Clinical Analysis of 9 Patients with Primary Thyroid Lymphoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 NIULu-wei ^1,2 ,  ZHANGJia-xin ¹

1. The second Department of Thyroid and Breast surgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221000, Jiangsu Province, China;
2. Graduate school of Xuzhou Medical College, Xuzhou 221000, Jiangsu Province, China;

Corresponding author：

ZHANGJia-xin, Email: xyfyzjx@163.com

Keywords：

Primary thyroid lymphoma; Hashimoto thyroiditis

DOI：

10.7507/1007-9424.20160159

Video：

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Objective To analyze clinical manifestation, diagnosis, therapy, and prognosis of primary thyroid lymphoma. Method From April 2012 to September 2015, the clinical data of 9 patients with primary thyroid lymphoma admitted to The Affiliated Hospital of Xuzhou Medical College, including clinical manifestation, diagnosis procedure, treatment project, and prognosis, were reviewed retrospectively. Results The thyroids or nodules of 4 patients increased rapidly in 1-3 months, with the surrounding tissues and organs oppression symptoms. The preoperative examination revealed that there were 5 patients with swollen lymph nodes. Eight patients were received preoperative thyroid function examination, there were 4 patients with subclinical hypothyroidism, 4 patients with rose TSH, 6 patients with rose thyroglobulin antibody. There were 5 cases of primary thyroid lymphoma associated with Hashimoto thyroiditis. Eight patients were underwent surgical treatment in our hospital, 1 patient was underwent surgery in the other hospital. The results of pathological histology showed that 5 patients with mucosa associated lymphadenoma were stageⅠE, 3 patients with diffuse large B cell lymphoma were stageⅠE, 1 patient with diffuse large B cell lymphoma was stageⅡE. Two patients with diffuse large B cell lymphoma were received chemotherapy, the scheme was CHOP and COP respectively. Seven patients were received follow-up, the follow-up time was 2-42 months, the median follow-up time was 20 months, all of them were survived. Conclusions Primary thyroid lymphoma should be considered for patients with rapid growth of thyroid mass in a short term, which relies on the histopathologic and immunohistochemical diagnosis finally. The individualized treatment should be performed for primary thyroid lymphoma according to pathological classification.

Citation： NIULu-wei, ZHANGJia-xin. Clinical Analysis of 9 Patients with Primary Thyroid Lymphoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(5): 594-597. doi: 10.7507/1007-9424.20160159 Copy

1.	Kharrat S, Sethom A, Chelly I, et al. Primary thyroid lymphoma. Tunis Med, 2011, 89(7):648-649.
2.	Derringer GA, Thompson LD, Frommelt RA, et al. Malignant lymphoma of the thyroid gland:a clinicopathologic study of 108 cases. Am J surg Pathol, 2000, 24(5):623-639.
3.	Orita Y, Sato Y, Kimura N, et al. Characteristic ultrasound features of mucosa-associated lymphoid tissue lymphoma of the salivary and thyroid gland. Acta Otolaryngol, 2014, 134(1):93-99.
4.	Watanabe N, Noh JY, Narimatsu H, et al. Clinicopathological features of 171 cases of primary thyroid lymphoma:a long-term study involving 24553 patients with Hashimoto's disease. Br J Haematol, 2011, 153(2):236-243.
5.	Takakuwa T, Miyauchi A, Aozasa K. Aberrant somatic hypermutations in thyroid lymphomas. Leuk Res, 2009, 33(5):649-654.
6.	Stein SA, Wartofsky L. Primary thyroid lymphoma:a clinical review. J Clin Endocrinol Metab, 2013, 98(8):3131-3138.
7.	Ruggiero FP, Frauenhoffer E, Stack BC Jr. Thyroid lymphoma:a single institution's experience. Otolaryngol Head Neck surg, 2005, 133(6):888-896.
8.	张平, 王志宏, 贺亮, 等.原发性甲状腺恶性淋巴瘤的诊断与治疗:附23例报告.中国普通外科杂志, 2012, 21(11):1369-1372.
9.	朱精强, 李缨来, 陈国经, 等.桥本病合并甲状腺恶性肿瘤的诊治(附8例报告).中国普外基础与临床杂志, 2000, 7(4):252-254.
10.	孙治君, 姚榛祥, 管小琴.甲状腺原发性恶性淋巴瘤的诊断与治疗(附7例报告).中国普外基础与临床杂志, 2003, 10(4):393-394.
11.	Katna R, Shet T, Sengar M, et al. Clinicopathologic study and outcome analysis of thyroid lymphomas:experience from a tertiary cancer center. Head Neck, 2013, 35(2):165-171.
12.	夏青萍, 卫骆云.原发性甲状腺恶性淋巴瘤合并桥本氏甲状腺炎11例诊治分析.浙江实用医学, 2015, 20(5):335-337.
13.	骆惊涛, 魏玺, 张仑.原发性甲状腺淋巴瘤的超声表现病理及其他影像学特征分析.中国肿瘤临床, 2014, 41(2):123-126.
14.	孔德军, 王平, 刘家开.原发性甲状腺淋巴瘤的超声表现及病理学特征分析.实用临床医药杂志, 2015, 19(z1):145-147.
15.	杨盼, 孙映荷, 马步云, 等.原发性甲状腺非霍奇金淋巴瘤的超声征象分析.中国普外基础与临床杂志, 2014, 21(9):1092-1096.
16.	Takashima S, Tomiyama N, Morimoto S, et al. Nonpalpable primary thyroid lymphoma diagnosed by ultrasound-guided fine needle biopsy. J Clin Ultrasound, 1992, 20(2):142-145.
17.	宋扬, 刘华, 卢满存.13例原发性甲状腺淋巴瘤的临床分析.重庆医学, 2012, 41(36):3844-3846.
18.	李建华, 李利文, 付利军, 等.外科手术在原发性甲状腺淋巴瘤综合诊治中的作用.肿瘤基础与临床, 2015, 28(3):213-217.
19.	Takano T, Asahi S, Matsuzuka F, et al. Aspiration biopsy-nucleic acid diagnosis of thyroid malignant lymphoma by vectorette PCR:experience of eight cases. Leuk Res, 2008, 32(1):151-4.
20.	Motta G, Cea M, Carbone F, et al. Current standards and future strategies in immunochemotherapy of non-Hodgkin's lymphoma. J BUON, 2011, 16(1):9-15.
21.	Sakorafas GH. What's the role of surgery in the management of primary thyroid lymphoma? Acta Oncol, 2011, 50(2):319-320.
22.	徐晓帆, 顾军, 张新华, 等.甲状腺黏膜相关淋巴组织淋巴瘤的诊断及治疗.江苏医药, 2014, 40(20):2485-2487.
23.	谢婧, 邓先兆, 樊友本, 等.原发性甲状腺淋巴瘤疗效分析(附20例报道).中国普外基础与临床杂志, 2014, 21(9):1097-1102.
24.	张秉栋, 薛勇敢, 刘洪一, 等.20例原发性甲状腺淋巴瘤的临床分析.解放军医学院学报, 2015, 36(5):419-424.
25.	杨栋, 王磊, 汪颖厚, 等.原发性甲状腺恶性淋巴瘤22例临床分析.临床外科杂志, 2014, 22(12):903-905, 906.

1. Kharrat S, Sethom A, Chelly I, et al. Primary thyroid lymphoma. Tunis Med, 2011, 89(7):648-649.
2. Derringer GA, Thompson LD, Frommelt RA, et al. Malignant lymphoma of the thyroid gland:a clinicopathologic study of 108 cases. Am J surg Pathol, 2000, 24(5):623-639.
3. Orita Y, Sato Y, Kimura N, et al. Characteristic ultrasound features of mucosa-associated lymphoid tissue lymphoma of the salivary and thyroid gland. Acta Otolaryngol, 2014, 134(1):93-99.
4. Watanabe N, Noh JY, Narimatsu H, et al. Clinicopathological features of 171 cases of primary thyroid lymphoma:a long-term study involving 24553 patients with Hashimoto's disease. Br J Haematol, 2011, 153(2):236-243.
5. Takakuwa T, Miyauchi A, Aozasa K. Aberrant somatic hypermutations in thyroid lymphomas. Leuk Res, 2009, 33(5):649-654.
6. Stein SA, Wartofsky L. Primary thyroid lymphoma:a clinical review. J Clin Endocrinol Metab, 2013, 98(8):3131-3138.
7. Ruggiero FP, Frauenhoffer E, Stack BC Jr. Thyroid lymphoma:a single institution's experience. Otolaryngol Head Neck surg, 2005, 133(6):888-896.
8. 张平, 王志宏, 贺亮, 等.原发性甲状腺恶性淋巴瘤的诊断与治疗:附23例报告.中国普通外科杂志, 2012, 21(11):1369-1372.
9. 朱精强, 李缨来, 陈国经, 等.桥本病合并甲状腺恶性肿瘤的诊治(附8例报告).中国普外基础与临床杂志, 2000, 7(4):252-254.
10. 孙治君, 姚榛祥, 管小琴.甲状腺原发性恶性淋巴瘤的诊断与治疗(附7例报告).中国普外基础与临床杂志, 2003, 10(4):393-394.
11. Katna R, Shet T, Sengar M, et al. Clinicopathologic study and outcome analysis of thyroid lymphomas:experience from a tertiary cancer center. Head Neck, 2013, 35(2):165-171.
12. 夏青萍, 卫骆云.原发性甲状腺恶性淋巴瘤合并桥本氏甲状腺炎11例诊治分析.浙江实用医学, 2015, 20(5):335-337.
13. 骆惊涛, 魏玺, 张仑.原发性甲状腺淋巴瘤的超声表现病理及其他影像学特征分析.中国肿瘤临床, 2014, 41(2):123-126.
14. 孔德军, 王平, 刘家开.原发性甲状腺淋巴瘤的超声表现及病理学特征分析.实用临床医药杂志, 2015, 19(z1):145-147.
15. 杨盼, 孙映荷, 马步云, 等.原发性甲状腺非霍奇金淋巴瘤的超声征象分析.中国普外基础与临床杂志, 2014, 21(9):1092-1096.
16. Takashima S, Tomiyama N, Morimoto S, et al. Nonpalpable primary thyroid lymphoma diagnosed by ultrasound-guided fine needle biopsy. J Clin Ultrasound, 1992, 20(2):142-145.
17. 宋扬, 刘华, 卢满存.13例原发性甲状腺淋巴瘤的临床分析.重庆医学, 2012, 41(36):3844-3846.
18. 李建华, 李利文, 付利军, 等.外科手术在原发性甲状腺淋巴瘤综合诊治中的作用.肿瘤基础与临床, 2015, 28(3):213-217.
19. Takano T, Asahi S, Matsuzuka F, et al. Aspiration biopsy-nucleic acid diagnosis of thyroid malignant lymphoma by vectorette PCR:experience of eight cases. Leuk Res, 2008, 32(1):151-4.
20. Motta G, Cea M, Carbone F, et al. Current standards and future strategies in immunochemotherapy of non-Hodgkin's lymphoma. J BUON, 2011, 16(1):9-15.
21. Sakorafas GH. What's the role of surgery in the management of primary thyroid lymphoma? Acta Oncol, 2011, 50(2):319-320.
22. 徐晓帆, 顾军, 张新华, 等.甲状腺黏膜相关淋巴组织淋巴瘤的诊断及治疗.江苏医药, 2014, 40(20):2485-2487.
23. 谢婧, 邓先兆, 樊友本, 等.原发性甲状腺淋巴瘤疗效分析(附20例报道).中国普外基础与临床杂志, 2014, 21(9):1097-1102.
24. 张秉栋, 薛勇敢, 刘洪一, 等.20例原发性甲状腺淋巴瘤的临床分析.解放军医学院学报, 2015, 36(5):419-424.
25. 杨栋, 王磊, 汪颖厚, 等.原发性甲状腺恶性淋巴瘤22例临床分析.临床外科杂志, 2014, 22(12):903-905, 906.

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Clinical Analysis of 9 Patients with Primary Thyroid Lymphoma

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