Research Progress of Gastric Cancer Related lncRNAs_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 YANGZi-guo ,  GUOXiao-bo , SHIYu-long , LILe-ping

Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong Province, China;

Corresponding author：

GUOXiao-bo, Email: guo992352@hotmail.com

Keywords：

Long noncoding RNA; Gastric cancer; Metastasis; Development

DOI：

10.7507/1007-9424.20150136

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the research progress of long noncoding RNA (lncRNA) in the metastasis of gastric cancer. Methods The related works of lncRNAs in gastric cancer metastasis were searched from databases like Web of Knowledge and Pubmed, and analyzed after collected. Results The emerging of lncRNAs has led to mounting interest in recent years.Increasing studies have elucidated that lncRNAs can regulate gene expression at the level of chromatin, transcription or posttranscription.Some aberrantly expressed lncRNAs have been revealed to modulate gastric cancer metastasis by regulating angiogenesis, cell to cell junction, and extracellar matrix. Conclusion As essential regulators, lncRNAs can act as therapeutic targets, providing therapeutic bases to prevent gastric cancer metastasis.

Citation： YANGZi-guo, GUOXiao-bo, SHIYu-long, LILe-ping. Research Progress of Gastric Cancer Related lncRNAs. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(4): 513-516. doi: 10.7507/1007-9424.20150136 Copy

1.	Jemal A, Bray F, Center MM, et al.Global cancer statistics.CA Cancer J Clin, 2011, 61(2):69-90.
2.	Bertuccio P, Chatenoud L, Levi F, et al.Recent patterns in gastric cancer:a global overview.Int J Cancer, 2009, 125(3):666-673.
3.	Shi X, Sun M, Liu H, et al.Long non-coding RNAs:a new frontier in the study of human diseases.Cancer Lett, 2013, 339(2):159-166.
4.	Ponting CP, Oliver PL, Reik W.Evolution and functions of long noncoding RNAs.Cell, 2009, 136(4):629-641.
5.	Wang X, Song X, Glass CK, et al.The long arm of long noncoding RNAs:roles as sensors regulating gene transcriptional programs.Cold Spring Harb Perspect Biol, 2011, 3(1):a003756.
6.	Arita T, Ichikawa D, Konishi H, et al.Circulating long non-coding RNAs in plasma of patients with gastric cancer.Anticancer Res, 2013, 33(8):3185-3193.
7.	Hajjari M, Behmanesh M, Sadeghizadeh M, et al.Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues.Medical Oncology, 2013, 30(3):670.
8.	Xu ZY, Yu QM, Du YA, et al.Knockdown of long non-coding RNA HOTAIR suppresses tumor invasion and reverses epithelial-mesenchymal transition in gastric cancer.Int J Biol Sci, 2013, 9(6):587-597.
9.	Zhuang M, Gao W, Xu J, et al.The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1.Biochem Biophys Res Commun, 2014, 448(3):315-322.
10.	Sun M, Xia R, Jin F, et al.Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell prolifera-tion in gastric cancer.Tumour Biol, 2014, 35(2):1065-1073.
11.	Li H, Yu B, Li J, et al.Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer.Oncotarget, 2014, 5(8):2318-2329.
12.	Zhang EB, Han L, Yin DD, et al.c-Myc-induced, long, noncoding H19 affects cell proliferation and predicts a poor prognosis in patients with gastric cancer.Med Oncol, 2014, 31(5):914.
13.	Yang F, Bi J, Xue X, et al.Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells.FEBS J, 2012, 279(17):3159-3165.
14.	Song H, Sun W, Ye G, et al.Long non-coding RNA expression profile in human gastric cancer and its clinical significances.J Transl Med, 2013, 11:225.
15.	Park SM, Park SJ, Kim HJ, et al.A known expressed sequence tag, BM742401, is a potent lincRNA inhibiting cancer metastasis.Exp Mol Med, 2013, 45:e31.
16.	Yang F, Xue X, Bi J, et al.Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma.J Cancer Res Clin Oncol, 2013, 139(3):437-445.
17.	Mei D, Song H, Wang K, et al.Up-regulation of SUMO1 pseudo-gene 3 (SUMO1P3) in gastric cancer and its clinical association.Med Oncol, 2013, 30(4):709.
18.	Pang Q, Ge J, Shao Y, et al.Increased expression of long intergenic non-coding RNA LINC00152 in gastric cancer and its clinical significance.Tumour Biol, 2014.35(6):5441-5447.
19.	Zhao Y, Guo Q, Chen J, et al.Role of long non-coding RNA HULC in cell proliferation, apoptosis and tumor metastasis of gastric cancer:a clinical and in vitro investigation.Oncol Rep, 2014, 31(1):358-364.
20.	Liu XH, Sun M, Nie FQ, et al.Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer.Mol Cancer, 2014, 13:92.
21.	Yang F, Xue X, Zheng L, et al.Long non-coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c-Myc mRNA stability.FEBS J, 2014, 281(3):802-813.
22.	Lin X, Yang M, Xia T, et al.Increased expression of long noncoding RNA ABHD11-AS1 in gastric cancer and its clinical significance.Med Oncol, 2014, 31(7):42.
23.	Lin XC, Zhu Y, Chen WB, et al.Integrated analysis of long non-coding RNAs and mRNA expression profiles reveals the potential role of lncRNAs in gastric cancer pathogenesis.Int J Oncol, 2014, 45(2):619-628.
24.	Sun W, Wu Y, Yu X, et al.Decreased expression of long noncoding RNA AC096655.1-002 in gastric cancer and its clinical significance.Tumour Biol, 2013, 34(5):2697-2701.
25.	Xiao B, Guo J.Long noncoding RNA AC096655.1-002 has been officially named as gastric cancer-associated transcript 1, GACAT1.Tumour Biol, 2013, 34(5):3271.
26.	Sun M, Jin FY, Xia R, et al.Decreased expression of long nonco-ding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer.BMC Cancer, 2014, 14:319.
27.	Xu TP, Huang MD, Xia R, et al.Decreased expression of the long non-coding RNA FENDRR is associated with poor prognosis in gastric cancer and FENDRR regulates gastric cancer cell metastasis by affecting fibronectin1 expression.J Hematol Oncol, 2014, 7:63.
28.	Lay AJ, Jiang XM, Kisker O, et al.Phosphoglycerate kinase acts in tumour angiogenesis as a disulphide reductase.Nature, 2000, 408(6814):869-873.
29.	Yuan SX, Yang F, Yang Y, et al.Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma patients' poor recurrence-free survival after hepatectomy.Hepato-logy, 2012, 56(6):2231-2241.
30.	Ayesh S, Matouk I, Schneider T, et al.Possible physiological role of H19 RNA.Mol Carcinog, 2002, 35(2):63-74.
31.	Michalik KM, You X, Manavski Y, et al.Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth.Circ Res, 2014, 114(9):1389-1397.
32.	Gordon FE, Nutt CL, Cheunsuchon P, et al.Increased expression of angiogenic genes in the brains of mouse meg3-null embryos.Endocrinology, 2010, 151(6):2443-2452.
33.	Zhou Y, Zhang X, Klibanski A.MEG3 noncoding RNA:a tumor suppressor.J Mol Endocrinol, 2012, 48(3):R45-R53.
34.	Martin TA.The role of tight junctions in cancer metastasis.Semin Cell Dev Biol, 2014, 36:224-231.
35.	Martin TA, Jiang WG.Loss of tight junction barrier function and its role in cancer metastasis.Biochim Biophys Acta, 2009, 1788(4):872-891.
36.	Gomez-Maldonado L, Tiana M, Roche O, et al.EFNA3 long nonco-ding RNAs induced by hypoxia promote metastatic dissemination.Oncogene, 2014, [Epub ahead of print].
37.	Zhao W, Luo J, Jiao S.Comprehensive characterization of cancer subtype associated long non-coding RNAs and their clinical implications.Sci Rep, 2014, 4:6591.
38.	Guo F, Parker Kerrigan BC, Yang D, et al.Post-transcriptional regulatory network of epithelial-to-mesenchymal and mesench-ymal-to-epithelial transitions.J Hematol Oncol, 2014, 7:19.
39.	Lv Q, Hua F, Hu ZW.DEDD, a novel tumor repressor, reverses epithelial-mesenchymal transition by activating selective autophagy.Autophagy, 2012, 8(11):1675-1676.
40.	Rinn JL, Kertesz M, Wang JK, et al.Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.Cell, 2007, 129(7):1311-1323.
41.	Ying L, Chen Q, Wang Y, et al.Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition.Mol Biosyst, 2012, 8(9):2289-2294.
42.	Westermarck J, Kahari VM.Regulation of matrix metalloproteinase expression in tumor invasion.FASEB J, 1999, 13(8):781-792.
43.	Zhu M, Chen Q, Liu X, et al.lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI.FEBS J, 2014, 281(16):3766-3775.

1. Jemal A, Bray F, Center MM, et al.Global cancer statistics.CA Cancer J Clin, 2011, 61(2):69-90.
2. Bertuccio P, Chatenoud L, Levi F, et al.Recent patterns in gastric cancer:a global overview.Int J Cancer, 2009, 125(3):666-673.
3. Shi X, Sun M, Liu H, et al.Long non-coding RNAs:a new frontier in the study of human diseases.Cancer Lett, 2013, 339(2):159-166.
4. Ponting CP, Oliver PL, Reik W.Evolution and functions of long noncoding RNAs.Cell, 2009, 136(4):629-641.
5. Wang X, Song X, Glass CK, et al.The long arm of long noncoding RNAs:roles as sensors regulating gene transcriptional programs.Cold Spring Harb Perspect Biol, 2011, 3(1):a003756.
6. Arita T, Ichikawa D, Konishi H, et al.Circulating long non-coding RNAs in plasma of patients with gastric cancer.Anticancer Res, 2013, 33(8):3185-3193.
7. Hajjari M, Behmanesh M, Sadeghizadeh M, et al.Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues.Medical Oncology, 2013, 30(3):670.
8. Xu ZY, Yu QM, Du YA, et al.Knockdown of long non-coding RNA HOTAIR suppresses tumor invasion and reverses epithelial-mesenchymal transition in gastric cancer.Int J Biol Sci, 2013, 9(6):587-597.
9. Zhuang M, Gao W, Xu J, et al.The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1.Biochem Biophys Res Commun, 2014, 448(3):315-322.
10. Sun M, Xia R, Jin F, et al.Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell prolifera-tion in gastric cancer.Tumour Biol, 2014, 35(2):1065-1073.
11. Li H, Yu B, Li J, et al.Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer.Oncotarget, 2014, 5(8):2318-2329.
12. Zhang EB, Han L, Yin DD, et al.c-Myc-induced, long, noncoding H19 affects cell proliferation and predicts a poor prognosis in patients with gastric cancer.Med Oncol, 2014, 31(5):914.
13. Yang F, Bi J, Xue X, et al.Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells.FEBS J, 2012, 279(17):3159-3165.
14. Song H, Sun W, Ye G, et al.Long non-coding RNA expression profile in human gastric cancer and its clinical significances.J Transl Med, 2013, 11:225.
15. Park SM, Park SJ, Kim HJ, et al.A known expressed sequence tag, BM742401, is a potent lincRNA inhibiting cancer metastasis.Exp Mol Med, 2013, 45:e31.
16. Yang F, Xue X, Bi J, et al.Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma.J Cancer Res Clin Oncol, 2013, 139(3):437-445.
17. Mei D, Song H, Wang K, et al.Up-regulation of SUMO1 pseudo-gene 3 (SUMO1P3) in gastric cancer and its clinical association.Med Oncol, 2013, 30(4):709.
18. Pang Q, Ge J, Shao Y, et al.Increased expression of long intergenic non-coding RNA LINC00152 in gastric cancer and its clinical significance.Tumour Biol, 2014.35(6):5441-5447.
19. Zhao Y, Guo Q, Chen J, et al.Role of long non-coding RNA HULC in cell proliferation, apoptosis and tumor metastasis of gastric cancer:a clinical and in vitro investigation.Oncol Rep, 2014, 31(1):358-364.
20. Liu XH, Sun M, Nie FQ, et al.Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer.Mol Cancer, 2014, 13:92.
21. Yang F, Xue X, Zheng L, et al.Long non-coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c-Myc mRNA stability.FEBS J, 2014, 281(3):802-813.
22. Lin X, Yang M, Xia T, et al.Increased expression of long noncoding RNA ABHD11-AS1 in gastric cancer and its clinical significance.Med Oncol, 2014, 31(7):42.
23. Lin XC, Zhu Y, Chen WB, et al.Integrated analysis of long non-coding RNAs and mRNA expression profiles reveals the potential role of lncRNAs in gastric cancer pathogenesis.Int J Oncol, 2014, 45(2):619-628.
24. Sun W, Wu Y, Yu X, et al.Decreased expression of long noncoding RNA AC096655.1-002 in gastric cancer and its clinical significance.Tumour Biol, 2013, 34(5):2697-2701.
25. Xiao B, Guo J.Long noncoding RNA AC096655.1-002 has been officially named as gastric cancer-associated transcript 1, GACAT1.Tumour Biol, 2013, 34(5):3271.
26. Sun M, Jin FY, Xia R, et al.Decreased expression of long nonco-ding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer.BMC Cancer, 2014, 14:319.
27. Xu TP, Huang MD, Xia R, et al.Decreased expression of the long non-coding RNA FENDRR is associated with poor prognosis in gastric cancer and FENDRR regulates gastric cancer cell metastasis by affecting fibronectin1 expression.J Hematol Oncol, 2014, 7:63.
28. Lay AJ, Jiang XM, Kisker O, et al.Phosphoglycerate kinase acts in tumour angiogenesis as a disulphide reductase.Nature, 2000, 408(6814):869-873.
29. Yuan SX, Yang F, Yang Y, et al.Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma patients' poor recurrence-free survival after hepatectomy.Hepato-logy, 2012, 56(6):2231-2241.
30. Ayesh S, Matouk I, Schneider T, et al.Possible physiological role of H19 RNA.Mol Carcinog, 2002, 35(2):63-74.
31. Michalik KM, You X, Manavski Y, et al.Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth.Circ Res, 2014, 114(9):1389-1397.
32. Gordon FE, Nutt CL, Cheunsuchon P, et al.Increased expression of angiogenic genes in the brains of mouse meg3-null embryos.Endocrinology, 2010, 151(6):2443-2452.
33. Zhou Y, Zhang X, Klibanski A.MEG3 noncoding RNA:a tumor suppressor.J Mol Endocrinol, 2012, 48(3):R45-R53.
34. Martin TA.The role of tight junctions in cancer metastasis.Semin Cell Dev Biol, 2014, 36:224-231.
35. Martin TA, Jiang WG.Loss of tight junction barrier function and its role in cancer metastasis.Biochim Biophys Acta, 2009, 1788(4):872-891.
36. Gomez-Maldonado L, Tiana M, Roche O, et al.EFNA3 long nonco-ding RNAs induced by hypoxia promote metastatic dissemination.Oncogene, 2014, [Epub ahead of print].
37. Zhao W, Luo J, Jiao S.Comprehensive characterization of cancer subtype associated long non-coding RNAs and their clinical implications.Sci Rep, 2014, 4:6591.
38. Guo F, Parker Kerrigan BC, Yang D, et al.Post-transcriptional regulatory network of epithelial-to-mesenchymal and mesench-ymal-to-epithelial transitions.J Hematol Oncol, 2014, 7:19.
39. Lv Q, Hua F, Hu ZW.DEDD, a novel tumor repressor, reverses epithelial-mesenchymal transition by activating selective autophagy.Autophagy, 2012, 8(11):1675-1676.
40. Rinn JL, Kertesz M, Wang JK, et al.Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.Cell, 2007, 129(7):1311-1323.
41. Ying L, Chen Q, Wang Y, et al.Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition.Mol Biosyst, 2012, 8(9):2289-2294.
42. Westermarck J, Kahari VM.Regulation of matrix metalloproteinase expression in tumor invasion.FASEB J, 1999, 13(8):781-792.
43. Zhu M, Chen Q, Liu X, et al.lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI.FEBS J, 2014, 281(16):3766-3775.

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Research Progress of Gastric Cancer Related lncRNAs

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