Analysis of Influence Factors of Gallstone_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIUQing ,  JINJun-zhe , LÜHong-yang , XINGBao-jian

Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China;

Corresponding author：

JINJun-zhe, Email: jccccj@126.com

Keywords：

Gallstone; Influence factor; Serum lipids; Fasting blood glucose; Gender; Age; Diabetes

DOI：

10.7507/1007-9424.20160376

Video：

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Objective To explore the influence factors of gallstone. Methods Clinical data of 511 patients who were admitted to our hospital from Apr. 2015 to Apr. 2016 were retrospectively analyzed. Results Of 511 patients, there were 274 patients with gallstone (gallstone group) and 237 patients without gallstone (control group). Univariate analysis results showed that, no significant difference of age, gender, and diabetes was found between gallstone group and control group (P > 0.050), but the levels of serum total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C), and fasting blood glucose (FBG) were significantly higher in patients of gallstone group (P < 0.050), but the level of serum high density lipoprotein (HDL-C) was significantly lower in patients of gallstone group (P=0.001). Logistic regression results showed that four factors including diabetes〔OR=4.491; 95% CI is (2.021, 9.976); P < 0.001〕, the serum TC〔OR=2.548; 95% CI is (1.944, 3.338); P < 0.001〕, HDL-C〔OR=0.115; 95% CI is (0.056, 0.237); P < 0.001〕, and FBG〔OR=1.277; 95% CI is (1.086, 1.502); P=0.003〕 entered the final regression model after controlling confounding factors. The results showed that patients who combined with diabetes, high levels of serum TC and FBG, and low level of serum HDL-C, had higher ratio of galls-tone. Conclusion Diabetes, high-level of serum TC and FBG, low-level of serum HDL-C were risk factors of gallstone.

Citation： LIUQing, JINJun-zhe, LÜHong-yang, XINGBao-jian. Analysis of Influence Factors of Gallstone. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(12): 1492-1495. doi: 10.7507/1007-9424.20160376 Copy

1.	陈孝平, 汪建平.外科学.第8版.北京:人民卫生出版社, 2013:453.
2.	裘法祖.外科学.第4版.北京:人民卫生出版社, 1995:551.
3.	李前春, 钟立明.血脂与胆囊结石的相关性分析.安徽医药, 2015, 19(5):937-938.
4.	孙晓敏, 徐萍, 马志红, 等.上海松江地区胆囊良性疾病的流行病学调查30901例.世界华人消化杂志, 2011, 19(27):2881-2885.
5.	陈敏, 张涛, 克力木, 等.维吾尔族和汉族胆囊结石患病现状及特点分析.中华临床医师杂志:电子版, 2015, 9(8):1352-1358.
6.	刘江伟, 吕复君, 吕辉琴, 等.新疆地区维吾尔族、汉族和哈萨克族三个民族胆囊结石的流行病学分析.中华临床医师杂志:电子版, 2013, 7(21):9542-9548.
7.	Wang W, Li N. The association of gallstone disease and diabetes mellitus. A meta-analysis. Saudi Med J, 2014, 35(9):1005-1012.
8.	韩天权, 蒋兆彦, 张圣道.胆固醇结石形成机制的基因研究现状与展望.外科理论与实践, 2009, 14(2):125-127.
9.	Liu FL, Lu WB, Niu WX. XbaI polymorphisms of apolipoprotein B gene:another risk factor of gallstone formation after radical gastrectomy. World J Gastroenterol, 2010, 16(20):2549-2553.
10.	沈安红.胆囊结石患者血脂水平检测分析.国际检验医学杂志, 2012, 33(20):2552-2554.
11.	吴著学. 356例机关工作人员脂肪肝和胆囊结石与血脂水平的关系分析.中国现代医生, 2007, 45(9):57.
12.	Scragg RK, Calvert GD, Oliver JR. Plasma lipids and insulin in gall stone disease:a case-control study. Br Med J (Clin Res Ed), 1984, 289(6444):521-525.
13.	沈安东, 马荣赓, 文洽先.胆囊结石与血脂水平的关系.实用医学杂志, 1993, 9(5):53.
14.	Yu JG, Javorschi S, Hevener AL, et al. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes, 2002, 51(10):2968-2974.
15.	Xue Y, Sheng Y, Dai H, et al. Risk of development of acute pancreatitis with pre-existing diabetes:a meta-analysis. Eur J Gastroenterol Hepatol, 2012, 24(9):1092-1098.
16.	王春城, 张万星, 曹月敏.胆囊结石与糖尿病的关系.河北医科大学学报, 2015, 36(11):1362-1364.
17.	陈子广.血糖、血脂水平与胆囊结石发病的关系分析.医学理论与实践, 2015, 28(7):910-911.
18.	孙明德.分析胆囊结石相关危险因素及防治对策.当代医学, 2013, 19(25):99.
19.	朱颖, 吴治宇, 马向明, 等.开滦集团职工胆囊结石临床流行病学调查.临床肝胆病杂志, 2015, 31(10):1621-1624.
20.	Abu-Eshy SA, Mahfouz AA, Badr A, et al. Prevalence and risk factors of gallstone disease in a high altitude Saudi population. East Mediterr Health J, 2007, 13(4):794-802.
21.	张静, 刘静, 陈丹, 等.新疆地区体检人群胆囊结石与代谢综合征及其组分相关性分析.中华实用诊断与治疗杂志, 2016, 30(9):894-896.
22.	Barbara L, Sama C, Morselli Labate AM, et al. A population study on the prevalence of gallstone disease:the Sirmione Study. Hepatology, 1987, 7(5):913-917.
23.	张超, 王旺河.性激素与胆囊结石成因临床研究.肝胆胰外科杂志, 1997, 9(3):119-120.
24.	Einarsson K, Nilsell K, Leijd B, et al. Influence of age on secretion of cholesterol and synthesis of bile acids by the liver. N Engl J Med, 1985, 313(5):277-282.
25.	Ansari-Moghaddam A, Khorram A, Miri-Bonjar M, et al. The preva-lence and risk factors of gallstone among adults in south-east of Iran:a population-based study. Glob J Health Sci, 2015, 8(4):60-67.

1. 陈孝平, 汪建平.外科学.第8版.北京:人民卫生出版社, 2013:453.
2. 裘法祖.外科学.第4版.北京:人民卫生出版社, 1995:551.
3. 李前春, 钟立明.血脂与胆囊结石的相关性分析.安徽医药, 2015, 19(5):937-938.
4. 孙晓敏, 徐萍, 马志红, 等.上海松江地区胆囊良性疾病的流行病学调查30901例.世界华人消化杂志, 2011, 19(27):2881-2885.
5. 陈敏, 张涛, 克力木, 等.维吾尔族和汉族胆囊结石患病现状及特点分析.中华临床医师杂志:电子版, 2015, 9(8):1352-1358.
6. 刘江伟, 吕复君, 吕辉琴, 等.新疆地区维吾尔族、汉族和哈萨克族三个民族胆囊结石的流行病学分析.中华临床医师杂志:电子版, 2013, 7(21):9542-9548.
7. Wang W, Li N. The association of gallstone disease and diabetes mellitus. A meta-analysis. Saudi Med J, 2014, 35(9):1005-1012.
8. 韩天权, 蒋兆彦, 张圣道.胆固醇结石形成机制的基因研究现状与展望.外科理论与实践, 2009, 14(2):125-127.
9. Liu FL, Lu WB, Niu WX. XbaI polymorphisms of apolipoprotein B gene:another risk factor of gallstone formation after radical gastrectomy. World J Gastroenterol, 2010, 16(20):2549-2553.
10. 沈安红.胆囊结石患者血脂水平检测分析.国际检验医学杂志, 2012, 33(20):2552-2554.
11. 吴著学. 356例机关工作人员脂肪肝和胆囊结石与血脂水平的关系分析.中国现代医生, 2007, 45(9):57.
12. Scragg RK, Calvert GD, Oliver JR. Plasma lipids and insulin in gall stone disease:a case-control study. Br Med J (Clin Res Ed), 1984, 289(6444):521-525.
13. 沈安东, 马荣赓, 文洽先.胆囊结石与血脂水平的关系.实用医学杂志, 1993, 9(5):53.
14. Yu JG, Javorschi S, Hevener AL, et al. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes, 2002, 51(10):2968-2974.
15. Xue Y, Sheng Y, Dai H, et al. Risk of development of acute pancreatitis with pre-existing diabetes:a meta-analysis. Eur J Gastroenterol Hepatol, 2012, 24(9):1092-1098.
16. 王春城, 张万星, 曹月敏.胆囊结石与糖尿病的关系.河北医科大学学报, 2015, 36(11):1362-1364.
17. 陈子广.血糖、血脂水平与胆囊结石发病的关系分析.医学理论与实践, 2015, 28(7):910-911.
18. 孙明德.分析胆囊结石相关危险因素及防治对策.当代医学, 2013, 19(25):99.
19. 朱颖, 吴治宇, 马向明, 等.开滦集团职工胆囊结石临床流行病学调查.临床肝胆病杂志, 2015, 31(10):1621-1624.
20. Abu-Eshy SA, Mahfouz AA, Badr A, et al. Prevalence and risk factors of gallstone disease in a high altitude Saudi population. East Mediterr Health J, 2007, 13(4):794-802.
21. 张静, 刘静, 陈丹, 等.新疆地区体检人群胆囊结石与代谢综合征及其组分相关性分析.中华实用诊断与治疗杂志, 2016, 30(9):894-896.
22. Barbara L, Sama C, Morselli Labate AM, et al. A population study on the prevalence of gallstone disease:the Sirmione Study. Hepatology, 1987, 7(5):913-917.
23. 张超, 王旺河.性激素与胆囊结石成因临床研究.肝胆胰外科杂志, 1997, 9(3):119-120.
24. Einarsson K, Nilsell K, Leijd B, et al. Influence of age on secretion of cholesterol and synthesis of bile acids by the liver. N Engl J Med, 1985, 313(5):277-282.
25. Ansari-Moghaddam A, Khorram A, Miri-Bonjar M, et al. The preva-lence and risk factors of gallstone among adults in south-east of Iran:a population-based study. Glob J Health Sci, 2015, 8(4):60-67.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Analysis of Influence Factors of Gallstone

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