Research status of relationship between hepatitis B virus genotypes and hepatocarcinogenesis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

XU Yuantong ,  HU Zongqiang , CHEN Gang , JIANG Jie , CHEN Jiachuan

Department of Hepatobiliary and Pancreatic Surgery, Kunming First People’s Hospital, Kunming 650011, P. R. China;

Corresponding author：

HU Zongqiang, Email: 2509484088@qq.com

Keywords：

hepatitis B virus; hepatitis B virus X protein; hepatitis B virus genotypes; hepatocellular carcinoma

DOI：

10.7507/1007-9424.202103013

Video：

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Objective To summarize the research status of the relationship between hepatitis B virus X protein (HBx), hepatitis B virus (HBV) genotypes and hepatocellular carcinoma (HCC) at home and abroad, and to prospect its clinical significance.Method The literatures about HBx, HBV genotypes and HCC were reviewed.Results There was a close relationship between HBx and the occurrence, development, migration and metastasis of HCC. There was a certain association between HBV genotypes and HCC, but the specific mechanism had not been clarified.Conclusions HBx and HBV genotypes play an important role in the occurrence and development of HCC. With the further study of molecular mechanism, it will promote the diagnosis and treatment of hepatitis B, liver cirrhosis and liver cancer, and provide more individualized intervention for clinical workers.

Citation： XU Yuantong, HU Zongqiang, CHEN Gang, JIANG Jie, CHEN Jiachuan. Research status of relationship between hepatitis B virus genotypes and hepatocarcinogenesis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(1): 107-111. doi: 10.7507/1007-9424.202103013 Copy

1.	Martin-Vilchez S, Lara-Pezzi E, Trapero-Marugán M, et al. The molecular and pathophysiological implications of hepatitis B X antigen in chronic hepatitis B virus infection. Rev Med Virol, 2011, 21(5): 315-329.
2.	Li J, Lindner DJ, Farver C, et al. Efficacy of SSG and SSG/IFNα2 against human prostate cancer xenograft tumors in mice: a role for direct growth inhibition in SSG anti-tumor action. Cancer Chemother Pharmacol, 2007, 60(3): 341-349.
3.	Hu J, Tang L, Cheng J, et al. Hepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases. Emerg Microbes Infect, 2021, 10(1): 852-864.
4.	Schreiner S, Nassal M. A role for the host DNA damage response in hepatitis B vrus cccDNA formation-and beyond? Viruses, 2017, 9(5): 125.
5.	Rivière L, Quioc-Salomon B, Fallot G, et al. Hepatitis B virus replicating in hepatocellular carcinoma encodes HBx variants with preserved ability to antagonize restriction by Smc 5/6. Antiviral Res, 2019, 172: 104618.
6.	Sekiba K, Otsuka M, Koike K. Identifying inhibitors of the HBx-DDB1 interaction using a split luciferase assay system. J Vis Exp, 2019, (154).
7.	Sekiba K, Otsuka M, Ohno M, et al. Inhibition of HBV transcription from cccDNA with nitazoxanide by targeting the HBx-DDB1 interaction. Cell Mol Gastroenterol Hepatol, 2019, 7(2): 297-312.
8.	Tang LSY, Covert E, Wilson E, et al. Chronic hepatitis B infection: a review. JAMA, 2018, 319(17): 1802-1813.
9.	Chong CK, Cheng CYS, Tsoi SYJ, et al. HBV X protein mutations affect HBV transcription and association of histone-modifying enzymes with covalently closed circular DNA. Sci Rep, 2020, 10(1): 802.
10.	Fu L, Fu X, Mo J, et al. MiR-146a-5p enhances hepatitis B virus replication through autophagy to promote aggravation of chronic hepatitis B. IUBMB Life, 2019, 71(9): 1336-1346.
11.	Jiao F, Shen C, Ning J, et al. HBV T1719G mutation reduced HBV replication through mutant Enh Ⅱ and HBx protein in vitro. J Viral Hepat, 2019, 26(6): 710-717.
12.	Shen B, Chen Y, Hu J, et al. Hepatitis B virus X protein modulates upregulation of DHX9 to promote viral DNA replication. Cell Microbiol, 2020, 22(3): e13148.
13.	Huang SX, Mou JF, Luo Q, et al. Anti-hepatitis B virus activity of esculetin from microsorium fortunei in vitro and in vivo. Molecules, 2019, 24(19): 3475.
14.	Ren L, Zeng M, Tang Z, et al. The antiresection activity of the X protein encoded by hepatitis virus B. Hepatology, 2019, 69(6): 2546-2561.
15.	Jeong H, Cha S, Jang KL. HBx natural variants containing Ser-101 instead of Pro-101 evade ubiquitin-dependent proteasomal degradation by activating proteasomal activator 28 gamma expression. J Gen Virol, 2019, 100(11): 1554-1566.
16.	Woodley CM, Romer AS, Wang J, et al. Multiple interactions of the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler. Oncogene, 2021, 40(20): 3593-3609.
17.	Chen H, Zhang Y, Ye S, et al. Chromatin remodelling factor BAF155 protects hepatitis B virus X protein (HBx) from ubiquitin-independent proteasomal degradation. Emerg Microbes Infect, 2019, 8(1): 1393-1405.
18.	Chen MJ, Wu DW, Shen CJ, et al. Hepatitis B virus X protein promotes tumor invasion and poor prognosis in hepatocellular carcinoma via phosphorylation of paxillin at Serine 178 by activation of the c-Jun NH2-terminal kinase. Am J Cancer Res, 2020, 10(1): 275-283.
19.	Li Y, Fu Y, Hu X, et al. The HBx-CTTN interaction promotes cell proliferation and migration of hepatocellular carcinoma via CREB1. Cell Death Dis, 2019, 10(6): 405.
20.	Deng Y, Wei Z, Huang M, et al. Long non-coding RNA F11-AS1 inhibits HBV-related hepatocellular carcinoma progression by regulating NR1I3 via binding to microRNA-211-5p. J Cell Mol Med, 2020, 24(2): 1848-1865.
21.	Gao W, Jia Z, Tian Y, et al. HBx protein contributes to liver carcinogenesis by H3K4me3 modification through stabilizing WD repeat domain 5 protein. Hepatology, 2020, 71(5): 1678-1695.
22.	Yen CJ, Yang ST, Chen RY, et al. Hepatitis B virus X protein (HBx) enhances centrosomal P4. 1-associated protein (CPAP) expression to promote hepatocarcinogenesis. J Biomed Sci, 2019, 26(1): 44.
23.	Yang Z, Li J, Feng G, et al. Hepatitis B virus X protein enhances hepatocarcinogenesis by depressing the targeting of NUSAP1 mRNA by miR- 18b. Cancer Biol Med, 2019, 16(2): 276-287.
24.	Elizalde MM, Speroni M, Campos RH, et al. Hepatitis B virus X gene differentially modulates subgenotype F1b and F4 replication. Viruses, 2019, 11(7): 655.
25.	Chen QY, Harrison TJ, Sabin CA, et al. The effect of HBV genotype C on the development of HCC differs between wild-type viruses and those with BCP double mutations [T(1762)A(1764)]. Hepat Mon, 2014, 14(2): e16214.
26.	Ching LK, Gounder PP, Bulkow L, et al. Incidence of hepatocellular carcinoma according to hepatitis B virus genotype in Alaska Native people. Liver Int, 2016, 36(10): 1507-1515.
27.	Chuon C, Takahashi K, Matsuo J, et al. High possibility of hepatocarcinogenesis in HBV genotype C1 infected Cambodians is indicated by 340 HBV C1 full-genomes analysis from GenBank. Sci Rep, 2019, 9(1): 12186.
28.	Haga H, Saito T, Okumoto K, et al. Incidence of development of hepatocellular carcinoma in Japanese patients infected with hepatitis B virus is equivalent between genotype B and C in long term. J Viral Hepat, 2019, 26(7): 866-872.
29.	Tada T, Kumada T, Toyoda H, et al. Long-term natural history of liver disease in patients with chronic hepatitis B virus infection: an analysis using the Markov chain model. J Gastroenterol, 2018, 53(11): 1196-1205.
30.	Taida T, Arai M, Kanda T, et al. The prognosis of hepatitis B inactive carriers in Japan: a multicenter prospective study. J Gastroenterol, 2017, 52(1): 113-122.
31.	吴明山, 刘振球, 吴学福, 等. HBV不同基因型致癌风险差异的系统综述和Meta分析. 中华疾病控制杂志, 2021, 25(3): 323-328.
32.	Sarma MP, Bhattacharjee M, Kar P, et al. Detection of HBV genotype C in hepatocellular carcinoma patients from north east India: a brief report. Asian Pac J Cancer Prev, 2018, 19(7): 1741-1746.
33.	Hayashi S, Khan A, Simons BC, et al. An association between core mutations in hepatitis B Virus genotype F1b and hepatocellular carcinoma in Alaskan Native People. Hepatology, 2019, 69(1): 19-33.
34.	Olusola BA, Faneye AO, Oluwasemowo OO, et al. Profiles of mutations in hepatitis B virus surface and polymerase genes isolated from treatment-naive Nigerians infected with genotype E. J Med Microbiol, 2021, 70(3): Epub 2021 Mar 11.
35.	Mokaya J, McNaughton AL, Hadley MJ, et al. A systematic review of hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: a call for urgent action. PLoS Negl Trop Dis, 2018, 12(8): e0006629.

1. Martin-Vilchez S, Lara-Pezzi E, Trapero-Marugán M, et al. The molecular and pathophysiological implications of hepatitis B X antigen in chronic hepatitis B virus infection. Rev Med Virol, 2011, 21(5): 315-329.
2. Li J, Lindner DJ, Farver C, et al. Efficacy of SSG and SSG/IFNα2 against human prostate cancer xenograft tumors in mice: a role for direct growth inhibition in SSG anti-tumor action. Cancer Chemother Pharmacol, 2007, 60(3): 341-349.
3. Hu J, Tang L, Cheng J, et al. Hepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases. Emerg Microbes Infect, 2021, 10(1): 852-864.
4. Schreiner S, Nassal M. A role for the host DNA damage response in hepatitis B vrus cccDNA formation-and beyond? Viruses, 2017, 9(5): 125.
5. Rivière L, Quioc-Salomon B, Fallot G, et al. Hepatitis B virus replicating in hepatocellular carcinoma encodes HBx variants with preserved ability to antagonize restriction by Smc 5/6. Antiviral Res, 2019, 172: 104618.
6. Sekiba K, Otsuka M, Koike K. Identifying inhibitors of the HBx-DDB1 interaction using a split luciferase assay system. J Vis Exp, 2019, (154).
7. Sekiba K, Otsuka M, Ohno M, et al. Inhibition of HBV transcription from cccDNA with nitazoxanide by targeting the HBx-DDB1 interaction. Cell Mol Gastroenterol Hepatol, 2019, 7(2): 297-312.
8. Tang LSY, Covert E, Wilson E, et al. Chronic hepatitis B infection: a review. JAMA, 2018, 319(17): 1802-1813.
9. Chong CK, Cheng CYS, Tsoi SYJ, et al. HBV X protein mutations affect HBV transcription and association of histone-modifying enzymes with covalently closed circular DNA. Sci Rep, 2020, 10(1): 802.
10. Fu L, Fu X, Mo J, et al. MiR-146a-5p enhances hepatitis B virus replication through autophagy to promote aggravation of chronic hepatitis B. IUBMB Life, 2019, 71(9): 1336-1346.
11. Jiao F, Shen C, Ning J, et al. HBV T1719G mutation reduced HBV replication through mutant Enh Ⅱ and HBx protein in vitro. J Viral Hepat, 2019, 26(6): 710-717.
12. Shen B, Chen Y, Hu J, et al. Hepatitis B virus X protein modulates upregulation of DHX9 to promote viral DNA replication. Cell Microbiol, 2020, 22(3): e13148.
13. Huang SX, Mou JF, Luo Q, et al. Anti-hepatitis B virus activity of esculetin from microsorium fortunei in vitro and in vivo. Molecules, 2019, 24(19): 3475.
14. Ren L, Zeng M, Tang Z, et al. The antiresection activity of the X protein encoded by hepatitis virus B. Hepatology, 2019, 69(6): 2546-2561.
15. Jeong H, Cha S, Jang KL. HBx natural variants containing Ser-101 instead of Pro-101 evade ubiquitin-dependent proteasomal degradation by activating proteasomal activator 28 gamma expression. J Gen Virol, 2019, 100(11): 1554-1566.
16. Woodley CM, Romer AS, Wang J, et al. Multiple interactions of the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler. Oncogene, 2021, 40(20): 3593-3609.
17. Chen H, Zhang Y, Ye S, et al. Chromatin remodelling factor BAF155 protects hepatitis B virus X protein (HBx) from ubiquitin-independent proteasomal degradation. Emerg Microbes Infect, 2019, 8(1): 1393-1405.
18. Chen MJ, Wu DW, Shen CJ, et al. Hepatitis B virus X protein promotes tumor invasion and poor prognosis in hepatocellular carcinoma via phosphorylation of paxillin at Serine 178 by activation of the c-Jun NH2-terminal kinase. Am J Cancer Res, 2020, 10(1): 275-283.
19. Li Y, Fu Y, Hu X, et al. The HBx-CTTN interaction promotes cell proliferation and migration of hepatocellular carcinoma via CREB1. Cell Death Dis, 2019, 10(6): 405.
20. Deng Y, Wei Z, Huang M, et al. Long non-coding RNA F11-AS1 inhibits HBV-related hepatocellular carcinoma progression by regulating NR1I3 via binding to microRNA-211-5p. J Cell Mol Med, 2020, 24(2): 1848-1865.
21. Gao W, Jia Z, Tian Y, et al. HBx protein contributes to liver carcinogenesis by H3K4me3 modification through stabilizing WD repeat domain 5 protein. Hepatology, 2020, 71(5): 1678-1695.
22. Yen CJ, Yang ST, Chen RY, et al. Hepatitis B virus X protein (HBx) enhances centrosomal P4. 1-associated protein (CPAP) expression to promote hepatocarcinogenesis. J Biomed Sci, 2019, 26(1): 44.
23. Yang Z, Li J, Feng G, et al. Hepatitis B virus X protein enhances hepatocarcinogenesis by depressing the targeting of NUSAP1 mRNA by miR- 18b. Cancer Biol Med, 2019, 16(2): 276-287.
24. Elizalde MM, Speroni M, Campos RH, et al. Hepatitis B virus X gene differentially modulates subgenotype F1b and F4 replication. Viruses, 2019, 11(7): 655.
25. Chen QY, Harrison TJ, Sabin CA, et al. The effect of HBV genotype C on the development of HCC differs between wild-type viruses and those with BCP double mutations [T(1762)A(1764)]. Hepat Mon, 2014, 14(2): e16214.
26. Ching LK, Gounder PP, Bulkow L, et al. Incidence of hepatocellular carcinoma according to hepatitis B virus genotype in Alaska Native people. Liver Int, 2016, 36(10): 1507-1515.
27. Chuon C, Takahashi K, Matsuo J, et al. High possibility of hepatocarcinogenesis in HBV genotype C1 infected Cambodians is indicated by 340 HBV C1 full-genomes analysis from GenBank. Sci Rep, 2019, 9(1): 12186.
28. Haga H, Saito T, Okumoto K, et al. Incidence of development of hepatocellular carcinoma in Japanese patients infected with hepatitis B virus is equivalent between genotype B and C in long term. J Viral Hepat, 2019, 26(7): 866-872.
29. Tada T, Kumada T, Toyoda H, et al. Long-term natural history of liver disease in patients with chronic hepatitis B virus infection: an analysis using the Markov chain model. J Gastroenterol, 2018, 53(11): 1196-1205.
30. Taida T, Arai M, Kanda T, et al. The prognosis of hepatitis B inactive carriers in Japan: a multicenter prospective study. J Gastroenterol, 2017, 52(1): 113-122.
31. 吴明山, 刘振球, 吴学福, 等. HBV不同基因型致癌风险差异的系统综述和Meta分析. 中华疾病控制杂志, 2021, 25(3): 323-328.
32. Sarma MP, Bhattacharjee M, Kar P, et al. Detection of HBV genotype C in hepatocellular carcinoma patients from north east India: a brief report. Asian Pac J Cancer Prev, 2018, 19(7): 1741-1746.
33. Hayashi S, Khan A, Simons BC, et al. An association between core mutations in hepatitis B Virus genotype F1b and hepatocellular carcinoma in Alaskan Native People. Hepatology, 2019, 69(1): 19-33.
34. Olusola BA, Faneye AO, Oluwasemowo OO, et al. Profiles of mutations in hepatitis B virus surface and polymerase genes isolated from treatment-naive Nigerians infected with genotype E. J Med Microbiol, 2021, 70(3): Epub 2021 Mar 11.
35. Mokaya J, McNaughton AL, Hadley MJ, et al. A systematic review of hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: a call for urgent action. PLoS Negl Trop Dis, 2018, 12(8): e0006629.

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Research status of relationship between hepatitis B virus genotypes and hepatocarcinogenesis

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