Preliminary Investigation on Correlation between Brain Natriuretic Peptide and Cardiopulmonary Function, Prognosis of Patients with Interstitial Lung Disease_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 HuangZhijian , LuoQin , SunFeiyu , WuAiqun , LinWei , ZhangJiangdong

Emergency Department, The Affiliated Chinese Traditional Medicine Hospital in Xiamen of Fujian TMC University, Xiamen, Fujian, 361009, China;

Corresponding author：

HuangZhijian, Email: doctorhzj_xj@sina.cn

Keywords：

Brain natriuretic peptide; Interstitial lung disease; Cardiopulmonary function

DOI：

10.7507/1671-6205.2014119

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Objective To investigate the correlation between brain natriuretic peptide (BNP) and cardiopulmonary function, as well as explore prognostic value of BNP in patients with interstitial lung disease(ILD). Methods The clinical data of ILD patients admitted between February 2010 and April 2013 were retrospectively analyzed.The relationship between serum BNP level and cardiopulmonary function was analyzed by Pearson's or Spearman's rank correlation test.Meanwhile, the patients were divided into a survivor group and a death group, as well as a pulmonary hypertention (PH) group and a normal group respectively.Clinical data were compared between two groups. Results There were 38 patients included in the study.BNP concentration was correlated with echocardiographic indices of right heart function, including systolic pressure of pulmonary artery, right atrial inlet diameter, right ventricular inlet diameter, and right ventricular end-diastollc diameter (P < 0.05), but not correlated with echocardiographic parameters of left heart function (P > 0.05).BNP was also correlated with D_LCO%pred.BNP and right heart function parameters except right atrial inlet diameter were significantly higher, and D_LCO%pred, were significantly lower in the death group and the PH group than those in the survivor group and the normal group (P < 0.05). Conclusions Serum BNP concentration can reflect right heart function appropriately, suggesting pulmonary vascular impairment in ILD patients contributes to increased pulmonary vascular resistance.Elevated BNP levels are associated with increased mortality and poor prognosis in patients with ILD.

Citation： HuangZhijian, LuoQin, SunFeiyu, WuAiqun, LinWei, ZhangJiangdong. Preliminary Investigation on Correlation between Brain Natriuretic Peptide and Cardiopulmonary Function, Prognosis of Patients with Interstitial Lung Disease. Chinese Journal of Respiratory and Critical Care Medicine, 2014, 13(5): 490-493. doi: 10.7507/1671-6205.2014119 Copy

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1. Lettieri CJ, Nathan SD, Barnett SD, et al.Prevalence and outcomes of pulmonary arterial hypertension in advanced idiopathic pulmonary fibrosis.Chest, 2006, 129:746-752.
2. Hamada K, Nagai S, Tanaka S, et al.Significance of pulmonary arterial pressure and diffusion capacity of the lung as prognosticator in patients with idiopathic pulmonary fibrosis.Chest, 2007, 131:650-656.
3. Hamada K, Nagai S, Tanaka S, et al.Significance of pulmonary arterial pressure and diffusion capacity of the lung as prognosticators in patients with idiopathic pulmonary fibrosis.Chest, 2007, 131:650-656.
4. King TE Jr, Tooze JA, Schwarz MI, et al.Predicting survival in idiopathic pulmonary fibrosis:scoring system and survival model.Am J Respir Crit Care Med, 2001, 164:1171-1181.
5. Barst R, McGoon M, Torbicki A, et al.Diagnosis and differential assessment of pulmonary arterial hypertension.J Am Coll Cardiol, 2004, 43:40-47.
6. Sztrymf B, Souza R, Bertoletti L, et al.Prognostic factors of acute heart failure in patients with pulmonary arterial hypertension.Eur Respir J, 2010, 35:1286-1293.
7. Dentali F, Donadini M, Gianni M, et al.Brain natriuretic peptide as a preclinical marker of chronic pulmonary hypertension in patients with pulmonary embolism.Intern Emerg Med, 2009, 4:123-128.
8. Leuchte H, Baumgartner R, Elnounou M, et al.Brain natriuretic peptide is a prognostic parameter in chronic lung disease.Am J Respir Crit Care Med, 2006, 173:744-750.
9. Nathan SD, Shlobin OA, Ahmad S, et al.Pulmonary hypertension and pulmonary function testing in idiopathic pulmonary fibrosis.Chest, 2007, 131:657-663.
10. Shorr AF, Helman DL, Davies DB, et al.Pulmonary hypertension in advanced sarcoidosis:epidemiology and clinical characteristics.Eur Respir J, 2005, 25:783-788.
11. Steen VD, Graham G, Conte C, et al.Isolated diffusing capacity reduction in systemic sclerosis.Arthritis Rheum, 1992, 35:765-770.

Chinese Journal of Respiratory and Critical Care Medicine

Preliminary Investigation on Correlation between Brain Natriuretic Peptide and Cardiopulmonary Function, Prognosis of Patients with Interstitial Lung Disease

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