Objective To explore the clinical features of atypical bronchial asthma with chief complaint of palpitations.
Methods Twelve cases with unexplained palpitations diagnosed by asthma were analyzed retrospectively.
Results The patients were diagnosed with asthma through bronchodilation test,skin prick tests,fractional exhaled nitric oxide (FeNO) and diagnostic treatment.The ratio of male to female cases was 1:5. The ventilation lung function of all patients was in normal range. The median time of misdiagnosis was 13.5(3-120) months. 41.6% of cases had dust mite positive skin prick test. The median value of FeNO was 32.75(18-54) ppb. The symptoms of all patients were relieved completely after standard treatment.
Conclusion Palpatation may be a specific presentation of asthma characterized with eosinophilic airway inflammation which may be misdiagnosed as other diseases for a long time,especially in elder women. To improve the knowledge of this kind of atypical asthma,detailed medical history, experimental examinations and diagnostic treatment response are important to confirm the diagnosis in time.
Citation：
Zhang Jingxi, Han Yiping, Bai Chong, Li Qiang. Atypical Asthma with Chief Complaint of Palpitations: Twelve Cases Analysis. Chinese Journal of Respiratory and Critical Care Medicine, 2013, 12(2): 112-115. doi: 10.7507/1671-6205.2014029
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Copyright © the editorial department of Chinese Journal of Respiratory and Critical Care Medicine of West China Medical Publisher. All rights reserved
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- 3. Global Strategy for Asthma Management and Prevention,Global Initiative for Asthma(GINA)2011.Available from:http://ginasthma.org.
- 4. Shen H,Hua W,Wang P,et al.A new phenotype of asthma: chest tightness as the sole presenting manifestation.Ann Allergy Asthma Immunol,2013,111:226-227.
- 5. Foschino Barbaro MP,Costa VR,Resta O,et al.Menopausal asthma: a new biological phenotype?Allergy,2010,65:1306-1312.
- 6. 王晓芝,赵铭山.夜间哮喘发生机制的研究.中华结核和呼吸杂志,2000,23: 576.
- 7. Skovsted GF,Pedersen AF,Larsen R,et al.Rapid functional upregulation of vasocontractile endothelin ETB receptors in rat coronary arteries.Life Sci,2012,91:593-599.
- 8. Romero KM,Robinson CL,Baumann LM,et al.PURA Study Investigators.Role of exhaled nitric oxide as a predictor of atopy.Respir Res,2013,14:48.
- 9. van den Berge M,Heijink HI,van Oosterhout AJ,et al.The role of female sex hormones in the development and severity of allergic and non-allergic asthma.Clin Exp Allergy,2009,39:1477-1481.
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