Value of Dynamic Serum sTREM-1 in Diagnosing Sepsis,Severity Assessment,and Prognostic Prediction_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

LiangWeibo , PangXiaoqing , LiuXiaoqing , HeWeiqun , MaoPu ,  LiYimin

Critical Care Medicine Department of The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, China;

Corresponding author：

LiYimin, Email: dryiminli@vip.163.com

Keywords：

Sepsis; Soluble triggering receptor expressed on myeloid cell-1; Interleukin-6; Interleukin-10

DOI：

10.7507/1671-6205.2014013

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the clinical value of soluble triggering receptor expressed on myeloid cell-1 (sTREM-1) for diagnosis and prognosis of sepsis. Methods Patients with SIRS (n=58) were divided into a sepsis group (n=40) and a non-sepsis group (n=18),and 12 healthy adults were admitted as control. Serum concentrations of sTREM-1,interleukin-6 (IL-6) and IL-10 were measured on days 1,3,7 and 14 by ELISA. According to the survival on 28^th day after admission,the sepsis group was divided into survivors (n=27) and non-survivors (n=13). APACHEⅡ score and SOFA score were used to evaluate the severity of sepsis. The correlations between sTREM-1 and IL-6,IL-10,disease progression or prognosis were analyzed respectively. Results On the first day of enrollment,sTREM-1,IL-6 and IL-10 [217.28(136.02-377.01) pg/mL,218.76(123.32-548.58) pg/mL and 93.86(54.23-143.1) pg/mL,respectively] in the sepsis group were significantly higher than those in the non-sepsis group [55.51(39.50-77.33) pg/mL,75.98(34.89-141.03) pg/mL and 52.49(45.66-56.72) pg/mL,respectively] and the control group [43.99(36.28-53.81) pg/mL,46.07(40.23-53.72) pg/mL and 49.79(43.31-53.14) pg/mL, respectively] (All P<0.01). For diagnosis of sepsis,the area under the curve (AUC) for sTREM-1 was 0.82 (95%CI 0.70-0.94). Levels of sTREM-1 and IL-10 in survivors of sepsis were gradually increased on 1^st,3^rd,7^th day of enrollment,while level of sTREM-1 in non-survivors showed an obvious decrease during the observation. On the 14^th of admission,sTREM-1,IL-6,IL-10 and IL-6/IL-10 ratio of non-survivors were significantly higher than those of survivors (P<0.05). There were significantly positive correlations between sTREM-1 and APACHEⅡ score,SOFA score,IL-6,IL-10 or IL-6/IL-10 ratio (r=0.624,0.454,0.407 and 0.324,respectively,all P<0.05). Logistic regression analysis indicated that serum level of sTREM-1 may be used as a prognostic factor of sepsis,but not an independent risk factor. Conclusion Serum sTREM-1 could be used as a marker to detect sepsis early,and sTREM-1 is also involved in systemic inflammatory reaction of sepsis patient and appears to be a prognostic value of sepsis.

Citation： LiangWeibo, PangXiaoqing, LiuXiaoqing, HeWeiqun, MaoPu, LiYimin. Value of Dynamic Serum sTREM-1 in Diagnosing Sepsis,Severity Assessment,and Prognostic Prediction. Chinese Journal of Respiratory and Critical Care Medicine, 2014, 13(1): 53-57. doi: 10.7507/1671-6205.2014013 Copy

1.	Levy MM,Fink MP,Marshall JC,et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med,2003,31:1250-1256.
2.	Calvano SE,Xiao W,Richards DR,et al. A network-based analysis of systemic inflammation in humans. Nature,2005,437:1032-1037.
3.	Pierrakos C,Vincent JL. Sepsis biomarkers: a review. Crit Care,2010,14:R15.
4.	Bouchon A,Facchetti F,Weigand MA,et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature,2001,410:1103-1107.
5.	Giamarellos-Bourboulis EJ,Zakynthinos S,Baziaka F,et al. Soluble triggering receptor expressed on myeloid cells 1 as an anti-inflammatory mediator in sepsis. Intensive Care Med,2006,32:237-243.
6.	吴友平,李金宝,邓小明. 血浆可溶性髓细胞触发受体-1对脓毒症诊断价值的系统评价. 中国循证医学杂志,2013,13:425-430.
7.	Mahdy AM,Lowes DA,Galley HF,et al. Production of soluble triggering receptor expressed on myeloid cells by lipopolysaccharide-stimulated human neutrophils involves de novo protein synthesis. Clin Vaccine Immunol,2006,13:492-495.
8.	Gibot S,Cravoisy A. Soluble form of the triggering receptor expressed on myeloid cells-1 as a marker of microbial infection. Clin Med Res,2004,2:181-187.
9.	Wunder C,Eichelbronner O,Roewer N. Are IL-6,IL-10 and PCT plasma concentrations reliable for outcome prediction in severe sepsis? A comparison with APACHE III and SAPS II. Inflamm Res,2004,53:158-163.
10.	Spittler A,Razenberger M,Kupper H,et al. Relationship between interleukin-6 plasma concentration in patients with sepsis,monocyte phenotype,monocyte phagocytic properties,and cytokine production. Clin Infect Dis,2000,31:1338-1342.
11.	Gaini S,Koldkjaer OG,Pedersen C,et al. Procalcitonin,lipopolysaccharide-binding protein,interleukin-6 and C-reactive protein in community-acquired infections and sepsis: a prospective study. Crit Care,2006,10:R53.
12.	Brivet FG,Emilie D,Galanaud P. Pro- and anti-inflammatory cytokines during acute severe pancreatitis: an early and sustained response,although unpredictable of death. Parisian Study Group on Acute Pancreatitis. Crit Care Med,1999,27:749-755.
13.	Rodriguez-Gaspar M,Santolaria F,Jarque-Lopez A,et al. Prognostic value of cytokines in SIRS general medical patients. Cytokine,2001,15:232-236.
14.	曾小莉,张韶岩,郭晶,等. 可溶性髓样细胞触发受体1在脓毒症中的表达和临床意义. 中国呼吸与危重监护杂志,2011,10:538-542.

1. Levy MM,Fink MP,Marshall JC,et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med,2003,31:1250-1256.
2. Calvano SE,Xiao W,Richards DR,et al. A network-based analysis of systemic inflammation in humans. Nature,2005,437:1032-1037.
3. Pierrakos C,Vincent JL. Sepsis biomarkers: a review. Crit Care,2010,14:R15.
4. Bouchon A,Facchetti F,Weigand MA,et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature,2001,410:1103-1107.
5. Giamarellos-Bourboulis EJ,Zakynthinos S,Baziaka F,et al. Soluble triggering receptor expressed on myeloid cells 1 as an anti-inflammatory mediator in sepsis. Intensive Care Med,2006,32:237-243.
6. 吴友平,李金宝,邓小明. 血浆可溶性髓细胞触发受体-1对脓毒症诊断价值的系统评价. 中国循证医学杂志,2013,13:425-430.
7. Mahdy AM,Lowes DA,Galley HF,et al. Production of soluble triggering receptor expressed on myeloid cells by lipopolysaccharide-stimulated human neutrophils involves de novo protein synthesis. Clin Vaccine Immunol,2006,13:492-495.
8. Gibot S,Cravoisy A. Soluble form of the triggering receptor expressed on myeloid cells-1 as a marker of microbial infection. Clin Med Res,2004,2:181-187.
9. Wunder C,Eichelbronner O,Roewer N. Are IL-6,IL-10 and PCT plasma concentrations reliable for outcome prediction in severe sepsis? A comparison with APACHE III and SAPS II. Inflamm Res,2004,53:158-163.
10. Spittler A,Razenberger M,Kupper H,et al. Relationship between interleukin-6 plasma concentration in patients with sepsis,monocyte phenotype,monocyte phagocytic properties,and cytokine production. Clin Infect Dis,2000,31:1338-1342.
11. Gaini S,Koldkjaer OG,Pedersen C,et al. Procalcitonin,lipopolysaccharide-binding protein,interleukin-6 and C-reactive protein in community-acquired infections and sepsis: a prospective study. Crit Care,2006,10:R53.
12. Brivet FG,Emilie D,Galanaud P. Pro- and anti-inflammatory cytokines during acute severe pancreatitis: an early and sustained response,although unpredictable of death. Parisian Study Group on Acute Pancreatitis. Crit Care Med,1999,27:749-755.
13. Rodriguez-Gaspar M,Santolaria F,Jarque-Lopez A,et al. Prognostic value of cytokines in SIRS general medical patients. Cytokine,2001,15:232-236.
14. 曾小莉,张韶岩,郭晶,等. 可溶性髓样细胞触发受体1在脓毒症中的表达和临床意义. 中国呼吸与危重监护杂志,2011,10:538-542.

Chinese Journal of Respiratory and Critical Care Medicine

Value of Dynamic Serum sTREM-1 in Diagnosing Sepsis,Severity Assessment,and Prognostic Prediction

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content