Research progress of microRNA in colorectal cancer-related signaling pathways_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WEI Nianjin , LIU Xin , WEI Jiufeng ,  CHEN Hongsheng

The First Department of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, P. R. China;

Corresponding author：

CHEN Hongsheng, Email: chs75@163.com

Keywords：

colorectal cancer; microRNA; signaling pathway

DOI：

10.7507/1007-9424.202211017

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the latest progress of microRNA (miRNA or miR) in colorectal cancer (CRC)-related signaling pathways in the past three years, and provide new ideas for miRNA-targeted intervention or miRNA as tumor molecular markers for early diagnosis of CRC. Method The literature on the roles of miRNA in the CRC-related signaling pathways was retrieved and reviewed. Results MiRNAs were associated with cancers in nearly all critical pathways, which regulated almost all important signaling pathways associated with CRC. At present, the signaling pathways and miRNAs related to CRC mainly included Wnt-β-catenin (miR-520e, miR-8063, miR-576-5p, miR-142-3p, miR-19a-3p, miR-381, miR-411, miR-1205), phosphatidylinositol-3-kinaset-Akt (miR-19a, miR-493-5p, miR-3064-5p, mi-196b-5p, miR-3651), mitogen-activated protein kinase (miR-1288-3p, miR-3651, miR-152-3p), transforming growth factor-β (miR-183-5p, miR-21-5p, miR-195-5p, miR-581, miR-2911, miR-128-3p, let-7a), nuclear factor kappa B (miR-155, miR-129, miR-21), Janus kinase/signal transducers and activators of transcription (miR-198, miR-452, miR-128-3p, miR-495), Notch (miR-223, miR-10b, miR-449a), Hippo (miR-30a-5p, miR-375, miR-9), and Hedgehog (miR-372, miR-373), etc. signaling pathways. Conclusions MiRNA play a role in one or more signaling pathways at the same time, and play an important regulatory role in the occurrence and development of CRC. MiRNAs have great potential as tumor markers in the diagnosis, treatment, and prognosis of colorectal cancer.

Citation： WEI Nianjin, LIU Xin, WEI Jiufeng, CHEN Hongsheng. Research progress of microRNA in colorectal cancer-related signaling pathways. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2023, 30(4): 506-512. doi: 10.7507/1007-9424.202211017 Copy

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2.	肖文博, 朱广涵, 朱云, 等. 1990–2019年中国主要消化系统恶性肿瘤发病变化分析. 中国肿瘤, 2022, 31(9): 693-700.
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7.	Rahmani F, Avan A, Hashemy SI, et al. Role of Wnt/β-catenin signaling regulatory microRNAs in the pathogenesis of colorectal cancer. J Cell Physiol, 2018, 233(2): 811-817.
8.	Wan ML, Wang Y, Zeng Z, et al. Colorectal cancer (CRC) as a multifactorial disease and its causal correlations with multiple signaling pathways. Biosci Rep, 2020, 40(3): BSR20200265. doi: 10.1042/BSR20200265.
9.	Lv S, Zhang J, He Y, et al. MicroRNA-520e targets AEG-1 to suppress the proliferation and invasion of colorectal cancer cells through Wnt/GSK-3β/β-catenin signalling. Clin Exp Pharmacol Physiol, 2020, 47(1): 158-167.
10.	Chen ZQ, Yuan T, Jiang H, et al. MicroRNA-8063 targets heterogeneous nuclear ribonucleoprotein AB to inhibit the self-renewal of colorectal cancer stem cells via the Wnt/β-catenin pathway. Oncol Rep, 2021, 46(4): 219. doi: 10.3892/or.2021.8170.
11.	Luo J, Liu L, Shen J, et al. miR-576-5p promotes epithelial-to-mesenchymal transition in colorectal cancer by targeting the Wnt5a-mediated Wnt/β-catenin signaling pathway. Mol Med Rep, 2021, 23(2): 94. doi: 10.3892/mmr.2020.11733.
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16.	Noorolyai S, Mokhtarzadeh A, Baghbani E, et al. The role of microRNAs involved in PI3-kinase signaling pathway in colorectal cancer. J Cell Physiol, 2019, 234(5): 5664-5673.
17.	Kontomanolis EN, Koutras A, Syllaios A, et al. Role of oncogenes and tumor-suppressor genes in carcinogenesis: a review. Anticancer Res, 2020, 40(11): 6009-6015.
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23.	Li C, Ding D, Gao Y, et al. MicroRNA-3651 promotes colorectal cancer cell proliferation through directly repressing T-box transcription factor 1. Int J Mol Med, 2020, 45(3): 956-966.
24.	Stefani C, Miricescu D, Stanescu-Spinu II, et al. Growth factors, PI3K/AKT/mTOR and MAPK signaling pathways in colorectal cancer pathogenesis: where are we now?. Int J Mol Sci, 2021, 22(19): 10260. doi: 10.3390/ijms221910260.
25.	Soleimani A, Rahmani F, Saeedi N, et al. The potential role of regulatory microRNAs of RAS/MAPK signaling pathway in the pathogenesis of colorectal cancer. J Cell Biochem, 2019, 120(12): 19245-19253.
26.	Hou R, Liu Y, Su Y, et al. Overexpression of long non-coding RNA FGF14-AS2 inhibits colorectal cancer proliferation via the RERG/Ras/ERK signaling by sponging microRNA-1288-3p. Pathol Oncol Res, 2020, 26(4): 2659-2667.
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40.	Wang J, Zhang Y, Song H, et al. The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway. Mol Cancer, 2021, 20(1): 81. doi: 10.1186/s12943-021-01375-x.
41.	Li LX, Lam IH, Liang FF, et al. MiR-198 affects the proliferation and apoptosis of colorectal cancer through regulation of ADAM28/JAK-STAT signaling pathway. Eur Rev Med Pharmacol Sci, 2019, 23(4): 1487-1493.
42.	Lamichhane S, Mo JS, Sharma G, et al. MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in inflammatory colitis and colorectal cancer. Inflamm Res, 2021, 70(8): 903-914.
43.	Liu X, Qin Y, Tang X, et al. Circular RNA circ_0000372 contributes to the proliferation, migration and invasion of colorectal cancer by elevating IL6 expression via sponging miR-495. Anticancer Drugs, 2021, 32(3): 296-305.
44.	Liu Z, Ma T, Duan J, et al. MicroRNA-223-induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways. Mol Med Rep, 2021, 23(2): 154. doi: 10.3892/mmr.2020.11793.
45.	Shen Y, Dai X, Chen H, et al. Comprehensive evaluation of microRNA-10b in digestive system cancers reveals prognostic implication and signaling pathways associated with tumor progression. J Cancer, 2021, 12(13): 4011-4024.
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49.	Xu X, Chen X, Xu M, et al. MiR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells. Aging (Albany NY), 2019, 11(18): 7357-7385.
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1. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2021, 71(3): 209-249.
2. 肖文博, 朱广涵, 朱云, 等. 1990–2019年中国主要消化系统恶性肿瘤发病变化分析. 中国肿瘤, 2022, 31(9): 693-700.
3. Jung G, Hernández-Illán E, Moreira L, et al. Epigenetics of colorectal cancer: biomarker and therapeutic potential. Nat Rev Gastroenterol Hepatol, 2020, 17(2): 111-130.
4. Strubberg AM, Madison BB. MicroRNAs in the etiology of colorectal cancer: pathways and clinical implications. Dis Model Mech, 2017, 10(3): 197-214.
5. Clevers H, Nusse R. Wnt/β-catenin signaling and disease. Cell, 2012, 149(6): 1192-1205.
6. Bian J, Dannappel M, Wan C, et al. Transcriptional regulation of Wnt/β-catenin pathway in colorectal cancer. Cells, 2020, 9(9): 2125. doi: 10.3390/cells9092125.
7. Rahmani F, Avan A, Hashemy SI, et al. Role of Wnt/β-catenin signaling regulatory microRNAs in the pathogenesis of colorectal cancer. J Cell Physiol, 2018, 233(2): 811-817.
8. Wan ML, Wang Y, Zeng Z, et al. Colorectal cancer (CRC) as a multifactorial disease and its causal correlations with multiple signaling pathways. Biosci Rep, 2020, 40(3): BSR20200265. doi: 10.1042/BSR20200265.
9. Lv S, Zhang J, He Y, et al. MicroRNA-520e targets AEG-1 to suppress the proliferation and invasion of colorectal cancer cells through Wnt/GSK-3β/β-catenin signalling. Clin Exp Pharmacol Physiol, 2020, 47(1): 158-167.
10. Chen ZQ, Yuan T, Jiang H, et al. MicroRNA-8063 targets heterogeneous nuclear ribonucleoprotein AB to inhibit the self-renewal of colorectal cancer stem cells via the Wnt/β-catenin pathway. Oncol Rep, 2021, 46(4): 219. doi: 10.3892/or.2021.8170.
11. Luo J, Liu L, Shen J, et al. miR-576-5p promotes epithelial-to-mesenchymal transition in colorectal cancer by targeting the Wnt5a-mediated Wnt/β-catenin signaling pathway. Mol Med Rep, 2021, 23(2): 94. doi: 10.3892/mmr.2020.11733.
12. Liu P, Cao F, Sui J, et al. MicroRNA-142-3p inhibits tumorigenesis of colorectal cancer via suppressing the activation of Wnt signaling by directly targeting to β-catenin. Front Oncol, 2021, 10: 552944. doi: 10.3389/fonc.2020.552944.
13. Yu FB, Sheng J, Yu JM, et al. MiR-19a-3p regulates the Forkhead box F2-mediated Wnt/β-catenin signaling pathway and affects the biological functions of colorectal cancer cells. World J Gastroenterol, 2020, 26(6): 627-644.
14. Zhou L, Wang H, Fang Z, et al. The microRNA-381 (miR-381)/Spindlin1 (SPIN1) axis contributes to cell proliferation and invasion of colorectal cancer cells by regulating the Wnt/β-catenin pathway. Bioengineered, 2021, 12(2): 12036-12048.
15. Liu R, Deng P, Zhang Y, et al. Circ_0082182 promotes oncogenesis and metastasis of colorectal cancer in vitro and in vivo by sponging miR-411 and miR-1205 to activate the Wnt/β-catenin pathway. World J Surg Oncol, 2021, 19(1): 51. doi: 10.1186/s12957-021-02164-y.
16. Noorolyai S, Mokhtarzadeh A, Baghbani E, et al. The role of microRNAs involved in PI3-kinase signaling pathway in colorectal cancer. J Cell Physiol, 2019, 234(5): 5664-5673.
17. Kontomanolis EN, Koutras A, Syllaios A, et al. Role of oncogenes and tumor-suppressor genes in carcinogenesis: a review. Anticancer Res, 2020, 40(11): 6009-6015.
18. Moafian Z, Maghrouni A, Soltani A, et al. Cross-talk between non-coding RNAs and PI3K/AKT/mTOR pathway in colorectal cancer. Mol Biol Rep, 2021, 48(5): 4797-4811.
19. Tang Y, Weng X, Liu C, et al. Hypoxia enhances activity and malignant behaviors of colorectal cancer cells through the STAT3/MicroRNA-19a/PTEN/PI3K/AKT axis. Anal Cell Pathol (Amst), 2021, 2021: 4132488. doi: 10.1155/2021/4132488.
20. Cui FC, Chen Y, Wu XY, et al. MicroRNA-493-5p suppresses colorectal cancer progression via the PI3K-Akt-FoxO3a signaling pathway. Eur Rev Med Pharmacol Sci, 2020, 24(8): 4212-4223.
21. Luo Z, Hao S, Yuan J, et al. Long non-coding RNA LINC00958 promotes colorectal cancer progression by enhancing the expression of LEM domain containing 1 via microRNA miR-3064-5p. Bioengineered, 2021, 12(1): 8100-8115.
22. Xin H, Wang C, Chi Y, et al. MicroRNA-196b-5p promotes malignant progression of colorectal cancer by targeting ING5. Cancer Cell Int, 2020, 20: 119. doi: 10.1186/s12935-020-01200-3.
23. Li C, Ding D, Gao Y, et al. MicroRNA-3651 promotes colorectal cancer cell proliferation through directly repressing T-box transcription factor 1. Int J Mol Med, 2020, 45(3): 956-966.
24. Stefani C, Miricescu D, Stanescu-Spinu II, et al. Growth factors, PI3K/AKT/mTOR and MAPK signaling pathways in colorectal cancer pathogenesis: where are we now?. Int J Mol Sci, 2021, 22(19): 10260. doi: 10.3390/ijms221910260.
25. Soleimani A, Rahmani F, Saeedi N, et al. The potential role of regulatory microRNAs of RAS/MAPK signaling pathway in the pathogenesis of colorectal cancer. J Cell Biochem, 2019, 120(12): 19245-19253.
26. Hou R, Liu Y, Su Y, et al. Overexpression of long non-coding RNA FGF14-AS2 inhibits colorectal cancer proliferation via the RERG/Ras/ERK signaling by sponging microRNA-1288-3p. Pathol Oncol Res, 2020, 26(4): 2659-2667.
27. Liu X, Li L, Bai J, et al. Long noncoding RNA plasmacytoma variant translocation 1 promotes progression of colorectal cancer by sponging microRNA-152-3p and regulating E2F3/MAPK8 signaling. Cancer Sci, 2022, 113(1): 109-119.
28. Soleimani A, Pashirzad M, Avan A, et al. Role of the transforming growth factor-β signaling pathway in the pathogenesis of colorectal cancer. J Cell Biochem, 2019, 120(6): 8899-8907.
29. Koveitypour Z, Panahi F, Vakilian M, et al. Signaling pathways involved in colorectal cancer progression. Cell Biosci, 2019, 9: 97. doi: 10.1186/s13578-019-0361-4.
30. Falzone L, Scola L, Zanghì A, et al. Integrated analysis of colorectal cancer microRNA datasets: identification of microRNAs associated with tumor development. Aging (Albany NY), 2018, 10(5): 1000-1014.
31. Zhao X, Liu S, Yan B, et al. MiR-581/SMAD7 axis contributes to colorectal cancer metastasis: a bioinformatic and experimental validation-based study. Int J Mol Sci, 2020, 21(18): 6499. doi: 10.3390/ijms21186499.
32. Liu C, Xu M, Yan L, et al. Honeysuckle-derived microRNA2911 inhibits tumor growth by targeting TGF-β1. Chin Med, 2021, 16(1): 49. doi: 10.1186/s13020-021-00453-y.
33. Bai J, Zhang X, Shi D, et al. Exosomal miR-128-3p promotes epithelial-to-mesenchymal transition in colorectal cancer cells by targeting FOXO4 via TGF-β/SMAD and JAK/STAT3 signaling. Front Cell Dev Biol, 2021, 9: 568738. doi: 10.3389/fcell.2021.568738.
34. Cao W, Wang Q, Huang C. Let-7a inhibits tumor metastasis by regulating TGF-β/Smad signaling in the colorectal adenocarcinoma cell line LS-174T. Anticancer Res, 2021, 41(8): 3801-3808.
35. Soleimani A, Rahmani F, Ferns GA, et al. Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer. Gene, 2020, 726: 144132. doi: 10.1016/j.gene.2019.144132.
36. Gao Y, Han T, Han C, et al. Propofol regulates the TLR4/NF-κB pathway through miRNA-155 to protect colorectal cancer intestinal barrier. Inflammation, 2021, 44(5): 2078-2090.
37. Chen Z, Zhong T, Zhong J, et al. MicroRNA-129 inhibits colorectal cancer cell proliferation, invasion and epithelial-to-mesenchymal transition by targeting SOX4. Oncol Rep, 2021, 45(5): 61. doi: 10.3892/or.2021.8012.
38. Lai CY, Yeh KY, Liu BF, et al. MicroRNA-21 plays multiple oncometabolic roles in colitis-associated carcinoma and colorectal cancer via the PI3K/AKT, STAT3, and PDCD4/TNF-α signaling pathways in Zebrafish. Cancers (Basel), 2021, 13(21): 5565. doi: 10.3390/cancers13215565.
39. Wang LQ, Yu P, Li B, et al. MiR-372 and miR-373 enhance the stemness of colorectal cancer cells by repressing differentiation signaling pathways. Mol Oncol, 2018, 12(11): 1949-1964.
40. Wang J, Zhang Y, Song H, et al. The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway. Mol Cancer, 2021, 20(1): 81. doi: 10.1186/s12943-021-01375-x.
41. Li LX, Lam IH, Liang FF, et al. MiR-198 affects the proliferation and apoptosis of colorectal cancer through regulation of ADAM28/JAK-STAT signaling pathway. Eur Rev Med Pharmacol Sci, 2019, 23(4): 1487-1493.
42. Lamichhane S, Mo JS, Sharma G, et al. MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in inflammatory colitis and colorectal cancer. Inflamm Res, 2021, 70(8): 903-914.
43. Liu X, Qin Y, Tang X, et al. Circular RNA circ_0000372 contributes to the proliferation, migration and invasion of colorectal cancer by elevating IL6 expression via sponging miR-495. Anticancer Drugs, 2021, 32(3): 296-305.
44. Liu Z, Ma T, Duan J, et al. MicroRNA-223-induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways. Mol Med Rep, 2021, 23(2): 154. doi: 10.3892/mmr.2020.11793.
45. Shen Y, Dai X, Chen H, et al. Comprehensive evaluation of microRNA-10b in digestive system cancers reveals prognostic implication and signaling pathways associated with tumor progression. J Cancer, 2021, 12(13): 4011-4024.
46. Ji G, Zhou W, Li X, et al. Melatonin inhibits proliferation and viability and promotes apoptosis in colorectal cancer cells via upregulation of the microRNA-34a/449a cluster. Mol Med Rep, 2021, 23(3): 187. doi: 10.3892/mmr.2021.11826.
47. Wierzbicki PM, Rybarczyk A. The Hippo pathway in colorectal cancer. Folia Histochem Cytobiol, 2015, 53(2): 105-119.
48. Yu D, Liu H, Qin J, et al. Curcumol inhibits the viability and invasion of colorectal cancer cells via miR-30a-5p and Hippo signaling pathway. Oncol Lett, 2021, 21(4): 299. doi: 10.3892/ol.2021.12560.
49. Xu X, Chen X, Xu M, et al. MiR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells. Aging (Albany NY), 2019, 11(18): 7357-7385.
50. Bahrami A, Jafari A, Ferns GA. The dual role of microRNA-9 in gastrointestinal cancers: oncomiR or tumor suppressor?. Biomed Pharmacother, 2022, 145: 112394. doi: 10.1016/j.biopha.2021.112394.
51. Wu C, Zhu X, Liu W, et al. Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy. Onco Targets Ther, 2017, 10: 3249-3259.
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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research progress of microRNA in colorectal cancer-related signaling pathways

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