• 1. School of Clinical Medicine, Guizhou Medical University, Guiyang 550000, P. R. China;
  • 2. Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550000, P. R. China;
HU Chaoquan, Email: kevinhucn@yahoo.com
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Objective To review the present situation of immune checkpoint inhibitors in treatment of advanced hepatocellular carcinoma (HCC), and discuss the advance of combined immunotherapy.Methods The relevant literatures on researches of immune checkpoint inhibitors in the treatment of advanced HCC were retrieved to make an review.Results Immunotherapy intervention had been becoming a novel and promising therapeutic approach for HCC, which could suppress the progression of aggressive tumor and could inhibit tumor recurrence and metastasis shown in some pre-clinical trials. Other studies had found that the combined strategy of specific immunotherapy and conventional therapies could significantly improve the clinical outcomes of HCC patients.Conclusion Combined immunotherapy can significantly improve the clinical outcomes of HCC and benefit more patients with advanced HCC.

Citation: YIN Peng, HU Chaoquan. Progress of immune checkpoint inhibitors in treatment of advanced hepatocellular carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(4): 524-529. doi: 10.7507/1007-9424.202006125 Copy

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