Clinical application of early enteral nutrition following radical resection for patients with gastric cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIANG Tao , GUO Yulan ,  WU Xiaoting

Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

WU Xiaoting, Email: wxt1@medmail.com.cn

Keywords：

gastric cancer; early enteral nutrition; radical resection; gastrointestinal function

DOI：

10.7507/1007-9424.201708057

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To analyze clinical value of early enteral nutrition following radical resection of gastric cancer. Methods Seventy-six patients with gastric cancer underwent radical resection from May 1, 2016 to July 1, 2016 in the West China Hospital of Sichuan University were included according to the inclusion criteria and exclusion criteria, then were randomly divided into observation group (36 cases) and control group (40 cases). The patients in the observation group received the enteral nutrition on day 2 following the surgery, in the control group received the conventional management. The gastrointestinal recovery and the adverse reaction were compared in these two groups. The preoperative and postoperative laboratory indicators and the body weight of the patients in both groups were analyzed. Results ① The general data such as age, gender, and body weight had no significant differences in these two groups (P>0.05). ② The first anus exhaust time and the first defecation time of the observation group were significantly shorter than those of the control group (P<0.05). ③ The adverse reaction rate of the observation group was significantly lower than that of the control group (P<0.05). ④ On admission, the serum albumin, urea nitrogen, creatinine, and lymphocyte count had no significant differences in these two groups (P>0.05). On day 5 after the operation, the serum albumin of the observation group was significantly higher than that of the control group (P<0.05). ⑤ The body weight had no significant difference in these two groups before the operation (P>0.05), which in the observation group was significantly heavier than that of the control group on day 30 after the operation (P<0.05). Conclusion Preliminary results of limited cases in this study show that early enteral nutrition following radical resection of gastric cancer is safe and effective, it could promote gastrointestinal function resumption and effectively improve nutritional status.

Citation： LIANG Tao, GUO Yulan, WU Xiaoting. Clinical application of early enteral nutrition following radical resection for patients with gastric cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2018, 25(2): 197-201. doi: 10.7507/1007-9424.201708057 Copy

1.	Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
2.	Tian J, Chen JS. Nutritional status and quality of life of the gastric cancer patients in Changle County of China. World J Gastroenterol, 2005, 11(11): 1582-1586.
3.	杜艳平, 李玲玲, 贺青, 等. 胃肠道肿瘤患者的营养风险筛查及营养状况评价. 中华胃肠外科杂志, 2012, 15 (5): 460-463.
4.	李文英, 曹淑红, 张晓峰, 等. 胃癌术后患者生活质量研究. 现代预防医学, 2011, 38(21): 4441-4443.
5.	裴成林. 快速康复外科对胃肠道手术患者围术期的作用. 大家健康 (学术版), 2014, 8(15): 135-136.
6.	余伦. 胃癌患者术前营养状况对远期预后影响分析. 中华普外科手术学杂志 (电子版), 2016, 10(1): 44-46.
7.	Sachlova M, Majek O, Tucek S. Prognostic value of scores based on malnutrition or systemic inflammatory response in patients with metastatic or recurrent gastric cancer. Nutr Cancer, 2014, 66(8): 1362-1370.
8.	李剑, 周福有, 耿明飞, 等. 快速康复外科理念下食管癌术后肠内营养途径的选择. 河南外科学杂志, 2013, 19(3): 8-10.
9.	王文娟, 孙冬岩, 孙笑非, 等. 肠道屏障功能损伤与细菌易位研究进展. 饲料研究, 2012, (7): 38-39.
10.	袁琮韡, 李俊生, 嵇振岭, 等. 全肠外营养及早期肠内营养在胃癌全胃切除术后患者中的对比研究, 中国普外基础与临床杂志, 2010, 17(4): 357-361.
11.	李国立, 李宁, 黎介寿. 胃癌病人的临床营养支持. 外科理论与实践, 2006, 11(6): 486-488.
12.	冯立, 王峰, 董培德, 等. 胃癌患者根治术后早期肠内营养的临床疗效观察. 中国普外基础与临床杂志, 2014, 21(3): 325-329.
13.	梁冀望, 郑志超, 赵岩, 等. 胃癌根治术应用快速康复外科的系统评价. 中国肿瘤, 2012, 21(1): 75- 80.
14.	张振彬, 宁进尧, 胡金晨, 等. 快速康复外科在腹腔镜胃癌根治术围手术期的应用. 腹腔镜外科杂志, 2012, 17(9): 671-673.
15.	Wang D, Kong Y, Zhong B, et al. Fast-track surgery improves postoperative recovery in patients with gastric cancer: a randomized comparison with conventional postoperative care. J Gastrointest Surg, 2010, 14(4): 620-627.
16.	Rothnie NG, Harper RA, Catchpole BN. Early postoperative gastrointestinal activity. Lancet, 1963, 2(7298): 64-67.
17.	彭鹏, 黄杰安. 危重症患者早期肠内营养最新进展. 临床荟萃, 2011, 26-(6): 543-546-50.
18.	赵秉清, 祝振忠, 王征. 危重患者早期肠内营养支持治疗研究. 中外医疗, 2011, (1): 48-49.
19.	杨朝纲, 熊斌, 杨帅龙. 胃癌术后早期肠内营养支持的研究现状. 中华普通外科杂志, 2015, 30(6): 500-502.
20.	何彦坤, 张静, 何若冲. 肠内与肠外营养对胃癌根治手术后患者恢复情况的 Meta 分析. 中华临床医师杂志 (电子版), 2013, 7(5): 2077-2081.
21.	王鸿波, 王华龙, 王新民, 等. 营养风险筛查在结直肠癌快速康复外科治疗中的作用. 现代生物医学进展, 2014, 14(30): 5926-5929.
22.	Mueller C, Compher C, Ellen DM, et al. A.S.P.E.N. clinical guidelines: Nutrition screening, assessment, and intervention in adults. JPEN J Parenter Enteral Nutr, 2011, 35(1): 16-24.
23.	Kondrup J, Rasmussen HH, Hamberg O, et al. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials. Clin Nutr, 2003, 22(3): 321-336.
24.	米磊, 仲蓓, 张佃良, 等. 胃癌患者术后早期肠内营养对临床结局的影响. 中华胃肠外科杂志, 2012, 15(5): 464-467.
25.	黎介寿. 肠内营养—外科临床营养支持的首选途径. 中国实用外科杂志, 2003, 23(2): 67.
26.	朱俊杰, 郭明贤, 王士祺, 等. 胃癌患者术后早期肠内营养耐受状况及其相关因素. 中华临床营养杂志, 2014, 22(3): 131-135.
27.	黄涛阳, 张应辉, 黄和. 肠内营养剂的临床合理应用. 医药导报, 2011, 30(10): 1369-1372.

1. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
2. Tian J, Chen JS. Nutritional status and quality of life of the gastric cancer patients in Changle County of China. World J Gastroenterol, 2005, 11(11): 1582-1586.
3. 杜艳平, 李玲玲, 贺青, 等. 胃肠道肿瘤患者的营养风险筛查及营养状况评价. 中华胃肠外科杂志, 2012, 15 (5): 460-463.
4. 李文英, 曹淑红, 张晓峰, 等. 胃癌术后患者生活质量研究. 现代预防医学, 2011, 38(21): 4441-4443.
5. 裴成林. 快速康复外科对胃肠道手术患者围术期的作用. 大家健康 (学术版), 2014, 8(15): 135-136.
6. 余伦. 胃癌患者术前营养状况对远期预后影响分析. 中华普外科手术学杂志 (电子版), 2016, 10(1): 44-46.
7. Sachlova M, Majek O, Tucek S. Prognostic value of scores based on malnutrition or systemic inflammatory response in patients with metastatic or recurrent gastric cancer. Nutr Cancer, 2014, 66(8): 1362-1370.
8. 李剑, 周福有, 耿明飞, 等. 快速康复外科理念下食管癌术后肠内营养途径的选择. 河南外科学杂志, 2013, 19(3): 8-10.
9. 王文娟, 孙冬岩, 孙笑非, 等. 肠道屏障功能损伤与细菌易位研究进展. 饲料研究, 2012, (7): 38-39.
10. 袁琮韡, 李俊生, 嵇振岭, 等. 全肠外营养及早期肠内营养在胃癌全胃切除术后患者中的对比研究, 中国普外基础与临床杂志, 2010, 17(4): 357-361.
11. 李国立, 李宁, 黎介寿. 胃癌病人的临床营养支持. 外科理论与实践, 2006, 11(6): 486-488.
12. 冯立, 王峰, 董培德, 等. 胃癌患者根治术后早期肠内营养的临床疗效观察. 中国普外基础与临床杂志, 2014, 21(3): 325-329.
13. 梁冀望, 郑志超, 赵岩, 等. 胃癌根治术应用快速康复外科的系统评价. 中国肿瘤, 2012, 21(1): 75- 80.
14. 张振彬, 宁进尧, 胡金晨, 等. 快速康复外科在腹腔镜胃癌根治术围手术期的应用. 腹腔镜外科杂志, 2012, 17(9): 671-673.
15. Wang D, Kong Y, Zhong B, et al. Fast-track surgery improves postoperative recovery in patients with gastric cancer: a randomized comparison with conventional postoperative care. J Gastrointest Surg, 2010, 14(4): 620-627.
16. Rothnie NG, Harper RA, Catchpole BN. Early postoperative gastrointestinal activity. Lancet, 1963, 2(7298): 64-67.
17. 彭鹏, 黄杰安. 危重症患者早期肠内营养最新进展. 临床荟萃, 2011, 26-(6): 543-546-50.
18. 赵秉清, 祝振忠, 王征. 危重患者早期肠内营养支持治疗研究. 中外医疗, 2011, (1): 48-49.
19. 杨朝纲, 熊斌, 杨帅龙. 胃癌术后早期肠内营养支持的研究现状. 中华普通外科杂志, 2015, 30(6): 500-502.
20. 何彦坤, 张静, 何若冲. 肠内与肠外营养对胃癌根治手术后患者恢复情况的 Meta 分析. 中华临床医师杂志 (电子版), 2013, 7(5): 2077-2081.
21. 王鸿波, 王华龙, 王新民, 等. 营养风险筛查在结直肠癌快速康复外科治疗中的作用. 现代生物医学进展, 2014, 14(30): 5926-5929.
22. Mueller C, Compher C, Ellen DM, et al. A.S.P.E.N. clinical guidelines: Nutrition screening, assessment, and intervention in adults. JPEN J Parenter Enteral Nutr, 2011, 35(1): 16-24.
23. Kondrup J, Rasmussen HH, Hamberg O, et al. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials. Clin Nutr, 2003, 22(3): 321-336.
24. 米磊, 仲蓓, 张佃良, 等. 胃癌患者术后早期肠内营养对临床结局的影响. 中华胃肠外科杂志, 2012, 15(5): 464-467.
25. 黎介寿. 肠内营养—外科临床营养支持的首选途径. 中国实用外科杂志, 2003, 23(2): 67.
26. 朱俊杰, 郭明贤, 王士祺, 等. 胃癌患者术后早期肠内营养耐受状况及其相关因素. 中华临床营养杂志, 2014, 22(3): 131-135.
27. 黄涛阳, 张应辉, 黄和. 肠内营养剂的临床合理应用. 医药导报, 2011, 30(10): 1369-1372.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical application of early enteral nutrition following radical resection for patients with gastric cancer

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content