The Clinical Analysis of 74 Cases with Gastrointestinal Neuroendocrine Neoplasm_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 NIULu-wei ¹ , LIUHao ² , WANGKai ² , FUHai-xiao ² ,  FUWei ²

1. The Graduate School of Xuzhou Medical College, Xuzhou, 221000, Jiangsu Province, China;
2. Department of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, 221000, Jiangsu Province, China;

Corresponding author：

FUWei, Email: master-fuwei@163.com

Keywords：

Neuroendocrine neoplasm; Gastrointestinal; Surgery

DOI：

10.7507/1007-9424.20160124

Video：

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Objective To investigate the clinical characteristic and treatment of gastrointestinal neuroendocrine neoplasm. Methods From January 2011 to July 2015, the clinical characteristic and treatment of 74 patients with gastrointestinal neuroendocrine neoplasm in The Affiliated Hospital of Xuzhou Medical College were retrospectively analyzed. Results Cases of gastrointestinal neuroendocrine neoplasm were increasing year by year. This study includes statistics of 74 patients. The number of male and female were 47 and 27, the rate was 1.74:1, the median age was 57.5 years old ranging from 24 up to 82 years. Of all the 74 cases, there were 38 cases (51.4%) in the stomach, 23 cases (31.1%) in rectum, 12 cases (16.2%) in colon, 1 case in duodenum. Of all the 74 cases with clinical symptom information, non-functional symptom accounts for 95.9% (71/74), while functional symptom accounts only for 4.1% (3/74). There were treatment data of 74 cases, including 34 cases in radical surgery, 23 cases in endoscopic excision, 8 cases in local resection, 4 cases in palliative resection, and 5cases in conservative treatment. The lymphatic metastasis was associated with gender, tumor size, tumor depth of invasion and tumor differentiation (P < 0.05). There was no statistically significant between the lymphatic metastasis and tumor location (P > 0.05). Preoperative distant metastasis was associated with tumor size and tumor depth of invasion (P < 0.05). Syn had a higher positive rate than CgA (P < 0.01). The positive rate of Syn and CgA was respectively 96.1% (49/51) and 72.9% (35/48). Conciusions Cases of gastrointestinal neuroendocrine neoplasm are increasing year by year, of which men has a higher morbidity than women. Radical surgery and endoscopic resection are the main treatment methods. The Syn and CgA test are helpful to the diagnosis of gastrointestinal neuroendocrine neoplasm.

Citation： NIULu-wei, LIUHao, WANGKai, FUHai-xiao, FUWei. The Clinical Analysis of 74 Cases with Gastrointestinal Neuroendocrine Neoplasm. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(4): 467-471. doi: 10.7507/1007-9424.20160124 Copy

1.	Massironi S, Sciola V, Peracchi M, et al. Neuroendocrine tumors of the gastro-entero-pancreatic system. World J Gastroenterol, 2008, 14(35):5377-5384.
2.	Niederle MB, Hackl M, Kaserer K, et al. Gastroenteropancreatic neumendocrine tumours:the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification:an analysis based on prospectively collected parameters. Endocr Relat Cancer, 2010, 17(4):909-918.
3.	朱雄增.胃肠胰神经内分泌肿瘤新分类的临床意义.中华胃肠外科杂志, 2013, 16(1):12-14.
4.	Lawrence B, Gustafsson BI, Chan A, et al. The epidemiology of gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin North Am, 2011, 40(1):1-18.
5.	Yao JC, Hassan M, Phan A, et al. One hundred years after "carcinoid":epidemiology of and prognostic factors for neuroendocrine tumors in 35 825 cases in the United States. J Clin Oncol, 2008, 26(18):3063-3072.
6.	叶郁红, 张声, 王行富, 等. 90例胃肠道神经内分泌肿瘤病理学重新诊断评估.华中科技大学学报:医学版, 2012, 41(4):440-444.
7.	依荷芭丽·迟, 姜文昌, 杜丰, 等.神经内分泌瘤252例临床分析.中华肿瘤杂志, 2013, 35(1):67-70.
8.	张辉亮. 113例胃肠道神经内分泌肿瘤临床病理及预后分析.山东大学, 2014.
9.	王霄, 宋争放, 姚文秀, 等.胃肠胰神经内分泌瘤的临床病理特点及预后的多因素分析.中华医学杂志, 2013, 93(18):1411-1414.
10.	郭林杰, 唐承薇.中国胃肠胰神经内分泌肿瘤临床研究现状分析.胃肠病学, 2012, 17(5):276-278.
11.	刘忠, 李俊强, 田大宇, 等.消化系统神经内分泌肿瘤29例临床分析.中华胃肠外科杂志, 2013, 16(11):1084-1087.
12.	龚海燕, 戈伟, 蒋松松, 等. 70例胃肠胰神经内分泌肿瘤的诊治分析.中国普外基础与临床杂志, 2014, 21(9):1145-1148.
13.	高巍, 刘尚梅, 鲁海珍, 等.肠道神经内分泌肿瘤的临床病理特点及预后分析.中华肿瘤杂志, 2012, 34(6):450-456.
14.	王钰虹, 林原, 薛玲, 等. 87例胃肠胰神经内分泌肿瘤的诊治分析.中华消化杂志, 2011, 31(8):531-535.
15.	潘定宇, 孙来宝, 陈纪伟, 等.胃肠道神经内分泌癌诊治分析.武汉大学学报:医学版, 2002, 23(3):238-240.
16.	Sarmiento JM, Heywood G, Rubin J, et al. Surgical treatment of neuroendocrine metastases to the liver:a plea for resection to increase survival. J Am Coll Surg, 2003, 197(1):29-37.
17.	陈伟伟, 谷云飞, 陈邑岐.直肠神经内分泌肿瘤16例临床分析.中国普外基础与临床杂志, 2014, 21(12):1576-1578.
18.	冯金燕, 伍晓汀.胃肠道神经内分泌肿瘤的诊疗进展.中国普外基础与临床杂志, 2013, 20(3):334-339.
19.	王辉, 宋军, 徐为, 等. 15例胃肠道类癌的诊治分析.徐州医学院学报, 2012, 32(4):254-255.
20.	高茹, 高峰, 张杰, 等.消化道类癌38例的临床分析.中华临床医师杂志:电子版, 2012, 6(14):4096-4098.
21.	王化冰, 王连鹏.直肠神经内分泌肿瘤的临床病理特点分析.中华医学杂志, 2010, 90(24):1686-1689.
22.	朱军, 丁健华, 赵克, 等.直肠类癌预后影响因素分析.中国普外基础与临床杂志, 2012, 19(4):387-390.
23.	Soga J. Early-stage carcinoids of the gastrointestinal tract:an analysis of 1 914 reported cases. Cancer, 2005, 103(8):1587-1595.
24.	Hodul PJ, Strosberg JR, Kvols LK. Aggressive surgical resection in the management of pancreatic neuroendocrine tumors:when is it indicated. Cancer Control, 2008, 15(4):314-321.
25.	Rindi G, D'Adda T, Froio E, et al.Prognostic factors in gastrointestinal endocrine tumors. Endocr Pathol, 2007, 18(3):145-149.

1. Massironi S, Sciola V, Peracchi M, et al. Neuroendocrine tumors of the gastro-entero-pancreatic system. World J Gastroenterol, 2008, 14(35):5377-5384.
2. Niederle MB, Hackl M, Kaserer K, et al. Gastroenteropancreatic neumendocrine tumours:the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification:an analysis based on prospectively collected parameters. Endocr Relat Cancer, 2010, 17(4):909-918.
3. 朱雄增.胃肠胰神经内分泌肿瘤新分类的临床意义.中华胃肠外科杂志, 2013, 16(1):12-14.
4. Lawrence B, Gustafsson BI, Chan A, et al. The epidemiology of gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin North Am, 2011, 40(1):1-18.
5. Yao JC, Hassan M, Phan A, et al. One hundred years after "carcinoid":epidemiology of and prognostic factors for neuroendocrine tumors in 35 825 cases in the United States. J Clin Oncol, 2008, 26(18):3063-3072.
6. 叶郁红, 张声, 王行富, 等. 90例胃肠道神经内分泌肿瘤病理学重新诊断评估.华中科技大学学报:医学版, 2012, 41(4):440-444.
7. 依荷芭丽·迟, 姜文昌, 杜丰, 等.神经内分泌瘤252例临床分析.中华肿瘤杂志, 2013, 35(1):67-70.
8. 张辉亮. 113例胃肠道神经内分泌肿瘤临床病理及预后分析.山东大学, 2014.
9. 王霄, 宋争放, 姚文秀, 等.胃肠胰神经内分泌瘤的临床病理特点及预后的多因素分析.中华医学杂志, 2013, 93(18):1411-1414.
10. 郭林杰, 唐承薇.中国胃肠胰神经内分泌肿瘤临床研究现状分析.胃肠病学, 2012, 17(5):276-278.
11. 刘忠, 李俊强, 田大宇, 等.消化系统神经内分泌肿瘤29例临床分析.中华胃肠外科杂志, 2013, 16(11):1084-1087.
12. 龚海燕, 戈伟, 蒋松松, 等. 70例胃肠胰神经内分泌肿瘤的诊治分析.中国普外基础与临床杂志, 2014, 21(9):1145-1148.
13. 高巍, 刘尚梅, 鲁海珍, 等.肠道神经内分泌肿瘤的临床病理特点及预后分析.中华肿瘤杂志, 2012, 34(6):450-456.
14. 王钰虹, 林原, 薛玲, 等. 87例胃肠胰神经内分泌肿瘤的诊治分析.中华消化杂志, 2011, 31(8):531-535.
15. 潘定宇, 孙来宝, 陈纪伟, 等.胃肠道神经内分泌癌诊治分析.武汉大学学报:医学版, 2002, 23(3):238-240.
16. Sarmiento JM, Heywood G, Rubin J, et al. Surgical treatment of neuroendocrine metastases to the liver:a plea for resection to increase survival. J Am Coll Surg, 2003, 197(1):29-37.
17. 陈伟伟, 谷云飞, 陈邑岐.直肠神经内分泌肿瘤16例临床分析.中国普外基础与临床杂志, 2014, 21(12):1576-1578.
18. 冯金燕, 伍晓汀.胃肠道神经内分泌肿瘤的诊疗进展.中国普外基础与临床杂志, 2013, 20(3):334-339.
19. 王辉, 宋军, 徐为, 等. 15例胃肠道类癌的诊治分析.徐州医学院学报, 2012, 32(4):254-255.
20. 高茹, 高峰, 张杰, 等.消化道类癌38例的临床分析.中华临床医师杂志:电子版, 2012, 6(14):4096-4098.
21. 王化冰, 王连鹏.直肠神经内分泌肿瘤的临床病理特点分析.中华医学杂志, 2010, 90(24):1686-1689.
22. 朱军, 丁健华, 赵克, 等.直肠类癌预后影响因素分析.中国普外基础与临床杂志, 2012, 19(4):387-390.
23. Soga J. Early-stage carcinoids of the gastrointestinal tract:an analysis of 1 914 reported cases. Cancer, 2005, 103(8):1587-1595.
24. Hodul PJ, Strosberg JR, Kvols LK. Aggressive surgical resection in the management of pancreatic neuroendocrine tumors:when is it indicated. Cancer Control, 2008, 15(4):314-321.
25. Rindi G, D'Adda T, Froio E, et al.Prognostic factors in gastrointestinal endocrine tumors. Endocr Pathol, 2007, 18(3):145-149.

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The Clinical Analysis of 74 Cases with Gastrointestinal Neuroendocrine Neoplasm

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