高强度超声聚焦刀序贯同步放化疗治疗结肠癌肝转移的临床疗效观察_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 舒畅 ,  龚军

鄂东医疗集团黄石市中心医院普爱院区腹盆肿瘤内科, 湖北黄石 435002;

Corresponding author：

龚军, Email: gongjun32@163.com

Keywords：

高强度超声聚焦刀; 同步放化疗; 结肠癌; 肝转移

DOI：

10.7507/1007-9424.20160207

Video：

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目的观察高强度超声聚焦刀序贯同步放化疗治疗结肠癌肝转移的临床疗效方法选取笔者所在医院2011年9月至2014年12月期间收治的结肠癌肝转移患者120例，根据治疗方法的不同分为观察组与对照组，各60例，对照组给予同步放化疗治疗，观察组在对照组治疗的基础上给予高强度超声聚焦刀序贯治疗，2组均治疗观察3个月。结果治疗后观察组与对照组的近期有效率分别为70.0%和40.0%，观察组的有效率明显高于对照组（P＜0.05）。观察组治疗期间的肝肾毒性、消化道出血、骨髓抑制、感染等毒性反应情况与对照组比较差异无统计学意义（P＞0.05）。所有患者随访（30.25±8.24）个月（12～48个月），观察组1年生存率与中位生存时间分别为50.0%和（12.42±2.45）个月，高于或长于对照组的33.3%和（8.98±2.87）个月，其差异有统计学意义（P＜0.05）。结论高强度超声聚焦刀序贯同步放化疗治疗结肠癌肝转移能提高近期疗效，延长生存时间，有很好的应用安全性，值得推广应用。

Citation： 舒畅, 龚军. 高强度超声聚焦刀序贯同步放化疗治疗结肠癌肝转移的临床疗效观察. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(7): 787-789. doi: 10.7507/1007-9424.20160207 Copy

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2.	严冬, 戴红.恩度联合XELOX方案一线治疗老年晚期结直肠癌的临床观察.中华肿瘤防治杂志, 2011, 18(12): 961-964.
3.	Mearini L. High intensity focused ultrasound, liver disease and bridging therapy. World J Gastroenterol, 2013, 19(43): 7494-7499.
4.	杜海峰, 魏长宏, 王作志, 等.体部伽玛刀联合高强度聚焦超声治疗中晚期原发性肝癌的疗效观察.医学综述, 2015, 3(21): 572-573.
5.	于龙, 张绢绢, 陈英红, 等.高强度聚焦超声刀治疗原发性肝癌合并门静脉癌栓50例分析.中国实用医药, 2013, 8(30): 110-112.
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7.	洪立立, 郭志, 于海鹏, 等.低功率高强度聚焦超声联合SOX方案治疗结直肠癌伴盆腔转移.中华医学杂志, 2014, 25(13): 1929-1932.
8.	Imperatori A, Rotolo N, Dominioni L, et al. Durable recurrence-free survival after pneumonectomy for late lung metastasis from rectal cancer: case report with genetic and epigenetic analyses. BMC Cancer, 2015, 15(1): 567-568.
9.	袁选举, 陈萍, 曹风军, 等.高强度超声聚焦刀联合鸦胆子油乳介入治疗中晚期肝癌35例临床观察.临床和实验医学杂志, 2013, 12(21): 1765-1767.
10.	Dupré A, Melodelima D, Pérol D, et al. First clinical experience of intra-operative high intensity focused ultrasound in patients with colorectal liver metastases: a phase I-IIa study. PLoS One, 2015, 10(2): 212-213.
11.	Lei J, Yan L. Outcome comparisons among the Hangzhou, Chengdu, and UCSF criteria for hepatocellular carcinoma liver transplantation after successful downstaging therapies. J Gastrointest Surg, 2013, 17(6): 1116-1122.
12.	张秀峰, 杨关根, 张莹, 等.血管内皮抑素微泡联合聚焦超声抗结肠癌肿瘤血管生成的实验研究.中华胃肠外科杂志, 2013, 16(12): 1208-1214.
13.	Mainenti PP, Romano F, Pizzuti L, et al. Non-invasive diagnostic imaging of colorectal liver metastases. World J Radiol, 2015, 7(7): 157-169.
14.	王宏伟, 王崑, 包全, 等.结直肠癌肝转移切除术后并发症对生存影响.中华普通外科杂志, 2015, 30(1): 42-45.
15.	Ramírez-Plaza CP, Moreno-Ruiz FJ, Pérez-Daga JA. A multidisci-plinary approach for peritoneal carcinomatosis and bilobar liver metastases from colorectal cancer: case report and review of the literature. World J Surg Oncol, 2015, 13(1): 233-235.
16.	刘文稚, 李孟考, 陈祥明.雷替曲塞联合奥沙利铂治疗结直肠癌肝转移的临床研究.中华临床医师杂志:电子版, 2015, 1(22): 146-148.
17.	Fan Z, Luo W, Song Z, et al. Effect of healthy tissue ablation surroun-ding VX2 rabbit liver tumors by high-intensity focused ultrasound combined with an ultrasound contrast agent. J Ultrasound Med, 2012, 31(6): 863-871.
18.	钟华, 李锐, 郭燕丽, 等.高机械指数超声辐照微泡对结肠癌细胞骨架的影响.中华超声影像学杂志, 2011, 20(11): 996-999.

1. 杨武威, 尉承泽.肝细胞肝癌的微创消融治疗.中华肝脏外科手术学电子杂志, 2012, 1(2): 132-137.
2. 严冬, 戴红.恩度联合XELOX方案一线治疗老年晚期结直肠癌的临床观察.中华肿瘤防治杂志, 2011, 18(12): 961-964.
3. Mearini L. High intensity focused ultrasound, liver disease and bridging therapy. World J Gastroenterol, 2013, 19(43): 7494-7499.
4. 杜海峰, 魏长宏, 王作志, 等.体部伽玛刀联合高强度聚焦超声治疗中晚期原发性肝癌的疗效观察.医学综述, 2015, 3(21): 572-573.
5. 于龙, 张绢绢, 陈英红, 等.高强度聚焦超声刀治疗原发性肝癌合并门静脉癌栓50例分析.中国实用医药, 2013, 8(30): 110-112.
6. De Divitiis C, Cassata A, Nasti G, et al. Late complete response after long remission from treatment with FOLFIRI-aflibercept for metas-tatic colorectal cancer after progression to FOLFOX-bevacizumab. Recenti Prog Med, 2015, 106(8): 407-413.
7. 洪立立, 郭志, 于海鹏, 等.低功率高强度聚焦超声联合SOX方案治疗结直肠癌伴盆腔转移.中华医学杂志, 2014, 25(13): 1929-1932.
8. Imperatori A, Rotolo N, Dominioni L, et al. Durable recurrence-free survival after pneumonectomy for late lung metastasis from rectal cancer: case report with genetic and epigenetic analyses. BMC Cancer, 2015, 15(1): 567-568.
9. 袁选举, 陈萍, 曹风军, 等.高强度超声聚焦刀联合鸦胆子油乳介入治疗中晚期肝癌35例临床观察.临床和实验医学杂志, 2013, 12(21): 1765-1767.
10. Dupré A, Melodelima D, Pérol D, et al. First clinical experience of intra-operative high intensity focused ultrasound in patients with colorectal liver metastases: a phase I-IIa study. PLoS One, 2015, 10(2): 212-213.
11. Lei J, Yan L. Outcome comparisons among the Hangzhou, Chengdu, and UCSF criteria for hepatocellular carcinoma liver transplantation after successful downstaging therapies. J Gastrointest Surg, 2013, 17(6): 1116-1122.
12. 张秀峰, 杨关根, 张莹, 等.血管内皮抑素微泡联合聚焦超声抗结肠癌肿瘤血管生成的实验研究.中华胃肠外科杂志, 2013, 16(12): 1208-1214.
13. Mainenti PP, Romano F, Pizzuti L, et al. Non-invasive diagnostic imaging of colorectal liver metastases. World J Radiol, 2015, 7(7): 157-169.
14. 王宏伟, 王崑, 包全, 等.结直肠癌肝转移切除术后并发症对生存影响.中华普通外科杂志, 2015, 30(1): 42-45.
15. Ramírez-Plaza CP, Moreno-Ruiz FJ, Pérez-Daga JA. A multidisci-plinary approach for peritoneal carcinomatosis and bilobar liver metastases from colorectal cancer: case report and review of the literature. World J Surg Oncol, 2015, 13(1): 233-235.
16. 刘文稚, 李孟考, 陈祥明.雷替曲塞联合奥沙利铂治疗结直肠癌肝转移的临床研究.中华临床医师杂志:电子版, 2015, 1(22): 146-148.
17. Fan Z, Luo W, Song Z, et al. Effect of healthy tissue ablation surroun-ding VX2 rabbit liver tumors by high-intensity focused ultrasound combined with an ultrasound contrast agent. J Ultrasound Med, 2012, 31(6): 863-871.
18. 钟华, 李锐, 郭燕丽, 等.高机械指数超声辐照微泡对结肠癌细胞骨架的影响.中华超声影像学杂志, 2011, 20(11): 996-999.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

高强度超声聚焦刀序贯同步放化疗治疗结肠癌肝转移的临床疗效观察

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