Correlation between CYP1A1 MspI gene polymorphisms and the risk of breast cancer in Chinese population: a meta-analysis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Lingling ¹ , LONG Binbin ² , YANG Yao ¹ , WU Yaqiong ¹ ,  ZHANG Chao ³

1. Department of Dermatology, Taihe Hospital, Affiliated Taihe Hospital of Hubei University of Medicine, Shiyan, Hubei 442000, P. R. China;
2. Department of General Surgery Ⅲ, Taihe Hospital, Affiliated Taihe Hospital of Hubei University of Medicine, Shiyan, Hubei 442000,P. R. China;
3. Department of Evidence-Based Medicine Center, Taihe Hospital, Affiliated Taihe Hospital of Hubei University of Medicine, Shiyan, Hubei 442000, P. R. China;

Corresponding author：

ZHANG Chao, Email: 286806931@qq.com

Keywords：

breast cancer; CYP1A1; gene polymorphism; cytochrome P450; meta-analysis

DOI：

10.7507/1007-9424.201908118

Video：

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Objective To study the correlation between CYP1A1 MspI gene polymorphisms and the risk of breast cancer (BC) in Chinese population.Methods The case-control studies on the correlation between polymorphisms of CYP1A1 MspI and BC in Chinese population were electronically retrieved in online English database (PubMed and Web of Science) and Chinese database (Chinese National Knowledge Infrastructure, Wanfang, and VIP database) from the date of their establishment to December 31, 2018. Two reviewers completed literature screening according to the inclusion and exclusion criteria, data extraction, and methodological quality assessment of the included studies independently. Reman 5.3 software was used to meta-analysis.Results A total 14 case-control studies involving 3 372 cases and 3 510 controls were finally included. The meta-analysis results showed that the CYP1A1 MspI gene polymorphism was associated with BC in Chinese population. Dominant genetic model [OR=1.24, 95%CI was (0.98, 1.58), P=0.08] and heterozygote model [OR=1.11, 95%CI was (0.89, 1.39), P=0.37] had no association with BC in Chinese population, while recessive genetic model [OR=1.66, 95%CI was (1.28, 2.14), P=0.000 1], homozygote model [OR=1.76, 95%CI was (1.26, 2.45), P=0.000 9], and allele contrast genetic model [OR=1.30, 95%CI was (1.08, 1.56), P=0.005] increased the risk of BC in Chinese population.Conclusion It is demonstrated that in Chinese population, CYP1A1 MspI gene polymorphisms related to the risk of BC, recessive genetic model, homozygote model, and allele contrast genetic model might be the risk factor for BC.

Citation： WANG Lingling, LONG Binbin, YANG Yao, WU Yaqiong, ZHANG Chao. Correlation between CYP1A1 MspI gene polymorphisms and the risk of breast cancer in Chinese population: a meta-analysis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2020, 27(7): 846-854. doi: 10.7507/1007-9424.201908118 Copy

1.	World Health Organization. Globocan 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012. http://globocan.iarc.fr/Pages/fact_sheets_population.aspx.
2.	Torre LA, Islami F, Siegel RL, et al. Global cancer in women: burden and trends. Cancer Epidemiol Biomarkers Prev, 2017, 26(4): 444-457.
3.	陈万青, 郑荣寿. 中国女性乳腺癌的发病死亡和生存状况. 中国肿瘤临床, 2015, 42(13): 668-674.
4.	师金, 梁迪, 李道娟, 等. 全球女性乳腺癌流行情况研究. 中国肿瘤, 2017, 26(9): 683-690.
5.	Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
6.	Dickson RB, Thompson EW, Lippman ME. Regulation of proliferation, invasion and growth factor synthesis in breast cancer by steroids. J Steroid Biochem Mol Biol, 1990, 37(3): 305-316.
7.	徐小乐, 靳雅丽, 沈月平. CYP1A1 MspI基因多态性与乳腺癌关系的Meta分析. 苏州大学学报: 医学版, 2005, 25(6): 1078-1080.
8.	曾宪涛, 刘慧, 陈曦, 等. Meta分析系列之四: 观察性研究的质量评价工具. 中国循证心血管医学杂志, 2012, 4(4): 297-299.
9.	张燕舞, 蒋朱明, 王杨, 等. 与转化医学有关的临床研究质量及研究报告质量的评价工具. 中华临床营养杂志, 2011, 19(1): 1-6.
10.	DerSimonian R, Laird N. Meta-analysis in clinical trials revisited. Contemp Clin Trials, 2015, 45(Pt A): 139-145.
11.	Huang CS, Chern HD, Chang KJ, et al. Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility. Cancer Res, 1999, 59(19): 4870-4875.
12.	Huang CS, Shen CY, Chang KJ, et al. Cytochrome P4501A1 polymorphism as a susceptibility factor for breast cancer in postmenopausal Chinese women in Taiwan. Br J Cancer, 1999, 80(11): 1838-1843.
13.	Boyapati SM, Shu XO, Gao YT, et al. Polymorphisms in CYP1A1 and breast carcinoma risk in a population-based case-control study of Chinese women. Cancer, 2005, 103(11): 2228-2235.
14.	吐尔逊·买买提, 哈木拉提·吾甫尔, 白岚, 等. CYP1A1基因3′-UTR6235T-C位点多态性与维医分型乳腺癌遗传易感性的关系. 中华医学杂志, 2011, 91(2): 86-91.
15.	吐尔逊·买买提, 哈木拉提·吾甫尔, 夏坤, 等. CYP1A1、CYP1B1、NET、DAT1单个和联合基因型与汉族人群乳腺癌易感性的研究. 生命科学研究, 2015, 19(6): 521-529.
16.	崔壮. 雌激素代谢酶相关基因多态性及其它危险因素与乳腺癌关系的病例对照研究. 天津: 天津医科大学, 2005.
17.	崔壮, 钱碧云, 陈可欣, 等. CYP1A1、GSTT1、GSTM1基因与乳腺癌易感性的病例对照研究. 中国慢性病预防与控制, 2010, 18(3): 249-252.
18.	帕孜来提·阿布都热西提. CYP1A1基因多态性与新疆维、汉民族女性乳腺癌相关性研究. 乌鲁木齐: 新疆医科大学, 2016.
19.	张明, 高嫦娥, 陈莹, 等. 彝族乳腺癌遗传易感性CYP1A1基因MspI多态性的相关性研究. 西部医学, 2014, 26(12): 1581-1584.
20.	张明, 高嫦娥, 陈莹, 等. 云南省彝族及汉族乳腺癌遗传易感性与CYP1A1基因多态性的研究. 实用医学杂志, 2014, 30(15): 2398-2401.
21.	张珍连, 闻淑娟, 胡欣, 等. ERα PvuⅡ、XbaⅠ及CYP1A1 Msp Ⅰ基因多态性联合作用与新疆维吾尔族女性乳腺癌发病相关性研究. 中国肿瘤, 2018, 27(3): 234-240.
22.	沈月平. CYP1A1 MspⅠ、ER PvuⅡ、ER XbaⅠ基因多态性与乳腺癌关系的病例-对照研究. 上海: 复旦大学, 2004.
23.	白淑芬, 杨立新, 张爱臣, 等. 乳腺癌患者CYP1A1基因MspⅠ酶切位点多态性的分析. 吉林大学学报: 医学版, 2009, 35(2): 377-380.
24.	黄燚, 刘丹, 饶绍琴, 等. CYP1A1和CYP1A2基因多态性与汉族女性乳腺癌的关系. 中华乳腺病杂志: 电子版, 2013, 7(5): 345-350.
25.	Higgins JPT, Green S. Cochrane Handbook for Systematic Reviewsof Interventions 4.2.5 [updated May 2005]. http://www.cochrane.org/resources/handbook/hbook.htm.
26.	Pastor-Barriuso R, Fernández MF, Castaño-Vinyals G, et al. Total effective xenoestrogen burden in serum samples and risk for breast cancer in a population-based multicase-control study in Spain. Environ Health Perspect, 2016, 124(10): 1575-1582.
27.	Upadhyaya A, Smith RA, Chacon-Cortes D, et al. Association of the microRNA-single nucleotide polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: a case control study. Gene, 2016, 576(1 Pt 2): 256-260.
28.	Dai ZM, Kang HF, Zhang WG, et al. The associations of single nucleotide polymorphisms in miR196a2, miR-499, and miR-608 with breast cancer susceptibility: a STROBE-compliant observational study. Medicine (Baltimore), 2016, 95(7): e2826.
29.	Yan R, Cao J, Song C, et al. Polymorphisms in lncRNA HOTAIR and susceptibility to breast cancer in a Chinese population. Cancer Epidemiol, 2015, 39(6): 978-985.
30.	Yan R, Wang K, Peng R, et al. Genetic variants in lncRNA SRA and risk of breast cancer. Oncotarget, 2016, 7(16): 22486-22496.
31.	Wielsøe M, Gudmundsdottir S, Bonefeld-Jørgensen EC. Reproductive history and dietary habits and breast cancer risk in Greenlandic Inuit: a case control study. Public Health, 2016, 137: 50-58.
32.	Hanf V, Hanf D. Reproduction and breast cancer risk. Breast Care (Basel), 2014, 9(6): 398-405.
33.	Namiranian N, Moradi-Lakeh M, Razavi-Ratki SK, et al. Risk factors of breast cancer in the Eastern Mediterranean Region: a systematic review and meta-analysis. Asian Pac J Cancer Prev, 2014, 15(21): 9535-9541.
34.	Wang X, Li L, Gao J, et al. The association between body size and breast cancer in han women in Northern and Eastern China. Oncologist, 2016, 21(11): 1362-1368.
35.	姜勇, 张梅, 李镒冲, 等. 2010年我国中心型肥胖流行状况及腰围分布特征分析. 中国慢性病预防与控制, 2013, 21(3): 288-291.
36.	倪国华, 张璟, 郑风田. 中国肥胖流行的现状与趋势. 中国食物与营养, 2013, 19(10): 70-74.
37.	Shield KD, Soerjomataram I, Rehm J. Alcohol use and breast cancer: a critical review. Alcohol Clin Exp Res, 2016, 40(6): 1166-1181.
38.	Li B, Wang L, Lu MS, et al. Passive smoking and breast cancer risk among non-smoking women: a case-control study in China. PLoS One, 2015, 10(4): e0125894.
39.	Kiruthiga PV, Kannan MR, Saraswathi C, et al. CYP1A1 gene polymorphisms: lack of association with breast cancer susceptibility in the southern region (Madurai) of India. Asian Pac J Cancer Prev, 2011, 12(8): 2133-2138.
40.	Miyoshi Y, Takahashi Y, Egawa C, et al. Breast cancer risk associated with CYP1A1 genetic polymorphisms in Japanese women. Breast J, 2002, 8(4): 209-215.
41.	Moreno-Galván M, Herrera-González NE, Robles-Pérez V, et al. Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study. Int J Biol Markers, 2010, 25(3): 157-163.
42.	Shin A, Kang D, Choi JY, et al. Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women. Exp Mol Med, 2007, 39(3): 361-366.

1. World Health Organization. Globocan 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012. http://globocan.iarc.fr/Pages/fact_sheets_population.aspx.
2. Torre LA, Islami F, Siegel RL, et al. Global cancer in women: burden and trends. Cancer Epidemiol Biomarkers Prev, 2017, 26(4): 444-457.
3. 陈万青, 郑荣寿. 中国女性乳腺癌的发病死亡和生存状况. 中国肿瘤临床, 2015, 42(13): 668-674.
4. 师金, 梁迪, 李道娟, 等. 全球女性乳腺癌流行情况研究. 中国肿瘤, 2017, 26(9): 683-690.
5. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
6. Dickson RB, Thompson EW, Lippman ME. Regulation of proliferation, invasion and growth factor synthesis in breast cancer by steroids. J Steroid Biochem Mol Biol, 1990, 37(3): 305-316.
7. 徐小乐, 靳雅丽, 沈月平. CYP1A1 MspI基因多态性与乳腺癌关系的Meta分析. 苏州大学学报: 医学版, 2005, 25(6): 1078-1080.
8. 曾宪涛, 刘慧, 陈曦, 等. Meta分析系列之四: 观察性研究的质量评价工具. 中国循证心血管医学杂志, 2012, 4(4): 297-299.
9. 张燕舞, 蒋朱明, 王杨, 等. 与转化医学有关的临床研究质量及研究报告质量的评价工具. 中华临床营养杂志, 2011, 19(1): 1-6.
10. DerSimonian R, Laird N. Meta-analysis in clinical trials revisited. Contemp Clin Trials, 2015, 45(Pt A): 139-145.
11. Huang CS, Chern HD, Chang KJ, et al. Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility. Cancer Res, 1999, 59(19): 4870-4875.
12. Huang CS, Shen CY, Chang KJ, et al. Cytochrome P4501A1 polymorphism as a susceptibility factor for breast cancer in postmenopausal Chinese women in Taiwan. Br J Cancer, 1999, 80(11): 1838-1843.
13. Boyapati SM, Shu XO, Gao YT, et al. Polymorphisms in CYP1A1 and breast carcinoma risk in a population-based case-control study of Chinese women. Cancer, 2005, 103(11): 2228-2235.
14. 吐尔逊·买买提, 哈木拉提·吾甫尔, 白岚, 等. CYP1A1基因3′-UTR6235T-C位点多态性与维医分型乳腺癌遗传易感性的关系. 中华医学杂志, 2011, 91(2): 86-91.
15. 吐尔逊·买买提, 哈木拉提·吾甫尔, 夏坤, 等. CYP1A1、CYP1B1、NET、DAT1单个和联合基因型与汉族人群乳腺癌易感性的研究. 生命科学研究, 2015, 19(6): 521-529.
16. 崔壮. 雌激素代谢酶相关基因多态性及其它危险因素与乳腺癌关系的病例对照研究. 天津: 天津医科大学, 2005.
17. 崔壮, 钱碧云, 陈可欣, 等. CYP1A1、GSTT1、GSTM1基因与乳腺癌易感性的病例对照研究. 中国慢性病预防与控制, 2010, 18(3): 249-252.
18. 帕孜来提·阿布都热西提. CYP1A1基因多态性与新疆维、汉民族女性乳腺癌相关性研究. 乌鲁木齐: 新疆医科大学, 2016.
19. 张明, 高嫦娥, 陈莹, 等. 彝族乳腺癌遗传易感性CYP1A1基因MspI多态性的相关性研究. 西部医学, 2014, 26(12): 1581-1584.
20. 张明, 高嫦娥, 陈莹, 等. 云南省彝族及汉族乳腺癌遗传易感性与CYP1A1基因多态性的研究. 实用医学杂志, 2014, 30(15): 2398-2401.
21. 张珍连, 闻淑娟, 胡欣, 等. ERα PvuⅡ、XbaⅠ及CYP1A1 Msp Ⅰ基因多态性联合作用与新疆维吾尔族女性乳腺癌发病相关性研究. 中国肿瘤, 2018, 27(3): 234-240.
22. 沈月平. CYP1A1 MspⅠ、ER PvuⅡ、ER XbaⅠ基因多态性与乳腺癌关系的病例-对照研究. 上海: 复旦大学, 2004.
23. 白淑芬, 杨立新, 张爱臣, 等. 乳腺癌患者CYP1A1基因MspⅠ酶切位点多态性的分析. 吉林大学学报: 医学版, 2009, 35(2): 377-380.
24. 黄燚, 刘丹, 饶绍琴, 等. CYP1A1和CYP1A2基因多态性与汉族女性乳腺癌的关系. 中华乳腺病杂志: 电子版, 2013, 7(5): 345-350.
25. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviewsof Interventions 4.2.5 [updated May 2005]. http://www.cochrane.org/resources/handbook/hbook.htm.
26. Pastor-Barriuso R, Fernández MF, Castaño-Vinyals G, et al. Total effective xenoestrogen burden in serum samples and risk for breast cancer in a population-based multicase-control study in Spain. Environ Health Perspect, 2016, 124(10): 1575-1582.
27. Upadhyaya A, Smith RA, Chacon-Cortes D, et al. Association of the microRNA-single nucleotide polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: a case control study. Gene, 2016, 576(1 Pt 2): 256-260.
28. Dai ZM, Kang HF, Zhang WG, et al. The associations of single nucleotide polymorphisms in miR196a2, miR-499, and miR-608 with breast cancer susceptibility: a STROBE-compliant observational study. Medicine (Baltimore), 2016, 95(7): e2826.
29. Yan R, Cao J, Song C, et al. Polymorphisms in lncRNA HOTAIR and susceptibility to breast cancer in a Chinese population. Cancer Epidemiol, 2015, 39(6): 978-985.
30. Yan R, Wang K, Peng R, et al. Genetic variants in lncRNA SRA and risk of breast cancer. Oncotarget, 2016, 7(16): 22486-22496.
31. Wielsøe M, Gudmundsdottir S, Bonefeld-Jørgensen EC. Reproductive history and dietary habits and breast cancer risk in Greenlandic Inuit: a case control study. Public Health, 2016, 137: 50-58.
32. Hanf V, Hanf D. Reproduction and breast cancer risk. Breast Care (Basel), 2014, 9(6): 398-405.
33. Namiranian N, Moradi-Lakeh M, Razavi-Ratki SK, et al. Risk factors of breast cancer in the Eastern Mediterranean Region: a systematic review and meta-analysis. Asian Pac J Cancer Prev, 2014, 15(21): 9535-9541.
34. Wang X, Li L, Gao J, et al. The association between body size and breast cancer in han women in Northern and Eastern China. Oncologist, 2016, 21(11): 1362-1368.
35. 姜勇, 张梅, 李镒冲, 等. 2010年我国中心型肥胖流行状况及腰围分布特征分析. 中国慢性病预防与控制, 2013, 21(3): 288-291.
36. 倪国华, 张璟, 郑风田. 中国肥胖流行的现状与趋势. 中国食物与营养, 2013, 19(10): 70-74.
37. Shield KD, Soerjomataram I, Rehm J. Alcohol use and breast cancer: a critical review. Alcohol Clin Exp Res, 2016, 40(6): 1166-1181.
38. Li B, Wang L, Lu MS, et al. Passive smoking and breast cancer risk among non-smoking women: a case-control study in China. PLoS One, 2015, 10(4): e0125894.
39. Kiruthiga PV, Kannan MR, Saraswathi C, et al. CYP1A1 gene polymorphisms: lack of association with breast cancer susceptibility in the southern region (Madurai) of India. Asian Pac J Cancer Prev, 2011, 12(8): 2133-2138.
40. Miyoshi Y, Takahashi Y, Egawa C, et al. Breast cancer risk associated with CYP1A1 genetic polymorphisms in Japanese women. Breast J, 2002, 8(4): 209-215.
41. Moreno-Galván M, Herrera-González NE, Robles-Pérez V, et al. Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study. Int J Biol Markers, 2010, 25(3): 157-163.
42. Shin A, Kang D, Choi JY, et al. Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women. Exp Mol Med, 2007, 39(3): 361-366.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Correlation between CYP1A1 MspI gene polymorphisms and the risk of breast cancer in Chinese population: a meta-analysis

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