Clinical Value of Magnetic Resonance Imaging in Differentiating Xanthogranulomatous Cholecystitis with Gallbladder Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 GOUWen-xiao ^1,2 ,  YINLong-lin ¹ , CHENXiao-yu ² , XIEHuan ^1,2 , WANGFu-min ²

1. Department of Medical Imaging, Southwest Medical University, Luzhou 646000, Sichuan Province, China;
2. Department of Radiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China;

Corresponding author：

YINLong-lin, Email: yinlonglin@163.com

Keywords：

Xanthogranulomatous cholecystitis; Gallbladder cancer; Magnetic resonance imaging

DOI：

10.7507/1007-9424.20160167

Video：

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Objective To investigate clinical value of magnetic resonance imaging (MRI) in differentiating xanthogranulomatous cholecystitis (XGC) with gallbladder cancer (GBC). Methods MRI data of 7 patients with XGC and 13 patients with GBC proved by surgery and pathology were analyzed retrospectively. The main contents of the observation included:①Maximum thickness of gallbladder wall; ②Diffuse thickening or localized thickening of gallbladder wall; ③Enhancement pattern (uniform or nonuniform) of gallbladder wall; ④Gallbladder wall sandwiches enhancement; ⑤Gallbladder wall nodules; ⑥Completeness of gallbladder mucosa lines; ⑦Obstruction of biliary tract; ⑧Calculus in gallbladder or bile duct; ⑨Involvement of adjacent liver; ⑩Definition of surrounding fat layer; Lymphadenopathy. Results In above 11 MRI comparing features, these features such as the gallbladder wall sandwiches enhancement, the gallbladder wall nodules, the completeness of gallbladder mucosa lines, the biliary obstruction, and the lymphadenopathy were statistically significant between the XGC and the GBC (P < 0.05), while the rest features such as the maximum thickness of gallbladder wall, the type of gallbladder wall thickening, the gallbladder wall enhancement pattern, the calculus in gallbladder or bile duct, the involvement of adjacent liver, and the definition of surrounding fat layer were not statistically significant between the XGC and the GBC (P > 0.05). Conclusion MRI has important values in differentiating XGC with GBC.

Citation： GOUWen-xiao, YINLong-lin, CHENXiao-yu, XIEHuan, WANGFu-min. Clinical Value of Magnetic Resonance Imaging in Differentiating Xanthogranulomatous Cholecystitis with Gallbladder Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(5): 615-619. doi: 10.7507/1007-9424.20160167 Copy

1.	Guzmán-Valdivia G. Xanthogranulomatous cholecystitis: 15 years' experience. World J Surg, 2004, 28(3): 254-257.
2.	McCoy JJ, Vila R, Petrossian G, et al. Xanthogranulomatous cholecystitis. Report of two cases. J S C Med Assoc, 1976, 72(3): 78-79.
3.	马光慧, 嵇鸣, 叶春涛, 等.黄色肉芽肿性胆囊炎的MRI特征.磁共振成像, 2014, 5(4): 283-286.
4.	Parra JA, Acinas O, Bueno J, et al. Xanthogranulomatous cholecystitis: clinical, sonographic, andCTfindings in 26 patients. AJR Am J Roentgenol, 2000, 174(4): 979-983.
5.	Goshima S, Chang S, Wang JH, et al. Xanthogranulomatous cholecystitis: diagnostic performance ofCTto differentiate from gallbladder cancer. Eur J Radiol, 2010, 74(3): e79-e83.
6.	龚海燕, 戈伟, 蒋松松, 等. 48例黄色肉芽肿性胆囊炎的诊治分析.中国普外基础与临床杂志, 2014, 21(8): 1009-1012.
7.	Takahashi K, Oka K, Hakozaki H, et al. Ceroid-like histiocytic granuloma of gallbladder-a previously undescribed lesion. Acta Pathol Jpn, 1976, 26(1): 25-46.
8.	Singal R, Gupta S, Pande P, et al. Xanthogranulomatouscholecystitis: case series in a rural area, clinicopathologicalstudy and review of literature. Acta Gastroenterol Latinoam, 2011, 41(4): 331-334.
9.	王蔚蓝, 孙海明.黄色肉芽肿性胆囊炎45例诊治分析.肝胆胰外科杂志, 2015, 27(1): 74-75.
10.	蒋兆彦, 韩天权, 张圣道.对胆囊结石导致胆囊癌发病的认识.中国实用外科杂志, 2011, 31(3): 202-204.
11.	Agrawal V, Goel A, Krishnani N, et al. p53, carcinoembryonic antigen and carbohydrate antigen 19.9 expression in gall bladder cancer, precursor epithelial lesions and xanthogranulomatous cholecystitis. J Postgrad Med, 2010, 56(4): 262-266.
12.	Han SH, Chen YL. Diagnosis and treatment of xanthogranulomatous cholecystitis: a report of 39 cases. Cell Biochem Biophys, 2012, 64(2): 131-135.
13.	13吴森炎, 蔡军.胆囊癌诊疗现状.实用临床医学, 2016, 17(2): 102-107.
14.	14戚成, 闫长春.血清CEA、CA199、CA125、CA50单独及联合检测诊断胆囊癌的价值.山东医药, 2013, 53(14): 38-39.
15.	Lee ES, Kim JH, Joo I, et al. Xanthogranulomatous cholecystitis: diagnostic performance of US, CT, and MRI for differentiation from gallbladder carcinoma. Abdom Imaging, 2015, 40(7): 2281-2292.
16.	Shuto R, Kiyosue H, Komatsu E, et al.CTand MR imaging findings of xanthogranulomatous cholecystitis: correlation with pathologic findings. Eur Radiol, 2004, 14(3): 440-446.
17.	赵黎明, 宋彬.急性胆囊炎的CT和MRI诊断价值.中国普外基础与临床杂志, 2008, 15(9): 699-703.
18.	梁廷波, 白雪莉.胆囊癌分期临床意义及评价.中国实用外科杂志, 2011, 31(3): 194-197.
19.	Chang BJ, Kim SH, Park HY, et al. Distinguishing xanthogranulomatous cholecystitis fromthe wall-thickening type of early-stage gallbladder cancer. Gut Liver, 2010, 4(4): 518-523.
20.	Zhao F, Lu PX, Yan SX.CTand MR features of xanthogranulomatous cholecystitis: an analysis of consecutive 49 cases. Eur J Radiol, 2013, 89(9): 1391-1397.
21.	李代欣, 朱西琪, 田玉亭, 等. CT及MRI在黄色肉芽肿性胆囊炎诊断中的应用.生物医学工程与临床, 2015, 19(2): 164-168.
22.	王建良, 朱玉春.黄色肉芽肿性胆囊炎与厚壁型胆囊癌的螺旋CT鉴别诊断.腹部放射学, 2015, 34(1): 74-78.
23.	Yoshimitsu K, Irie H, Aibe H, et al. Well-differentiated adenocarcinoma of the gallbladder with intratumoral cystic components due to abundant mucin production: a mimicker of adenomyomatosis. Eur Radiol, 2005, 15(2): 229-233.
24.	Chun KA, Ha HK, Yu ES, et al. Xanthogranulomatous cholecystitis:CTfeatures with emphasis on differentiation from gallbladder carcinoma. Radiology, 1997, 203(1): 93-97.
25.	Guermazi A. Are there other imaging features to differentiate xanthogranulomatous cholecystitis from gallbladder carcinoma. Eur Radiol, 2005, 15(6): 1271-1272.

1. Guzmán-Valdivia G. Xanthogranulomatous cholecystitis: 15 years' experience. World J Surg, 2004, 28(3): 254-257.
2. McCoy JJ, Vila R, Petrossian G, et al. Xanthogranulomatous cholecystitis. Report of two cases. J S C Med Assoc, 1976, 72(3): 78-79.
3. 马光慧, 嵇鸣, 叶春涛, 等.黄色肉芽肿性胆囊炎的MRI特征.磁共振成像, 2014, 5(4): 283-286.
4. Parra JA, Acinas O, Bueno J, et al. Xanthogranulomatous cholecystitis: clinical, sonographic, andCTfindings in 26 patients. AJR Am J Roentgenol, 2000, 174(4): 979-983.
5. Goshima S, Chang S, Wang JH, et al. Xanthogranulomatous cholecystitis: diagnostic performance ofCTto differentiate from gallbladder cancer. Eur J Radiol, 2010, 74(3): e79-e83.
6. 龚海燕, 戈伟, 蒋松松, 等. 48例黄色肉芽肿性胆囊炎的诊治分析.中国普外基础与临床杂志, 2014, 21(8): 1009-1012.
7. Takahashi K, Oka K, Hakozaki H, et al. Ceroid-like histiocytic granuloma of gallbladder-a previously undescribed lesion. Acta Pathol Jpn, 1976, 26(1): 25-46.
8. Singal R, Gupta S, Pande P, et al. Xanthogranulomatouscholecystitis: case series in a rural area, clinicopathologicalstudy and review of literature. Acta Gastroenterol Latinoam, 2011, 41(4): 331-334.
9. 王蔚蓝, 孙海明.黄色肉芽肿性胆囊炎45例诊治分析.肝胆胰外科杂志, 2015, 27(1): 74-75.
10. 蒋兆彦, 韩天权, 张圣道.对胆囊结石导致胆囊癌发病的认识.中国实用外科杂志, 2011, 31(3): 202-204.
11. Agrawal V, Goel A, Krishnani N, et al. p53, carcinoembryonic antigen and carbohydrate antigen 19.9 expression in gall bladder cancer, precursor epithelial lesions and xanthogranulomatous cholecystitis. J Postgrad Med, 2010, 56(4): 262-266.
12. Han SH, Chen YL. Diagnosis and treatment of xanthogranulomatous cholecystitis: a report of 39 cases. Cell Biochem Biophys, 2012, 64(2): 131-135.
13. 13吴森炎, 蔡军.胆囊癌诊疗现状.实用临床医学, 2016, 17(2): 102-107.
14. 14戚成, 闫长春.血清CEA、CA199、CA125、CA50单独及联合检测诊断胆囊癌的价值.山东医药, 2013, 53(14): 38-39.
15. Lee ES, Kim JH, Joo I, et al. Xanthogranulomatous cholecystitis: diagnostic performance of US, CT, and MRI for differentiation from gallbladder carcinoma. Abdom Imaging, 2015, 40(7): 2281-2292.
16. Shuto R, Kiyosue H, Komatsu E, et al.CTand MR imaging findings of xanthogranulomatous cholecystitis: correlation with pathologic findings. Eur Radiol, 2004, 14(3): 440-446.
17. 赵黎明, 宋彬.急性胆囊炎的CT和MRI诊断价值.中国普外基础与临床杂志, 2008, 15(9): 699-703.
18. 梁廷波, 白雪莉.胆囊癌分期临床意义及评价.中国实用外科杂志, 2011, 31(3): 194-197.
19. Chang BJ, Kim SH, Park HY, et al. Distinguishing xanthogranulomatous cholecystitis fromthe wall-thickening type of early-stage gallbladder cancer. Gut Liver, 2010, 4(4): 518-523.
20. Zhao F, Lu PX, Yan SX.CTand MR features of xanthogranulomatous cholecystitis: an analysis of consecutive 49 cases. Eur J Radiol, 2013, 89(9): 1391-1397.
21. 李代欣, 朱西琪, 田玉亭, 等. CT及MRI在黄色肉芽肿性胆囊炎诊断中的应用.生物医学工程与临床, 2015, 19(2): 164-168.
22. 王建良, 朱玉春.黄色肉芽肿性胆囊炎与厚壁型胆囊癌的螺旋CT鉴别诊断.腹部放射学, 2015, 34(1): 74-78.
23. Yoshimitsu K, Irie H, Aibe H, et al. Well-differentiated adenocarcinoma of the gallbladder with intratumoral cystic components due to abundant mucin production: a mimicker of adenomyomatosis. Eur Radiol, 2005, 15(2): 229-233.
24. Chun KA, Ha HK, Yu ES, et al. Xanthogranulomatous cholecystitis:CTfeatures with emphasis on differentiation from gallbladder carcinoma. Radiology, 1997, 203(1): 93-97.
25. Guermazi A. Are there other imaging features to differentiate xanthogranulomatous cholecystitis from gallbladder carcinoma. Eur Radiol, 2005, 15(6): 1271-1272.

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Clinical Value of Magnetic Resonance Imaging in Differentiating Xanthogranulomatous Cholecystitis with Gallbladder Cancer

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