Progress and prospects: regulated cell death in cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

GONG Linjing ^1,2 ,  SHI Yujun ¹

1. Institute of Clinical Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

SHI Yujun, Email: shiyujun@scu.edu.cn

Keywords：

cancer; regulated cell death; pathogenesis; treatment

DOI：

10.7507/1007-9424.202203088

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Cancer is a heterogeneous disease characterized by maladjustment of cell death. The types of cell death were mainly divided into two forms including accidental cell death and regulated cell death (RCD). In recent years, researchers have discovered dozens of RCD modes, among which apoptosis, pyroptosis, necroptosis, and ferroptosis are the most widely studied. Cuproptosis is a new cell death mechanism that first proposed on 17 March 2022. It is recognized as a unique and both copper and mitochondria dependent RCD. The research and development of targeted drugs for regulating different cell death pathways will be hots and difficulties in the treatment of refractory cancer in the future.

Citation： GONG Linjing, SHI Yujun. Progress and prospects: regulated cell death in cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(5): 582-584. doi: 10.7507/1007-9424.202203088 Copy

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1. Galluzzi L, Vitale I, Aaronson SA, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ, 2018, 25(3): 486-541.
2. Tang D, Kang R, Berghe TV, et al. The molecular machinery of regulated cell death. Cell Res, 2019, 29(5): 347-364.
3. Tsvetkov P, Coy S, Petrova B, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science, 2022, 375(6586): 1254-1261.
4. Chen X, Kang R, Kroemer G, et al. Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol, 2021, 18(5): 280-296.
5. Christgen S, Tweedell RE, Kanneganti TD. Programming inflammatory cell death for therapy. Pharmacol Ther, 2022, Epub 2021 Oct 4. doi: 10.1016/j.pharmthera.2021.108010.
6. Lee S, Karki R, Wang Y, et al. AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. Nature, 2021, 597(7876): 415-419.
7. Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell, 2012, 149(5): 1060-1072.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Progress and prospects: regulated cell death in cancer

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