上气道咳嗽综合征的研究新进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

余莉 , 徐镶怀 , 吕寒静 ,  邱忠民

同济大学附属同济医院呼吸内科(上海 200065);

Corresponding author：

邱忠民, Email: qiuzhongmin@tongji.edu.cn

Keywords：

DOI：

10.7507/1671-6205.2014129

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Citation： 余莉, 徐镶怀, 吕寒静, 邱忠民. 上气道咳嗽综合征的研究新进展. Chinese Journal of Respiratory and Critical Care Medicine, 2014, 13(5): 526-530. doi: 10.7507/1671-6205.2014129 Copy

1.	Pratter MR.Chronic upper airway cough syndrome secondary to rhinosinus diseases (previously referred to as postnasal drip syndrome):ACCP evidence-based clinical practice guidelines.Chest, 2006, 129:63S-71S.
2.	Irwin RS, Boulet LP, Cloutier MM, et al.Managing cough as a defense mechanism and as a symptom.A consensus panel report of the American College of Chest Physicians.Chest, 1998, 114(2 Suppl Managing):133S-181S.
3.	中华医学会呼吸病学分会哮喘学组.咳嗽的诊断与治疗指南(2009版).中华结核和呼吸杂志, 2009, 32:407-413.
4.	Birring SS.Controversies in the evaluation and management of chronic cough.Am J Respir Crit Care Med, 2011, 183:708-715.
5.	Gibson PG, Chang AB, Glasgow NJ, et al.CICADA:Cough in children and adults:diagnosis and assessment.australian cough guidelines summary statement.Med J Aust, 2010, 192:265-271.
6.	Morice AH, Fontana GA, Sovijarvi AR, et al.The diagnosis and management of chronic cough.Eur Respir J, 2004, 24:481-492.
7.	赖克方, 陈如冲, 刘春丽, 等.不明原因慢性咳嗽的病因分布及诊断程序的建立.中华结核和呼吸杂志, 2006, 29:96-99.
8.	Wei W, Yu L, LüH, et al.Comparison of cause distribution between elderly and non-elderly patients with chronic cough.Respiration, 2009, 77:259-264.
9.	Palombini BC, Villanova CA, Araújo E, et al.A pathogenic triad in chronic cough:asthma, postnasal drip syndrome, and gastroesophageal reflux disease.Chest, 1999, 116:279-284.
10.	Kastelik JA, Aziz I, Ojoo JC, et al.Investigation and management of chronic cough using a probability-based algorithm.Eur Respir J, 2005, 25:235-243.
11.	Grabczak EM, Dabrowska M, Krenke R, et al.Does the established cause of chronic cough depend on diagnostic approach? J Physiol Pharmacol, 2008, 59 Suppl 6:285-296.
12.	Sanu A, Eccles R.Postnasal drip syndrome.Two hundred years of controversy between UK and USA.Rhinology, 2008, 46:86-91.
13.	Pratter MR, Bartter T, Aker S, et al.An algorithmic approach to chronic cough.Ann Internal Med, 1993, 119:977-983.
14.	Birring SS.New concepts in the management of chronic cough.Pulm Pharmacol Ther, 2011, 24:334-338.
15.	Morice AH, McGarvey L, Pavord I, et al.Recommendations for the management of cough in adults.Thorax, 2006, 61 Suppl 1:1-24.
16.	Saleh H.Rhinosinusitis, laryngopharyngeal reflux and cough:An ENT viewpoint.Pulm Pharmacol Ther, 2009, 22:127-129.
17.	Kohno S, Ishida T, Uchida Y, et al.The Japanese Respiratory Society guidelines for management of cough.Respirology, 2006, 11 Suppl 4:S135-S186.
18.	吕寒静, 邱忠民.2009年版开始诊治指南的解读.临床药物治疗杂志, 2011, 9:6-10.
19.	Bardin PG, Van Heerden BB, Joubert JR, et al.Absence of pulmonary aspiration of sinus contents in patients with asthma and sinusitis.J Allergy Clin Immunol, 1990, 86:82-88.
20.	O'Hara J, Jones NS. "Post-nasal drip syndrome":most patients with purulent nasal secretions do not complain of chronic cough.Rhinology, 2006, 44:270-273.
21.	Birring SS, Parker D, brightling CE, et al.Induced sputuminflammatory mediator concentrations in chronic cough.Am J Respir Crit Care Med, 2004, 169:15-19.
22.	时翠芹, 余莉, 魏为利, 等.气道炎症在上气道咳嗽综合征发生中的作用.中国呼吸与危重监护杂志, 2009, 8:256-258.
23.	Boulet LP, Milot J, Boutet M, et al.Airway inflammationin nonasthmatic chronic cough.Am J Respir Crit Care Med, 1994, 149:482-489.
24.	McGarvey LPA, Forsythe P, Heaney LG, et al.Bronchoalveolarlavage findings in patients with chronic nonproductive cough.Eur Respir J, 1999, 13:59-65.
25.	Jatakanon A, Lalloo UG, Lim S, et al.Increased neutrophils andcytokines, TNF-alpha and IL-8 in induced sputum of non-asthmatic patients with chronic dry cough.Thorax, 1999, 54:234-237.
26.	Lee SY, Cho JY, Shim JJ, et al.Airway inflammationas an assessment of chronic nonproductive cough.Chest, 2001, 120:1114-1120.
27.	Birring SS, Brightling CE, Symon FA, et al.Idiopathic chronic cough:association with organ specific autoimmune disease and bronchoalveolar lymphocytosis.Thorax, 2003, 58:1066-1070.
28.	Mund E, Christensson B, Gr nneberg R, et al.Noneosinophilic CD4 lymphocytic airway in flammation in menopausal women with chronic drycough.Chest, 2005, 127:1714-1721.
29.	Niimi A, Torrego A, Nicholson AG, et al.Nature of airway inflammation and remodeling in chronic cough.J Allergy Clin Immunol, 2005, 116:565-570.
30.	Niimi A.Structural changes in the airways:cause or effect of chronic cough? Pulm Pharmacol Ther, 2011, 24:328-333.
31.	马洪明, 刘升明, 林敏娟, 等.感觉神经肽在鼻后滴漏综合征性咳嗽中的作用.中国实用内科杂志, 2007, 27:531-532.
32.	O'Hanlon S, Facer P, Simpson KD, et al.Neuronalmarkers in allergic rhinitis:expression and correlation with sensory testing.Laryngoscope, 2007, 117:1519-527.
33.	Keh SM, Facer P, Simpson KD, et al.Increased nerve fiberexpression of sensory sodium channels Nav1.7, Nav1.8, and Nav1.9 inrhinitis.Laryngoscope, 2008, 118:573-579.
34.	Irwin RS, Ownbey R, Cagle PT, et al.Interpreting the histopathology of chronic cough:a prospective, controlled, comparative study.Chest, 2006, 130:362-370.
35.	Hara J, Fujimura M, Ueda A, et al.Effect of pressure stress applied to the airway on cough-reflex sensitivity in guinea pigs.Am J Respir Crit Care Med, 2008, 177:585-592.
36.	Wang de Y.Genetic predisposition for atopy and allergic rhinitis in the Singapore Chinese population.Asia Pac Allergy, 2011, 1:152-156.
37.	Pecova R, Zucha J, Pec M, et al.Cough reflex sensitivity testing in in seasonal allergic rhinitis patients and healthy volunteers.J Physiol Pharmacol, 2008, 59 Suppl 6:557-564.
38.	Pecova R, Vrlik M, Tatar M.Cough sensitivity in allergic rhinitis.J Physiol Pharmacol, 2005, 56 Suppl 4:171-178.
39.	Tatar M, Plevkova J, Brozmanova M, et al.Mechanisms of the cough associated with rhinosinusitis.Pulm Pharmacol Ther, 2009, 22:121-126.
40.	Plevkova J, Brozmanova M, Pecova R, et al.Effects of intranasal capsaicinchallenge on cough reflex in healthy human volunteers.J Physiol Pharmacol, 2004, 55 Suppl 3:101-106.
41.	Plevkova J, Brozmanova M, Pecova R, et al.The effects of nasal histamine challenge on cough reflex in healthy volunteers.Pulm Pharmacol Ther, 2006, 19:120-127.
42.	Plevkova J, Brozmanova M, Pecova R, et al.Effects of intranasal histamine on the cough reflex in subjects with allergic rhinitis.J Physiol Pharmacol, 2005, 56 Suppl 4:185-195.
43.	Plevkova J, Kollarik M, Brozmanova M, et al.Modulation of experimentally-induced cough by stimulation of nasal mucosa in cats and guinea pigs.Respir Physiol Neurobiol, 2004, 142:225-235.
44.	Brozmanova M, Bartos V, Plank L, et al.Experimental allergic rhinitis-related cough and airway eosinophilia in sensitized guinea pigs.J Physiol Pharmacol, 2007, 58 Suppl 5(Pt 1):57-65.
45.	Woodcock A, Young EC, Smith JA.New insights in cough.Br Med Bull, 2010, 96:61-73.
46.	Plevkova J, Song WJ.Chronic cough in subjects with upper airway diseases-analysis of mechanisms and clinical applications.Asia Pac Allergy, 2013, 3:127-135.
47.	Plevkova J, Poliacek I, Antosiewicz J, et al.Intranasal TRPV1 agonist capsaicin challenge and its effect on c-fos expression in the guinea pig brainstem.Respir Physiol Neurobiol, 2010, 173:11-15.
48.	PlevkováJ, Poliacek I, Adamkov M, et al.Brainstem neuronal populations activated in the model of ovalbumine induced allergic rhinitis in guinea pigs-the c-Fos study.Biologia, 2011, 66:922-927.
49.	Bucca C, Rolla G, ScappaticciE, et al.Histamine hyperresponsiveness of the extrathoracic airway in patient with asthmatic symptoms.Allergy, 1991, 46:147-153.
50.	Bucca CB, Bugiani M, Culla B, et al.Chronic cough and irritable larynx.J Allergy Clin Immunol, 2011, 127:412-419.
51.	Morice AH.The cough hypersensitivity syndrome:a novel paradigm for understanding cough.Lung, 2010, 188(Suppl 1):S87-S90.
52.	Millqvist E.The airway sensory hyperreactivity syndrome.Pulm Pharmacol Ther, 2011, 24:263-266.
53.	Vertigan AE, Gibson PG.Chronic refractory cough as a sensory neuropathy:evidence from a reinterpretation of cough triggers.J Voice, 2011, 25:596-601.
54.	Bessac BF, Jordt SE.Breathtaking TRP channels:TRPA1 and TRPV1 in airway chemosensation and reflex control.Physiology (Bethesda), 2008, 23:360-370.
55.	Groneberg DA, Niimi A, Dinh QT, et al.Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough.Am J Respir Crit Care Med, 2004, 170:1276-1280.
56.	Gibson PG, Ryan NM.Cough pharmacotherapy:current and future status.Expert Opin Pharmacother, 2011, 12:1745-1755.
57.	Kamei J, Nakanishi Y, Ishikawa Y, et al.Possible involvement of tetrodotoxin-resistant sodium channels in cough reflex.Eur J Pharmacol, 2011, 652:117-120.
58.	Muroi Y, Ru F, Chou YL, et al.Selective inhibition of vagal afferent nerve pathways regulating cough using Nav 1.7 shRNA silencing in guinea pig nodose ganglia.Am J Physiol Regul Integr Comp Physiol, 2013, 304:R1017-1023.

1. Pratter MR.Chronic upper airway cough syndrome secondary to rhinosinus diseases (previously referred to as postnasal drip syndrome):ACCP evidence-based clinical practice guidelines.Chest, 2006, 129:63S-71S.
2. Irwin RS, Boulet LP, Cloutier MM, et al.Managing cough as a defense mechanism and as a symptom.A consensus panel report of the American College of Chest Physicians.Chest, 1998, 114(2 Suppl Managing):133S-181S.
3. 中华医学会呼吸病学分会哮喘学组.咳嗽的诊断与治疗指南(2009版).中华结核和呼吸杂志, 2009, 32:407-413.
4. Birring SS.Controversies in the evaluation and management of chronic cough.Am J Respir Crit Care Med, 2011, 183:708-715.
5. Gibson PG, Chang AB, Glasgow NJ, et al.CICADA:Cough in children and adults:diagnosis and assessment.australian cough guidelines summary statement.Med J Aust, 2010, 192:265-271.
6. Morice AH, Fontana GA, Sovijarvi AR, et al.The diagnosis and management of chronic cough.Eur Respir J, 2004, 24:481-492.
7. 赖克方, 陈如冲, 刘春丽, 等.不明原因慢性咳嗽的病因分布及诊断程序的建立.中华结核和呼吸杂志, 2006, 29:96-99.
8. Wei W, Yu L, LüH, et al.Comparison of cause distribution between elderly and non-elderly patients with chronic cough.Respiration, 2009, 77:259-264.
9. Palombini BC, Villanova CA, Araújo E, et al.A pathogenic triad in chronic cough:asthma, postnasal drip syndrome, and gastroesophageal reflux disease.Chest, 1999, 116:279-284.
10. Kastelik JA, Aziz I, Ojoo JC, et al.Investigation and management of chronic cough using a probability-based algorithm.Eur Respir J, 2005, 25:235-243.
11. Grabczak EM, Dabrowska M, Krenke R, et al.Does the established cause of chronic cough depend on diagnostic approach? J Physiol Pharmacol, 2008, 59 Suppl 6:285-296.
12. Sanu A, Eccles R.Postnasal drip syndrome.Two hundred years of controversy between UK and USA.Rhinology, 2008, 46:86-91.
13. Pratter MR, Bartter T, Aker S, et al.An algorithmic approach to chronic cough.Ann Internal Med, 1993, 119:977-983.
14. Birring SS.New concepts in the management of chronic cough.Pulm Pharmacol Ther, 2011, 24:334-338.
15. Morice AH, McGarvey L, Pavord I, et al.Recommendations for the management of cough in adults.Thorax, 2006, 61 Suppl 1:1-24.
16. Saleh H.Rhinosinusitis, laryngopharyngeal reflux and cough:An ENT viewpoint.Pulm Pharmacol Ther, 2009, 22:127-129.
17. Kohno S, Ishida T, Uchida Y, et al.The Japanese Respiratory Society guidelines for management of cough.Respirology, 2006, 11 Suppl 4:S135-S186.
18. 吕寒静, 邱忠民.2009年版开始诊治指南的解读.临床药物治疗杂志, 2011, 9:6-10.
19. Bardin PG, Van Heerden BB, Joubert JR, et al.Absence of pulmonary aspiration of sinus contents in patients with asthma and sinusitis.J Allergy Clin Immunol, 1990, 86:82-88.
20. O'Hara J, Jones NS. "Post-nasal drip syndrome":most patients with purulent nasal secretions do not complain of chronic cough.Rhinology, 2006, 44:270-273.
21. Birring SS, Parker D, brightling CE, et al.Induced sputuminflammatory mediator concentrations in chronic cough.Am J Respir Crit Care Med, 2004, 169:15-19.
22. 时翠芹, 余莉, 魏为利, 等.气道炎症在上气道咳嗽综合征发生中的作用.中国呼吸与危重监护杂志, 2009, 8:256-258.
23. Boulet LP, Milot J, Boutet M, et al.Airway inflammationin nonasthmatic chronic cough.Am J Respir Crit Care Med, 1994, 149:482-489.
24. McGarvey LPA, Forsythe P, Heaney LG, et al.Bronchoalveolarlavage findings in patients with chronic nonproductive cough.Eur Respir J, 1999, 13:59-65.
25. Jatakanon A, Lalloo UG, Lim S, et al.Increased neutrophils andcytokines, TNF-alpha and IL-8 in induced sputum of non-asthmatic patients with chronic dry cough.Thorax, 1999, 54:234-237.
26. Lee SY, Cho JY, Shim JJ, et al.Airway inflammationas an assessment of chronic nonproductive cough.Chest, 2001, 120:1114-1120.
27. Birring SS, Brightling CE, Symon FA, et al.Idiopathic chronic cough:association with organ specific autoimmune disease and bronchoalveolar lymphocytosis.Thorax, 2003, 58:1066-1070.
28. Mund E, Christensson B, Gr nneberg R, et al.Noneosinophilic CD4 lymphocytic airway in flammation in menopausal women with chronic drycough.Chest, 2005, 127:1714-1721.
29. Niimi A, Torrego A, Nicholson AG, et al.Nature of airway inflammation and remodeling in chronic cough.J Allergy Clin Immunol, 2005, 116:565-570.
30. Niimi A.Structural changes in the airways:cause or effect of chronic cough? Pulm Pharmacol Ther, 2011, 24:328-333.
31. 马洪明, 刘升明, 林敏娟, 等.感觉神经肽在鼻后滴漏综合征性咳嗽中的作用.中国实用内科杂志, 2007, 27:531-532.
32. O'Hanlon S, Facer P, Simpson KD, et al.Neuronalmarkers in allergic rhinitis:expression and correlation with sensory testing.Laryngoscope, 2007, 117:1519-527.
33. Keh SM, Facer P, Simpson KD, et al.Increased nerve fiberexpression of sensory sodium channels Nav1.7, Nav1.8, and Nav1.9 inrhinitis.Laryngoscope, 2008, 118:573-579.
34. Irwin RS, Ownbey R, Cagle PT, et al.Interpreting the histopathology of chronic cough:a prospective, controlled, comparative study.Chest, 2006, 130:362-370.
35. Hara J, Fujimura M, Ueda A, et al.Effect of pressure stress applied to the airway on cough-reflex sensitivity in guinea pigs.Am J Respir Crit Care Med, 2008, 177:585-592.
36. Wang de Y.Genetic predisposition for atopy and allergic rhinitis in the Singapore Chinese population.Asia Pac Allergy, 2011, 1:152-156.
37. Pecova R, Zucha J, Pec M, et al.Cough reflex sensitivity testing in in seasonal allergic rhinitis patients and healthy volunteers.J Physiol Pharmacol, 2008, 59 Suppl 6:557-564.
38. Pecova R, Vrlik M, Tatar M.Cough sensitivity in allergic rhinitis.J Physiol Pharmacol, 2005, 56 Suppl 4:171-178.
39. Tatar M, Plevkova J, Brozmanova M, et al.Mechanisms of the cough associated with rhinosinusitis.Pulm Pharmacol Ther, 2009, 22:121-126.
40. Plevkova J, Brozmanova M, Pecova R, et al.Effects of intranasal capsaicinchallenge on cough reflex in healthy human volunteers.J Physiol Pharmacol, 2004, 55 Suppl 3:101-106.
41. Plevkova J, Brozmanova M, Pecova R, et al.The effects of nasal histamine challenge on cough reflex in healthy volunteers.Pulm Pharmacol Ther, 2006, 19:120-127.
42. Plevkova J, Brozmanova M, Pecova R, et al.Effects of intranasal histamine on the cough reflex in subjects with allergic rhinitis.J Physiol Pharmacol, 2005, 56 Suppl 4:185-195.
43. Plevkova J, Kollarik M, Brozmanova M, et al.Modulation of experimentally-induced cough by stimulation of nasal mucosa in cats and guinea pigs.Respir Physiol Neurobiol, 2004, 142:225-235.
44. Brozmanova M, Bartos V, Plank L, et al.Experimental allergic rhinitis-related cough and airway eosinophilia in sensitized guinea pigs.J Physiol Pharmacol, 2007, 58 Suppl 5(Pt 1):57-65.
45. Woodcock A, Young EC, Smith JA.New insights in cough.Br Med Bull, 2010, 96:61-73.
46. Plevkova J, Song WJ.Chronic cough in subjects with upper airway diseases-analysis of mechanisms and clinical applications.Asia Pac Allergy, 2013, 3:127-135.
47. Plevkova J, Poliacek I, Antosiewicz J, et al.Intranasal TRPV1 agonist capsaicin challenge and its effect on c-fos expression in the guinea pig brainstem.Respir Physiol Neurobiol, 2010, 173:11-15.
48. PlevkováJ, Poliacek I, Adamkov M, et al.Brainstem neuronal populations activated in the model of ovalbumine induced allergic rhinitis in guinea pigs-the c-Fos study.Biologia, 2011, 66:922-927.
49. Bucca C, Rolla G, ScappaticciE, et al.Histamine hyperresponsiveness of the extrathoracic airway in patient with asthmatic symptoms.Allergy, 1991, 46:147-153.
50. Bucca CB, Bugiani M, Culla B, et al.Chronic cough and irritable larynx.J Allergy Clin Immunol, 2011, 127:412-419.
51. Morice AH.The cough hypersensitivity syndrome:a novel paradigm for understanding cough.Lung, 2010, 188(Suppl 1):S87-S90.
52. Millqvist E.The airway sensory hyperreactivity syndrome.Pulm Pharmacol Ther, 2011, 24:263-266.
53. Vertigan AE, Gibson PG.Chronic refractory cough as a sensory neuropathy:evidence from a reinterpretation of cough triggers.J Voice, 2011, 25:596-601.
54. Bessac BF, Jordt SE.Breathtaking TRP channels:TRPA1 and TRPV1 in airway chemosensation and reflex control.Physiology (Bethesda), 2008, 23:360-370.
55. Groneberg DA, Niimi A, Dinh QT, et al.Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough.Am J Respir Crit Care Med, 2004, 170:1276-1280.
56. Gibson PG, Ryan NM.Cough pharmacotherapy:current and future status.Expert Opin Pharmacother, 2011, 12:1745-1755.
57. Kamei J, Nakanishi Y, Ishikawa Y, et al.Possible involvement of tetrodotoxin-resistant sodium channels in cough reflex.Eur J Pharmacol, 2011, 652:117-120.
58. Muroi Y, Ru F, Chou YL, et al.Selective inhibition of vagal afferent nerve pathways regulating cough using Nav 1.7 shRNA silencing in guinea pig nodose ganglia.Am J Physiol Regul Integr Comp Physiol, 2013, 304:R1017-1023.

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