Clinical Application of Indocyanine Green Fluorescence in Sentinel Lymph Nodes Biopsy for Breast Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 GONGXiao-jun , MAOHong-yan , LIUHui-min ,  BAIHai-ya , YANGPing

Department of Breast, Maternal and Child Care Service Centre of Gansu Province, Lanzhou 730050, Gansu Province, China;

Corresponding author：

BAIHai-ya, Email: gsbhy@sina.cn

Keywords：

Breast cancer; Sentinel lymph node biopsy; Indocyanine green; Methylene blue dye

DOI：

10.7507/1007-9424.20160057

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate clinical value of indocyanine green (ICG) fluorescence in sentinel lymph node (SLN) biopsy (SLNB) for breast cancer. Method The SLNBs were performed in 66 patients with breast cancer,who were divided into ICG group (n=34) and methylene blue dye group (n=32) according to the tracing method. Results The SLNs were found in 59 patients,the detection rate was 89.39%(59/66).One hundred and sixty-two SLNs in 59 patients were detected,the average number of detected SLNs was 2.75.The SLNs detection rate was 97.06%(33/34) and 81.25%(26/32) in the ICG group and in the methylene blue dye group,respectively,which in the ICG group was significantly higher than that in the methylene blue dye group (P<0.05).The positive SLNs were found in 32 cases,within which was 20 cases in the ICG group,12 cases in the methylene blue dye group.The axillary lymph node metastases were found in 35 of 66 cases,within which was 21 cases in the ICG group,14 cases in the methylene blue dye group.The sensitivity and false negative rate had no significant differences between the ICG group and the methylene blue dye group (sensitivity:95.2% versus 85.7%,P>0.05;false negative rate:4.8% versus 14.3%,P>0.05). Conclusion The ICG fluorescence in SLNB for breast cancer has many advantages,including shorter time,simple operation,high sensitivity,and high detection rate as compared with methylene blue dye.

Citation： GONGXiao-jun, MAOHong-yan, LIUHui-min, BAIHai-ya, YANGPing. Clinical Application of Indocyanine Green Fluorescence in Sentinel Lymph Nodes Biopsy for Breast Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(2): 221-224. doi: 10.7507/1007-9424.20160057 Copy

1.	Theriault RL, Carlson RW, Allred C, et al. Breast cancer, version 3.2013:featured updates to the NCCN guidelines. J Natl Compr Canc Netw, 2013, 11(7):753-761.
2.	中国抗癌协会乳腺癌专业委员会. 中国抗癌协会乳腺癌诊治指南与规范(2013版). 中国癌症杂志, 2013, 23(8):637-693.
3.	Lyman GH, Giuliano AE, Somerfield MR, et al. American society of clinical oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol, 2005, 23(30):7703-7720.
4.	颜宁, 刘少杰, 彭伟强, 等. 早期乳腺癌前哨淋巴结活检对预测腋窝淋巴结状态的临床探讨. 当代医学, 2013, 1(1):107-108.
5.	郭嘉嘉, 杨厚圃, 周礼馨, 等. 自发荧光物质在前哨淋巴结活检中的应用. 中国肿瘤临床, 2011, 3(22):1397-1399.
6.	陈国际, 张保宁, 邵永孚, 等. 前哨淋巴结活检在乳腺癌治疗中的应用价值. 实用肿瘤杂志, 2004, 1(3):226-228.
7.	Martin RC, Chagpar A, Scoggins CR, et al. Clinicopathologic factors associated with false-negative sentinel lymph-node biopsy in breast cancer. Ann Surg, 2005, 241(6):1005-1015.
8.	崔一尧, 王水. 前哨淋巴结活检在乳腺癌治疗中的意义. 医学与哲学:临床决策论坛版, 2011, 32(8):41-42, 76.
9.	吴祥德. 乳腺疾病诊治. 第2版. 北京:人民卫生出版社, 2009:151.
10.	Dauphine CE, Khalkhali I, Vargas MP, et al. Intraoperative injection of technetium-99m Sulfur colloid is effective in the detection of sentinel lymph nodes in breast cancer. Am J Surg, 2006, 192(4):423-426.
11.	中国抗癌协会乳腺癌专业委员会. 中国抗癌协会乳腺癌诊治指南与规范(2013). 中国癌症杂志, 2013, 23(8):637-685.
12.	Moody LC, Wen X, Mcknight T, et al. Indications for sentinel lymph node biopsy in multifocal and multicentric breast cancer. Surgery, 2012, 152(3):389-396.
13.	林文旭, 黄两喜, 谢春发, 等. 荧光探测技术在乳腺癌前哨淋巴结活检中的应用. 中国煤炭工业医学杂志, 2014, 17(3):421-422.
14.	张雅媛, 周冬仙, 丁雪青. 美蓝在乳癌前哨淋巴结定位活检中的应用研究. 当代医学, 2012, 9(1):69-70.
15.	王永胜. 乳腺癌前哨淋巴结活检:共识与展望. 中国普外基础与临床杂志, 2009, 16(7):505-509..
16.	Tagaya N, Yamazaki R, Nakagawa A, et al. Intraoperative identifi-cation of sentinel lymph nodes by near-infrared fluorescence imaging in patients with breast cancer. Am J Surg, 2008, 195(6):850-853.

1. Theriault RL, Carlson RW, Allred C, et al. Breast cancer, version 3.2013:featured updates to the NCCN guidelines. J Natl Compr Canc Netw, 2013, 11(7):753-761.
2. 中国抗癌协会乳腺癌专业委员会. 中国抗癌协会乳腺癌诊治指南与规范(2013版). 中国癌症杂志, 2013, 23(8):637-693.
3. Lyman GH, Giuliano AE, Somerfield MR, et al. American society of clinical oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol, 2005, 23(30):7703-7720.
4. 颜宁, 刘少杰, 彭伟强, 等. 早期乳腺癌前哨淋巴结活检对预测腋窝淋巴结状态的临床探讨. 当代医学, 2013, 1(1):107-108.
5. 郭嘉嘉, 杨厚圃, 周礼馨, 等. 自发荧光物质在前哨淋巴结活检中的应用. 中国肿瘤临床, 2011, 3(22):1397-1399.
6. 陈国际, 张保宁, 邵永孚, 等. 前哨淋巴结活检在乳腺癌治疗中的应用价值. 实用肿瘤杂志, 2004, 1(3):226-228.
7. Martin RC, Chagpar A, Scoggins CR, et al. Clinicopathologic factors associated with false-negative sentinel lymph-node biopsy in breast cancer. Ann Surg, 2005, 241(6):1005-1015.
8. 崔一尧, 王水. 前哨淋巴结活检在乳腺癌治疗中的意义. 医学与哲学:临床决策论坛版, 2011, 32(8):41-42, 76.
9. 吴祥德. 乳腺疾病诊治. 第2版. 北京:人民卫生出版社, 2009:151.
10. Dauphine CE, Khalkhali I, Vargas MP, et al. Intraoperative injection of technetium-99m Sulfur colloid is effective in the detection of sentinel lymph nodes in breast cancer. Am J Surg, 2006, 192(4):423-426.
11. 中国抗癌协会乳腺癌专业委员会. 中国抗癌协会乳腺癌诊治指南与规范(2013). 中国癌症杂志, 2013, 23(8):637-685.
12. Moody LC, Wen X, Mcknight T, et al. Indications for sentinel lymph node biopsy in multifocal and multicentric breast cancer. Surgery, 2012, 152(3):389-396.
13. 林文旭, 黄两喜, 谢春发, 等. 荧光探测技术在乳腺癌前哨淋巴结活检中的应用. 中国煤炭工业医学杂志, 2014, 17(3):421-422.
14. 张雅媛, 周冬仙, 丁雪青. 美蓝在乳癌前哨淋巴结定位活检中的应用研究. 当代医学, 2012, 9(1):69-70.
15. 王永胜. 乳腺癌前哨淋巴结活检:共识与展望. 中国普外基础与临床杂志, 2009, 16(7):505-509..
16. Tagaya N, Yamazaki R, Nakagawa A, et al. Intraoperative identifi-cation of sentinel lymph nodes by near-infrared fluorescence imaging in patients with breast cancer. Am J Surg, 2008, 195(6):850-853.

Previous Article
Experiences of Laparoscopic Extralevator Abdominoperineal Excision for 46 Cases of Advanced Low Rectal Cancer
Next Article
左侧腹股沟恶性透明细胞汗腺瘤1例报道

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Application of Indocyanine Green Fluorescence in Sentinel Lymph Nodes Biopsy for Breast Cancer

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content