ALPPS 在原发性肝癌治疗中的价值和评价_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 杜成友 , 肖衡

重庆医科大学附属第一医院肝胆外科（重庆 400016）;

Corresponding author：

杜成友, Email: duchengyou@126.com

Keywords：

DOI：

10.7507/1007-9424.201710028

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Citation： 杜成友, 肖衡. ALPPS 在原发性肝癌治疗中的价值和评价. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(12): 1435-1441. doi: 10.7507/1007-9424.201710028 Copy

1.	Truant S, Scatton O, Dokmak S, et al. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): impact of the inter-stages course on morbi-mortality and implications for management. Eur J Surg Oncol, 2015, 41(5): 674-682.
2.	Zhang GQ, Zhang ZW, Lau WY, et al. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): a new strategy to increase resectability in liver surgery. Int J Surg, 2014, 12(5): 437-441.
3.	Truant S, Oberlin O, Sergent G, et al. Remnant liver volume to body weight ratio ≥0.5%: A new cut-off to estimate postoperative risks after extended resection in noncirrhotic liver. J Am Coll Surg, 2007, 204(1): 22-33.
4.	Makuuchi M, Thai BL, Takayasu K, et al. Preoperative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma: a preliminary report. Surgery, 1990, 107(5): 521-527.
5.	Clavien PA, Petrowsky H, De Oliveira ML, et al. Strategies for safer liver surgery and partial liver transplantation. N Engl J Med, 2007, 356(15): 1545-1559.
6.	Song T. Recent advances in surgical treatment of hepatocellular carcinoma. Drug Discov Ther, 2015, 9(5): 319-330.
7.	Lam VW, Laurence JM, Johnston E, et al. A systematic review of two-stage hepatectomy in patients with initially unresectable colorectal liver metastases. HPB (Oxford), 2013, 15(7): 483-491.
8.	Baumgart J, Lang S, Lang H. A new method for induction of liver hypertrophy prior to right trisectionectomy: A report of three cases. HPB, 2011, 13(Suppl 2): 1-145.
9.	de Santibañes E, Clavien PA. Playing Play-Doh to prevent postoperative liver failure: the " ALPPS” approach. Ann Surg, 2012, 255(3): 415-417.
10.	Croome KP, Hernandez-Alejandro R, Parker M,et al. Is the liver kinetic growth rate in ALPPS unprecedented when compared with PVE and living donor liver transplant? A multicentre analysis. HPB (Oxford) 2015, 17(6): 477-484.
11.	Shindoh J, Vauthey JN, Zimmitti G, et al. Analysis of the efficacy of portal vein embolization for patients with extensive liver malignancy and very low future liver remnant volume, including a comparison with the associating liver partition with portal vein ligation for staged hepatectomy approach. J Am Coll Surg, 2013, 217(1): 126-1334.
12.	Schadde E, Raptis DA, Schnitzbauer AA, et al. Prediction of mortality after ALPPS stage-1: an analysis of 320 patients from the International ALPPS Registry. Ann Surg, 2015, 262(5): 780-786.
13.	Linecker M, Stavrou GA, Oldhafer KJ, et al. The ALPPS risk score: avoiding futile use of ALPPS. Ann Surg, 2016, 264(5): 763-771.
14.	D’Haese JG, Neumann J, Weniger M, et al. Should ALPPS be used for liver resection in intermediate-stage HCC? Ann Surg Oncol, 2016, 23(4): 1335-1343.
15.	Lang SA, Loss M, Benseler V, et al. Long-term results after in-situ split (ISS) liver resection. Langenbecks Arch Surg, 2015, 400(3): 361-369.
16.	黄拼搏, 胡志刚, 许侨东, 等. ALPPS在具有乙肝肝硬化背景的巨块型肝癌中的应用. 岭南现代临床外科, 2015, 15(5): 527-532.
17.	Cucchetti A, Ercolani G, Vivarelli M, et al. Is portal hypertension a contraindication to hepatic resection? Ann Surg, 2009, 250(6): 922-928.
18.	Robles R, Parrilla P, López-Conesa A, et al. Tourniquet modification of the associating liver partition and portal ligation for staged hepatectomy procedure. Br J Surg, 2014, 101(9): 1129-1134.
19.	Cai X, Peng S, Duan L, et al. Completely laparoscopic ALPPS using round-the-liver ligation to replace parenchymal transection for a patient with multiple right liver cancers complicated with liver cirrhosis. J Laparoendosc Adv Surg Tech A, 2014, 24(12): 883-886.
20.	Hong DF, Zhang YB, Peng SY, et al. Percutaneous microwave ablation liver partition and portal vein embolization for rapid liver regeneration: a minimally invasive first step of ALPPS for hepatocellular carcinoma. Ann Surg, 2016, 264(1): e1-e2.
21.	Gall TM, Sodergren MH, Frampton AE, et al. Radio-frequency-assisted liver partition with portal vein ligation (RALPP) for liver regeneration. Ann Surg, 2015, 261(2): e45-e46.
22.	Gringeri E, Boetto R, D'Amico FE, et al. Laparoscopic microwave ablation and portal vein ligation for staged hepatectomy (LAPS): a minimally invasive first-step approach. Ann Surg, 2015, 261(2): e42-e43.
23.	Vicente E, Quijano Y, Ielpo B, et al. First ALPPS procedure using a total robotic approach. Surg Oncol, 2016, 25(4): 457.
24.	Oldhafer KJ, Donati M, Jenner RM, et al. ALPPS for patients with colorectal liver metastases: effective liver hypertrophy, but early tumor recurrence. World J Surg, 2014, 38(6): 1504-1509.
25.	Nadalin S, Capobianco I, Li J, et al. Indications and limits for associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). Lessons learned from 15 cases at a single centre. Z Gastroenterol, 2014, 52(1): 35-42.
26.	Vennarecci G, Laurenzi A, Levi Sandri GB, et al. The ALPPS procedure for hepatocellular carcinoma. Eur J Surg Oncol, 2014, 40(8): 982-988.
27.	Cavaness KM, Doyle MB, Lin Y, et al. Using ALPPS to induce rapid liver hypertrophy in a patient with hepatic fibrosis and portal vein thrombosis. J Gastrointest Surg, 2013, 17(1): 207-212.
28.	Cai X, Tong Y, Yu H, et al. The ALPPS in the treatment of hepatitis B-related hepatocellular carcinoma with cirrhosis: a single-center study and literature review. Surg Innov, 2017, 24(4): 358-364.
29.	Tanaka K, Matsuo K, Murakami T, et al. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): short-term outcome, functional changes in the future liver remnant, and tumor growth activity. Eur J Surg Oncol, 2015, 41(4): 506-512.
30.	Schadde E, Malagó M, Hernandez-Alejandro R, et al. Monosegment ALPPS hepatectomy: extending resectability by rapid hypertrophy. Surgery, 2015, 157(4): 676-689.
31.	Olthof PB, Coelen RJS, Wiggers JK, et al. High mortality after ALPPS for perihilar cholangiocarcinoma: case-control analysis including the first series from the international ALPPS registry. HPB (Oxford), 2017, 19(5): 381-387.
32.	Stockmann M, Bednarsch J, Malinowski M, et al. Functional considerations in ALPPS—consequences for clinical management. HPB (Oxford), 2017 Aug 22. pii: S1365-182X(17)30865-1. doi: 10.1016/j.hpb.2017.07.010.[Epub ahead of print].
33.	Olthof PB, Tomassini F, Huespe PE, et al. Hepatobiliary scintigraphy to evaluate liver function in associating liver partition and portal vein ligation for staged hepatectomy: Liver volume overestimates liver function. Surgery, 2017, 162(4): 775-783.
34.	Matsuo K, Hiroshima Y, Yamazaki K, et al. Immaturity of bile canalicular-ductule networks in the future liver remnant while associating liver partition and portal vein occlusion for staged hepatectomy (ALPPS). Ann Surg Oncol, 2017, 24(9): 2456-2464.
35.	王强, 马宽生. ALPPS的发展衍变、问题争议及未来展望. 国际外科学杂志, 2017, 44(4): 217-221.
36.	Langiewicz M, Schlegel A, Saponara E, et al. Hedgehog pathway mediates early acceleration of liver regeneration induced by a novel two-staged hepatectomy in mice. J Hepatol, 2017, 66(3): 560-570.
37.	Schlegel A, Lesurtel M, Melloul E, et al. ALPPS: from human to mice highlighting accelerated and novel mechanisms of liver regeneration. Ann Surg, 2014, 260(5): 839-847.
38.	Wullaert A, Heyninck K, Beyaert R. Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes. Biochem Pharmacol, 2006, 72(9): 1090-1101.
39.	Park EJ, Lee JH, Yu GY, et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell, 2010, 140(2): 197-208.
40.	Nakagawa H, Umemura A, Taniguchi K, et al. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell, 2014, 26(3): 331-343.
41.	Benson AB 3rd, Abrams TA, Ben-Josef E, et al. NCCN clinical practice guidelines in oncology: hepatobiliary cancers. J Natl Compr Canc Netw, 2009, 7(4): 350-391.
42.	Cai YL, Song PP, Tang W, et al. An updated systematic review of the evolution of ALPPS and evaluation of its advantages and disadvantages in accordance with current evidence. Medicine (Baltimore), 2016, 95(24): e3941.
43.	Ding BS, Nolan DJ, Butler JM, et al. Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature, 2010, 468(7321): 310-315.
44.	Kordes C, Sawitza I, Götze S, et al. Hepatic stellate cells contribute to progenitor cells and liver regeneration. J Clin Invest, 2014, 124(12): 5503-5515.
45.	Yao L, Li C, Ge X, et al. Establishment of a rat model of portal vein ligation combined with in situ splitting. PLoS One, 2014, 9(8): e105511.
46.	Xie Q, Su Y, Dykema K, et al. Overexpression of HGF promotes HBV-induced hepatocellular carcinoma progression and is an effective indicator for Met-targeting therapy. Genes Cancer, 2013, 4(7-8): 247-260.
47.	Cao Y, Ke R, Wang S, et al. DNA topoisomerase Ⅱα and Ki67 are prognostic factors in patients with hepatocellular carcinoma. Oncol Lett, 2017, 13(6): 4109-4116.

1. Truant S, Scatton O, Dokmak S, et al. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): impact of the inter-stages course on morbi-mortality and implications for management. Eur J Surg Oncol, 2015, 41(5): 674-682.
2. Zhang GQ, Zhang ZW, Lau WY, et al. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): a new strategy to increase resectability in liver surgery. Int J Surg, 2014, 12(5): 437-441.
3. Truant S, Oberlin O, Sergent G, et al. Remnant liver volume to body weight ratio ≥0.5%: A new cut-off to estimate postoperative risks after extended resection in noncirrhotic liver. J Am Coll Surg, 2007, 204(1): 22-33.
4. Makuuchi M, Thai BL, Takayasu K, et al. Preoperative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma: a preliminary report. Surgery, 1990, 107(5): 521-527.
5. Clavien PA, Petrowsky H, De Oliveira ML, et al. Strategies for safer liver surgery and partial liver transplantation. N Engl J Med, 2007, 356(15): 1545-1559.
6. Song T. Recent advances in surgical treatment of hepatocellular carcinoma. Drug Discov Ther, 2015, 9(5): 319-330.
7. Lam VW, Laurence JM, Johnston E, et al. A systematic review of two-stage hepatectomy in patients with initially unresectable colorectal liver metastases. HPB (Oxford), 2013, 15(7): 483-491.
8. Baumgart J, Lang S, Lang H. A new method for induction of liver hypertrophy prior to right trisectionectomy: A report of three cases. HPB, 2011, 13(Suppl 2): 1-145.
9. de Santibañes E, Clavien PA. Playing Play-Doh to prevent postoperative liver failure: the " ALPPS” approach. Ann Surg, 2012, 255(3): 415-417.
10. Croome KP, Hernandez-Alejandro R, Parker M,et al. Is the liver kinetic growth rate in ALPPS unprecedented when compared with PVE and living donor liver transplant? A multicentre analysis. HPB (Oxford) 2015, 17(6): 477-484.
11. Shindoh J, Vauthey JN, Zimmitti G, et al. Analysis of the efficacy of portal vein embolization for patients with extensive liver malignancy and very low future liver remnant volume, including a comparison with the associating liver partition with portal vein ligation for staged hepatectomy approach. J Am Coll Surg, 2013, 217(1): 126-1334.
12. Schadde E, Raptis DA, Schnitzbauer AA, et al. Prediction of mortality after ALPPS stage-1: an analysis of 320 patients from the International ALPPS Registry. Ann Surg, 2015, 262(5): 780-786.
13. Linecker M, Stavrou GA, Oldhafer KJ, et al. The ALPPS risk score: avoiding futile use of ALPPS. Ann Surg, 2016, 264(5): 763-771.
14. D’Haese JG, Neumann J, Weniger M, et al. Should ALPPS be used for liver resection in intermediate-stage HCC? Ann Surg Oncol, 2016, 23(4): 1335-1343.
15. Lang SA, Loss M, Benseler V, et al. Long-term results after in-situ split (ISS) liver resection. Langenbecks Arch Surg, 2015, 400(3): 361-369.
16. 黄拼搏, 胡志刚, 许侨东, 等. ALPPS在具有乙肝肝硬化背景的巨块型肝癌中的应用. 岭南现代临床外科, 2015, 15(5): 527-532.
17. Cucchetti A, Ercolani G, Vivarelli M, et al. Is portal hypertension a contraindication to hepatic resection? Ann Surg, 2009, 250(6): 922-928.
18. Robles R, Parrilla P, López-Conesa A, et al. Tourniquet modification of the associating liver partition and portal ligation for staged hepatectomy procedure. Br J Surg, 2014, 101(9): 1129-1134.
19. Cai X, Peng S, Duan L, et al. Completely laparoscopic ALPPS using round-the-liver ligation to replace parenchymal transection for a patient with multiple right liver cancers complicated with liver cirrhosis. J Laparoendosc Adv Surg Tech A, 2014, 24(12): 883-886.
20. Hong DF, Zhang YB, Peng SY, et al. Percutaneous microwave ablation liver partition and portal vein embolization for rapid liver regeneration: a minimally invasive first step of ALPPS for hepatocellular carcinoma. Ann Surg, 2016, 264(1): e1-e2.
21. Gall TM, Sodergren MH, Frampton AE, et al. Radio-frequency-assisted liver partition with portal vein ligation (RALPP) for liver regeneration. Ann Surg, 2015, 261(2): e45-e46.
22. Gringeri E, Boetto R, D'Amico FE, et al. Laparoscopic microwave ablation and portal vein ligation for staged hepatectomy (LAPS): a minimally invasive first-step approach. Ann Surg, 2015, 261(2): e42-e43.
23. Vicente E, Quijano Y, Ielpo B, et al. First ALPPS procedure using a total robotic approach. Surg Oncol, 2016, 25(4): 457.
24. Oldhafer KJ, Donati M, Jenner RM, et al. ALPPS for patients with colorectal liver metastases: effective liver hypertrophy, but early tumor recurrence. World J Surg, 2014, 38(6): 1504-1509.
25. Nadalin S, Capobianco I, Li J, et al. Indications and limits for associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). Lessons learned from 15 cases at a single centre. Z Gastroenterol, 2014, 52(1): 35-42.
26. Vennarecci G, Laurenzi A, Levi Sandri GB, et al. The ALPPS procedure for hepatocellular carcinoma. Eur J Surg Oncol, 2014, 40(8): 982-988.
27. Cavaness KM, Doyle MB, Lin Y, et al. Using ALPPS to induce rapid liver hypertrophy in a patient with hepatic fibrosis and portal vein thrombosis. J Gastrointest Surg, 2013, 17(1): 207-212.
28. Cai X, Tong Y, Yu H, et al. The ALPPS in the treatment of hepatitis B-related hepatocellular carcinoma with cirrhosis: a single-center study and literature review. Surg Innov, 2017, 24(4): 358-364.
29. Tanaka K, Matsuo K, Murakami T, et al. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): short-term outcome, functional changes in the future liver remnant, and tumor growth activity. Eur J Surg Oncol, 2015, 41(4): 506-512.
30. Schadde E, Malagó M, Hernandez-Alejandro R, et al. Monosegment ALPPS hepatectomy: extending resectability by rapid hypertrophy. Surgery, 2015, 157(4): 676-689.
31. Olthof PB, Coelen RJS, Wiggers JK, et al. High mortality after ALPPS for perihilar cholangiocarcinoma: case-control analysis including the first series from the international ALPPS registry. HPB (Oxford), 2017, 19(5): 381-387.
32. Stockmann M, Bednarsch J, Malinowski M, et al. Functional considerations in ALPPS—consequences for clinical management. HPB (Oxford), 2017 Aug 22. pii: S1365-182X(17)30865-1. doi: 10.1016/j.hpb.2017.07.010.[Epub ahead of print].
33. Olthof PB, Tomassini F, Huespe PE, et al. Hepatobiliary scintigraphy to evaluate liver function in associating liver partition and portal vein ligation for staged hepatectomy: Liver volume overestimates liver function. Surgery, 2017, 162(4): 775-783.
34. Matsuo K, Hiroshima Y, Yamazaki K, et al. Immaturity of bile canalicular-ductule networks in the future liver remnant while associating liver partition and portal vein occlusion for staged hepatectomy (ALPPS). Ann Surg Oncol, 2017, 24(9): 2456-2464.
35. 王强, 马宽生. ALPPS的发展衍变、问题争议及未来展望. 国际外科学杂志, 2017, 44(4): 217-221.
36. Langiewicz M, Schlegel A, Saponara E, et al. Hedgehog pathway mediates early acceleration of liver regeneration induced by a novel two-staged hepatectomy in mice. J Hepatol, 2017, 66(3): 560-570.
37. Schlegel A, Lesurtel M, Melloul E, et al. ALPPS: from human to mice highlighting accelerated and novel mechanisms of liver regeneration. Ann Surg, 2014, 260(5): 839-847.
38. Wullaert A, Heyninck K, Beyaert R. Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes. Biochem Pharmacol, 2006, 72(9): 1090-1101.
39. Park EJ, Lee JH, Yu GY, et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell, 2010, 140(2): 197-208.
40. Nakagawa H, Umemura A, Taniguchi K, et al. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell, 2014, 26(3): 331-343.
41. Benson AB 3rd, Abrams TA, Ben-Josef E, et al. NCCN clinical practice guidelines in oncology: hepatobiliary cancers. J Natl Compr Canc Netw, 2009, 7(4): 350-391.
42. Cai YL, Song PP, Tang W, et al. An updated systematic review of the evolution of ALPPS and evaluation of its advantages and disadvantages in accordance with current evidence. Medicine (Baltimore), 2016, 95(24): e3941.
43. Ding BS, Nolan DJ, Butler JM, et al. Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature, 2010, 468(7321): 310-315.
44. Kordes C, Sawitza I, Götze S, et al. Hepatic stellate cells contribute to progenitor cells and liver regeneration. J Clin Invest, 2014, 124(12): 5503-5515.
45. Yao L, Li C, Ge X, et al. Establishment of a rat model of portal vein ligation combined with in situ splitting. PLoS One, 2014, 9(8): e105511.
46. Xie Q, Su Y, Dykema K, et al. Overexpression of HGF promotes HBV-induced hepatocellular carcinoma progression and is an effective indicator for Met-targeting therapy. Genes Cancer, 2013, 4(7-8): 247-260.
47. Cao Y, Ke R, Wang S, et al. DNA topoisomerase Ⅱα and Ki67 are prognostic factors in patients with hepatocellular carcinoma. Oncol Lett, 2017, 13(6): 4109-4116.

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ALPPS 在原发性肝癌治疗中的价值和评价

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