Research Progress of Relationship Between CD147 and Hepatocellular Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 YANGJie , ZHOUQing , XUXiao-yong , JIANGWei-ming ,  ZHOUDing-hua

Department of Hepatobiliary Surgery, General Hospital of The Second Artillery of PLA, Beijing 100088, China;

Corresponding author：

ZHOUDing-hua, Email: zhoudh@sina.com

Keywords：

Hepatocellular carcinoma; CD147; Biological characteristics; Therapy

DOI：

10.7507/1007-9424.20150333

Video：

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Objective To summary the relationship between CD147 and the occurrence and development of hepatocellular carcinoma, and its roles in clinical diagnosis and treatment. Method Referring to the related literatures in recent years at home and abroad, the concept of CD147, and its relationship with the occurrence, development, invasion, and metastasis of hepatocellular carcinoma were reviewed. Results CD147 plays a key role in the development, progress, invasion, and metastasis of hepatocellular carcinoma. CD147 can be used as a long-term outcome predictor for hepatocellular carcinoma patients and also began to show its in hepatocellular carcinoma target therapy. Conclusion There are numerous studies about the relationship between CD147 and hepatocellular carcinoma, but still exists some problems to be further studied.

Citation： YANGJie, ZHOUQing, XUXiao-yong, JIANGWei-ming, ZHOUDing-hua. Research Progress of Relationship Between CD147 and Hepatocellular Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(10): 1279-1283. doi: 10.7507/1007-9424.20150333 Copy

1.	Xiong LJ, Edward CK, Zhou LJ. The biological function and clinical utilization of CD147 in human diseases:a review of the current scientific literature. Int J Mol Sci, 2014, 15(10):17411-17441.
2.	Biswas C, Zhang Y, DeCastro R, et al. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of immunoglobulin superfamily. Cancer Res, 1995, 55(2):434-439.
3.	Nabeshima K, Iwasaki H, Koga K, et al. Emmprin (basigin/CD147):matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression. Pathol Int, 2006, 56(7):359-367.
4.	Liao CG, Kong LM, Song F, et al. Characterization of basigin isoforms and the inhibitory function of basigin-3 in human hepatocellular carcinoma proliferation and invasion. Mol Cell Biol, 2011, 31(13):2591-2604.
5.	Bai Y, Huang W, Ma LT, et al. Importance of N-glycosylation on CD147 for its biological functions. Int J Mol Sci, 2014, 15(4):6356-6377.
6.	Yurchenko V, Zybarth G, O'Connor M, et al. Active site residues of cyclophilin A are crucial for its signaling activity via CD147. J Biol Chem, 2002, 277(25):22959-22965.
7.	Tian X, Zhao C, Zhu H, et al. Hepatitis B virus (HBV) surface antigen interacts with and promotes cyclophilin a secretion:possible link to pathogenesis of HBV infection. J Virol, 2010, 84(7):3373-3381.
8.	Feng X, Xiu B, Xu L, et al. Hepatitis C virus core protein promotes the migration and invasion of hepatocyte via activating transcription of extracellular matrix metalloproteinase inducer. Virus Res, 2011, 158(1-2):146-153.
9.	Su TH, Kao JH, Liu CJ. Molecular mechanism and treatment of viral hepatitis-related liver fibrosis. Int J Mol Sci, 2014, 15(6):10578-10640.
10.	Calabro SR, Maczurek AE, Morgan AJ, et al. Hepatocyte produced matrix metalloproteinase are regulated by CD147 in liver fibrogenesis. PLoS One, 2014, 9(7):e90571.
11.	Weidle UH, Scheuer W, Eggle D, et al. Cancer-related issues of CD147. Cancer Genomics Proteomics, 2010, 7(3):157-169.
12.	Xu J, Xu HY, Zhang Q, et al. HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma. Mol Cancer Res, 2007, 5(6):605-614.
13.	Qian AR, Zhang W, Cao JP, et al. Downregulation of CD147 expression alterscytoskeleton architecture and inhibits gelatinase production and SAPK pathway in human hepatocellular carcinoma cells. J Exp Clin Cancer Res, 2008, 27:50.
14.	Li Y, Wu J, Song F, et al. Extracellular membrane-proximal domain of HAb18G/CD147 binds to metal ion-dependent adhesion site (MIDAS) motif of integrinβ1 to modulate malignant properties of hepatoma cells. J Biol Chem, 2012, 287(7):4759-4772.
15.	Wu J, Hao ZW, Zhao YX, et al. Full-length soluble CD147 promotes MMP-2 expression and is a potential serological marker in detection of hepatocellular carcinoma. J Transl Med, 2014, 12:190.
16.	Tang X, Guo N, Xu L, et al. CD147/EMMPRIN:an effective therapeutic target for hepatocellular carcinoma. J Drug Target, 2012 Aug 29.[Epub ahead of print].
17.	Tang Y, Nakada MT, Rafferty P, et al. Regulation of vascular endothelial growth factor expression by EMMPRIN via the PI3KAkt signaling pathway. Mol Cancer Res, 2006, 4(6):371-377.
18.	Amit-Cohen BC, Rahat MM, Rahat MA. Tumor cell-macrophage interactions increase angiogenesis through secretion of EMMPRIN. Front Physiol, 2013, 4:178.
19.	Zhao P, Zhang W, Wang SJ, et al. HAb18G/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in HCC cells. Hepatology, 2011, 54(6):2012-2024.
20.	Liang Q, Han Q, Huang W, et al. HAb18G/CD147 Regulates Vinculin-Mediated Focal Adhesion and Cytoskeleton Organization in Cultured Human Hepatocellular Carcinoma cells. PLoS One, 2014, 9(7):e102496.
21.	Jiang J L, Zhou Q, Yu M K, et al. The involvement of HAbl8G/CD147 in regulation of store-operated calcium entry and metastasis of human hepatoma cells. J Bio Chem, 2001, 276(50):46870-46877.
22.	Cui HY, Guo T, Wang SJ, et al. Dimerization is essential for HAb18G/CD147 promoting tumor invasion via MAPK pathway. Biochem Biophys Res Commun, 2012, 419(3):517-522.
23.	Hou Q, Tang X, Liu HQ, et al. Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147. Cancer Sci, 2011, 102(7):1287-1292.
24.	王乐天, 毛沙, 吕裕霞, 等.抗人CD147单克隆抗体对人肝癌细胞MHCC97-H裸鼠肝脏原位移植瘤生长抑制的实验研究.中国医院用药评价与分析, 2010, 10(1):31-33.
25.	Jia L, Xu H, Zhao Y, et al. Expression of CD147 mediates tumor cells invasion and multidrug resistance in hepatocellular carcinoma. Cancer Invest, 2008, 26(10):977-983.
26.	Zhou S, Liao L, Chen C, et al. CD147 mediates chemoresistance in breast cancer via ABCG2 by affecting its cellular localization and dimerization. Cancer Lett, 2013, 337(2):285-292.
27.	Grass GD, Dai L, Qin Z, et al. CD147:Regulator of hyaluronan signaling in invasiveness and chemoresistance. Adv Cancer Res, 2014, 123:351-373.
28.	Mishra A, Verma M. Cancer biomarkers:are we ready for the prime time? Cancers, 2010, 2(1):190-208.
29.	Mamori S, Nagatsuma K, Matsuura T, et al. Useful detection of cd147 for pathological diagnosis of early hepatocellular carcinoma in needle biopsy samples. World J Gastioenterol, 2007, 13(21):2913-2917.
30.	Wang WD, Zhao M, Li YJ, et al. Expressions and clinical significance of CD147 and CK19 in hepatocellular carcinoma. Chinese-German J Clin Oncol, 2012, 11(9):517-521.
31.	Zhu S, Li Y, Zhang Y, et al. Expression and clinical implications of HAb18G/CD147 in hepatocellular carcinoma. Hepatol Res. 2015, 45(1):97-106.
32.	Li Y, Xu J, Chen L. HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection. Histopathology, 2009, 54(6):677-687.
33.	Niu H, Wang R, Cheng J, et al. Treatment of (131)I-labeled anti-CD147 monoclonal antibody in VX2 carcinoma-induced liver tumors. Oncol Rep, 2013, 30(1):246-252.
34.	Chen ZN, Mi L, Xu J, et al. Targeting radioimmunotherapy of hepatocellular carcinoma with iodine (131I) metuximab injection:clinical phase I/II trials. Int J Radiat Oncol Biol Phys, 2006, 65(2):435-444.
35.	封兰兰, 朱少君, 张阳, 等. HAb18G/CD147在多种恶性肿瘤中的表达及其临床意义.细胞与分子免疫学杂志, 2013, 29(9):958-961.

1. Xiong LJ, Edward CK, Zhou LJ. The biological function and clinical utilization of CD147 in human diseases:a review of the current scientific literature. Int J Mol Sci, 2014, 15(10):17411-17441.
2. Biswas C, Zhang Y, DeCastro R, et al. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of immunoglobulin superfamily. Cancer Res, 1995, 55(2):434-439.
3. Nabeshima K, Iwasaki H, Koga K, et al. Emmprin (basigin/CD147):matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression. Pathol Int, 2006, 56(7):359-367.
4. Liao CG, Kong LM, Song F, et al. Characterization of basigin isoforms and the inhibitory function of basigin-3 in human hepatocellular carcinoma proliferation and invasion. Mol Cell Biol, 2011, 31(13):2591-2604.
5. Bai Y, Huang W, Ma LT, et al. Importance of N-glycosylation on CD147 for its biological functions. Int J Mol Sci, 2014, 15(4):6356-6377.
6. Yurchenko V, Zybarth G, O'Connor M, et al. Active site residues of cyclophilin A are crucial for its signaling activity via CD147. J Biol Chem, 2002, 277(25):22959-22965.
7. Tian X, Zhao C, Zhu H, et al. Hepatitis B virus (HBV) surface antigen interacts with and promotes cyclophilin a secretion:possible link to pathogenesis of HBV infection. J Virol, 2010, 84(7):3373-3381.
8. Feng X, Xiu B, Xu L, et al. Hepatitis C virus core protein promotes the migration and invasion of hepatocyte via activating transcription of extracellular matrix metalloproteinase inducer. Virus Res, 2011, 158(1-2):146-153.
9. Su TH, Kao JH, Liu CJ. Molecular mechanism and treatment of viral hepatitis-related liver fibrosis. Int J Mol Sci, 2014, 15(6):10578-10640.
10. Calabro SR, Maczurek AE, Morgan AJ, et al. Hepatocyte produced matrix metalloproteinase are regulated by CD147 in liver fibrogenesis. PLoS One, 2014, 9(7):e90571.
11. Weidle UH, Scheuer W, Eggle D, et al. Cancer-related issues of CD147. Cancer Genomics Proteomics, 2010, 7(3):157-169.
12. Xu J, Xu HY, Zhang Q, et al. HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma. Mol Cancer Res, 2007, 5(6):605-614.
13. Qian AR, Zhang W, Cao JP, et al. Downregulation of CD147 expression alterscytoskeleton architecture and inhibits gelatinase production and SAPK pathway in human hepatocellular carcinoma cells. J Exp Clin Cancer Res, 2008, 27:50.
14. Li Y, Wu J, Song F, et al. Extracellular membrane-proximal domain of HAb18G/CD147 binds to metal ion-dependent adhesion site (MIDAS) motif of integrinβ1 to modulate malignant properties of hepatoma cells. J Biol Chem, 2012, 287(7):4759-4772.
15. Wu J, Hao ZW, Zhao YX, et al. Full-length soluble CD147 promotes MMP-2 expression and is a potential serological marker in detection of hepatocellular carcinoma. J Transl Med, 2014, 12:190.
16. Tang X, Guo N, Xu L, et al. CD147/EMMPRIN:an effective therapeutic target for hepatocellular carcinoma. J Drug Target, 2012 Aug 29.[Epub ahead of print].
17. Tang Y, Nakada MT, Rafferty P, et al. Regulation of vascular endothelial growth factor expression by EMMPRIN via the PI3KAkt signaling pathway. Mol Cancer Res, 2006, 4(6):371-377.
18. Amit-Cohen BC, Rahat MM, Rahat MA. Tumor cell-macrophage interactions increase angiogenesis through secretion of EMMPRIN. Front Physiol, 2013, 4:178.
19. Zhao P, Zhang W, Wang SJ, et al. HAb18G/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in HCC cells. Hepatology, 2011, 54(6):2012-2024.
20. Liang Q, Han Q, Huang W, et al. HAb18G/CD147 Regulates Vinculin-Mediated Focal Adhesion and Cytoskeleton Organization in Cultured Human Hepatocellular Carcinoma cells. PLoS One, 2014, 9(7):e102496.
21. Jiang J L, Zhou Q, Yu M K, et al. The involvement of HAbl8G/CD147 in regulation of store-operated calcium entry and metastasis of human hepatoma cells. J Bio Chem, 2001, 276(50):46870-46877.
22. Cui HY, Guo T, Wang SJ, et al. Dimerization is essential for HAb18G/CD147 promoting tumor invasion via MAPK pathway. Biochem Biophys Res Commun, 2012, 419(3):517-522.
23. Hou Q, Tang X, Liu HQ, et al. Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147. Cancer Sci, 2011, 102(7):1287-1292.
24. 王乐天, 毛沙, 吕裕霞, 等.抗人CD147单克隆抗体对人肝癌细胞MHCC97-H裸鼠肝脏原位移植瘤生长抑制的实验研究.中国医院用药评价与分析, 2010, 10(1):31-33.
25. Jia L, Xu H, Zhao Y, et al. Expression of CD147 mediates tumor cells invasion and multidrug resistance in hepatocellular carcinoma. Cancer Invest, 2008, 26(10):977-983.
26. Zhou S, Liao L, Chen C, et al. CD147 mediates chemoresistance in breast cancer via ABCG2 by affecting its cellular localization and dimerization. Cancer Lett, 2013, 337(2):285-292.
27. Grass GD, Dai L, Qin Z, et al. CD147:Regulator of hyaluronan signaling in invasiveness and chemoresistance. Adv Cancer Res, 2014, 123:351-373.
28. Mishra A, Verma M. Cancer biomarkers:are we ready for the prime time? Cancers, 2010, 2(1):190-208.
29. Mamori S, Nagatsuma K, Matsuura T, et al. Useful detection of cd147 for pathological diagnosis of early hepatocellular carcinoma in needle biopsy samples. World J Gastioenterol, 2007, 13(21):2913-2917.
30. Wang WD, Zhao M, Li YJ, et al. Expressions and clinical significance of CD147 and CK19 in hepatocellular carcinoma. Chinese-German J Clin Oncol, 2012, 11(9):517-521.
31. Zhu S, Li Y, Zhang Y, et al. Expression and clinical implications of HAb18G/CD147 in hepatocellular carcinoma. Hepatol Res. 2015, 45(1):97-106.
32. Li Y, Xu J, Chen L. HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection. Histopathology, 2009, 54(6):677-687.
33. Niu H, Wang R, Cheng J, et al. Treatment of (131)I-labeled anti-CD147 monoclonal antibody in VX2 carcinoma-induced liver tumors. Oncol Rep, 2013, 30(1):246-252.
34. Chen ZN, Mi L, Xu J, et al. Targeting radioimmunotherapy of hepatocellular carcinoma with iodine (131I) metuximab injection:clinical phase I/II trials. Int J Radiat Oncol Biol Phys, 2006, 65(2):435-444.
35. 封兰兰, 朱少君, 张阳, 等. HAb18G/CD147在多种恶性肿瘤中的表达及其临床意义.细胞与分子免疫学杂志, 2013, 29(9):958-961.

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