Pulmonary Mucosa-associated Lymphoid Tissue (MALT) Lymphoma with Diffuse Lung Disease: Two Cases Report and Literature Review_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

DingJingjing ¹ , CaoMin ¹ , LiuYin ¹ , MiaoLiyun ¹ , MengFanqing ² , YeQing ² ,  CaiHourong ¹

1. Department of Respiratory Medicine, The Affiliated Drum Tower Hospital of Medical School of Nanjing University, Nanjing, Jiangsu, 210008, China;
2. ;

Corresponding author：

CaiHourong, Email: caihourong2013@163.com

Keywords：

Mucosa-associated lymphoid tissue lymphoma; Diffuse lung disease; Gene rearrangement

DOI：

10.7507/1671-6205.2014016

Video：

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Objective To highlight the characteristics of pulmonary MALT lymphoma with diffuse lung disease. Methods The clinical,radiological and pathological data of two patients with pulmonary MALT lymphoma were analyzed,and relevant literature was reviewed. Results One patient was a 59-year-old male with cough for five years while antibiotic treatment was ineffective. The chest CT scan demonstrated diffuse lung disease,bilateral multiple consolidation and ground-glass opacities,small nodules and bronchiectasis. Thoracoscopy biopsy was performed and the pathology study confirmed the diagnosis of MALT lymphoma. Another case was a 50-year-old female,who suffered from fever,cough and dyspnea. The chest CT scan revealed bilateral multiple patchy consolidation,with air bronchogram. The eosinophils count in blood was high. Diagnosed initially as eosinophilic pneumonia,she was treated with corticosteroids. The clinical symptoms were improved,but the CT scan revealed no change. After the computed tomography guided percutaneous lung biopsy,pathological examination confirmed the diagnosis of MALT lymphoma. Conclusion MALT lymphoma with diffuse lung disease is rare and easy to be misdiagnosed. The positive rate of bronchoscopy is low and percutaneous lung biopsy or thoracoscopy biopsy is more useful for diagnosis.

Citation： DingJingjing, CaoMin, LiuYin, MiaoLiyun, MengFanqing, YeQing, CaiHourong. Pulmonary Mucosa-associated Lymphoid Tissue (MALT) Lymphoma with Diffuse Lung Disease: Two Cases Report and Literature Review. Chinese Journal of Respiratory and Critical Care Medicine, 2014, 13(1): 67-71. doi: 10.7507/1671-6205.2014016 Copy

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2.	Arnaoutakis K,Oo TH.Bronchus-associated lymphoid tissue lymphomas.South Med J,2009,102:1229-1233.
3.	Cordier JF,Chaillenx E,Lauque D,et al.Primary pulmonary lymphomas.A clinical study of 70 cases in nonimmunocompromised patients.Chest,1993,103:201-208.
4.	Borie R,Wislez M,Thabut G,et al.Clinical characteristics and prognostic factors of pulmonary MALT lymphoma.Eur Respir J,2009,34:1408-1416.
5.	Bae YA,Lee KS,Han J,et al.Marginal zone B-cell lymphoma of ronchus-associated lymphoid tissue:imaging findings in 21 patients.Chest,2008,133:433-400.
6.	King LJ,Padley SP,Wotherspoon AC,et al.Pulmonary MALT lymphoma:imaging findings in 24 cases.Eur Radiol,2000,10:1932-1938.
7.	Swerdlow SH,Campo E,Harris NL,et al.WHO classification of tumors of haematopoietic and lymphoid tissues.Lyon:IARC Press,2008:179-226.
8.	Travis WD,Muler-Hermelink HK,Harris CC,et al.World Health Organization Classification of Tumours:Pathology and genetics of tumours of the lung,pleura,thymus and heart .Lyon:IARC Press,2004:95-98.
9.	姚成才,张义,姜杰.肺MALT淋巴瘤并腮腺淋巴上皮病1例并文献复习.现代肿瘤医学,2010,18:1206-1209.
10.	李百周,王聪,李天女,等.综合影像学、组织学和免疫组织化学特点诊断肺MALT淋巴瘤.中国癌症杂志,2007,17:796-800.
11.	余国攀,田欣伦,冯瑞娥,等.肺黏膜相关淋巴组织淋巴瘤4例报道并文献复习.中国呼吸与危重监护杂志,2007,6:303-304.
12.	Yuji I,Hiroshi M,Kiyoshi M,et al.Two cases with pulmonary mucosa-associated lymphoid tissue lymphoma successfully treated with clarithromycin.Chest,2010,138:730-733.

1. Fiche M,Captron F,Berger F,et al.Primary pulmonary non-Hodgkin's lymphomas.Histopathology,1995,26:529-537.
2. Arnaoutakis K,Oo TH.Bronchus-associated lymphoid tissue lymphomas.South Med J,2009,102:1229-1233.
3. Cordier JF,Chaillenx E,Lauque D,et al.Primary pulmonary lymphomas.A clinical study of 70 cases in nonimmunocompromised patients.Chest,1993,103:201-208.
4. Borie R,Wislez M,Thabut G,et al.Clinical characteristics and prognostic factors of pulmonary MALT lymphoma.Eur Respir J,2009,34:1408-1416.
5. Bae YA,Lee KS,Han J,et al.Marginal zone B-cell lymphoma of ronchus-associated lymphoid tissue:imaging findings in 21 patients.Chest,2008,133:433-400.
6. King LJ,Padley SP,Wotherspoon AC,et al.Pulmonary MALT lymphoma:imaging findings in 24 cases.Eur Radiol,2000,10:1932-1938.
7. Swerdlow SH,Campo E,Harris NL,et al.WHO classification of tumors of haematopoietic and lymphoid tissues.Lyon:IARC Press,2008:179-226.
8. Travis WD,Muler-Hermelink HK,Harris CC,et al.World Health Organization Classification of Tumours:Pathology and genetics of tumours of the lung,pleura,thymus and heart .Lyon:IARC Press,2004:95-98.
9. 姚成才,张义,姜杰.肺MALT淋巴瘤并腮腺淋巴上皮病1例并文献复习.现代肿瘤医学,2010,18:1206-1209.
10. 李百周,王聪,李天女,等.综合影像学、组织学和免疫组织化学特点诊断肺MALT淋巴瘤.中国癌症杂志,2007,17:796-800.
11. 余国攀,田欣伦,冯瑞娥,等.肺黏膜相关淋巴组织淋巴瘤4例报道并文献复习.中国呼吸与危重监护杂志,2007,6:303-304.
12. Yuji I,Hiroshi M,Kiyoshi M,et al.Two cases with pulmonary mucosa-associated lymphoid tissue lymphoma successfully treated with clarithromycin.Chest,2010,138:730-733.

Chinese Journal of Respiratory and Critical Care Medicine

Pulmonary Mucosa-associated Lymphoid Tissue (MALT) Lymphoma with Diffuse Lung Disease: Two Cases Report and Literature Review

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