Target and mechanism of traditional Chinese medicine in acute pancreatitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

CAO Fei ,  CHEN Weiwei

1. Department of Gastroenterology, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu 225200, P. R. China;

Corresponding author：

CHEN Weiwei, Email: cww1984@126.com

Keywords：

acute pancreatitis; traditional Chinese medicine; target; mechanism

DOI：

10.7507/1007-9424.202312036

Video：

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Acute pancreatitis (AP) is a common clinical emergency of the abdomen with increasing incidence and lack of effective treatment. Traditional Chinese medicine, as a treasure of the Chinese people, has been used in the treatment of AP for decades with favorable therapeutic effects. Currently, clinical trials and experimental studies have shown that traditional Chinese medicine has the effects of inhibiting pancreatic enzyme activity, anti-inflammation, promoting gastrointestinal dynamics, as well as delaying the progress of AP, improving clinical symptoms, reducing related complications, and reducing the mortality rate. Therefore, traditional Chinese medicine has considerable clinic value in treating AP. Based on the related research progress and clinical practice of our team, the authors summarized the targets and mechanism of traditional Chinese medicine in treating AP.

Citation： CAO Fei, CHEN Weiwei. Target and mechanism of traditional Chinese medicine in acute pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2024, 31(2): 146-154. doi: 10.7507/1007-9424.202312036 Copy

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1. Forsmark CE, Vege SS, Wilcox CM. Acute pancreatitis. N Engl J Med, 2016, 375(20): 1972-1981.
2. Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis–2012: revision of the Atlanta classification and definitions by international consensus. Gut, 2013, 62(1): 102-111.
3. Lee PJ, Papachristou GI. New insights into acute pancreatitis. Nat Rev Gastroenterol Hepatol, 2019, 16(8): 479-496.
4. Saluja A, Dudeja V, Dawra R, et al. Early intra-acinar events in pathogenesis of pancreatitis. Gastroenterology, 2019, 156(7): 1979-1993.
5. Habtezion A, Gukovskaya AS, Pandol SJ. Acute pancreatitis: a multifaceted set of organelle and cellular interactions. Gastroenterology, 2019, 156(7): 1941-1950.
6. Szatmary P, Grammatikopoulos T, Cai W, et al. Acute pancreatitis: diagnosis and treatment. Drugs, 2022, 82(12): 1251-1276.
7. Mederos MA, Reber HA, Girgis MD. Acute pancreatitis: a review. JAMA, 2021, 325(4): 382-390.
8. Yang C, Wang T, Chen J, et al. Traditional Chinese medicine formulas alleviate acute pancreatitis: pharmacological activities and mechanisms. Pancreas, 2021, 50(10): 1348-1356.
9. Xiang H, Zhang Q, Qi B, et al. Chinese herbal medicines attenuate acute pancreatitis: pharmacological activities and mechanisms. Front Pharmacol, 2017, 8: 216. doi: 10.3389/fphar.2017.00216.
10. 李君秋, 肖铁刚, 曹红燕, 等. 大承气汤治疗急性胰腺炎的临床疗效观察与分析. 中华危重病急救医学, 2022, 34(1): 91-94.
11. Lin J, Han C, Dai N, et al. Effectiveness of Chengqi-series decoctions in treating severe acute pancreatitis: a systematic review and meta-analysis. Phytomedicine, 2023, 113: 154727. doi: 10.1016/j.phymed.2023.154727.
12. 李君秋, 戴彦成, 曹红燕, 等. 大承气汤能够通过调节肠道微生物群抑制轻症急性胰腺炎患者炎症反应并促进胃肠功能恢复. 中华危重病急救医学, 2023, 35(2): 170-176.
13. Wan MH, Li J, Huang W, et al. Modified Da-Cheng-Qi Decoction reduces intra-abdominal hypertension in severe acute pancreatitis: a pilot study. Chin Med J (Engl), 2012, 125(11): 1941-1944.
14. 王忠朝, 薛平, 黄宗文, 等. 早期应用柴芩承气汤治疗重症急性胰腺炎并发急性呼吸窘迫综合征的临床观察. 中国中西医结合杂志, 2009, 29(4): 322-324.
15. Guo J, Xue P, Yang XN, et al. The effect of Chaiqin Chengqi Decoction () on modulating serum matrix metalloproteinase 9 in patients with severe acute pancreatitis. Chin J Integr Med, 2013, 19(12): 913-917.
16. 薛平, 黄宗文, 郭佳, 等. 早期应用柴芩承气汤治疗胆源性重症急性胰腺炎的临床研究. 中西医结合学报, 2005, 3(4): 263-265.
17. Wang L, Li Y, Ma Q, et al. Chaiqin Chengqi Decoction decreases IL-6 levels in patients with acute pancreatitis. J Zhejiang Univ Sci B, 2011, 12(12): 1034-1040.
18. Chen W, Yang X, Huang L, et al. Qing-Yi decoction in participants with severe acute pancreatitis: a randomized controlled trial. Chin Med, 2015, 10: 11. doi: 10.1186/s13020-015-0039-8.
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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Target and mechanism of traditional Chinese medicine in acute pancreatitis

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