Clinical Significance of Serum TGF-β1 and IL-23 in The Diagnosis of Gastric Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 QUXin-yu , HUXiao-hai , LIUJun , LIUHong-xia , GONGYu-feng

Department of General Surgery, People's Hospital of Pingshan District, Shenzhen 518118, Guangdong Province, China;

Corresponding author：

QUXin-yu, Email: szns120@126.com

Keywords：

Gastric cancer; Gastric ulcer; Transforming growth factorβ1; Interleukin-23

DOI：

10.7507/1007-9424.20160214

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Objective To study the serum transforming growth factorβ1 (TGF-β1) and interleukin-23 (IL-23) expression in the patients with chronic gastric ulcer or gastric cancer, and to investigate the clinical value of TGF-β1 and IL-23 on the prevention and treatment of gastric cancer. Methods The serum levels of TGF-β1 and IL-23 in cancer group (83 cases), gastric ulcer group (184 cases), and control group (58 cases) were detected by using ELISA assay method. The difference of serum TGF-β1 and IL-23 levels in patients with gastric cancer with different pathological parameters were compared. Results The serum levels of TGF-β1〔(15.96±3.92) ng/mL〕and IL-23〔(645.25±234.18) ng/mL〕in gastric cancer group were higher than those of the gastric ulcer group〔(10.10±3.58) ng/mL, (496.10±108.32) ng/mL〕and normal control group〔(9.87±2.86) ng/mL, (372.75±89.27) ng/mL〕, the difference were statistically significant (P < 0.05). The levels of serum TGF-β1 in gastric cancer patients of stageⅠ-Ⅱ, ⅢandⅣwere successively increased, and the differences were statistically significant (P < 0.05). The levels of serum TGF-β1 in poorly differentiated gastric cancer or with lymph node metastasis patients were higher than those in high-middle differentiation or without lymph node metastasis patients, the difference were statistically significant (P < 0.05). There were no significant difference in the levels of serum TGF-β1 between different tumor diameter and different location (P > 0.05). The level of serum IL-23 in patients with stageⅠ-Ⅱwas higher than that in stageⅢandⅣ, the difference was statistically significant (P < 0.05). Ther were no significant difference in serum IL-23 levels between the different degree of differentiation, lymph node metastasis or not, different tumor diameter and different location of the tumor (P > 0.05). Conclusion TGF-β1 and IL-23 have important reference value in judging the stage and malignancy degree of gastric cancer.

Citation： QUXin-yu, HUXiao-hai, LIUJun, LIUHong-xia, GONGYu-feng. Clinical Significance of Serum TGF-β1 and IL-23 in The Diagnosis of Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(7): 818-821. doi: 10.7507/1007-9424.20160214 Copy

1.	Chen CY, Wang FY, Wan HJ, et al. Amino acid polymorphisms flanking the EPIYA-A motif of Helicobacter pylori Cag A C-terminal region is associated with gastric cancer in east China: experience from a single center. J Dig Dis, 2013, 14(7): 358-365.
2.	邹文斌, 李兆申.中国胃癌发病率及死亡率研究进展.中国实用内科杂志, 2014, 34(4): 408-415.
3.	郑朝旭, 郑荣寿, 张思维.中国2010年胃癌发病与死亡分析.中国肿瘤, 2014, 23(10): 795-800.
4.	王凌云, 黄开红, 闵军, 等.胃癌患者外周血调节性T细胞的多种细胞因子水平的检测及其意义.中华实验外科杂志, 2006, 23(11): 1375-1377.
5.	Prendes MA, Harris A, Wirostko BM, et al. The role of transforming growth factor beta in glaucoma and the therapeutic implications. Br J Ophthalmol, 2013, 97(6): 680-686.
6.	胡涛, 王红霞, 刘希伟, 等.白介素-12及白介素-23对胃癌组织中CD4⁺记忆T细胞的影响.解剖学杂志, 2009, 32(2): 170-173.
7.	玄延花, 张凤艳, 林贞花.转化生长因子β1及其受体以及Smad4和Smad7在胃癌组织表达的临床病理学意义.中国综合临床, 2009, 25(10): 1009-1013.
8.	冯刚, 高忠, 李辉, 等. IL-23在肿瘤免疫中的作用.中国实验诊断学, 2010, 14(6): 960-963.
9.	姜可伟.规范全球第二大致死率疾病的诊断-《胃癌诊断标准》.中国卫生标准管理, 2010, 1(4): 26-29.
10.	Mo ML, Li MR, Chen Z, et al. Inhibition of the Wnt palmitoyl transferase porcupine suppresses cell growth and downregulates the Wnt/beta-catenin pathway in gastric cancer. Oncol Lett, 2013, 5(5): 1719-1723.
11.	杨清峰, 江泳, 张旭.幽门螺杆菌感染者Th1/Th2细胞免疫应答变化.中国微生态学杂志, 2011, 23(10): 914-915.
12.	彭素芳, 王胜军, 陈建国, 等.胃癌患者外周血Th17和Treg细胞的特异性转录因子与相关细胞因子的检测及临床意义.中华肿瘤杂志, 2010, 32(3): 185-189.
13.	Kerdiles YM, Stone EL, Beisner DR, et al. Foxo transcription factors control regulatory T cell development and function. Immunity, 2010, 33(6): 890-904.
14.	张亚婕, 滕爱军. TGF-β1, Smad4及Ki-67在胃癌组织中的表达及临床病理意义.西北国防医学杂志, 2009, 30(1): 24-26.
15.	郑英娟, 汤建华, 张志林, 等.肺癌中SPARC和TGFβ1的表达及意义.肿瘤防治研究, 2014, 41(6): 593-597.
16.	Ma GF, Miao Q, Zeng XQ, et al. Transforming growth factor-β1 and-β2 in gastric precancer and cancer and roles in tumor-cell interactions with peripheral blood mononuclear cells in vitro. PloS One, 2013, 8(1): e54249.
17.	严波, 杨善峰, 燕善军.胃癌患者腹水及外周血中PTN、IL-16表达及其意义.中国肿瘤, 2014, 23(6): 528-530.
18.	van Meeteren LA, Goumans MJ, ten Dijke P. TGF-beta receptor signaling pathways in angiogenesis; emerging targets for anti-angiogenesis therapy. Curr Pharm Biotechnol, 2011, 12(12): 2108-2115.
19.	马颖杰, 曹邦伟, 李琴.胃癌患者及其化疗后胃蛋白酶原与胃泌素变化的临床意义.临床和实验医学杂志, 2014, 13(3): 186-189.
20.	Wendt MK, Tian M, Schiemann WP. Deconstructing the mechanisms and consequences of TGF-beta-induced EMT during cancer prog-ression. Cell Tissue Res, 2012, 347(1): 85-95.
21.	Prendes MA, Harris A, Wirostko BM, et al. The role of transforming growth factor beta in glaucoma and the therapeutic implications. Bri J Ophthalmol, 2013, 97(6): 680-686.
22.	Duerr RH, Taylor KD, Brant SR, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science, 2006, 314(5804): 1461-1463.
23.	Kan SH, Mancini G, Gallagher G. Identification and characterization of multiple splice forms of the human inter-leukin-23 receptor alpha chain in mitogen-activated leukocytes. Genes Immun, 2008, 9(7): 631-639.
24.	Langowski JL, Kastelein RA, Oft M. Swords into plowshares: IL-23 repur-poses tumor immune surveillance. Trends Immunol, 2007, 28(5): 207-211.
25.	韩伟, 杨迷玲, 翟丽丽, 等.胃癌中SPARC、TGFβ1和Ki-67的表达及意义.临床与实验病理学杂志, 2011, 27(6): 594-597.
26.	李春辉, 潘理会, 张德利.胃癌组织TGF-β1、Smad7与ki-67mRNA表达及其相关性分析.实用医学杂志, 2014(5): 751-754.

1. Chen CY, Wang FY, Wan HJ, et al. Amino acid polymorphisms flanking the EPIYA-A motif of Helicobacter pylori Cag A C-terminal region is associated with gastric cancer in east China: experience from a single center. J Dig Dis, 2013, 14(7): 358-365.
2. 邹文斌, 李兆申.中国胃癌发病率及死亡率研究进展.中国实用内科杂志, 2014, 34(4): 408-415.
3. 郑朝旭, 郑荣寿, 张思维.中国2010年胃癌发病与死亡分析.中国肿瘤, 2014, 23(10): 795-800.
4. 王凌云, 黄开红, 闵军, 等.胃癌患者外周血调节性T细胞的多种细胞因子水平的检测及其意义.中华实验外科杂志, 2006, 23(11): 1375-1377.
5. Prendes MA, Harris A, Wirostko BM, et al. The role of transforming growth factor beta in glaucoma and the therapeutic implications. Br J Ophthalmol, 2013, 97(6): 680-686.
6. 胡涛, 王红霞, 刘希伟, 等.白介素-12及白介素-23对胃癌组织中CD4⁺记忆T细胞的影响.解剖学杂志, 2009, 32(2): 170-173.
7. 玄延花, 张凤艳, 林贞花.转化生长因子β1及其受体以及Smad4和Smad7在胃癌组织表达的临床病理学意义.中国综合临床, 2009, 25(10): 1009-1013.
8. 冯刚, 高忠, 李辉, 等. IL-23在肿瘤免疫中的作用.中国实验诊断学, 2010, 14(6): 960-963.
9. 姜可伟.规范全球第二大致死率疾病的诊断-《胃癌诊断标准》.中国卫生标准管理, 2010, 1(4): 26-29.
10. Mo ML, Li MR, Chen Z, et al. Inhibition of the Wnt palmitoyl transferase porcupine suppresses cell growth and downregulates the Wnt/beta-catenin pathway in gastric cancer. Oncol Lett, 2013, 5(5): 1719-1723.
11. 杨清峰, 江泳, 张旭.幽门螺杆菌感染者Th1/Th2细胞免疫应答变化.中国微生态学杂志, 2011, 23(10): 914-915.
12. 彭素芳, 王胜军, 陈建国, 等.胃癌患者外周血Th17和Treg细胞的特异性转录因子与相关细胞因子的检测及临床意义.中华肿瘤杂志, 2010, 32(3): 185-189.
13. Kerdiles YM, Stone EL, Beisner DR, et al. Foxo transcription factors control regulatory T cell development and function. Immunity, 2010, 33(6): 890-904.
14. 张亚婕, 滕爱军. TGF-β1, Smad4及Ki-67在胃癌组织中的表达及临床病理意义.西北国防医学杂志, 2009, 30(1): 24-26.
15. 郑英娟, 汤建华, 张志林, 等.肺癌中SPARC和TGFβ1的表达及意义.肿瘤防治研究, 2014, 41(6): 593-597.
16. Ma GF, Miao Q, Zeng XQ, et al. Transforming growth factor-β1 and-β2 in gastric precancer and cancer and roles in tumor-cell interactions with peripheral blood mononuclear cells in vitro. PloS One, 2013, 8(1): e54249.
17. 严波, 杨善峰, 燕善军.胃癌患者腹水及外周血中PTN、IL-16表达及其意义.中国肿瘤, 2014, 23(6): 528-530.
18. van Meeteren LA, Goumans MJ, ten Dijke P. TGF-beta receptor signaling pathways in angiogenesis; emerging targets for anti-angiogenesis therapy. Curr Pharm Biotechnol, 2011, 12(12): 2108-2115.
19. 马颖杰, 曹邦伟, 李琴.胃癌患者及其化疗后胃蛋白酶原与胃泌素变化的临床意义.临床和实验医学杂志, 2014, 13(3): 186-189.
20. Wendt MK, Tian M, Schiemann WP. Deconstructing the mechanisms and consequences of TGF-beta-induced EMT during cancer prog-ression. Cell Tissue Res, 2012, 347(1): 85-95.
21. Prendes MA, Harris A, Wirostko BM, et al. The role of transforming growth factor beta in glaucoma and the therapeutic implications. Bri J Ophthalmol, 2013, 97(6): 680-686.
22. Duerr RH, Taylor KD, Brant SR, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science, 2006, 314(5804): 1461-1463.
23. Kan SH, Mancini G, Gallagher G. Identification and characterization of multiple splice forms of the human inter-leukin-23 receptor alpha chain in mitogen-activated leukocytes. Genes Immun, 2008, 9(7): 631-639.
24. Langowski JL, Kastelein RA, Oft M. Swords into plowshares: IL-23 repur-poses tumor immune surveillance. Trends Immunol, 2007, 28(5): 207-211.
25. 韩伟, 杨迷玲, 翟丽丽, 等.胃癌中SPARC、TGFβ1和Ki-67的表达及意义.临床与实验病理学杂志, 2011, 27(6): 594-597.
26. 李春辉, 潘理会, 张德利.胃癌组织TGF-β1、Smad7与ki-67mRNA表达及其相关性分析.实用医学杂志, 2014(5): 751-754.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Significance of Serum TGF-β1 and IL-23 in The Diagnosis of Gastric Cancer

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