• Department of Respiratory Medicine, Hunan Provincial Hospital, Changsha, Hunan, 410005, China;
LiuZhiguang, Email: liuzhiguang0404@126.com
Export PDF Favorites Scan Get Citation

Objective To evaluate the efficacy and safety of selective large volume broncholavage by bronchonscopy in treatment of patients with acute exacerbation of bronchiectasis. Methods A single-center randomized control,non-blind clinical trial was conducted.A total of 65 patients were randomly divided into Group A(large volume broncholavage group,n=21),Group B (mini- large volume broncholavage group,n=22) and Group C (control group,n=22).All patients received routine therapy of acute exacerbation of bronchiectasis while additional broncholavage was administered in the treatment groups for only once.Warm normal saline solution was instilled for Group A at volume of 500 to 2 000 mL and for Group B at volume of 100 to 200 mL.The baseline characteristics,Simplified Clinical Pulmonary Infection Score(CPIS) and C-reactive protein (CRP) were recorded at the first and on 7th day.The duration of antibiotic use,the length of hospital stay and total effective rate were compared among three groups. Results The lavage volume was (1 250.0±403.3)mL for Group A and (141.0±41.2)mL for Group B.The length of hospital stay and duration of antibiotic use were (8.4±1.0)d and (7.9±1.1)d respectively,shorter than those in Group B[(13.5±1.6)d,(11.6±2.4)d] and Group C[(15.3±3.2)d,(13.3±2.6)d] with significant difference between three groups(all P<0.05).The total effective rates was 95.23% in Group A,higher than those in Group B (81.82%) and Group C (68.19%)(all P<0.05).The CPIS on the 7th day of Group A was 1.9±1.4,lower than that in Group B (2.7±0.8) and Group C (3.7±0.9)(P<0.05).The CRP of Group A decreased more quickly than Group B and Group C.The adverse events occurred in Group A and Group B including transient hypoxemia (23.81%,9.09%, respectively),tarchycardia(100%,68.18%, respectively),airway mucosal injury(38.09%,13.64%, respectively) and elevated blood pressure (19.05%,13.64%, respectively). Conclusion Selective large volume broncholavage through bronchonscopy is an effective and safe treatment for patients with acute exacerbation or bronchiectasis.

Citation: LiuZhiguang, WuHuaiqiu, ZhangWeidong, DengHongying, TanJianlong, LiJianming, JiangGang, LiuNian, TaoYin. Selective Large Volume Broncholavage for Acute Exacerbation of Bronchiectasis by Bronchonscopy. Chinese Journal of Respiratory and Critical Care Medicine, 2014, 13(6): 574-578. doi: 10.7507/1671-6205.2014140 Copy

  • Previous Article

    The Value of Bronchoalveolar Lavage in Diagnosis of Fungal Pneumonia
  • Next Article

    IgG4 Related Lung Disease: Two Cases Report and Literature Review