Research progress of non-coding RNA in acute pancreatitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Zhipeng ,  ZHANG Weihui

Department of Minimally Invasive Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, P. R. China;

Corresponding author：

ZHANG Weihui, Email: zhangweihui626@hotmail.com

Keywords：

acute pancreatitis; non-coding RNA; microRNA; long non-coding RNA; review

DOI：

10.7507/1007-9424.202101006

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To summarize research progress of non-coding RNAs (ncRNAs) in acute pancreatitis (AP), so as to provide new ideas for pathogenesis, diagnosis, and therapy of AP.Method The literatures on studies of ncRNAs in AP in recent years were read and reviewed.Results The incidence of AP was currently increasing, but its etiology was diverse, and its pathogenesis was still fully unclear. In recent years, a large number of studies had confirmed that the ncRNA played an important role in the occurrence of many cellulars and diseases processes. Through continuous exploration for potential mechanisms of AP based on ncRNA (including long non-coding RNA and microRNA) function, it was found that the specificity and sensitivity of ncRNAs in the diagnosis of AP were better than of the traditional biomarkers. Meanwhile, ncRNAs were involved in the regulation of inflammatory response through a variety of ways.Conclusions ncRNAs are involved in altering gene expression (including up-regulation or down-regulation) in the key physiological functions of AP through a variety of ways, it might provide new ideas for understanding pathogenesis of AP and help to find new therapeutic targets. A variety of ncRNAs closely related to AP are expected to become biomarkers and molecular targets for early diagnosis and treatment of AP, so as to achieve early diagnosis and targeted treatment of AP.

Citation： ZHANG Zhipeng, ZHANG Weihui. Research progress of non-coding RNA in acute pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2021, 28(11): 1536-1540. doi: 10.7507/1007-9424.202101006 Copy

1.	Liu S, Zou H, Wang Y, et al. miR-155-5p is negatively associated with acute pancreatitis and inversely regulates pancreatic acinar cell progression by targeting Rela and Traf3. Cell Physiol Biochem, 2018, 51(4): 1584-1599.
2.	Lee PJ, Papachristou GI. New insights into acute pancreatitis. Nat Rev Gastroenterol Hepatol, 2019, 16(8): 479-496.
3.	Paul J. Recent advances in diagnosis and severity assessment of acute pancreatitis. Prague Med Rep, 2020, 121(2): 65-86.
4.	Machicado JD, Papachristou GI. Pharmacologic management and prevention of acute pancreatitis. Curr Opin Gastroenterol, 2019, 35(5): 460-467.
5.	Zhou B, Yang H, Yang C, et al. Translation of noncoding RNAs and cancer. Cancer Lett, 2021, 497: 89-99.
6.	张洋, 郭海, 马莉, 等. 长链非编码 RNA MALAT1 吸附微小 RNA-124 调控 MSCs 成骨分化的实验研究. 中国修复重建外科杂志, 2020, 34(2): 240-245.
7.	侯婉婷, 唐秋琳, 毕锋. 肾透明细胞癌中 lncRNA 和 miRNA 差异表达及相关 ceRNA 调控网络的分析研究. 生物医学工程学杂志, 2019, 36(2): 267-273.
8.	陈舒泽, 于正桐, 王梓鸿, 等. 长链非编码 RNA 中 INK4 基因座中反义非编码 RNA 在糖尿病视网膜病变中的研究现状. 中华眼底病杂志, 2020, 36(1): 78-81.
9.	Lankisch PG, Apte M, Banks PA. Acute pancreatitis. Lancet, 2015, 386(9988): 85-96.
10.	Cao Z, Qiu J, Yang G, et al. MiR-135a biogenesis and regulation in malignancy: a new hope for cancer research and therapy. Cancer Biol Med, 2020, 17(3): 569-582.
11.	Wang J, Yang J, Zhang H, et al. Effects of miR-135a-5p and miR-141 on proliferation, invasion and apoptosis of colorectal cancer SW620 cells. Oncol Lett, 2020, 20(1): 914-920.
12.	Tang Y, Cao G, Zhao G, et al. LncRNA differentiation antagonizing non-protein coding RNA promotes proliferation and invasion through regulating miR-135a/NLRP37 axis in pancreatic cancer. Invest New Drugs, 2020, 38(3): 714-721.
13.	Pan J, Xu X, Wang G. lncRNA ZFAS1 is involved in the proliferation, invasion and metastasis of prostate cancer cells through competitively binding to miR-135a-5p. Cancer Manag Res, 2020, 12: 1135-1149.
14.	Zhao Y, Sun X, Zhu K, et al. miR-135a inhibits malignant proliferation and diffusion of non-small cell lung cancer cells by down-regulating ROCK1 protein. Biosci Rep, 2020, 40(6): BSR20201276.
15.	Qin T, Fu Q, Pan YF, et al. Expressions of miR-22 and miR-135a in acute pancreatitis. J Huazhong Univ Sci Technolog Med Sci, 2014, 34(2): 225-233.
16.	Zhang KK, Yu SS, Li GY, et al. miR-135a deficiency inhibits the AR42J cells damage in cerulein-induced acute pancreatitis through targeting FAM129A. Pflugers Arch, 2019, 471(11-12): 1519-1527.
17.	张禾, 张玉龙, 邹凌琳. miR-21 在乳腺癌中的研究进展. 生物医学工程学杂志, 2015, 32(3): 712-716.
18.	彭建强, 黄年盛, 黄胜, 等. H₂O₂ 下调 miR-21 对 MC3T3-E1 细胞成骨分化影响的研究. 中国修复重建外科杂志, 2018, 32(3): 276-284.
19.	Zhu Y, Tang H, Zhang L, et al. Suppression of miR-21-3p enhances TRAIL-mediated apoptosis in liver cancer stem cells by suppressing the PI3K/Akt/Bad cascade via regulating PTEN. Cancer Manag Res, 2019, 11: 955-968.
20.	Ge X, Li W, Huang S, et al. Increased miR-21-3p in injured brain microvascular endothelial cells after traumatic brain injury aggravates blood-brain barrier damage by promoting cellular apoptosis and inflammation through targeting MAT2B. J Neurotrauma, 2019, 36(8): 1291-1305.
21.	Loboda A, Sobczak M, Jozkowicz A, et al. TGF-β1/Smads and miR-21 in renal fibrosis and inflammation. Mediators Inflamm, 2016, 2016: 8319283.
22.	Degueurce G, D’Errico I, Pich C, et al. Identification of a novel PPARβ/δ/miR-21-3p axis in UV-induced skin inflammation. EMBO Mol Med, 2016, 8(8): 919-936.
23.	Shi B, Wang Y, Zhao R, et al. Bone marrow mesenchymal stem cell-derived exosomal miR-21 protects C-kit⁺ cardiac stem cells from oxidative injury through the PTEN/PI3K/Akt axis. PLoS One, 2018, 13(2): e0191616.
24.	Vychytilova-Faltejskova P, Kiss I, Klusova S, et al. MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma. Diagn Pathol, 2015, 10: 38.
25.	Dixit AK, Sarver AE, Yuan Z, et al. Comprehensive analysis of microRNA signature of mouse pancreatic acini: overexpression of miR-21-3p in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol, 2016, 311(5): G974-G980.
26.	Li X, Lin Z, Wang L, et al. RNA-seq analyses of the role of miR-21 in acute pancreatitis. Cell Physiol Biochem, 2018, 51(5): 2198-2211.
27.	Wang T, Jiang L, Wei X, et al. MiR-21-3p aggravates injury in rats with acute hemorrhagic necrotizing pancreatitis by activating TRP signaling pathway. Biomed Pharmacother, 2018, 107: 1744-1753.
28.	吴开李, 王连臣, 符国宏, 等. 急性胰腺炎患者血浆 miR-21-3p 和 miR-551-5p 表达水平及临床意义. 中华危重病急救医学, 2020, 32(4): 463-467.
29.	Lippai D, Bala S, Catalano D, et al. Micro-RNA-155 deficiency prevents alcohol-induced serum endotoxin increase and small bowel inflammation in mice. Alcohol Clin Exp Res, 2014, 38(8): 2217-2224.
30.	Wan J, Xia L, Xu W, et al. Expression and function of miR-155 in diseases of the gastrointestinal tract. Int J Mol Sci, 2016, 17(5): 709.
31.	Tian R, Wang RL, Xie H, et al. Overexpressed miRNA-155 dysregulates intestinal epithelial apical junctional complex in severe acute pancreatitis. World J Gastroenterol, 2013, 19(45): 8282-8291.
32.	Wang D, Tang M, Zong P, et al. MiRNA-155 regulates the Th17/Treg ratio by targeting SOCS1 in severe acute pancreatitis. Front Physiol, 2018, 9: 686.
33.	Zhang X, Chu J, Sun H, et al. MiR-155 aggravates impaired autophagy of pancreatic acinar cells through targeting Rictor. Acta Biochim Biophys Sin (Shanghai), 2020, 52(2): 192-199.
34.	Xiang H, Tao X, Xia S, et al. Targeting microRNA function in acute pancreatitis. Front Physiol, 2017, 8: 726.
35.	Yang Y, Huang Q, Luo C, et al. MicroRNAs in acute pancreatitis: from pathogenesis to novel diagnosis and therapy. J Cell Physiol, 2020, 235(3): 1948-1961.
36.	Chen J, Wan J, Ye J, et al. Emerging role of lncRNAs in the normal and diseased intestinal barrier. Inflamm Res, 2018, 67(9): 757-764.
37.	Song G, Zhou J, Song R, et al. Long noncoding RNA H19 regulates the therapeutic efficacy of mesenchymal stem cells in rats with severe acute pancreatitis by sponging miR-138-5p and miR-141-3p. Stem Cell Res Ther, 2020, 11(1): 420.
38.	李保军, 黄来, 孙远新. 长链非编码 RNAH19 在急性胰腺炎患者血清中的表达及意义. 临床肝胆病杂志, 2017, 33(3): 492-496.
39.	Wang Y, Hylemon PB, Zhou H. Long non-coding RNA H19: a key player in liver diseases. Hepatology, 2021, 74(3): 1652-1659.
40.	张旭, 张宏伟. 长链非编码 RNA-MEG3 在急性胰腺炎中对外分泌细胞凋亡作用及其临床意义的研究. 郑州: 郑州大学, 2018.
41.	Dai Y, Wan Y, Qiu M, et al. lncRNA MEG3 suppresses the tumorigenesis of hemangioma by sponging miR-494 and regulating PTEN/ PI3K/AKT pathway. Cell Physiol Biochem, 2018, 51(6): 2872-2886.
42.	Ballantyne MD, McDonald RA, Baker AH. lncRNA/microRNA interactions in the vasculature. Clin Pharmacol Ther, 2016, 99(5): 494-501.
43.	Chen X, Song D. LncRNA MEG3 participates in caerulein-induced inflammatory injury in human pancreatic cells via regulating miR-195-5p/FGFR2 axis and inactivating NF-κB pathway. Inflammation, 2021, 44(1): 160-173.
44.	张旭, 付强, 秦涛, 等. 急性胰腺炎患者血清长链非编码 RNA-MEG3 表达及意义. 中华实用诊断与治疗杂志, 2018, 32(1): 28-30.
45.	Wang L, Wei Z, Wu K, et al. Long noncoding RNA B3GALT5-AS1 suppresses colon cancer liver metastasis via repressing microRNA-203. Aging (Albany NY), 2018, 10(12): 3662-3682.
46.	Wang L, Zhao X, Wang Y. The pivotal role and mechanism of long non-coding RNA B3GALT5-AS1 in the diagnosis of acute pancreatitis. Artif Cells Nanomed Biotechnol, 2019, 47(1): 2307-2315.
47.	Xia S, Lin J, Wang L, et al. Characteristics of long noncoding RNAs in the pancreas of rats with acute pancreatitis. Pancreas, 2020, 49(1): 96-104.

1. Liu S, Zou H, Wang Y, et al. miR-155-5p is negatively associated with acute pancreatitis and inversely regulates pancreatic acinar cell progression by targeting Rela and Traf3. Cell Physiol Biochem, 2018, 51(4): 1584-1599.
2. Lee PJ, Papachristou GI. New insights into acute pancreatitis. Nat Rev Gastroenterol Hepatol, 2019, 16(8): 479-496.
3. Paul J. Recent advances in diagnosis and severity assessment of acute pancreatitis. Prague Med Rep, 2020, 121(2): 65-86.
4. Machicado JD, Papachristou GI. Pharmacologic management and prevention of acute pancreatitis. Curr Opin Gastroenterol, 2019, 35(5): 460-467.
5. Zhou B, Yang H, Yang C, et al. Translation of noncoding RNAs and cancer. Cancer Lett, 2021, 497: 89-99.
6. 张洋, 郭海, 马莉, 等. 长链非编码 RNA MALAT1 吸附微小 RNA-124 调控 MSCs 成骨分化的实验研究. 中国修复重建外科杂志, 2020, 34(2): 240-245.
7. 侯婉婷, 唐秋琳, 毕锋. 肾透明细胞癌中 lncRNA 和 miRNA 差异表达及相关 ceRNA 调控网络的分析研究. 生物医学工程学杂志, 2019, 36(2): 267-273.
8. 陈舒泽, 于正桐, 王梓鸿, 等. 长链非编码 RNA 中 INK4 基因座中反义非编码 RNA 在糖尿病视网膜病变中的研究现状. 中华眼底病杂志, 2020, 36(1): 78-81.
9. Lankisch PG, Apte M, Banks PA. Acute pancreatitis. Lancet, 2015, 386(9988): 85-96.
10. Cao Z, Qiu J, Yang G, et al. MiR-135a biogenesis and regulation in malignancy: a new hope for cancer research and therapy. Cancer Biol Med, 2020, 17(3): 569-582.
11. Wang J, Yang J, Zhang H, et al. Effects of miR-135a-5p and miR-141 on proliferation, invasion and apoptosis of colorectal cancer SW620 cells. Oncol Lett, 2020, 20(1): 914-920.
12. Tang Y, Cao G, Zhao G, et al. LncRNA differentiation antagonizing non-protein coding RNA promotes proliferation and invasion through regulating miR-135a/NLRP37 axis in pancreatic cancer. Invest New Drugs, 2020, 38(3): 714-721.
13. Pan J, Xu X, Wang G. lncRNA ZFAS1 is involved in the proliferation, invasion and metastasis of prostate cancer cells through competitively binding to miR-135a-5p. Cancer Manag Res, 2020, 12: 1135-1149.
14. Zhao Y, Sun X, Zhu K, et al. miR-135a inhibits malignant proliferation and diffusion of non-small cell lung cancer cells by down-regulating ROCK1 protein. Biosci Rep, 2020, 40(6): BSR20201276.
15. Qin T, Fu Q, Pan YF, et al. Expressions of miR-22 and miR-135a in acute pancreatitis. J Huazhong Univ Sci Technolog Med Sci, 2014, 34(2): 225-233.
16. Zhang KK, Yu SS, Li GY, et al. miR-135a deficiency inhibits the AR42J cells damage in cerulein-induced acute pancreatitis through targeting FAM129A. Pflugers Arch, 2019, 471(11-12): 1519-1527.
17. 张禾, 张玉龙, 邹凌琳. miR-21 在乳腺癌中的研究进展. 生物医学工程学杂志, 2015, 32(3): 712-716.
18. 彭建强, 黄年盛, 黄胜, 等. H₂O₂ 下调 miR-21 对 MC3T3-E1 细胞成骨分化影响的研究. 中国修复重建外科杂志, 2018, 32(3): 276-284.
19. Zhu Y, Tang H, Zhang L, et al. Suppression of miR-21-3p enhances TRAIL-mediated apoptosis in liver cancer stem cells by suppressing the PI3K/Akt/Bad cascade via regulating PTEN. Cancer Manag Res, 2019, 11: 955-968.
20. Ge X, Li W, Huang S, et al. Increased miR-21-3p in injured brain microvascular endothelial cells after traumatic brain injury aggravates blood-brain barrier damage by promoting cellular apoptosis and inflammation through targeting MAT2B. J Neurotrauma, 2019, 36(8): 1291-1305.
21. Loboda A, Sobczak M, Jozkowicz A, et al. TGF-β1/Smads and miR-21 in renal fibrosis and inflammation. Mediators Inflamm, 2016, 2016: 8319283.
22. Degueurce G, D’Errico I, Pich C, et al. Identification of a novel PPARβ/δ/miR-21-3p axis in UV-induced skin inflammation. EMBO Mol Med, 2016, 8(8): 919-936.
23. Shi B, Wang Y, Zhao R, et al. Bone marrow mesenchymal stem cell-derived exosomal miR-21 protects C-kit⁺ cardiac stem cells from oxidative injury through the PTEN/PI3K/Akt axis. PLoS One, 2018, 13(2): e0191616.
24. Vychytilova-Faltejskova P, Kiss I, Klusova S, et al. MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma. Diagn Pathol, 2015, 10: 38.
25. Dixit AK, Sarver AE, Yuan Z, et al. Comprehensive analysis of microRNA signature of mouse pancreatic acini: overexpression of miR-21-3p in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol, 2016, 311(5): G974-G980.
26. Li X, Lin Z, Wang L, et al. RNA-seq analyses of the role of miR-21 in acute pancreatitis. Cell Physiol Biochem, 2018, 51(5): 2198-2211.
27. Wang T, Jiang L, Wei X, et al. MiR-21-3p aggravates injury in rats with acute hemorrhagic necrotizing pancreatitis by activating TRP signaling pathway. Biomed Pharmacother, 2018, 107: 1744-1753.
28. 吴开李, 王连臣, 符国宏, 等. 急性胰腺炎患者血浆 miR-21-3p 和 miR-551-5p 表达水平及临床意义. 中华危重病急救医学, 2020, 32(4): 463-467.
29. Lippai D, Bala S, Catalano D, et al. Micro-RNA-155 deficiency prevents alcohol-induced serum endotoxin increase and small bowel inflammation in mice. Alcohol Clin Exp Res, 2014, 38(8): 2217-2224.
30. Wan J, Xia L, Xu W, et al. Expression and function of miR-155 in diseases of the gastrointestinal tract. Int J Mol Sci, 2016, 17(5): 709.
31. Tian R, Wang RL, Xie H, et al. Overexpressed miRNA-155 dysregulates intestinal epithelial apical junctional complex in severe acute pancreatitis. World J Gastroenterol, 2013, 19(45): 8282-8291.
32. Wang D, Tang M, Zong P, et al. MiRNA-155 regulates the Th17/Treg ratio by targeting SOCS1 in severe acute pancreatitis. Front Physiol, 2018, 9: 686.
33. Zhang X, Chu J, Sun H, et al. MiR-155 aggravates impaired autophagy of pancreatic acinar cells through targeting Rictor. Acta Biochim Biophys Sin (Shanghai), 2020, 52(2): 192-199.
34. Xiang H, Tao X, Xia S, et al. Targeting microRNA function in acute pancreatitis. Front Physiol, 2017, 8: 726.
35. Yang Y, Huang Q, Luo C, et al. MicroRNAs in acute pancreatitis: from pathogenesis to novel diagnosis and therapy. J Cell Physiol, 2020, 235(3): 1948-1961.
36. Chen J, Wan J, Ye J, et al. Emerging role of lncRNAs in the normal and diseased intestinal barrier. Inflamm Res, 2018, 67(9): 757-764.
37. Song G, Zhou J, Song R, et al. Long noncoding RNA H19 regulates the therapeutic efficacy of mesenchymal stem cells in rats with severe acute pancreatitis by sponging miR-138-5p and miR-141-3p. Stem Cell Res Ther, 2020, 11(1): 420.
38. 李保军, 黄来, 孙远新. 长链非编码 RNAH19 在急性胰腺炎患者血清中的表达及意义. 临床肝胆病杂志, 2017, 33(3): 492-496.
39. Wang Y, Hylemon PB, Zhou H. Long non-coding RNA H19: a key player in liver diseases. Hepatology, 2021, 74(3): 1652-1659.
40. 张旭, 张宏伟. 长链非编码 RNA-MEG3 在急性胰腺炎中对外分泌细胞凋亡作用及其临床意义的研究. 郑州: 郑州大学, 2018.
41. Dai Y, Wan Y, Qiu M, et al. lncRNA MEG3 suppresses the tumorigenesis of hemangioma by sponging miR-494 and regulating PTEN/ PI3K/AKT pathway. Cell Physiol Biochem, 2018, 51(6): 2872-2886.
42. Ballantyne MD, McDonald RA, Baker AH. lncRNA/microRNA interactions in the vasculature. Clin Pharmacol Ther, 2016, 99(5): 494-501.
43. Chen X, Song D. LncRNA MEG3 participates in caerulein-induced inflammatory injury in human pancreatic cells via regulating miR-195-5p/FGFR2 axis and inactivating NF-κB pathway. Inflammation, 2021, 44(1): 160-173.
44. 张旭, 付强, 秦涛, 等. 急性胰腺炎患者血清长链非编码 RNA-MEG3 表达及意义. 中华实用诊断与治疗杂志, 2018, 32(1): 28-30.
45. Wang L, Wei Z, Wu K, et al. Long noncoding RNA B3GALT5-AS1 suppresses colon cancer liver metastasis via repressing microRNA-203. Aging (Albany NY), 2018, 10(12): 3662-3682.
46. Wang L, Zhao X, Wang Y. The pivotal role and mechanism of long non-coding RNA B3GALT5-AS1 in the diagnosis of acute pancreatitis. Artif Cells Nanomed Biotechnol, 2019, 47(1): 2307-2315.
47. Xia S, Lin J, Wang L, et al. Characteristics of long noncoding RNAs in the pancreas of rats with acute pancreatitis. Pancreas, 2020, 49(1): 96-104.

Previous Article
Advances in the study of PD-1/PD-L1 inhibitors in breast cancer

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research progress of non-coding RNA in acute pancreatitis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Format

Content