• Department of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin 150001, P. R. China;
MA Yong, Email: doctormy80@163.com
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Objective To investigate relationship between liver non-parenchymal cells and hepatic ischemia-reperfusion injury (HIRI).Method The relevant literatures on researches of the relationship between HIRI and liver non-parenchymal cells were analyzed and reviewed.Results During HIRI, hepatocytes could be severely damaged by aseptic inflammatory reaction and apoptosis. The liver non-parenchymal cells included Kupffer cells, sinusoidal endothelial cells, hepatic stellate cells, and dendritic cells, which could release a variety of cytokines and inflammatory mediators to promote the damage, and some liver non-parenchymal cells also had effect on reducing HIRI, for example: Kupffer cells could express heme oxygenase-1 to reduce HIRI, and hepatic stellate cells may participate in the repair process after HIRI. The role of liver non-parenchymal cells in HIRI was complex, but it also had potential therapeutic value.Conclusion Liver non-parenchymal cells can affect HIRI through a variety of mechanisms, which provide new goals and strategies for clinical reduction of HIRI.

Citation: CHEN Bangliang, MA Yong. Research progress of the function of liver non-parenchymal cells in hepatic ischemia-reperfusion injury. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2020, 27(6): 755-758. doi: 10.7507/1007-9424.201910051 Copy

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