XiXin 1 , LiuZeying 1 , ZhangYing 1 , LiYamin 1 , WangLvya 2 , LiuShuang 1
  • 1. Department of Respiratory Medicine, Capital Medical University Affiliated Beijing Anzhen Hospital, Beijing, 100029, China;
  • 2. ;
LiuShuang, Email: liushuang862002@163.com
Acute pulmonary embolism; High-sensitivity troponin Ⅰ; Simple pulmonary embolism severity index; Prognosis
10.7507/1671-6205.2015068
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Objective To evaluate the predictive value of the high-sensitivity cardiac troponin I (hs-cTnI) in patients with acute pulmonary embolism (APE). Methods In a retrospective cohort study,272 consecutive patients with APE were reviewed and the 30-days death and in-hospital adverse events were evaluated. The patients were classified according to hs-cTnI value into a high hs-cTnI group and a low hs-cTnI group. The simple pulmonary embolism severity index (sPESI) was used for clinical risk determination. The adverse event was defined as intravenous thrombolytic therapy,noninvasive ventilator support to maintain oxygen saturation >90% and suffered with severe complications. The correlations of hs-cTnI with sPESI score,30-days adverse events and mortality were analyzed. The Kaplan-Meier curves and the log-rank test were used to compare time-to-event survival. Stepwise multivariate logistic regression analysis models were used to determine the incremental prognostic value of sPESI score and hs-cTnI. Results The incidence of 30-day death (6.1%),renal failure (14.6%),bleeding (13.4%) and thrombolytic therapy (7.9%) were higher in the high hs-cTnI group than those in the low hs-cTnI group (P values were 0.009,<0.001,0.018 and 0.003,respectively). The patients with sPESI ≥1 and low hs-cTnI had greater free adverse events survival (P=0.005). hs-cTnI provided incremental predictive value for in-hospital adverse events,beyond the sPESI score (P<0.001). Conclusion hs-cTnI has excellent negative predictive value of APE prognosis,especially when used combined with sPESI score.

Citation： XiXin, LiuZeying, ZhangYing, LiYamin, WangLvya, LiuShuang. Predictive Value of the High-Sensitivity Cardiac Troponin I in Patients with Acute Pulmonary Embolism. Chinese Journal of Respiratory and Critical Care Medicine, 2015, 14(3): 278-281. doi: 10.7507/1671-6205.2015068 Copy

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