Impact of Duodenal Jejunal Bypass and Hepatic Branch of Vagus on Glucose Metabolism in Non-Obese Rat with Type 2 Diabetes Mellitus_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 WANPeng ,  WANGYu

Department of General Surgery, Fuzhou General Hospital of Nanjing Military Command, Fuzhou 350025, Fujian Province, China;

Corresponding author：

WANGYu, Email: flyfishwang@hotmail.com

Keywords：

Type 2 diabetes mellitus; Duodenal jejunal bypass; Hepatic branch of vagus; Glucagon-like peptide-1; Peptide YY

DOI：

10.7507/1007-9424.20150150

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To observe the influence and interaction of duodenal jejunal bypass (DJB) and hepatic branch of vagus on glucose metabolism, and fasting serum glucagon like peptide-1 (GLP-1), peptide YY (PYY) in non-obese rat with type 2 diabetes mellitus (T2DM). Methods Forty non-obese Wistar rats (GK) with T2DM were randomly divided into four groups: sham operation group (SO group), sham operation plus hepatic branch of vagus resection (HBVR) group (SO+HBVR group), DJB group, and DJB+ HBVR group. The changes of preoperative and postoperative body weight, fasting blood glucose level, fasting serum insulin level, fasting serum GLP-1 and PYY contents among four groups were observed. Results In the DJB group, the postoperative body weight and fasting blood glucose level were decreased significantly (P < 0.05) and the fasting insulin level, fasting serum GLP-1 and PYY contents were increased significantly (P < 0.05) as compared with the preoperative corresponding values in the same group, and it was found that the hepatic branch of vagus could more lastingly maintain postoperative lower body weight (P < 0.05), improve the level of insulin (P < 0.05), increase the fasting serum GLP-1 and PYY contents (P < 0.05) as compared with the DJB+HBVR group. Conclusion DJB could improve glucose metabolism effect of GK rats, the hepatic branch of vagus might play a role in it, too.

Citation： WANPeng, WANGYu. Impact of Duodenal Jejunal Bypass and Hepatic Branch of Vagus on Glucose Metabolism in Non-Obese Rat with Type 2 Diabetes Mellitus. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(5): 565-570. doi: 10.7507/1007-9424.20150150 Copy

1.	Rubino F, Forgione A, Cummings DE, et al. The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes. Ann Surg, 2006, 244(5):741-749.
2.	Liu SZ, Sun D, Zhang GY, et al. A high-fat diet reverses improve ment in glucose tolerance induced by duodenal-jejunal bypass in type 2 diabetic rats. Chin Med J, 2012, 125(5):912-919.
3.	Klein S, Fabbrini E, Patterson BW, et al. Moderate effect of duodenal-jejunal bypass surgery on glucose homeostasis in patients with type 2 diabetes. Obesity (Silver Spring), 2012, 20(6):1266-1272.
4.	Geloneze B, Geloneze SR, Chaim E, et al. Metabolic surgery for non-obese type 2 diabetes:incretins, adipocytokines, and insulin secretion/resistance changes in a 1-year interventional clinical controlled study. Ann Surg, 2012, 256(1):72-78.
5.	刘彬, 喻敏, 张再重, 等. Goto-Kakizaki大鼠十二指肠空肠旷置术模型的建立.中国普外基础与临床杂志, 2013, 20(9):1013-1017.
6.	Rehfeld JF. A centenary of gastrointestinal endocrinology. Horm Metab Res, 2004, 36(11-12):735-741.
7.	胡春晓, 刘少壮, 胡三元.十二指肠空肠旁路术治疗2型糖尿病的作用及机制.中华胃肠外科杂志, 2014, 17(7):635-638.
8.	Lee HC, Kim MK, Kwon HS, et al. Early changes in incretin secretion after laparoscopic duodenal-jejunal bypass surgery in type 2 diabetic patients. Obes Surg, 2010, 20(11):1530-1535.
9.	Speck M, Cho YM, Asadi A, et al. Duodenal-jejunal bypass protects GK rats fromβ-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1. Am J Physiol Endocrinol Metab, 2011, 300(5):E923-E932.
10.	Koda S, Date Y, Murakami N, et al. The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats. Endocrinology, 2005, 146(5):2369-2375.
11.	Abbott CR, Monteiro M, Small CJ, et al. The inhibitory effects of peripheral administration of peptide YY (3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. Brain Res, 2005, 1044(1):127-131.
12.	Baggio LL, Drucker DJ. Biology of incretins:GLP-1 and GIP. Gastroenterology, 2007, 132(6):2131-2157.
13.	Baraboi ED, Michel C, Smith P, et al. Effects of albumin-conjugated PYY on food intake:the respective roles of the circumventricular organs and vagus nerve. Eur J Neurosci, 2010, 32(5):826-839.
14.	Zhou DL, Lu LS, Jiang X, et al. Effects and mechanism of duodenaljejunal bypass and sleeve gastrectomy on GLUT2 and glucokinase in diabetic Goto-Kakizaki rats. Eur J Med Res, 2012, 17(1):15.
15.	Trung VN, Yamamoto H, Yamaguchi T, et al. Intact neural system of the portal vein is important for maintaining normal glucose metabolism by regulating glucagon-like peptide-1 and insulin sensitivity. Peptides, 2014, 52(52):38-43.
16.	Matsuhisa M, Yamasaki Y, Shiba Y, et al. Important role of the hepatic vagus nerve in glucose uptake and production by the liver. Metabolism, 2000, 49(1):11-16.
17.	Breen DM, Rasmussen BA, Kokorovic A, et al. Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes. Nat Med, 2012, 18(6):950-955.
18.	Al-Rasheid N, Gray R, Sufi P, et al. Chronic elevation of systemic glucagon-like peptide-1 following surgical weight loss:association with nausea and vomiting and effects on adipokines. Obes Surg, 2015, 25(2):386-391.
19.	Lindegaard KK, Jorgensen NB, Just R, et al. Effects of Roux-en-Y gastric bypass on fasting and postprandial inflammation-related parameters in obese subjects with normal glucose tolerance and in obese subjects with type 2 diabetes. Diabetol Metab Syndr, 2015, 7:12.
20.	Hayes MR, Kanoski SE, De Jonghe BC, et al. The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1. Am J Physiol Regul Integr Comp Physiol, 2011, 301(5):R1479-R1485.
21.	Shin AC, Zheng H, Berthoud HR. Vagal innervation of the hepatic portal vein and liver is not necessary for Roux-en-Y gastric bypass surgery-induced hypophagia, weight loss, and hypermetabolism. Ann Surg, 2012, 255(2):294-301.
22.	Nakabayashi H, Nishizawa M, Nakagawa A, et al. Vagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1. Am J Physiol, 1996, 271(5 Pt 1):E808-E813.
23.	Moore MC, Satake S, Baranowski B, et al. Effect of hepatic denervation on peripheral insulin sensitivity in conscious dogs. Am J Physiol Endocrinol Metab, 2002, 282(2):E286-E296.
24.	Page AJ, Symonds E, Peiris M, et al. Peripheral neural targets in obesity. Br J Pharmacol, 2012, 166(5):1537-1558.

1. Rubino F, Forgione A, Cummings DE, et al. The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes. Ann Surg, 2006, 244(5):741-749.
2. Liu SZ, Sun D, Zhang GY, et al. A high-fat diet reverses improve ment in glucose tolerance induced by duodenal-jejunal bypass in type 2 diabetic rats. Chin Med J, 2012, 125(5):912-919.
3. Klein S, Fabbrini E, Patterson BW, et al. Moderate effect of duodenal-jejunal bypass surgery on glucose homeostasis in patients with type 2 diabetes. Obesity (Silver Spring), 2012, 20(6):1266-1272.
4. Geloneze B, Geloneze SR, Chaim E, et al. Metabolic surgery for non-obese type 2 diabetes:incretins, adipocytokines, and insulin secretion/resistance changes in a 1-year interventional clinical controlled study. Ann Surg, 2012, 256(1):72-78.
5. 刘彬, 喻敏, 张再重, 等. Goto-Kakizaki大鼠十二指肠空肠旷置术模型的建立.中国普外基础与临床杂志, 2013, 20(9):1013-1017.
6. Rehfeld JF. A centenary of gastrointestinal endocrinology. Horm Metab Res, 2004, 36(11-12):735-741.
7. 胡春晓, 刘少壮, 胡三元.十二指肠空肠旁路术治疗2型糖尿病的作用及机制.中华胃肠外科杂志, 2014, 17(7):635-638.
8. Lee HC, Kim MK, Kwon HS, et al. Early changes in incretin secretion after laparoscopic duodenal-jejunal bypass surgery in type 2 diabetic patients. Obes Surg, 2010, 20(11):1530-1535.
9. Speck M, Cho YM, Asadi A, et al. Duodenal-jejunal bypass protects GK rats fromβ-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1. Am J Physiol Endocrinol Metab, 2011, 300(5):E923-E932.
10. Koda S, Date Y, Murakami N, et al. The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats. Endocrinology, 2005, 146(5):2369-2375.
11. Abbott CR, Monteiro M, Small CJ, et al. The inhibitory effects of peripheral administration of peptide YY (3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. Brain Res, 2005, 1044(1):127-131.
12. Baggio LL, Drucker DJ. Biology of incretins:GLP-1 and GIP. Gastroenterology, 2007, 132(6):2131-2157.
13. Baraboi ED, Michel C, Smith P, et al. Effects of albumin-conjugated PYY on food intake:the respective roles of the circumventricular organs and vagus nerve. Eur J Neurosci, 2010, 32(5):826-839.
14. Zhou DL, Lu LS, Jiang X, et al. Effects and mechanism of duodenaljejunal bypass and sleeve gastrectomy on GLUT2 and glucokinase in diabetic Goto-Kakizaki rats. Eur J Med Res, 2012, 17(1):15.
15. Trung VN, Yamamoto H, Yamaguchi T, et al. Intact neural system of the portal vein is important for maintaining normal glucose metabolism by regulating glucagon-like peptide-1 and insulin sensitivity. Peptides, 2014, 52(52):38-43.
16. Matsuhisa M, Yamasaki Y, Shiba Y, et al. Important role of the hepatic vagus nerve in glucose uptake and production by the liver. Metabolism, 2000, 49(1):11-16.
17. Breen DM, Rasmussen BA, Kokorovic A, et al. Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes. Nat Med, 2012, 18(6):950-955.
18. Al-Rasheid N, Gray R, Sufi P, et al. Chronic elevation of systemic glucagon-like peptide-1 following surgical weight loss:association with nausea and vomiting and effects on adipokines. Obes Surg, 2015, 25(2):386-391.
19. Lindegaard KK, Jorgensen NB, Just R, et al. Effects of Roux-en-Y gastric bypass on fasting and postprandial inflammation-related parameters in obese subjects with normal glucose tolerance and in obese subjects with type 2 diabetes. Diabetol Metab Syndr, 2015, 7:12.
20. Hayes MR, Kanoski SE, De Jonghe BC, et al. The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1. Am J Physiol Regul Integr Comp Physiol, 2011, 301(5):R1479-R1485.
21. Shin AC, Zheng H, Berthoud HR. Vagal innervation of the hepatic portal vein and liver is not necessary for Roux-en-Y gastric bypass surgery-induced hypophagia, weight loss, and hypermetabolism. Ann Surg, 2012, 255(2):294-301.
22. Nakabayashi H, Nishizawa M, Nakagawa A, et al. Vagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1. Am J Physiol, 1996, 271(5 Pt 1):E808-E813.
23. Moore MC, Satake S, Baranowski B, et al. Effect of hepatic denervation on peripheral insulin sensitivity in conscious dogs. Am J Physiol Endocrinol Metab, 2002, 282(2):E286-E296.
24. Page AJ, Symonds E, Peiris M, et al. Peripheral neural targets in obesity. Br J Pharmacol, 2012, 166(5):1537-1558.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Impact of Duodenal Jejunal Bypass and Hepatic Branch of Vagus on Glucose Metabolism in Non-Obese Rat with Type 2 Diabetes Mellitus

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content