Objective To investigate the association between polymorphism of V4,F+1 in ADAM33 (adisintegrin and metalloproteinase 33) gene and COPD in a northwestern Uighur population. Methods A total of 100 Uighur COPD patients and 140 healthy volunteers were recruited in the study. Genotypes were determined by restriction fragment lengthpolymorphism(PCR-RFLP). All subjects had a epidemiological investigation including modified british medical research council(mMRC),COPD assessment test(CAT),and pulmonary function test. The 100 Uighur COPD patients were assessed by revised GOLD2011. Results Assessed by revised GOLD2011,the patients of A,B and C grade accounted for 22%,35% and 30%,respectively. There was no statistical significance in the distributions of the V4,F+1 alleles between the patients and the controls(P>0.05). There was no statistical significance between SNPs in ADAM33(V4 and F+1) with the decreased lung function and the grade of COPD(P>0.05). Conclusion There was no association between polymorphism of V4,F+1 in ADAM33 gene and COPD in a northwestern Uighur population.

Citation： Wang Qiong, Xia Yu, Hu Xin, Wang Jing, Sang Ke, Li Shuang, Qimanguli Wushouer. Association of ADAM33 Gene Polymorphisms with COPD in A Northwestern Uighur Population. Chinese Journal of Respiratory and Critical Care Medicine, 2013, 12(2): 136-141. doi: 10.7507/1671-6205.2014034 Copy