Levels of Serum IL-6, TNF-αand C-reactive Protein in Elderly Patients with Moderate to Severe COPD at Stable Stage and Its Relationship with Lung Function_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

LiYi ,  ChenQizhang , ChenXiaojun , MaHui , WangJiaqi , ZhangXiaojun , WeiLing

Department of Respiratory Medicine, Cadre Ward, Gansu Provincial Hospital, Lanzhou, Gansu, 730000, China;

Corresponding author：

ChenQizhang, Email: mj7690@163.com

Keywords：

Elderly patients; Chronic obstructive pulmonary disease; Stable phase; Interleukin-6; Tumor necrosis factor-α; C-reactive protein

DOI：

10.7507/1671-6205.2014111

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Objective To explore the relationship of levels of serum interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α) and C-reactive protein (CRP) with lung function in elderly patients with stable COPD and whose pulmonary function classification was levelⅡor above. Methods Sixty elderly patients with stable COPD and with the pulmonary function classification of levelⅡor above and 35 age-matched healthy subjects in the Gansu Provincial Hospital from November 2012 to March in 2014 were recruited in the study.Serum IL-6, TNF-αand CRP levels were detected by electro-chemiluminescence immunoassay (ECLI), enzyme-linked immunosorbent assay and immunoturbidimetric assay, respectively.And their relationships with lung function were explored by Spearman correlation analysis. Results The levels of serum IL-6[(33.0±15.1) mg/L vs.(15.9±8.7) mg/L], TNF-α[(53.8±20.1) pg/mL vs.(22.2±8.0) pg/mL] and CRP[(8.7±3.9) mg/L vs.(5.8±2.3) mg/L] were significantly higher in the stable COPD patients than those in the healthy controls (P < 0.01).With the increase of COPD severity grade, the levels of serum IL-6, TNF-αand CRP increased gradually, and the lung function of FEV₁%pred and FEV₁/FVC decreased gradually (P < 0.05).The levels of serum IL-6, TNF-αand CRP were negatively correlated with lung function (P < 0.05). Conclusions There is airway inflammation in elderly patients with stable COPD.Airway inflammation may be the reason of the decline of pulmonary function in patients with stable COPD.

Citation： LiYi, ChenQizhang, ChenXiaojun, MaHui, WangJiaqi, ZhangXiaojun, WeiLing. Levels of Serum IL-6, TNF-αand C-reactive Protein in Elderly Patients with Moderate to Severe COPD at Stable Stage and Its Relationship with Lung Function. Chinese Journal of Respiratory and Critical Care Medicine, 2014, 13(5): 449-452. doi: 10.7507/1671-6205.2014111 Copy

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12.	王春雷, 蔡日丹, 康健, 等.慢性阻塞性肺病患者细胞因子与氧自由基的相关性.中国老年学杂志, 2010, 30:310-312.
13.	Quint JK, Wedzicha JA.The neutrophil in chronic obstructive pulmonary disease.J Allergy Clin Immunol, 2007, 119:1065-1071.
14.	de Torres JP, Cordoba-Lanus E, López-Aguilar C, et al.C-reactive protein levels and clinically important predictive outcomes in stable COPD patients.Eur Respir J, 2006, 27:902-907.
15.	赵琳, 崔妙玲, 何志义.慢性阻塞性肺疾病合并症的研究进展.医学综述, 2013, 19:3899-3901.
16.	Semik-Orzech A, Barczyk A, Pierzchala W.The role of interleukin 17 cytokine family in inducing allergic inflammation in the pulmonary tract.Pneumonol Alergol Pol, 2006, 74:409-413.
17.	Joppa P, Petrasova D, Stancak B, R.T.Systemic inflammation in patients with COPD and pulmonary hypertension.Chest, 2006, 130:326-333.
18.	Attaran D, Lari SM, Towhidi M, et al.Interleukin-6 and airflow limitation in chemical warfare patients with chronic obstructive pulmonary disease.Int J Chron Obstruct Pulmon Dis, 2010, 5:335-340.
19.	Moermans C, Heinen V, Nguyen M, et al.Local and systemic cellular inflammation and cytokine release in chronic obstructive pulmonary disease.Cytokine, 2011, 56:298-304.
20.	苗丽君, 郑富霞, 王静, 等.炎性生物标志物与慢性阻塞性肺疾病患者生存关系的前瞻性研究.中华老年医学杂志, 2013, 32:404-407.

1. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013年修订版).中华结核和呼吸杂志, 2013, 36:255-264.
2. Young J, Donahue M, Farquhar M, Simpson C, G.R.Using opioids to treat dyspnea in advanced COPD:attitudes and experiences of family physicians and respiratory therapists.Can Fam Physician, 2012, 58:e401-407.
3. 何智辉, 陈平.慢性阻塞性肺疾病患者体内白介素-6和C反应蛋白质量浓度的变化及意义.中国实用内科杂志(临床版), 2006, 26:989-991.
4. Vestbo J, Hurd SS, R.R-R.The 2011 revision of the global strategy for the diagnosis, management and prevention of COPD (GOLD)——why and what? Clin Respir J, 2012, 6:208-214.
5. Rabe KF, Hurd S, Anzueto A, et al.Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease:GOLD executive summary.Am J Respir Crit Care Med, 2007, 17:532-555.
6. Weissenbach J, Chernajovsky Y, Zeevi M, et al.Two interferon mRNAs in human fibroblasts:in vitro translation and Escherichia coli cloning studies.Proc Natl Acad Sci U S A, 1980, 77:7152-7156.
7. 吴纪珍, 马利军, 李素云, 等.慢性阻塞性肺疾病发作期与缓解期体内胶原、细胞因子变化及临床意义.中国实用内科杂志(临床版), 2005, 25:703-704.
8. Lee TM, Lin MS, Chang NC.Usefulness of C-reactive protein and interleukin-6 as predictors of outcomes in patients with chronic obstructive pulmonary disease receiving pravastatin.Am J Cardiol, 2008, 101:530-535.
9. 鹏银芳, 于莹, 陆志芳.IL-13和TNF-α在肺炎支原体肺炎儿童血清中的表达及意义.中国当代儿科杂志, 2010, 12:275-277.
10. 王海龙, 孙丽蓉.IL-6基因多态性与COPD肺动脉高压研究进展.临床肺科杂志, 2011, 16:1928-1930.
11. 王化强, 吕沈源.慢性阻塞性肺疾病患者血清IL-6与FEV₁相关性研究.中国医药科学, 2011, 01:114-115.
12. 王春雷, 蔡日丹, 康健, 等.慢性阻塞性肺病患者细胞因子与氧自由基的相关性.中国老年学杂志, 2010, 30:310-312.
13. Quint JK, Wedzicha JA.The neutrophil in chronic obstructive pulmonary disease.J Allergy Clin Immunol, 2007, 119:1065-1071.
14. de Torres JP, Cordoba-Lanus E, López-Aguilar C, et al.C-reactive protein levels and clinically important predictive outcomes in stable COPD patients.Eur Respir J, 2006, 27:902-907.
15. 赵琳, 崔妙玲, 何志义.慢性阻塞性肺疾病合并症的研究进展.医学综述, 2013, 19:3899-3901.
16. Semik-Orzech A, Barczyk A, Pierzchala W.The role of interleukin 17 cytokine family in inducing allergic inflammation in the pulmonary tract.Pneumonol Alergol Pol, 2006, 74:409-413.
17. Joppa P, Petrasova D, Stancak B, R.T.Systemic inflammation in patients with COPD and pulmonary hypertension.Chest, 2006, 130:326-333.
18. Attaran D, Lari SM, Towhidi M, et al.Interleukin-6 and airflow limitation in chemical warfare patients with chronic obstructive pulmonary disease.Int J Chron Obstruct Pulmon Dis, 2010, 5:335-340.
19. Moermans C, Heinen V, Nguyen M, et al.Local and systemic cellular inflammation and cytokine release in chronic obstructive pulmonary disease.Cytokine, 2011, 56:298-304.
20. 苗丽君, 郑富霞, 王静, 等.炎性生物标志物与慢性阻塞性肺疾病患者生存关系的前瞻性研究.中华老年医学杂志, 2013, 32:404-407.

Chinese Journal of Respiratory and Critical Care Medicine

Levels of Serum IL-6, TNF-αand C-reactive Protein in Elderly Patients with Moderate to Severe COPD at Stable Stage and Its Relationship with Lung Function

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