慢性阻塞性肺疾病与细菌感染及抗感染治疗_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

李钊 ¹ ,  姚婉贞 ²

1. ;
2. ;

Corresponding author：

姚婉贞, Email: yaowanzhen@126.com

Keywords：

DOI：

10.7507/1671-6205.2014102

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Citation： 李钊, 姚婉贞. 慢性阻塞性肺疾病与细菌感染及抗感染治疗. Chinese Journal of Respiratory and Critical Care Medicine, 2014, 13(4): 414-418. doi: 10.7507/1671-6205.2014102 Copy

1.	Mannino DM,Buist AS.Global burden of COPD:risk factors,prevalence,and future trends.Lancet,2007,370:765-773.
2.	NHLBI.Chronic obstructive pulmonary disease data fact sheet.03-5229.NIH Publication; 2003.
3.	Global surveillance,prevention and control of chronic respiratory diseases.A comprehensive approach.WHO;2007,ISBN 9789241563468;2007 http://www.who.int/respiratory/publications/global_surveillance/en/index.html.
4.	Zhong N,Wang C,Yao W,et al.Prevalence of chronic obstructive pulmonary disease in China:a large,population-based survey.Am J Respir Crit Care Med,2007,176:753-760.
5.	Wilson R,Sethi S,Anzueto A,et al.Antibiotics for treatment and prevention of exacerbations of chronic obstructive pulmonary disease.J Infect,2013,67:495-515.
6.	Sethi S,Evans N,Grant BJ,et al.New strains of bacteria and exacerbations of chronic obstructive pulmonary disease.N Engl J Med,2002,347:465-471.
7.	Rothberg MB,Pekow PS,Lahti M,et al.Antibiotic therapy and treatment failure in patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease.JAMA,2010,303:2035-2042.
8.	Kumar V,Abbas AK,Aster JC,et al.Pathological basis of disease,8th Edition.Philadelphia:Elsevier Saunders,2009,161:683-688.
9.	Hoenderdos K,Condliffe A.The neutrophil in chronic obstructive pulmonary disease.Am J Respir Cell Mol Biol,2013,48:531-539.
10.	Murphy TF,Sethi S.Bacterial infection in chronic obstructive pulmonary disease.Am Rev Respir Dis,1992,146:1067-1083.
11.	Sethi S.Bacterial Infection and the Pathogenesis of COPD.Chest,2000,117:286-291.
12.	Ganesan S,Sajjan US.Repair and Remodeling of airway epithelium after injury in chronic obstructive pulmonary disease.Curr Respir Care Rep,2013,2(3).
13.	Zakharkina T,Heinzel E,Koczulla RA,et al.Analysis of the airway microbiota of healthy individuals and patients with chronic obstructive pulmonary disease by T-RFLP and clone sequencing.PLoS One,2013,8(7):e68302.
14.	Matkovic Z,Miravitlles M.Chronic bronchial infection in COPD.Is there an infective phenotype? Respir Med,2013,107:10-22.
15.	Bansal M,Khatri M,Taneja V.Potential role of periodontal infection in respiratory diseases-a review.J Med Life,2013,6:244-248.
16.	Hurst JR,Wilkinson TM,Perera WR.Relationships among bacteria,upper airway,lower airway,and systemic inflammation in COPD.Chest,2005,127:1219-1226.
17.	Wark PA,Tooze M,Powell H,et al.Viral and bacterial infection in acute asthma and chronic obstructive pulmonary disease increases the risk of readmission.Respirology,2013,18:996-1002.
18.	Murphy TF,Brauer AL,Eschberger K,et al.Pseudomonas aeruginosa in chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2008,177:853-860.
19.	Sethi S,Sethi R,EschbergerK,et al. Airway bacterial concentrations and exacerbations of chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2007,176:356-361.
20.	Murphy TF,Brauer AL,Sethi S,et al.Haemophilus haemolyticus:a human respiratory tract commensal to be distinguished from Haemophilus influenzae.J Infect Dis,2007,195:81-89.
21.	Miravitlles M,Kruesmann F,Haverstock D,et al.Sputum colour and bacteria in chronic bronchitis exacerbations:a pooled analysis.Eur Respir J,2012,39:1354-1360.
22.	Soler N,Agustí C,Angrill J,et al.Bronchoscopic validation of the signify-cance of sputum purulence in severe exacerbations of chronic obstructive pulmonary disease.Thorax,2007,62:29-35.
23.	Vollenweider DJ,Jarrett H,Steurer-Stey CA,et al.Antibiotics for exacer-bation of chronic obstructive pulmonary diseases.Cochrane Database Syst Rev,2012,12:CD010257.
24.	Daniels JMA,Snijders D,de Graaff CS,et al.Antibiotics in addition to systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2010,181:150-157.
25.	Llor C,Moragas A,Hem andez S,et al.Efficacy of antibiotic therapy for acute exacerbations of mild to moderate COPD.Am J Respir Crit Care Med,2012,186:716-723.
26.	Groenewegen KH,Wouters EF.Bacterial infections in patients requiring admission for an acute exacerbation of COPD; a 1-year prospective study.Respir Med,2003,97:770-777.
27.	Papi A,Bellettato CM,Braccioni F,et al.Infections and airway infla-mmation in chronic obstructive pulmonary disease severe exacerbations.Am J Respir Crit Care Med,2006,173:1114-1121.
28.	Monsó E,Garcia-Aymerich J,Soler N,et al.Bacterial infection in exacer-bated COPD with changes in sputum characteristics.Epidemiol Infect,2003,131:799-804.
29.	Leophonte P.Infections in chronic obstructive pulmonary disease.Ball Aead Natl Med,2004,188:47-64.
30.	Lieberman D,Lieberman D.Pseudomonal infections in patients with COPD:epidemiology and management.Am J Respir Med,2003,2:459-468.
31.	Lapteva IM,LaptevaEA,KorovkinVS.Lung function and bacterial pathogens in sputum of patients with acute exacerbation of COPD.Eur Respir J,2004,24:408.
32.	Ye F,He LX,Cai BQ,et al.Spectrum and antimicrobial resistance of common pathogenic bacteria isolated from patients with acute exacerbation of chronic obstructive pulmonary disease in mainland of China.Chin Med J (Engl),2013,126:2207-2214.
33.	Li XJ,Li Q,Si LY,Yuan QY.Bacteriological differences between COPD exacerbation and community-acquired pneumonia.Respir Care,2011,56:1818-1824.
34.	Domenech A,Puig C,Martí S,et al.Infectious etiology of acute exacer-bations in severe COPD patients.J Infect,2013,67:516-523.
35.	姚婉贞,路明.慢性阻塞性肺疾病急性加重如何合理使用抗生素.中国实用内科杂志,2012,32:558-560.
36.	National Institute of Health,National Heart Lung and Blood Institute.Global Initiative for Chronic Obstructive Pulmonary Disease.Global strategy for the Diagnosis,Management and Prevention of Chronic Obstructive Pulmonary Disease.Updated 2011; Available from URL:http://www.Goldcopd.Org.
37.	Bandak SI,Bolzon LD,Turnak MR,et al.Cefaclor versus amoxicillin/clavulanate in acute bacterial exacerbations of chronic bronchitis:a randomised multicentre study.Int J Clin Pract,1999,53:578-583.
38.	Chodosh S,DeAbate CA,Haverstock D,et al.The Bronchitis Study Group.Short course moxifloxacin therapy for treatment of acute bacterial exacerbations of chronic bronchitis.Respir Med,2000,94:18-27.
39.	Weiss LR.Open-label,randomized comparison of clarithromycin,levofloxacin and cefuroxime axetil in the treatment of adults with acute bacterial exacerbations of chronic bronchitis.Clin Ther,2002,24:1414-1424.
40.	Albert RK,Connett J,Bailey WC,et al.Azithromycin for prevention of exacerbations of COPD.N Engl J Med,2011,365:689-698.
41.	Suzuki T,Yanai M,Yamaya M,et al.Erythromycin and common cold in COPD.Chest,2001,120:730-733.
42.	Banerjee D,Honeybourne D,Khair OA.The effect of oral clarithromycin on bronchial airway inflammation in moderate-tosevere stable COPD:a randomized controlled trial.Treat Respir Med,2004,3:59-65.
43.	Blasi F,Bonardi D,Aliberti S,et al.Long-term azithromycin use in patients with chronic obstructive pulmonary disease and tracheostomy.Pulmon Phamacol Ther,2010,23:200-207.
44.	He ZY,Ou LM,Zhang JQ,et al.Effect of 6 months of erythromycin treatment on inflammatory cells in induced sputum and exacerbations in chronic obstructive pulmonary disease.Respiration,2010,80:445-452.
45.	Pomares X,Montón C,Espasa M,et al.Long-term azithromycin therapy in patients with severe COPD and repeated exacerbations.Int J COPD,2011,6:449-456.
46.	Seemungal TA,Wilkinson TM,Hurst JR,et al.Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations.Am J Respir Crit Care Med,2008,178:1139-1147.
47.	Hodge S,Reynolds PN.Low-dose azithromycin improves phagocytosis of bacteria by both alveolar and monocyte-derived macrophages in chronic obstructive pulmonary disease subjects.Respirology,2012,17:802-807.
48.	Albert RK,Connett J,Bailey WC,et al.Azithromycin for prevention of exacerbations of COPD.N Engl J Med,2011,365:689-698.
49.	Sethi S,Jones PW,Theron MS,et al.Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease:a randomized controlled trial.Respir Res,2010,11:10.
50.	Ray WA,Murray KT,Hall K,et al.Azithromycin and the risk of cardio-vascular death.N Engl J Med,2012,366:1881-1890.
51.	Miravitlles M,Soler-Cataluna JJ,Calle M,et al.Spanish COPD Guidelines (GesEPOC):pharmacological treatment of stable COPD.Arch Bronconeumol,2012,48:247-257.
52.	Wilson R,Sethi S,Anzueto A,et al.Antibiotics for treatment and pre-vention of exacerbations of chronic obstructive pulmonary disease.J Infect,2013,67:497-515.
53.	Ramsey B,Pepe MS,Quan JM,et al.Cystic Fibrosis Inhaled Tobramycin Study Group.Intermittent administration of inhaled tobramycin in patients with cystic fibrosis.N Engl J Med,1999,340:23-30.
54.	Murphy TD,Anbar RD,Lester LA,et al.Treatment with tobramycin solution for inhalation reduces hospitalizations in young CF subjects with mild lung disease.Pediatr Pulmonol,2004,38:314-320.
55.	Wilson R,Welte T,Polverino E,et al.Ciprofloxacin DPI in non-cystic fibrosis bronchiectasis:a phase Ⅱ randomised study.Eur Resp J,2013,41:1107-1115.
56.	Drobnic ME,Suñé P,Montoro JB,et al.Inhaled tobramycin in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection with Pseudomonas aeruginosa.Ann Pharmacother,2005,39:39-44.
57.	Murray MP,Govan JR,Doherty CJ,et al.A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis.Am J Respir Crit Care Med,2011,183:491-499.
58.	Wilson R,Welte T,Polverino E,et al.Ciprofloxacin DPI in non-cystic fibrosis bronchiectasis:a phase Ⅱ randomised study.Eur Resp J,2013,41:1107-1115.
59.	Dal Negro R,Micheletto C,Tognella S,et al.Tobramycin nebulizer solution in severe COPD patients colonized with Pseudomonas aeruginosa:effects on bronchial inflammation.Adv Ther,2008,25:1019-1030.
60.	Couch LA.Treatment with tobramycin solution for inhalation in bronchie-ctasis patients with Pseudomonas aeruginosa.Chest,2001,120:114S-117S.
61.	Bilton D,Henig N,Morrissey B,et al.Addition of inhaled tobramycin to ciprofloxacin for acute exacerbations of Pseudomonas aeruginosa infection in adult bronchiectasis.Chest,2006,130:1503-1510.
62.	Hagerman JK,Hancock KE,Klepser ME.Aerosolised antibiotics:a critical appraisal of their use.Expert Opin Drug Deliv,2006,3:71-86.
63.	康怡,赖国祥,柳德灵.慢性阻塞性肺疾病与细菌感染.中国呼吸与危重监护杂志,2011,10:298-300.

1. Mannino DM,Buist AS.Global burden of COPD:risk factors,prevalence,and future trends.Lancet,2007,370:765-773.
2. NHLBI.Chronic obstructive pulmonary disease data fact sheet.03-5229.NIH Publication; 2003.
3. Global surveillance,prevention and control of chronic respiratory diseases.A comprehensive approach.WHO;2007,ISBN 9789241563468;2007 http://www.who.int/respiratory/publications/global_surveillance/en/index.html.
4. Zhong N,Wang C,Yao W,et al.Prevalence of chronic obstructive pulmonary disease in China:a large,population-based survey.Am J Respir Crit Care Med,2007,176:753-760.
5. Wilson R,Sethi S,Anzueto A,et al.Antibiotics for treatment and prevention of exacerbations of chronic obstructive pulmonary disease.J Infect,2013,67:495-515.
6. Sethi S,Evans N,Grant BJ,et al.New strains of bacteria and exacerbations of chronic obstructive pulmonary disease.N Engl J Med,2002,347:465-471.
7. Rothberg MB,Pekow PS,Lahti M,et al.Antibiotic therapy and treatment failure in patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease.JAMA,2010,303:2035-2042.
8. Kumar V,Abbas AK,Aster JC,et al.Pathological basis of disease,8th Edition.Philadelphia:Elsevier Saunders,2009,161:683-688.
9. Hoenderdos K,Condliffe A.The neutrophil in chronic obstructive pulmonary disease.Am J Respir Cell Mol Biol,2013,48:531-539.
10. Murphy TF,Sethi S.Bacterial infection in chronic obstructive pulmonary disease.Am Rev Respir Dis,1992,146:1067-1083.
11. Sethi S.Bacterial Infection and the Pathogenesis of COPD.Chest,2000,117:286-291.
12. Ganesan S,Sajjan US.Repair and Remodeling of airway epithelium after injury in chronic obstructive pulmonary disease.Curr Respir Care Rep,2013,2(3).
13. Zakharkina T,Heinzel E,Koczulla RA,et al.Analysis of the airway microbiota of healthy individuals and patients with chronic obstructive pulmonary disease by T-RFLP and clone sequencing.PLoS One,2013,8(7):e68302.
14. Matkovic Z,Miravitlles M.Chronic bronchial infection in COPD.Is there an infective phenotype? Respir Med,2013,107:10-22.
15. Bansal M,Khatri M,Taneja V.Potential role of periodontal infection in respiratory diseases-a review.J Med Life,2013,6:244-248.
16. Hurst JR,Wilkinson TM,Perera WR.Relationships among bacteria,upper airway,lower airway,and systemic inflammation in COPD.Chest,2005,127:1219-1226.
17. Wark PA,Tooze M,Powell H,et al.Viral and bacterial infection in acute asthma and chronic obstructive pulmonary disease increases the risk of readmission.Respirology,2013,18:996-1002.
18. Murphy TF,Brauer AL,Eschberger K,et al.Pseudomonas aeruginosa in chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2008,177:853-860.
19. Sethi S,Sethi R,EschbergerK,et al. Airway bacterial concentrations and exacerbations of chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2007,176:356-361.
20. Murphy TF,Brauer AL,Sethi S,et al.Haemophilus haemolyticus:a human respiratory tract commensal to be distinguished from Haemophilus influenzae.J Infect Dis,2007,195:81-89.
21. Miravitlles M,Kruesmann F,Haverstock D,et al.Sputum colour and bacteria in chronic bronchitis exacerbations:a pooled analysis.Eur Respir J,2012,39:1354-1360.
22. Soler N,Agustí C,Angrill J,et al.Bronchoscopic validation of the signify-cance of sputum purulence in severe exacerbations of chronic obstructive pulmonary disease.Thorax,2007,62:29-35.
23. Vollenweider DJ,Jarrett H,Steurer-Stey CA,et al.Antibiotics for exacer-bation of chronic obstructive pulmonary diseases.Cochrane Database Syst Rev,2012,12:CD010257.
24. Daniels JMA,Snijders D,de Graaff CS,et al.Antibiotics in addition to systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2010,181:150-157.
25. Llor C,Moragas A,Hem andez S,et al.Efficacy of antibiotic therapy for acute exacerbations of mild to moderate COPD.Am J Respir Crit Care Med,2012,186:716-723.
26. Groenewegen KH,Wouters EF.Bacterial infections in patients requiring admission for an acute exacerbation of COPD; a 1-year prospective study.Respir Med,2003,97:770-777.
27. Papi A,Bellettato CM,Braccioni F,et al.Infections and airway infla-mmation in chronic obstructive pulmonary disease severe exacerbations.Am J Respir Crit Care Med,2006,173:1114-1121.
28. Monsó E,Garcia-Aymerich J,Soler N,et al.Bacterial infection in exacer-bated COPD with changes in sputum characteristics.Epidemiol Infect,2003,131:799-804.
29. Leophonte P.Infections in chronic obstructive pulmonary disease.Ball Aead Natl Med,2004,188:47-64.
30. Lieberman D,Lieberman D.Pseudomonal infections in patients with COPD:epidemiology and management.Am J Respir Med,2003,2:459-468.
31. Lapteva IM,LaptevaEA,KorovkinVS.Lung function and bacterial pathogens in sputum of patients with acute exacerbation of COPD.Eur Respir J,2004,24:408.
32. Ye F,He LX,Cai BQ,et al.Spectrum and antimicrobial resistance of common pathogenic bacteria isolated from patients with acute exacerbation of chronic obstructive pulmonary disease in mainland of China.Chin Med J (Engl),2013,126:2207-2214.
33. Li XJ,Li Q,Si LY,Yuan QY.Bacteriological differences between COPD exacerbation and community-acquired pneumonia.Respir Care,2011,56:1818-1824.
34. Domenech A,Puig C,Martí S,et al.Infectious etiology of acute exacer-bations in severe COPD patients.J Infect,2013,67:516-523.
35. 姚婉贞,路明.慢性阻塞性肺疾病急性加重如何合理使用抗生素.中国实用内科杂志,2012,32:558-560.
36. National Institute of Health,National Heart Lung and Blood Institute.Global Initiative for Chronic Obstructive Pulmonary Disease.Global strategy for the Diagnosis,Management and Prevention of Chronic Obstructive Pulmonary Disease.Updated 2011; Available from URL:http://www.Goldcopd.Org.
37. Bandak SI,Bolzon LD,Turnak MR,et al.Cefaclor versus amoxicillin/clavulanate in acute bacterial exacerbations of chronic bronchitis:a randomised multicentre study.Int J Clin Pract,1999,53:578-583.
38. Chodosh S,DeAbate CA,Haverstock D,et al.The Bronchitis Study Group.Short course moxifloxacin therapy for treatment of acute bacterial exacerbations of chronic bronchitis.Respir Med,2000,94:18-27.
39. Weiss LR.Open-label,randomized comparison of clarithromycin,levofloxacin and cefuroxime axetil in the treatment of adults with acute bacterial exacerbations of chronic bronchitis.Clin Ther,2002,24:1414-1424.
40. Albert RK,Connett J,Bailey WC,et al.Azithromycin for prevention of exacerbations of COPD.N Engl J Med,2011,365:689-698.
41. Suzuki T,Yanai M,Yamaya M,et al.Erythromycin and common cold in COPD.Chest,2001,120:730-733.
42. Banerjee D,Honeybourne D,Khair OA.The effect of oral clarithromycin on bronchial airway inflammation in moderate-tosevere stable COPD:a randomized controlled trial.Treat Respir Med,2004,3:59-65.
43. Blasi F,Bonardi D,Aliberti S,et al.Long-term azithromycin use in patients with chronic obstructive pulmonary disease and tracheostomy.Pulmon Phamacol Ther,2010,23:200-207.
44. He ZY,Ou LM,Zhang JQ,et al.Effect of 6 months of erythromycin treatment on inflammatory cells in induced sputum and exacerbations in chronic obstructive pulmonary disease.Respiration,2010,80:445-452.
45. Pomares X,Montón C,Espasa M,et al.Long-term azithromycin therapy in patients with severe COPD and repeated exacerbations.Int J COPD,2011,6:449-456.
46. Seemungal TA,Wilkinson TM,Hurst JR,et al.Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations.Am J Respir Crit Care Med,2008,178:1139-1147.
47. Hodge S,Reynolds PN.Low-dose azithromycin improves phagocytosis of bacteria by both alveolar and monocyte-derived macrophages in chronic obstructive pulmonary disease subjects.Respirology,2012,17:802-807.
48. Albert RK,Connett J,Bailey WC,et al.Azithromycin for prevention of exacerbations of COPD.N Engl J Med,2011,365:689-698.
49. Sethi S,Jones PW,Theron MS,et al.Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease:a randomized controlled trial.Respir Res,2010,11:10.
50. Ray WA,Murray KT,Hall K,et al.Azithromycin and the risk of cardio-vascular death.N Engl J Med,2012,366:1881-1890.
51. Miravitlles M,Soler-Cataluna JJ,Calle M,et al.Spanish COPD Guidelines (GesEPOC):pharmacological treatment of stable COPD.Arch Bronconeumol,2012,48:247-257.
52. Wilson R,Sethi S,Anzueto A,et al.Antibiotics for treatment and pre-vention of exacerbations of chronic obstructive pulmonary disease.J Infect,2013,67:497-515.
53. Ramsey B,Pepe MS,Quan JM,et al.Cystic Fibrosis Inhaled Tobramycin Study Group.Intermittent administration of inhaled tobramycin in patients with cystic fibrosis.N Engl J Med,1999,340:23-30.
54. Murphy TD,Anbar RD,Lester LA,et al.Treatment with tobramycin solution for inhalation reduces hospitalizations in young CF subjects with mild lung disease.Pediatr Pulmonol,2004,38:314-320.
55. Wilson R,Welte T,Polverino E,et al.Ciprofloxacin DPI in non-cystic fibrosis bronchiectasis:a phase Ⅱ randomised study.Eur Resp J,2013,41:1107-1115.
56. Drobnic ME,Suñé P,Montoro JB,et al.Inhaled tobramycin in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection with Pseudomonas aeruginosa.Ann Pharmacother,2005,39:39-44.
57. Murray MP,Govan JR,Doherty CJ,et al.A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis.Am J Respir Crit Care Med,2011,183:491-499.
58. Wilson R,Welte T,Polverino E,et al.Ciprofloxacin DPI in non-cystic fibrosis bronchiectasis:a phase Ⅱ randomised study.Eur Resp J,2013,41:1107-1115.
59. Dal Negro R,Micheletto C,Tognella S,et al.Tobramycin nebulizer solution in severe COPD patients colonized with Pseudomonas aeruginosa:effects on bronchial inflammation.Adv Ther,2008,25:1019-1030.
60. Couch LA.Treatment with tobramycin solution for inhalation in bronchie-ctasis patients with Pseudomonas aeruginosa.Chest,2001,120:114S-117S.
61. Bilton D,Henig N,Morrissey B,et al.Addition of inhaled tobramycin to ciprofloxacin for acute exacerbations of Pseudomonas aeruginosa infection in adult bronchiectasis.Chest,2006,130:1503-1510.
62. Hagerman JK,Hancock KE,Klepser ME.Aerosolised antibiotics:a critical appraisal of their use.Expert Opin Drug Deliv,2006,3:71-86.
63. 康怡,赖国祥,柳德灵.慢性阻塞性肺疾病与细菌感染.中国呼吸与危重监护杂志,2011,10:298-300.

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慢性阻塞性肺疾病与细菌感染及抗感染治疗

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