Castleman病9例报道_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 罗云 ¹ ,  王崇树 ¹ , 谢贤镛 ²

1. ;
2. ;

Corresponding author：

王崇树, Email: chongshu-wang@163.com

Keywords：

Castleman病; 临床特征; 诊断; 治疗

DOI：

10.7507/1007-9424.20160063

Video：

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目的总结Castleman病的临床特征及诊治经验。方法回顾性分析2010年1月至2014年12月期间我院收治的9例Castleman病患者的临床资料。结果本组患者发病部位以颈部多见（4例），病理分型以透明血管型多见（5例），5例局灶型Castleman病患者经手术治疗取得良好效果；3例多中心型Castleman病患者经环磷酰胺+多柔比星+长春新碱+泼尼松（CHOP）化疗后病情得到好转，1例中心型Castleman病患者因基础疾病未化疗而复发。结论 Castleman病是一种罕见的淋巴系统增生性疾病，无特异性表现，诊断依赖于病理组织学，手术是治疗局灶型Castleman病的首选方法，CHOP化疗方案是治疗中心型Castleman病的一种有效方案。

Citation： 罗云, 王崇树, 谢贤镛. Castleman病9例报道. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(2): 234-236. doi: 10.7507/1007-9424.20160063 Copy

1.	Castleman B, Towne VW. Case records of the Massachusetts General Hospital:Case No. 40231. N Engl J Med, 1954, 250(23):1001-1005.
2.	Castleman B, Iverson L, Menendez VP. Localized mediastinal lymphnode hyperplasia resembling thymoma. Cancer, 1956, 9(4):822-830.
3.	符刚, 田小波, 陈洁平, 等. 9例Castleman病临床观察及文献分析. 第三军医大学学报, 2013, 35(15):1636-1638.
4.	Dispenzieri A, Armitage JO, Loe MJ, et al. The clinical spectrum of Castleman,s disease. Am J Hematol, 2012, 87(11):997-1002.
5.	韩鸿雁, 李晓兵, 张博, 等. Castleman病临床病理分析并文献复习. 临床与实验病理学杂志, 2015, 31(1):58-61.
6.	Zhu SH, Yu YH, Zhang Y, et al. Clinical features and outcome of patients with HIV-negative multicentric Castleman,s disease treated with combination chemotherapy:a report on 10 patients. Med Oncol, 2013, 30(1):492.
7.	Uldrick TS, Polizzotto MN, Aleman KA, et al. High-dose zidovudine plus valganciclovir for Kaposi sarcoma herpesvirus-associated multicentric Castleman disease:a pilot study of virus-activated cytotoxic therapy. Blood, 2011, 117(26):6977-6986.
8.	Yuzuriha A, Saitoh T, Koiso H, et al. Successful treatment of autoim-mune hemolytic anemia associated with multicentric castleman disease by Anti-Interleukin-6 receptor antibody (tocilizumab) therapy. Acta Haematol, 2011, 126(3):147-150.
9.	Van Rhee F, Wong RS, Munshi N, et al. Siltuximab for multicentric Castleman,s disease:a randomised, double-blind, placebo-controlled trial. Lancet Oncol, 2014, 15(9):966-974.

1. Castleman B, Towne VW. Case records of the Massachusetts General Hospital:Case No. 40231. N Engl J Med, 1954, 250(23):1001-1005.
2. Castleman B, Iverson L, Menendez VP. Localized mediastinal lymphnode hyperplasia resembling thymoma. Cancer, 1956, 9(4):822-830.
3. 符刚, 田小波, 陈洁平, 等. 9例Castleman病临床观察及文献分析. 第三军医大学学报, 2013, 35(15):1636-1638.
4. Dispenzieri A, Armitage JO, Loe MJ, et al. The clinical spectrum of Castleman,s disease. Am J Hematol, 2012, 87(11):997-1002.
5. 韩鸿雁, 李晓兵, 张博, 等. Castleman病临床病理分析并文献复习. 临床与实验病理学杂志, 2015, 31(1):58-61.
6. Zhu SH, Yu YH, Zhang Y, et al. Clinical features and outcome of patients with HIV-negative multicentric Castleman,s disease treated with combination chemotherapy:a report on 10 patients. Med Oncol, 2013, 30(1):492.
7. Uldrick TS, Polizzotto MN, Aleman KA, et al. High-dose zidovudine plus valganciclovir for Kaposi sarcoma herpesvirus-associated multicentric Castleman disease:a pilot study of virus-activated cytotoxic therapy. Blood, 2011, 117(26):6977-6986.
8. Yuzuriha A, Saitoh T, Koiso H, et al. Successful treatment of autoim-mune hemolytic anemia associated with multicentric castleman disease by Anti-Interleukin-6 receptor antibody (tocilizumab) therapy. Acta Haematol, 2011, 126(3):147-150.
9. Van Rhee F, Wong RS, Munshi N, et al. Siltuximab for multicentric Castleman,s disease:a randomised, double-blind, placebo-controlled trial. Lancet Oncol, 2014, 15(9):966-974.

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Castleman病9例报道

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