Relationship between ABO blood type of patients with colorectal cancer and surgical characteristics and postoperative complications: a real world study based on DACCA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WEI Yuhao ^1,2 , XIE Xinyu ^1,2 , ZHAO Tianlang ^1,2 ,  WANG Xiaodong ¹ , LI Li ¹

1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. West China School of Medicine in Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

WANG Xiaodong, Email: wangxiaodong@wchscu.cn

Keywords：

ABO blood type; colorectal cancer; postoperative complications; surgical type; nature of surgery

DOI：

10.7507/1007-9424.202207048

Video：

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Objective To analyze the influence of the ABO blood types of colorectal cancer patients served by West China Hospital as a regional center on surgical characteristics and postoperative complications in the current version of Database from Colorectal Cancer (DACCA). Methods The DACCA version was updated on January 5, 2022. The data items included ABO blood type, sex, type of operation, nature of operation and postoperative complications. The operative characteristics and complications at different stages after operation (in hospital, short-term and long-term after operation) of colorectal cancer patients with different blood types (A, B, AB, O) were analyzed. Results According to the DACCA database, we obtained 5 010 analysable data rows, covering 2005–2022. The results of blood types analysis showed that there was no significant difference among different blood types in the overall postoperative complications and the occurrence of complications in hospital, short-term and long-term after operation (P>0.05). Further subgroup analysis showed that only the difference of anastomotic leakage among different blood types was statistically significant (χ²=9.588, P=0.022). There was no significant difference among different blood types in whether the primary focus of colon cancer surgery was removed or not, the degree of radical resection of the primary focus, and whether the anus was preserved or not in rectal cancer surgery (P>0.05), and there was significant difference among different blood types with different degrees of radical resection of primary rectal cancer (χ²=15.773, P=0.001). Conclusions The ABO blood types of patients with colorectal cancer has nothing to do with the occurrence of overall complications in the short and long term after operation, and has no impact on the implementation of different surgical methods. However, the occurrence of a single postoperative anastomotic leakage is related to blood type, and its possible causes need to be further explored.

Citation： WEI Yuhao, XIE Xinyu, ZHAO Tianlang, WANG Xiaodong, LI Li. Relationship between ABO blood type of patients with colorectal cancer and surgical characteristics and postoperative complications: a real world study based on DACCA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(9): 1226-1230. doi: 10.7507/1007-9424.202207048 Copy

1.	汪晓东, 林容若, 刘健博, 等. 数据库建设第七部分: 结直肠癌手术特征的标签与结构化(一). 中国普外基础与临床杂志, 2020, 27(9): 1150-1152.
2.	汪晓东, 刘健博, 孟鑫宇, 等. 数据库建设第八部分: 结直肠癌手术反应及围术期并发症的标签与结构化. 中国普外基础与临床杂志, 2021, 28(4): 508-511.
3.	龚佳祺, 刘莹, 曾渝, 等. 结直肠癌患者的就诊年龄与术前肿瘤相关特征的关系: 基于DACCA的真实世界数据研究. 中国普外基础与临床杂志, 2022, 29(3): 362-370.
4.	许沈华, 戴惠芳, 钱丽娟, 等. 2 014例结、直肠癌与ABO血型的关系. 浙江肿瘤通讯, 1990, 2: 29-32.
5.	Bolliger M, Kroehnert JA, Molineus F, et al. Experiences with the standardized classification of surgical complications (Clavien-Dindo) in general surgery patients. Eur Surg, 2018, 50(6): 256-261.
6.	汪晓东, 孟鑫宇, 刘健博, 等. 数据库研究第八部分: 结直肠癌术后风险与并发症. 中国普外基础与临床杂志, 2021, 28(3): 369-375.
7.	Sparreboom CL, van Groningen JT, Lingsma HF, et al. Different risk factors for early and late colorectal anastomotic leakage in a nationwide audit. Dis Colon Rectum, 2018, 61(11): 1258-1266.
8.	颜登国, 张汝一, 甄运寰, 等. 结直肠癌切除术后吻合口瘘的治疗. 中华胃肠外科杂志, 2006, 9(5): 408.
9.	柯海林, 池畔, 林惠铭, 等. 直肠癌术后吻合口瘘对长期预后的影响. 中华胃肠外科杂志, 2015, 18(9): 920-924.
10.	王利红. ABO血型因素对术后认知功能障碍的影响. 医学综述, 2015, 21(6): 983-985.
11.	黄津. 血清前白蛋白水平与食管癌术后吻合口瘘发生的临床研究. 重庆医科大学, 2020.
12.	张佩范, 吕化先, 白雅珍, 等. 远端结肠、直肠癌血型物质消长规律的初步研究—附89例手术切除标本病理形态分析(摘要). 浙江肿瘤通讯, 1980, 4: 164.
13.	曾志良. 结肠直肠癌的临床病例特征及预后分析. 医学理论与实践, 2013, 26(3): 283-284.

1. 汪晓东, 林容若, 刘健博, 等. 数据库建设第七部分: 结直肠癌手术特征的标签与结构化(一). 中国普外基础与临床杂志, 2020, 27(9): 1150-1152.
2. 汪晓东, 刘健博, 孟鑫宇, 等. 数据库建设第八部分: 结直肠癌手术反应及围术期并发症的标签与结构化. 中国普外基础与临床杂志, 2021, 28(4): 508-511.
3. 龚佳祺, 刘莹, 曾渝, 等. 结直肠癌患者的就诊年龄与术前肿瘤相关特征的关系: 基于DACCA的真实世界数据研究. 中国普外基础与临床杂志, 2022, 29(3): 362-370.
4. 许沈华, 戴惠芳, 钱丽娟, 等. 2 014例结、直肠癌与ABO血型的关系. 浙江肿瘤通讯, 1990, 2: 29-32.
5. Bolliger M, Kroehnert JA, Molineus F, et al. Experiences with the standardized classification of surgical complications (Clavien-Dindo) in general surgery patients. Eur Surg, 2018, 50(6): 256-261.
6. 汪晓东, 孟鑫宇, 刘健博, 等. 数据库研究第八部分: 结直肠癌术后风险与并发症. 中国普外基础与临床杂志, 2021, 28(3): 369-375.
7. Sparreboom CL, van Groningen JT, Lingsma HF, et al. Different risk factors for early and late colorectal anastomotic leakage in a nationwide audit. Dis Colon Rectum, 2018, 61(11): 1258-1266.
8. 颜登国, 张汝一, 甄运寰, 等. 结直肠癌切除术后吻合口瘘的治疗. 中华胃肠外科杂志, 2006, 9(5): 408.
9. 柯海林, 池畔, 林惠铭, 等. 直肠癌术后吻合口瘘对长期预后的影响. 中华胃肠外科杂志, 2015, 18(9): 920-924.
10. 王利红. ABO血型因素对术后认知功能障碍的影响. 医学综述, 2015, 21(6): 983-985.
11. 黄津. 血清前白蛋白水平与食管癌术后吻合口瘘发生的临床研究. 重庆医科大学, 2020.
12. 张佩范, 吕化先, 白雅珍, 等. 远端结肠、直肠癌血型物质消长规律的初步研究—附89例手术切除标本病理形态分析(摘要). 浙江肿瘤通讯, 1980, 4: 164.
13. 曾志良. 结肠直肠癌的临床病例特征及预后分析. 医学理论与实践, 2013, 26(3): 283-284.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship between ABO blood type of patients with colorectal cancer and surgical characteristics and postoperative complications: a real world study based on DACCA

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