Objective To explore the levels of serum leptin,TNF-α,IL-8 and hypersensitivity C-reactive protein (hs-CRP) in stable COPD patients with different body mass index (BMI).
Methods 30 healthy controls with BMI 18.5 to 23.9 kg/m2 and 105 patients with stable COPD were recruited in the study. The serum levels of leptin,TNF-α,and IL-8 were determined by radioimmunoassay and hs-CRP level was determined by versatile biochemical automatic analyzer. The COPD patients were divided into a low BMI group (BMI<18.5 kg/m2,n=32),a normal BMI group (BMI 18.5-23.9 kg/m2,n=48),and a high BMI group (BMI≥23.9 kg/m2,n=25).
Results Serum leptin level in the COPD patients was significantly reduced compared with the control subjects (P<0.05). Serum leptin levels were reduced in the low BMI and the high BMI groups compare with the normal BMI group [(7.89±3.16)ng/L and (10.52±5.98)ng/L vs. (13.04±5.73) ng/L,P<0.01 or P<0.05]. Leptin level in the low BMI group was lower than that in the high BMI group (P<0.05). Serum TNF-α levels were significantly increased in the low BMI group compared with the normal BMI and high BMI groups [(229.39±89.57)μg/L vs. (180.06±74.24) μg/L and (189.46±82.41) μg/L,P<0.01]. Serum TNF-α level in the COPD patients was significantly increased compared with the control subjects [(192.37±83.65) μg/L vs. (178.59±60.38) μg/L,P<0.05]. The IL-8 levels were not significant different among three BMI groups with COPD. The hs-CRP level in the high BMI group was higher than that in the low BMI and normal BMI groups (P<0.05).
Conclusion Leptin and TNF-α may be involved in weight-loss of COPD malnutritional patients.
Citation：
NieXiaohong, XiongShuguang, WangHui, LiXuemei. Spectrum of Inflammatory Factors in Stable COPD Patients with Three Different Types of Body Mass Index. Chinese Journal of Respiratory and Critical Care Medicine, 2014, 13(1): 14-17. doi: 10.7507/1671-6205.2014004
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Copyright © the editorial department of Chinese Journal of Respiratory and Critical Care Medicine of West China Medical Publisher. All rights reserved
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- 1. 颜雪琴,金玲湘,戴元荣.老年慢性阻塞性肺疾病白介素和肿瘤坏死因子-α测定的临床意义.实用老年医学,2007,21:34-35.
- 2. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病(COPD)诊治规范(2007修订版).中华结核和呼吸杂志, 2007, 30:8-17.
- 3. 陆明,蔡映云.慢性阻塞性肺疾病的全身表现.实用老年医学,2008,22:167-169.
- 4. Fernóandez-Riejos P, Najib S, Santos-Alvarez J,et al.Role of leptin in the activation of immune cells.Mediators of Inflamm, 2010 (2010), Article ID 568343.
- 5. Karakas S, Karadag F, Karul AB,et al.Circulating leptin and body composition in chronic obstructive pulmonary disease.Int J Clin Pract, 2005,59:1167-1170.
- 6. 王秋月, 张鸿, 闫雪, 等.慢性阻塞性肺疾病患者血清抵抗素和瘦素水平及其与营养状况关系.中华结核和呼吸杂志, 2005, 28:445-447.
- 7. Gaki E, Kontogianni K, Papaioannou AI,et al.Associations between BODE index and systemic inflammatory biomarkers in COPD.COPD,2011,8:408-413.
- 8. Calikoglu M, Sahin G, Unlu A, et al. Leptin and TNF-alpha levels in patients with chronic obstructive pulmonary disease and their relationship to nutritional parameters.Respiration, 2004 ,71:45-50.
- 9. 梁卫红,黄兰卿.慢性阻塞性肺疾病患者血清瘦素水平与炎性反应相关性.中国实用医刊,2010,37:28-29,32.
- 10. 罗勇,徐卫国,杨玲,等.不同营养状况COPD患者能量消耗、呼吸肌力和免疫功能的比较.中国临床康复,2003,7:2186-2188.
- 11. Guerra S, Sherrill DL, Bobadilla A,et al. The relation of body mass index to asthma, chronic bronchitis, and emphysema.Chest, 2002,122:1256-1263.
