Research progress on circRNA function and its relationship with gastric cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

CHENG Long ,  WANG Pan

Department of Gastrointestinal Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P. R. China;

Corresponding author：

WANG Pan, Email: ncwangpan@163.com

Keywords：

circRNA; gastric cancer; diagnosis

DOI：

10.7507/1007-9424.201901021

Video：

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Objective To further understand function of circular RNA (circRNA) and explore its relationship with occurrence and development of gastric cancer and its value in diagnosis and prognosis of gastric cancer.Method The published literatures on the circRNA function and its relationship with gastric cancer were reviewed and summarized.Results The closed loop structure of circRNA made it was enzymatically stable. At present, it was clear that the circRNA acted as a microRNA (miRNA) sponge and regulated the gene transcription by binding with the corresponding sites, even could be as a translation template to participate in the protein translation. Further the circRNA could act on the target gene regulated by the miRNA through the miRNA sponge. The biosignal pathway involved in the development of gastric cancer regulated by the growth of gastric cancer cells. The circRNA was differentially expressed in the gastric cancer tissue and its adjacent tissue as well as in the serums of patient and healthy human, which had the close relationships with the clinical features (pathological staging, lymph node metastasis, distant metastasis, CEA, CA19-9, etc.) and the poor prognosis and shorter postoperative survival time of patients with gastric cancer.Conclusions Due to structural characteristics of circRNA closed loop, it has an enzyme stability and can play a variety of biological functions based on miRNA sponge. Differential expression of circRNA in gastric cancer is expected to play an important role in diagnosis and prognosis evaluation of gastric cancer.

Citation： CHENG Long, WANG Pan. Research progress on circRNA function and its relationship with gastric cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2019, 26(7): 892-896. doi: 10.7507/1007-9424.201901021 Copy

1.	Sanger HL, Klotz G, Riesner D, et al. Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci U S A, 1976, 73(11): 3852-3856.
2.	Capel B, Swain A, Nicolis S, et al. Circular transcripts of the testis-determining gene Sry in adult mouse testis. Cell, 1993, 73(5): 1019-1030.
3.	Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA, 2013, 19(2): 141-157.
4.	Salzman J, Gawad C, Wang PL, et al. Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS One, 2012, 7(2): e30733.
5.	葛炜, 胡英君, 骆海燕, 等. 环状RNA的结构和功能特性及其与胃癌发生的关系. 中国生物工程杂志, 2018, 38(2): 82-88.
6.	Guo JU, Agarwal V, Guo H, et al. Expanded identification and characterization of mammalian circular RNAs. Genome Biol, 2014, 15(7): 409.
7.	Wilusz JE, Sharp PA. Molecular biology. A circuitous route to noncoding RNA. Science, 2013, 340(6131): 440-441.
8.	Zhang Y, Zhang XO, Chen T, et al. Circular intronic long noncoding RNAs. Mol Cell, 2013, 51(6): 792-806.
9.	Huang G, Li S, Yang N, et al. Recent progress in circular RNAs in human cancers. Cancer Lett, 2017, 404: 8-18.
10.	Greene J, Baird AM, Brady L, et al. Circular RNAs: Biogenesis, function and role in human diseases. Front Mol Biosci, 2017, 4: 38.
11.	Hansen TB, Jensen TI, Clausen BH, et al. Natural RNA circles function as efficient microRNA sponges. Nature, 2013, 495(7441): 384-388.
12.	Tang W, Ji M, He G, et al. Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7. Onco Targets Ther, 2017, 10: 2045-2056.
13.	Legnini I, Di Timoteo G, Rossi F, et al. Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis. Mol Cell, 2017, 66(1): 22-37.
14.	Pamudurti NR, Bartok O, Jens M, et al. Translation of circRNAs. Mol Cell, 2017, 66(1): 9-21.
15.	Yang Y, Gao X, Zhang M, et al. Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis. J Natl Cancer Inst, 2018, 110(3).
16.	Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol, 2015, 22(3): 256-264.
17.	Zeng Y, Du WW, Wu Y, et al. A circular RNA binds to and activates AKT phosphorylation and nuclear localization reducing apoptosis and enhancing cardiac repair. Theranostics, 2017, 7(16): 3842-3855.
18.	Du WW, Yang W, Liu E, et al. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res, 2016, 44(6): 2846-2858.
19.	Vidal AF, Ribeiro-Dos-Santos AM, Vinasco-Sandoval T, et al. The comprehensive expression analysis of circular RNAs in gastric cancer and its association with field cancerization. Sci Rep, 2017, 7(1): 14551.
20.	Vidal AF, Sandoval GT, Magalhães L, et al. Circular RNAs as a new field in gene regulation and their implications in translational research. Epigenomics, 2016, 8(4): 551-562.
21.	任生生, 许亮亮, 张鸣, 等. 体液环状RNA用于疾病诊断的研究进展. 中国普外基础与临床杂志, 2019, 26(5): 611-619.
22.	Nabih ES, Andrawes NG. The association between circulating levels of mirna-181a and pancreatic beta cells dysfunction via SMAD7 in type 1 diabetic children and adolescents. J Clin Lab Anal, 2016, 30(5): 727-731.
23.	Cheng J, Zhuo H, Xu M, et al. Regulatory network of circRNA-miRNA-mRNA contributes to the histological classification and disease progression in gastric cancer. J Transl Med, 2018, 16(1): 216.
24.	Zhang J, Liu H, Hou L, et al. Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression. Mol Cancer, 2017, 16(1): 151.
25.	Deng J, Lei W, Xiang X, et al. Cullin 4A (CUL4A), a direct target of miR-9 and miR-137, promotes gastric cancer proliferation and invasion by regulating the Hippo signaling pathway. Oncotarget, 2016, 7(9): 10037-10050.
26.	Wang L, Shen J, Jiang Y. Circ_0027599/PHDLA1 suppresses gastric cancer progression by sponging miR-101-3p.1. Cell Biosci, 2018, 8: 58.
27.	Chang P, Wang F, Li Y. Hsa_circ_0000673 is down-regulated in gastric cancer and inhibits the proliferation and invasion of tumor cells by targetting miR-532-5p. Biosci Rep, 2018, 38(5): pii: BSR20180538.
28.	Zhong Z, Lv M, Chen J. Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. Sci Rep, 2016, 6: 30919.
29.	Fang J, Hong H, Xue X, et al. A novel circular RNA, circFAT1(e2), inhibits gastric cancer progression by targeting miR-548g in the cytoplasm and interacting with YBX1 in the nucleus. Cancer Lett, 2019, 442: 222-232.
30.	Shao Y, Li J, Lu R, et al. Global circular RNA expression profile of human gastric cancer and its clinical significance. Cancer Med, 2017, 6(6): 1173-1180.
31.	Li J, Zhen L, Zhang Y, et al. Circ-104916 is downregulated in gastric cancer and suppresses migration and invasion of gastric cancer cells. Onco Targets Ther, 2017, 10: 3521-3529.
32.	Zhou LH, Yang YC, Zhang RY, et al. CircRNA_0023642 promotes migration and invasion of gastric cancer cells by regulating EMT. Eur Rev Med Pharmacol Sci, 2018, 22(8): 2297-2303.
33.	Rong D, Dong C, Fu K, et al. Upregulation of circ_0066444 promotes the proliferation, invasion, and migration of gastric cancer cells. Onco Targets Ther, 2018, 11: 2753-2761.
34.	Sun HD, Xu ZP, Sun ZQ, et al. Down-regulation of circPVRL3 promotes the proliferation and migration of gastric cancer cells. Sci Rep, 2018, 8(1): 10111.
35.	Sun H, Tang W, Rong D, et al. Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma. Cancer Biomark, 2018, 21(2): 299-306.
36.	Zhao Q, Chen S, Li T, et al. Clinical values of circular RNA 0000181 in the screening of gastric cancer. J Clin Lab Anal, 2018, 32(4): e22333.
37.	Lu R, Shao Y, Ye G, et al. Low expression of hsa_circ_0006633 in human gastric cancer and its clinical significances. Tumour Biol, 2017, 39(6): 1010428317704175.
38.	Shao Y, Chen L, Lu R, et al. Decreased expression of hsa_circ_0001895 in human gastric cancer and its clinical significances. Tumour Biol, 2017, 39(4): 1010428317699125.
39.	Xue M, Li G, Fang X, et al. Hsa_circ_0081143 promotes cisplatin resistance in gastric cancer by targeting miR-646/CDK6 pathway. Cancer Cell Int, 2019, 19: 25.
40.	Huang M, He YR, Liang LC, et al. Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer. World J Gastroenterol, 2017, 23(34): 6330-6338.
41.	Chen S, Li T, Zhao Q, et al. Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer. Clin Chim Acta, 2017, 466: 167-171.
42.	Li T, Shao Y, Fu L, et al. Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection. J Mol Med (Berl), 2018, 96(1): 85-96.
43.	Zhang H, Wang X, Huang H, et al. Hsa_circ_0067997 promotes the progression of gastric cancer by inhibition of miR-515-5p and activation of X chromosome-linked inhibitor of apoptosis (XIAP). Artif Cells Nanomed Biotechnol, 2019, 47(1): 308-318.

1. Sanger HL, Klotz G, Riesner D, et al. Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci U S A, 1976, 73(11): 3852-3856.
2. Capel B, Swain A, Nicolis S, et al. Circular transcripts of the testis-determining gene Sry in adult mouse testis. Cell, 1993, 73(5): 1019-1030.
3. Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA, 2013, 19(2): 141-157.
4. Salzman J, Gawad C, Wang PL, et al. Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS One, 2012, 7(2): e30733.
5. 葛炜, 胡英君, 骆海燕, 等. 环状RNA的结构和功能特性及其与胃癌发生的关系. 中国生物工程杂志, 2018, 38(2): 82-88.
6. Guo JU, Agarwal V, Guo H, et al. Expanded identification and characterization of mammalian circular RNAs. Genome Biol, 2014, 15(7): 409.
7. Wilusz JE, Sharp PA. Molecular biology. A circuitous route to noncoding RNA. Science, 2013, 340(6131): 440-441.
8. Zhang Y, Zhang XO, Chen T, et al. Circular intronic long noncoding RNAs. Mol Cell, 2013, 51(6): 792-806.
9. Huang G, Li S, Yang N, et al. Recent progress in circular RNAs in human cancers. Cancer Lett, 2017, 404: 8-18.
10. Greene J, Baird AM, Brady L, et al. Circular RNAs: Biogenesis, function and role in human diseases. Front Mol Biosci, 2017, 4: 38.
11. Hansen TB, Jensen TI, Clausen BH, et al. Natural RNA circles function as efficient microRNA sponges. Nature, 2013, 495(7441): 384-388.
12. Tang W, Ji M, He G, et al. Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7. Onco Targets Ther, 2017, 10: 2045-2056.
13. Legnini I, Di Timoteo G, Rossi F, et al. Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis. Mol Cell, 2017, 66(1): 22-37.
14. Pamudurti NR, Bartok O, Jens M, et al. Translation of circRNAs. Mol Cell, 2017, 66(1): 9-21.
15. Yang Y, Gao X, Zhang M, et al. Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis. J Natl Cancer Inst, 2018, 110(3).
16. Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol, 2015, 22(3): 256-264.
17. Zeng Y, Du WW, Wu Y, et al. A circular RNA binds to and activates AKT phosphorylation and nuclear localization reducing apoptosis and enhancing cardiac repair. Theranostics, 2017, 7(16): 3842-3855.
18. Du WW, Yang W, Liu E, et al. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res, 2016, 44(6): 2846-2858.
19. Vidal AF, Ribeiro-Dos-Santos AM, Vinasco-Sandoval T, et al. The comprehensive expression analysis of circular RNAs in gastric cancer and its association with field cancerization. Sci Rep, 2017, 7(1): 14551.
20. Vidal AF, Sandoval GT, Magalhães L, et al. Circular RNAs as a new field in gene regulation and their implications in translational research. Epigenomics, 2016, 8(4): 551-562.
21. 任生生, 许亮亮, 张鸣, 等. 体液环状RNA用于疾病诊断的研究进展. 中国普外基础与临床杂志, 2019, 26(5): 611-619.
22. Nabih ES, Andrawes NG. The association between circulating levels of mirna-181a and pancreatic beta cells dysfunction via SMAD7 in type 1 diabetic children and adolescents. J Clin Lab Anal, 2016, 30(5): 727-731.
23. Cheng J, Zhuo H, Xu M, et al. Regulatory network of circRNA-miRNA-mRNA contributes to the histological classification and disease progression in gastric cancer. J Transl Med, 2018, 16(1): 216.
24. Zhang J, Liu H, Hou L, et al. Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression. Mol Cancer, 2017, 16(1): 151.
25. Deng J, Lei W, Xiang X, et al. Cullin 4A (CUL4A), a direct target of miR-9 and miR-137, promotes gastric cancer proliferation and invasion by regulating the Hippo signaling pathway. Oncotarget, 2016, 7(9): 10037-10050.
26. Wang L, Shen J, Jiang Y. Circ_0027599/PHDLA1 suppresses gastric cancer progression by sponging miR-101-3p.1. Cell Biosci, 2018, 8: 58.
27. Chang P, Wang F, Li Y. Hsa_circ_0000673 is down-regulated in gastric cancer and inhibits the proliferation and invasion of tumor cells by targetting miR-532-5p. Biosci Rep, 2018, 38(5): pii: BSR20180538.
28. Zhong Z, Lv M, Chen J. Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. Sci Rep, 2016, 6: 30919.
29. Fang J, Hong H, Xue X, et al. A novel circular RNA, circFAT1(e2), inhibits gastric cancer progression by targeting miR-548g in the cytoplasm and interacting with YBX1 in the nucleus. Cancer Lett, 2019, 442: 222-232.
30. Shao Y, Li J, Lu R, et al. Global circular RNA expression profile of human gastric cancer and its clinical significance. Cancer Med, 2017, 6(6): 1173-1180.
31. Li J, Zhen L, Zhang Y, et al. Circ-104916 is downregulated in gastric cancer and suppresses migration and invasion of gastric cancer cells. Onco Targets Ther, 2017, 10: 3521-3529.
32. Zhou LH, Yang YC, Zhang RY, et al. CircRNA_0023642 promotes migration and invasion of gastric cancer cells by regulating EMT. Eur Rev Med Pharmacol Sci, 2018, 22(8): 2297-2303.
33. Rong D, Dong C, Fu K, et al. Upregulation of circ_0066444 promotes the proliferation, invasion, and migration of gastric cancer cells. Onco Targets Ther, 2018, 11: 2753-2761.
34. Sun HD, Xu ZP, Sun ZQ, et al. Down-regulation of circPVRL3 promotes the proliferation and migration of gastric cancer cells. Sci Rep, 2018, 8(1): 10111.
35. Sun H, Tang W, Rong D, et al. Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma. Cancer Biomark, 2018, 21(2): 299-306.
36. Zhao Q, Chen S, Li T, et al. Clinical values of circular RNA 0000181 in the screening of gastric cancer. J Clin Lab Anal, 2018, 32(4): e22333.
37. Lu R, Shao Y, Ye G, et al. Low expression of hsa_circ_0006633 in human gastric cancer and its clinical significances. Tumour Biol, 2017, 39(6): 1010428317704175.
38. Shao Y, Chen L, Lu R, et al. Decreased expression of hsa_circ_0001895 in human gastric cancer and its clinical significances. Tumour Biol, 2017, 39(4): 1010428317699125.
39. Xue M, Li G, Fang X, et al. Hsa_circ_0081143 promotes cisplatin resistance in gastric cancer by targeting miR-646/CDK6 pathway. Cancer Cell Int, 2019, 19: 25.
40. Huang M, He YR, Liang LC, et al. Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer. World J Gastroenterol, 2017, 23(34): 6330-6338.
41. Chen S, Li T, Zhao Q, et al. Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer. Clin Chim Acta, 2017, 466: 167-171.
42. Li T, Shao Y, Fu L, et al. Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection. J Mol Med (Berl), 2018, 96(1): 85-96.
43. Zhang H, Wang X, Huang H, et al. Hsa_circ_0067997 promotes the progression of gastric cancer by inhibition of miR-515-5p and activation of X chromosome-linked inhibitor of apoptosis (XIAP). Artif Cells Nanomed Biotechnol, 2019, 47(1): 308-318.

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