer medicine.Recent Pat Anticancer Drug Discov, 2009, 4(1):54-72.
15. Ewing GP, Goff LW.The insulin-like growth factor signaling pathway as a target for treatment of colorectal carcinoma.Clin Colorectal Cancer, 2010, 9(4):219-223.
16. 鞠昕丽, 初蕾蕾, 杨阅楼, 等.IGF-Ⅱ和IGF-ⅠR及IGFBP-3在结直肠癌组织中的表达及其临床意义.中国现代普通外科进展, 2013, 16(7):562-565.
17. 戚红霞, 李晓虹, 胡海强.血清IGF-1、IGFBP-3、VEGF及多项白介素在结直肠癌转移监测中的意义.海南医学院学报, 2013, 19(2):176-179.
18. 胡倚玲, 王爱红.结直肠癌患者血清中IGF-Ⅰ和IGF-BP3的水平及临床意义.中国高等医学教育, 2013, 9:132-133.
19. 陈权, 刘莉, 刘丽, 等.GHR、IGF-I在结直肠癌中的表达及其临床意义.华中科技大学学报, 2012, 41(5):597-602.
20. 郝敬鹏.血清IGF-Ⅱ和TGF-α水平变化在结直肠癌中的临床意义.中国现代医学杂志, 2013, 23(1):48-51.
21. Giovannucci E.Insulin and colon cancer.Cancer Causes Control, 1995, 6(2):164-179.
22. 吴青眉, 吴秋云, 张爱群.结直肠癌代谢紊乱与胰岛素抵抗的研究.中华胃肠外科杂志, 2011, 14(4):261-263.
23. 黄云, 王治国, 王强.腹腔镜与开放直肠乙状结肠癌切除术术后胰岛素抵抗的差异及其临床意义.中国现代普通外科进展, 2011, 14(12):933-936.
24. 魏晓萍, 惠起源, 刘小芸.糖尿病与恶性肿瘤.新医学, 2009, 40 (1):56-58.
25. Playford MP, Bicknell D, Bodmer W F, et al.Insulin like growth factor I regulates the location, stability, and transcriptional activity ofβ-catenin.Proc Natl Acid Sci USA, 2000, 97(22):12103-12108.
26. Zha J, O'Brien C, Savage H, et al.Molecular predictors of response to a humanized anti-insulin like growth factor-I receptor monoclonal antibody in breast and colorectal cancer.Mol Cancer Ther, 2009, 8(8):2110-2121.
27. Guo ST, Jiang CC, Wang GP, et al.MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer.Oncogene, 2013, 32(15):1910-1920.
28. Lim do Y, Cho HJ, Kim J, et al.Luteolin decreases IGF-Ⅱproduc-tion and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells.BMC Gastroenterol, 2012, 12:9.
29. Flanigan SA, Pitts TM, Eckhardt SG, et al.The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models.Clin Cancer Res, 2010, 16(22):5436-5446.
30. 李晴, 孔宪国, 郝杰民, 等.结直肠癌IGF-I mRNA表达与浸润转移的关系.癌症, 2000, 9(2):153-155.
31. Pechlivanis S, Wagner K, Chang-claude J, et al.Polymorphisms in the insulin like growth factor 1 and IGF bindingprotein 3 genes and risk of colorectal cancer.Cancer Detect Prev, 2007, 31(5):408-416.
32. 胡水清, 汤哲, 张玫.糖尿病与结直肠癌患病危险关系的调查分析.世界华人消化杂志, 2007, 15(1):88-91.
33. Kasprzak A, Szaflarski W, Szmeja J, et al.Expression of various insulin-like growth factor-1 mRNA isoforms in colorectal cancer.Contemp Oncol (Pozn), 2012, 16(2):147-153.
34. Cho YY, Kim JG, Chae YS, et al.No association of insulin-like growth factor gene polymorphisms with survival in patients with colorectal cancer.Cancer Res Treat, 2011, 43(3):189-194.
35. 甘德芳, 高天翼, 王书奎, 等.结直肠癌患者中IGF2 LOI以及表达的研究.现代生物医学进展, 2013, (11):2090-2092.

Previous Article
老年患者自发性乙状结肠穿孔合并胸腹壁气肿1例报道
Next Article
Research Progress of Gastric Cancer Related lncRNAs

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Progress of The Relationship Between The Insulin Resistance, IGF-Ⅰ, IGF-Ⅱ, and Colorectal Cancer

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content