Technical improvement and effect of donor red blood cell transfusion in liver transplantation with donation after citizen death_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LÜ Tao ¹ , XU Xi ¹ , SONG Jiulin ¹ , YAN Lünan ¹ , WEN Tianfu ¹ , WU Hong ¹ , ZHU Tao ² , JIANG Li ¹ , YANG Jian ¹ , ZHANG Weiyi ² , CHEN Panyu ² , PENG Wei ¹ ,  YANG Jiayin ¹

1. Department of Liver Surgery, Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

YANG Jiayin, Email: docotoryjy@scu.edu.cn

Keywords：

donation after citizen death; liver transplantation; donor specific transfusion

DOI：

10.7507/1007-9424.202111073

Video：

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Objective To explore modified methods and outcomes of collection of donor blood from donation after citizen death (DCD). Method The clinicopathologic data of 26 DCD donors underwent phase Ⅰ clinical trials and 6 patients who received donor blood by modified collection technique from May 2020 to November 2021 in the West China Hospital of Sichuan University were collected retrospectively. Results Compared with the data of 26 DCD donors at phase Ⅰ clinical trials, after the modified collection technique, the blood collection volume, the concentrated red blood cells following filtration, centrifugation, and the amount of concentrated red blood cell/kg body mass were more (P<0.05). In addition, compared with the components of stored red blood cell suspension, the pH value, sodium and chloride ions concentrations of the red blood cell suspension obtained after modified collection technique were higher (P<0.05), the potassium ion concentration was <1 mmol/L, and the lactic acid concentration of none of blood was >15 mmol/L. Conclusion The adoption of the modified collection technique increases the amount of donor red blood collected, and its biochemical and electrolyte indicators are more in line with physiological requirements than those of stored blood.

Citation： LÜ Tao, XU Xi, SONG Jiulin, YAN Lünan, WEN Tianfu, WU Hong, ZHU Tao, JIANG Li, YANG Jian, ZHANG Weiyi, CHEN Panyu, PENG Wei, YANG Jiayin. Technical improvement and effect of donor red blood cell transfusion in liver transplantation with donation after citizen death. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(1): 1-5. doi: 10.7507/1007-9424.202111073 Copy

1.	Wang Y, Han W, Pan L, et al. Impact of COVID-19 on blood centres in Zhejiang province China. Vox Sang, 2020, 115(6): 502-506.
2.	Lv T, Xu X, Song J, et al. Use of donor-specific red blood cell transfusions for patients undergoing liver transplantation during the COVID-19 pandemic. Hepatobiliary Surg Nutr, 2021, 10(4): 486-497.
3.	Newton WT, Anderson CB. Planned preimmunization of renal allograft recipients. Surgery, 1973, 74(3): 430-436.
4.	Cochrum KC, Hanes D, Potter D, et al. Donor-specific blood transfusions in HLA-D-disparate one-haplotype-related allografts. Transplant Proc, 1979, 11(4): 1903-1907.
5.	Salvatierra O, Vincenti F, Amend W, et al. Deliberate donor-specific blood transfusions prior to living related renal transplantation. A new approach. Ann Surg, 1980, 192(4): 543-552.
6.	Sollinger HW, Kalayoglu M, Belzer FO. Use of the donor specific transfusion protocol in living-unrelated donor-recipient combinations. Ann Surg, 1986, 204(3): 315-321.
7.	Koch CG, Figueroa PI, Li L, et al. Red blood cell storage: how long is too long? Ann Thorac Surg, 2013, 96(5): 1894-1899.
8.	Kim-Shapiro DB, Lee J, Gladwin MT. Storage lesion: role of red blood cell breakdown. Transfusion, 2011, 51(4): 844-851.
9.	Wolach B, Sazbon L, Gavrieli R, et al. Early immunological defects in comatose patients after acute brain injury. J Neurosurg, 2001, 94(5): 706-711.
10.	中华人民共和国卫生部, 中国国家标准化管理委员会. 献血健康检查要求. 中华人民共和国国家标准, 2011-12-30.
11.	Ison MG, Nalesnik MA. An update on donor-derived disease transmission in organ transplantation. Am J Transplant, 2011, 11(6): 1123-1130.
12.	Chiu CY, Miller SA. Clinical metagenomics. Nat Rev Genet, 2019, 20(6): 341-355.
13.	Wu TJ, Lee CF, Chou HS, et al. Suspect the donor with potential infection in the adult deceased donor liver transplantation. Transplant Proc, 2008, 40(8): 2486-2488.
14.	Waters JH, Tuohy MJ, Hobson DF, et al. Bacterial reduction by cell salvage washing and leukocyte depletion filtration. Anesthesiology, 2003, 99(3): 652-655.
15.	Liang TB, Li JJ, Li DL, et al. Intraoperative blood salvage and leukocyte depletion during liver transplantation with bacterial contamination. Clin Transplant, 2010, 24(2): 265-272.

1. Wang Y, Han W, Pan L, et al. Impact of COVID-19 on blood centres in Zhejiang province China. Vox Sang, 2020, 115(6): 502-506.
2. Lv T, Xu X, Song J, et al. Use of donor-specific red blood cell transfusions for patients undergoing liver transplantation during the COVID-19 pandemic. Hepatobiliary Surg Nutr, 2021, 10(4): 486-497.
3. Newton WT, Anderson CB. Planned preimmunization of renal allograft recipients. Surgery, 1973, 74(3): 430-436.
4. Cochrum KC, Hanes D, Potter D, et al. Donor-specific blood transfusions in HLA-D-disparate one-haplotype-related allografts. Transplant Proc, 1979, 11(4): 1903-1907.
5. Salvatierra O, Vincenti F, Amend W, et al. Deliberate donor-specific blood transfusions prior to living related renal transplantation. A new approach. Ann Surg, 1980, 192(4): 543-552.
6. Sollinger HW, Kalayoglu M, Belzer FO. Use of the donor specific transfusion protocol in living-unrelated donor-recipient combinations. Ann Surg, 1986, 204(3): 315-321.
7. Koch CG, Figueroa PI, Li L, et al. Red blood cell storage: how long is too long? Ann Thorac Surg, 2013, 96(5): 1894-1899.
8. Kim-Shapiro DB, Lee J, Gladwin MT. Storage lesion: role of red blood cell breakdown. Transfusion, 2011, 51(4): 844-851.
9. Wolach B, Sazbon L, Gavrieli R, et al. Early immunological defects in comatose patients after acute brain injury. J Neurosurg, 2001, 94(5): 706-711.
10. 中华人民共和国卫生部, 中国国家标准化管理委员会. 献血健康检查要求. 中华人民共和国国家标准, 2011-12-30.
11. Ison MG, Nalesnik MA. An update on donor-derived disease transmission in organ transplantation. Am J Transplant, 2011, 11(6): 1123-1130.
12. Chiu CY, Miller SA. Clinical metagenomics. Nat Rev Genet, 2019, 20(6): 341-355.
13. Wu TJ, Lee CF, Chou HS, et al. Suspect the donor with potential infection in the adult deceased donor liver transplantation. Transplant Proc, 2008, 40(8): 2486-2488.
14. Waters JH, Tuohy MJ, Hobson DF, et al. Bacterial reduction by cell salvage washing and leukocyte depletion filtration. Anesthesiology, 2003, 99(3): 652-655.
15. Liang TB, Li JJ, Li DL, et al. Intraoperative blood salvage and leukocyte depletion during liver transplantation with bacterial contamination. Clin Transplant, 2010, 24(2): 265-272.

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Technical improvement and effect of donor red blood cell transfusion in liver transplantation with donation after citizen death

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