光动力疗法联合胆道支架与<sup>125</sup>I粒子支架在不可切除肝外胆管癌的疗效对比研究_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

高彬 , 宁江红 , 丛赟 ,  邵英梅

新疆医科大学第一附属医院消化血管外科中心肝胆包虫病外科（乌鲁木齐 830054）;

Corresponding author：

邵英梅, Email: syingmei1@163.com

Keywords：

光动力疗法; 放射性粒子支架; 肝外胆管癌

DOI：

10.7507/1007-9424.202403062

Video：

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目的对比分析光动力疗法（photodynamic therapy，PDT）联合胆道支架和¹²⁵I粒子支架治疗晚期肝外胆管癌患者的疗效。方法回顾性收集2015年1月1日至2023年12月31日期间新疆医科大学第一附属医院收治的32例肝门部胆管癌(Bisnmuth Ⅰ ～Ⅱ型)或胆总管中下段癌患者的临床资料，根据治疗方法的不同分为PDT联合胆道支架组（简称PDT+支架组，9例）和¹²⁵I粒子支架组（23例），比较2组患者在手术时间、总住院时间、术后并发症发生率、支架通畅时间和生存时间方面的差异。结果 PDT+支架组的手术时间为（83.00±38.40）min，¹²⁵I粒子支架组的手术时间为（73.70±30.12）min，PDT+支架组的手术时间略长于¹²⁵I粒子支架组，但差异无统计学意义（P=0.471）； PDT+支架组的总住院时间长于¹²⁵I粒子支架组［15.0（11.5，17.5）d 比 9.0（7.0，12.0）d］，2组间的差异有统计学意义（P=0.038）。PDT+支架组术后出现并发症2例（22.2%），¹²⁵I粒子支架组术后出现并发症3例（13.0%），2组间的差异无统计学意义（P=0.604）。PDT+支架组的中位支架通畅时间和中位生存时间均长于¹²⁵I粒子支架组［8.0（4.5，10.0）个月比 7.0（4.0，11.0）个月；10.0（7.3，13.5）个月比 8.0（5.0，12.0）个月］，但2组间的差异均无统计学意义（P＞0.05）。结论单次PDT联合胆道支架治疗晚期胆管癌在延长支架通畅时间和生存时间方面具有一定优势，但其有效性和安全性与¹²⁵I粒子支架治疗差异并不显著。

Citation： 高彬, 宁江红, 丛赟, 邵英梅. 光动力疗法联合胆道支架与¹²⁵I粒子支架在不可切除肝外胆管癌的疗效对比研究. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2024, 31(8): 986-989. doi: 10.7507/1007-9424.202403062 Copy

1.	Benavides M, Antón A, Gallego J, et al. Biliary tract cancers: SEOM clinical guidelines. Clin Transl Oncol, 2015, 17(12): 982-987.
2.	Moris D, Palta M, Kim C, et al. Advances in the treatment of intrahepatic cholangiocarcinoma: an overview of the current and future therapeutic landscape for clinicians. CA Cancer J Clin, 2023, 73(2): 198-222.
3.	Wang T, Liu S, Zheng YB, et al. Clinical study on using ¹²⁵I seeds articles combined with biliary stent implantation in the treatment of malignant obstructive jaundice. Anticancer Res, 2017, 37(8): 4649-4653.
4.	Zhu HD, Guo JH, Huang M, et al. Irradiation stents vs. conventional metal stents for unresectable malignant biliary obstruction: a multicenter trial. J Hepatol, 2018, 68(5): 970-977.
5.	Ackroyd R, Kelty C, Brown N, et al. The history of photodetection and photodynamic therapy. Photochem Photobiol, 2001, 74(5): 656-669.
6.	Benson AB, D’Angelica MI, Abbott DE, et al. Hepatobiliary Cancers, Version 2. 2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw, 2021, 19(5): 541-565.
7.	Jung CFM, Lavole J, Barret M, et al. Local therapy in advanced cholangiocarcinoma: a review of current endoscopic, medical, and oncologic treatment options. Oncology, 2019, 97(4): 191-201.
8.	World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA, 2013, 310(20): 2191-2194.
9.	Luo JJ, Zhang ZH, Liu QX, et al. Endovascular brachytherapy combined with stent placement and TACE for treatment of HCC with main portal vein tumor thrombus. Hepatol Int, 2016, 10(1): 185-195.
10.	Banales JM, Marin JJG, Lamarca A, et al. Cholangiocarcinoma 2020: the next horizon in mechanisms and management. Nat Rev Gastroenterol Hepatol, 2020, 17(9): 557-588.
11.	Sengar P, Garcia-Tapia K, Chauhan K, et al. Dual-photosensitizer coupled nanoscintillator capable of producing type I and typeⅡROS for next generation photodynamic therapy. J Colloid Interface Sci, 2019, 536: 586-597.
12.	Banerjee SM, MacRobert AJ, Mosse CA, et al. Photodynamic therapy: inception to application in breast cancer. Breast, 2017, 31: 105-113.
13.	Feng JW, Yang XH, Wu BQ, et al. Progress in diagnosis and surgical treatment of perihilar cholangiocarcinoma. Gastroenterol Hepatol, 2019, 42(4): 271-279.
14.	Zheng Y, Ye J, Li Z, et al. Recent progress in sono-photodynamic cancer therapy: from developed new sensitizers to nanotechnology-based efficacy-enhancing strategies. Acta Pharm Sin B, 2021, 11(8): 2197-2219.
15.	Ortner ME, Caca K, Berr F, et al. Successful photodynamic therapy for nonresectable cholangiocarcinoma: a randomized prospective study. Gastroenterology, 2003, 125(5): 1355-1363.
16.	Zoepf T, Jakobs R, Arnold JC, et al. Palliation of nonresectable bile duct cancer: improved survival after photodynamic therapy. Am J Gastroenterol, 2005, 100(11): 2426-2430.
17.	许博, 席大勇, 蒲唯高, 等. 双金属支架联合光动力治疗及靶向、免疫治疗在远端胆管癌中的应用. 肝胆胰外科杂志, 2021, 33(7): 427-433.
18.	Moole H, Tathireddy H, Dharmapuri S, et al. Success of photodynamic therapy in palliating patients with nonresectable cholangiocarcinoma: a systematic review and meta-analysis. World J Gastroenterol, 2017, 23(7): 1278-1288.
19.	李艳, 徐文海, 王勇, 等. 胆道双金属支架联合¹²⁵I粒子条植入治疗高位恶性梗阻性黄疸的疗效. 医学影像学杂志, 2022, 32(7): 1183-1187, 1191.
20.	Yang S, Liu Y, Teng F, et al. Radioactive stent insertion for inoperable malignant common biliary obstruction. Surg Laparosc Endosc Percutan Tech, 2020, 31(1): 61-65.
21.	Höblinger A, Gerhardt T, Gonzalez-Carmona MA, et al. Feasibility and safety of long-term photodynamic therapy (PDT) in the palliative treatment of patients with hilar cholangiocarcinoma. Eur J Med Res, 2011, 16(9): 391-395.

1. Benavides M, Antón A, Gallego J, et al. Biliary tract cancers: SEOM clinical guidelines. Clin Transl Oncol, 2015, 17(12): 982-987.
2. Moris D, Palta M, Kim C, et al. Advances in the treatment of intrahepatic cholangiocarcinoma: an overview of the current and future therapeutic landscape for clinicians. CA Cancer J Clin, 2023, 73(2): 198-222.
3. Wang T, Liu S, Zheng YB, et al. Clinical study on using ¹²⁵I seeds articles combined with biliary stent implantation in the treatment of malignant obstructive jaundice. Anticancer Res, 2017, 37(8): 4649-4653.
4. Zhu HD, Guo JH, Huang M, et al. Irradiation stents vs. conventional metal stents for unresectable malignant biliary obstruction: a multicenter trial. J Hepatol, 2018, 68(5): 970-977.
5. Ackroyd R, Kelty C, Brown N, et al. The history of photodetection and photodynamic therapy. Photochem Photobiol, 2001, 74(5): 656-669.
6. Benson AB, D’Angelica MI, Abbott DE, et al. Hepatobiliary Cancers, Version 2. 2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw, 2021, 19(5): 541-565.
7. Jung CFM, Lavole J, Barret M, et al. Local therapy in advanced cholangiocarcinoma: a review of current endoscopic, medical, and oncologic treatment options. Oncology, 2019, 97(4): 191-201.
8. World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA, 2013, 310(20): 2191-2194.
9. Luo JJ, Zhang ZH, Liu QX, et al. Endovascular brachytherapy combined with stent placement and TACE for treatment of HCC with main portal vein tumor thrombus. Hepatol Int, 2016, 10(1): 185-195.
10. Banales JM, Marin JJG, Lamarca A, et al. Cholangiocarcinoma 2020: the next horizon in mechanisms and management. Nat Rev Gastroenterol Hepatol, 2020, 17(9): 557-588.
11. Sengar P, Garcia-Tapia K, Chauhan K, et al. Dual-photosensitizer coupled nanoscintillator capable of producing type I and typeⅡROS for next generation photodynamic therapy. J Colloid Interface Sci, 2019, 536: 586-597.
12. Banerjee SM, MacRobert AJ, Mosse CA, et al. Photodynamic therapy: inception to application in breast cancer. Breast, 2017, 31: 105-113.
13. Feng JW, Yang XH, Wu BQ, et al. Progress in diagnosis and surgical treatment of perihilar cholangiocarcinoma. Gastroenterol Hepatol, 2019, 42(4): 271-279.
14. Zheng Y, Ye J, Li Z, et al. Recent progress in sono-photodynamic cancer therapy: from developed new sensitizers to nanotechnology-based efficacy-enhancing strategies. Acta Pharm Sin B, 2021, 11(8): 2197-2219.
15. Ortner ME, Caca K, Berr F, et al. Successful photodynamic therapy for nonresectable cholangiocarcinoma: a randomized prospective study. Gastroenterology, 2003, 125(5): 1355-1363.
16. Zoepf T, Jakobs R, Arnold JC, et al. Palliation of nonresectable bile duct cancer: improved survival after photodynamic therapy. Am J Gastroenterol, 2005, 100(11): 2426-2430.
17. 许博, 席大勇, 蒲唯高, 等. 双金属支架联合光动力治疗及靶向、免疫治疗在远端胆管癌中的应用. 肝胆胰外科杂志, 2021, 33(7): 427-433.
18. Moole H, Tathireddy H, Dharmapuri S, et al. Success of photodynamic therapy in palliating patients with nonresectable cholangiocarcinoma: a systematic review and meta-analysis. World J Gastroenterol, 2017, 23(7): 1278-1288.
19. 李艳, 徐文海, 王勇, 等. 胆道双金属支架联合¹²⁵I粒子条植入治疗高位恶性梗阻性黄疸的疗效. 医学影像学杂志, 2022, 32(7): 1183-1187, 1191.
20. Yang S, Liu Y, Teng F, et al. Radioactive stent insertion for inoperable malignant common biliary obstruction. Surg Laparosc Endosc Percutan Tech, 2020, 31(1): 61-65.
21. Höblinger A, Gerhardt T, Gonzalez-Carmona MA, et al. Feasibility and safety of long-term photodynamic therapy (PDT) in the palliative treatment of patients with hilar cholangiocarcinoma. Eur J Med Res, 2011, 16(9): 391-395.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

光动力疗法联合胆道支架与¹²⁵I粒子支架在不可切除肝外胆管癌的疗效对比研究

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

光动力疗法联合胆道支架与125I粒子支架在不可切除肝外胆管癌的疗效对比研究

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光动力疗法联合胆道支架与¹²⁵I粒子支架在不可切除肝外胆管癌的疗效对比研究