• 1. Department of General Surgery, The Fourth Hospital of Harbin Medical University, Harbin 150001, P. R. China;
  • 2. Bio-Bank of Department of General Surgery, The Fourth Hospital of Harbin Medical University, Harbin 150001, P. R. China;
LI Guodong, Email: jonathanlgd@163.com
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Objective To summarize research progress of farnesoid X receptor (FXR) in regulation of hepatocellular carcinoma (HCC) and explore its potential clinical application value.Method The relevant literatures at home and abroad on the mechanism of FXR regulating occurrence and development of HCC were reviewed.Results In the occurrence and development of HCC, the FXR expression could be down-regulated through the inflammation-related pathways and epigenetic silencing. The FXR mightbe play an important role in the regulatory mechanisms of down-regulation in the HCC, therapeutic targets, drug resistance, and so on.Conclusion FXR plays an important regulatory role in occurrence and development of HCC, which makes FXR might become a potential target in treatment of HCC.

Citation: LI Xinglong, LI Zhongsheng, LI Guodong. Research progress of farnesoid X receptor in regulation of hepatocellular carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(4): 493-497. doi: 10.7507/1007-9424.201811003 Copy

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