半乳甘露聚糖实验诊断曲霉病的进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

李培 , 朱美英 ,  施毅

南京军区南京总医院呼吸内科(江苏南京 210002);

Corresponding author：

施毅, Email: shiyi56@126.com

Keywords：

DOI：

10.7507/1671-6205.2015075

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Citation： 李培, 朱美英, 施毅. 半乳甘露聚糖实验诊断曲霉病的进展. Chinese Journal of Respiratory and Critical Care Medicine, 2015, 14(3): 303-306. doi: 10.7507/1671-6205.2015075 Copy

1.	Upton A,Gugel A,Leisenring W,et al. Reproducibility of low galactomannan enzyme immunoassay index values tested in multiple laboratories. J Clin Microbiol,2005,43:4796-4800.
2.	Maertens J,Verhaegen J,Demuynck H,et al. Autopsy-controlled prospective evaluation of serial screening for circulating galactomannan by a sandwich enzyme-linked immunosorbent assay for hematological patients at risk for invasive Aspergillosis. J Clin Microbiol,1999,37:3223-3228.
3.	Ulusakarya A,Chachaty E,Vantelon JM,et al. Surveillance of Aspergillus galactomannan antigenemia for invasive aspergillosis by enzyme-linked immunosorbent assay in neutropenic patients treated for hematological malignancies. Hematol J,2000,1:111-116.
4.	Rovira M,Jimenez M,De La Bellacasa JP,et al. Detection of Aspergillus galactomannan by enzyme immunoabsorbent assay in recipients of allogeneic hematopoietic stem cell transplantation:a prospective study. Transplantation,2004,77:1260-1264.
5.	Foy PC,van Burik JA,Weisdorf DJ. Galactomannan antigen enzyme-linked immunosorbent assay for diagnosis of invasive aspergillosis after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant,2007,13:440-443.
6.	Badiee P,Alborzi A,Karimi M,et al. Diagnostic potential of nested PCR,galactomannan EIA,and beta-D-glucan for invasive aspergillosis in pediatric patients. J Infect Dev Ctries,2012,6:352-357.
7.	Choi SH,Kang ES,Eo H,et al. Aspergillus galactomannan antigen assay and invasive aspergillosis in pediatric cancer patients and hematopoietic stem cell transplant recipients. Pediatr Blood Cancer,2013,60:316-322.
8.	Jha AK,Bansal D,Chakrabarti A,et al. Serum galactomannan assay for the diagnosis of invasive aspergillosis in children with haematological malignancies. Mycoses,2013,56:442-448.
9.	Costa C,Costa JM,Desterke C,et al. Real-time PCR coupled with automated DNA extraction and detection of galactomannan antigen in serum by enzyme-linked immunosorbent assay for diagnosis of invasive aspergillosis. J Clin Microbiol,2002,40:2224-2227.
10.	Kawazu M,Kanda Y,Nannya Y,et al. Prospective comparison of the diagnostic potential of real-time PCR,double-sandwich enzyme-linked immunosorbent assay for galactomannan,and a (1-->3)-beta-D-glucan test in weekly screening for invasive aspergillosis in patients with hematological disorders. J Clin Microbiol,2004,42:2733-2741.
11.	Bretagne S,Costa JM,Bart-Delabesse E,et al. Comparison of serum galactomannan antigen detection and competitive polymerase chain reaction for diagnosing invasive aspergillosis. Clin Infect Dis,1998,26:1407-1412.
12.	Rogers TR,Morton CO,Springer J,et al. Combined real-time PCR and galactomannan surveillance improves diagnosis of invasive aspergillosis in high risk patients with haematological malignancies. Br J Haematol,2013,161:517-524.
13.	Yoo JH,Choi SM,Lee DG,et al. Comparison of the real-time nucleic acid sequence-based amplification (RTi-NASBA) with conventional NASBA,and galactomannan assay for the diagnosis of invasive aspergillosis. J Korean Med Sci,2007,22:672-676.
14.	Pazos C,Ponton J,Del PA. Contribution of (1->3)-beta-D-glucan chromogenic assay to diagnosis and therapeutic monitoring of invasive aspergillosis in neutropenic adult patients:a comparison with serial screening for circulating galactomannan. J Clin Microbiol,2005,43:299-305.
15.	Pfeiffer CD,Fine JP,Safdar N. Diagnosis of invasive aspergillosis using a galactomannan assay:a meta-analysis. Clin Infect Dis,2006,42:1417-1427.
16.	Maertens J,Theunissen K,Verhoef G,et al. Galactomannan and computed tomography-based preemptive antifungal therapy in neutropenic patients at high risk for invasive fungal infection:a prospective feasibility study. Clin Infect Dis,2005,41:1242-1250.
17.	Tan BH,Low JG,Chlebicka NL,et al. Galactomannan-guided preemptive vs. empirical antifungals in the persistently febrile neutropenic patient:a prospective randomized study. Int J Infect Dis,2011,15:e350-e356.
18.	Morrissey CO,Chen SC,Sorrell TC,et al. Galactomannan and PCR versus culture and histology for directing use of antifungal treatment for invasive aspergillosis in high-risk haematology patients:a randomised controlled trial. Lancet Infect Dis,2013,13:519-528.
19.	Miceli MH,Grazziutti ML,Woods G,et al. Strong correlation between serum aspergillus galactomannan index and outcome of aspergillosis in patients with hematological cancer:clinical and research implications. Clin Infect Dis,2008,46:1412-1422.
20.	Maertens J,Buve K,Theunissen K,et al. Galactomannan serves as a surrogate endpoint for outcome of pulmonary invasive aspergillosis in neutropenic hematology patients. Cancer,2009,115:355-362.
21.	Nouer SA,Nucci M,Kumar NS,et al. Earlier response assessment in invasive aspergillosis based on the kinetics of serum Aspergillus galactomannan:proposal for a new definition. Clin Infect Dis,2011,53:671-676.
22.	Koo S,Bryar JM,Baden LR,et al. Prognostic features of galactomannan antigenemia in galactomannan-positive invasive aspergillosis. J Clin Microbiol,2010,48:1255-1260.
23.	Chai LY,Kullberg BJ,Johnson EM,et al. Early serum galactomannan trend as a predictor of outcome of invasive aspergillosis. J Clin Microbiol,2012,50:2330-2336.
24.	Ku NS,Han SH,Choi JY,et al. Diagnostic value of the serum galactomannan assay for invasive aspergillosis:it is less useful in non-haematological patients. Scand J Infect Dis,2012,44:600-604.
25.	Nihtinen A,Anttila VJ,Richardson M,et al. Invasive Aspergillus infections in allo-SCT recipients:environmental sampling,nasal and oral colonization and galactomannan testing. Bone Marrow Transplant,2010,45:333-338.
26.	Kitasato Y,Tao Y,Hoshino T,et al. Comparison of Aspergillus galactomannan antigen testing with a new cut-off index and Aspergillus precipitating antibody testing for the diagnosis of chronic pulmonary aspergillosis. Respirology,2009,14:701-708.
27.	Fujiuchi S,Yamamoto Y,Takeda A,et al. Evaluation of galactomannan antigen and beta-D-glucan value for diagnosis of chronic necrotizing pulmomary aspergillosis. Nihon Kokyuki Gakkai Zasshi,2009,47:7-11.
28.	Park SY,Lee SO,Choi SH,et al. Serum and bronchoalveolar lavage fluid galactomannan assays in patients with pulmonary aspergilloma. Clin Infect Dis,2011,52:e149-e152.
29.	Danpornprasert P,Foongladda S,Tscheikuna J. Impact of bronchoalveolar lavage galactomannan on the outcome of patients at risk for invasive pulmonary aspergillosis. J Med Assoc Thai,2010,93 Suppl 1:S86-S93.
30.	Nguyen MH,Leather H,Clancy CJ,et al. Galactomannan testing in bronchoalveolar lavage fluid facilitates the diagnosis of invasive pulmonary aspergillosis in patients with hematologic malignancies and stem cell transplant recipients. Biol Blood Marrow Transplant,2011,17:1043-1050.
31.	Clancy CJ,Jaber RA,Leather HL,et al. Bronchoalveolar lavage galactomannan in diagnosis of invasive pulmonary aspergillosis among solid-organ transplant recipients. J Clin Microbiol,2007,45:1759-1765.
32.	Paugam A,Baixench MT,Lebuisson A,et al. Diagnosis of invasive pulmonary aspergillosis:value of bronchoalveolar lavage galactomannan for immunocompromised patients. Pathol Biol (Paris),2010,58:100-103.
33.	Luong ML,Clancy CJ,Vadnerkar A,et al. Comparison of an Aspergillus real-time polymerase chain reaction assay with galactomannan testing of bronchoalvelolar lavage fluid for the diagnosis of invasive pulmonary aspergillosis in lung transplant recipients. Clin Infect Dis,2011,52:1218-1226.
34.	Torelli R,Sanguinetti M,Moody A,et al. Diagnosis of invasive aspergillosis by a commercial real-time PCR assay for Aspergillus DNA in bronchoalveolar lavage fluid samples from high-risk patients compared to a galactomannan enzyme immunoassay. J Clin Microbiol,2011,49:4273-4278.
35.	Reinwald M,Spiess B,Heinz WJ,et al. Diagnosing pulmonary aspergillosis in patients with hematological malignancies:a multicenter prospective evaluation of an Aspergillus PCR assay and a galactomannan ELISA in bronchoalveolar lavage samples. Eur J Haematol,2012,89:120-127.
36.	Musher B,Fredricks D,Leisenring W,et al. Aspergillus galactomannan enzyme immunoassay and quantitative PCR for diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid. J Clin Microbiol,2004,42:5517-5522.
37.	Maertens J,Maertens V,Theunissen K,et al. Bronchoalveolar lavage fluid galactomannan for the diagnosis of invasive pulmonary aspergillosis in patients with hematologic diseases. Clin Infect Dis,2009,49:1688-1693.
38.	Bergeron A,Belle A,Sulahian A,et al. Contribution of galactomannan antigen detection in BAL to the diagnosis of invasive pulmonary aspergillosis in patients with hematologic malignancies. Chest,2010,137:410-415.
39.	Park SY,Lee SO,Choi SH,et al. Aspergillus galactomannan antigen assay in bronchoalveolar lavage fluid for diagnosis of invasive pulmonary aspergillosis. J Infect,2010,61:492-498.
40.	Guo YL,Chen YQ,Wang K,et al. Accuracy of BAL galactomannan in diagnosing invasive aspergillosis:a bivariate metaanalysis and systematic review. Chest,2010,138:817-824.
41.	Desai R,Ross LA,Hoffman JA. The role of bronchoalveolar lavage galactomannan in the diagnosis of pediatric invasive aspergillosis. Pediatr Infect Dis J,2009,28:283-286.
42.	Acosta J,Catalan M,del Palacio-Peréz-Medel A,et al. A prospective comparison of galactomannan in bronchoalveolar lavage fluid for the diagnosis of pulmonary invasive aspergillosis in medical patients under intensive care:comparison with the diagnostic performance of galactomannan and of (1→3)-β-D-glucan chromogenic assay in serum samples. Clin Microbiol Infect,2011,17:1053-1060.
43.	Nguyen MH,Jaber R,Leather HL,et al. Use of bronchoalveolar lavage to detect galactomannan for diagnosis of pulmonary aspergillosis among nonimmunocompromised hosts. J Clin Microbiol,2007,45:2787-2792.
44.	Brownback KR,Pitts LR,Simpson SQ. Utility of galactomannan antigen detection in bronchoalveolar lavage fluid in immunocompromised patients. Mycoses,2013,56:552-558.
45.	Racil Z,Kocmanova I,Toskova M,et al. Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological diseases-the role of factors affecting assay performance. Int J Infect Dis,2011,15:e874-e881.
46.	Fisher CE,Stevens AM,Leisenring W,et al. The serum galactomannan index predicts mortality in hematopoietic stem cell transplant recipients with invasive aspergillosis. Clin Infect Dis,2013,57:1001-1004.

1. Upton A,Gugel A,Leisenring W,et al. Reproducibility of low galactomannan enzyme immunoassay index values tested in multiple laboratories. J Clin Microbiol,2005,43:4796-4800.
2. Maertens J,Verhaegen J,Demuynck H,et al. Autopsy-controlled prospective evaluation of serial screening for circulating galactomannan by a sandwich enzyme-linked immunosorbent assay for hematological patients at risk for invasive Aspergillosis. J Clin Microbiol,1999,37:3223-3228.
3. Ulusakarya A,Chachaty E,Vantelon JM,et al. Surveillance of Aspergillus galactomannan antigenemia for invasive aspergillosis by enzyme-linked immunosorbent assay in neutropenic patients treated for hematological malignancies. Hematol J,2000,1:111-116.
4. Rovira M,Jimenez M,De La Bellacasa JP,et al. Detection of Aspergillus galactomannan by enzyme immunoabsorbent assay in recipients of allogeneic hematopoietic stem cell transplantation:a prospective study. Transplantation,2004,77:1260-1264.
5. Foy PC,van Burik JA,Weisdorf DJ. Galactomannan antigen enzyme-linked immunosorbent assay for diagnosis of invasive aspergillosis after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant,2007,13:440-443.
6. Badiee P,Alborzi A,Karimi M,et al. Diagnostic potential of nested PCR,galactomannan EIA,and beta-D-glucan for invasive aspergillosis in pediatric patients. J Infect Dev Ctries,2012,6:352-357.
7. Choi SH,Kang ES,Eo H,et al. Aspergillus galactomannan antigen assay and invasive aspergillosis in pediatric cancer patients and hematopoietic stem cell transplant recipients. Pediatr Blood Cancer,2013,60:316-322.
8. Jha AK,Bansal D,Chakrabarti A,et al. Serum galactomannan assay for the diagnosis of invasive aspergillosis in children with haematological malignancies. Mycoses,2013,56:442-448.
9. Costa C,Costa JM,Desterke C,et al. Real-time PCR coupled with automated DNA extraction and detection of galactomannan antigen in serum by enzyme-linked immunosorbent assay for diagnosis of invasive aspergillosis. J Clin Microbiol,2002,40:2224-2227.
10. Kawazu M,Kanda Y,Nannya Y,et al. Prospective comparison of the diagnostic potential of real-time PCR,double-sandwich enzyme-linked immunosorbent assay for galactomannan,and a (1-->3)-beta-D-glucan test in weekly screening for invasive aspergillosis in patients with hematological disorders. J Clin Microbiol,2004,42:2733-2741.
11. Bretagne S,Costa JM,Bart-Delabesse E,et al. Comparison of serum galactomannan antigen detection and competitive polymerase chain reaction for diagnosing invasive aspergillosis. Clin Infect Dis,1998,26:1407-1412.
12. Rogers TR,Morton CO,Springer J,et al. Combined real-time PCR and galactomannan surveillance improves diagnosis of invasive aspergillosis in high risk patients with haematological malignancies. Br J Haematol,2013,161:517-524.
13. Yoo JH,Choi SM,Lee DG,et al. Comparison of the real-time nucleic acid sequence-based amplification (RTi-NASBA) with conventional NASBA,and galactomannan assay for the diagnosis of invasive aspergillosis. J Korean Med Sci,2007,22:672-676.
14. Pazos C,Ponton J,Del PA. Contribution of (1->3)-beta-D-glucan chromogenic assay to diagnosis and therapeutic monitoring of invasive aspergillosis in neutropenic adult patients:a comparison with serial screening for circulating galactomannan. J Clin Microbiol,2005,43:299-305.
15. Pfeiffer CD,Fine JP,Safdar N. Diagnosis of invasive aspergillosis using a galactomannan assay:a meta-analysis. Clin Infect Dis,2006,42:1417-1427.
16. Maertens J,Theunissen K,Verhoef G,et al. Galactomannan and computed tomography-based preemptive antifungal therapy in neutropenic patients at high risk for invasive fungal infection:a prospective feasibility study. Clin Infect Dis,2005,41:1242-1250.
17. Tan BH,Low JG,Chlebicka NL,et al. Galactomannan-guided preemptive vs. empirical antifungals in the persistently febrile neutropenic patient:a prospective randomized study. Int J Infect Dis,2011,15:e350-e356.
18. Morrissey CO,Chen SC,Sorrell TC,et al. Galactomannan and PCR versus culture and histology for directing use of antifungal treatment for invasive aspergillosis in high-risk haematology patients:a randomised controlled trial. Lancet Infect Dis,2013,13:519-528.
19. Miceli MH,Grazziutti ML,Woods G,et al. Strong correlation between serum aspergillus galactomannan index and outcome of aspergillosis in patients with hematological cancer:clinical and research implications. Clin Infect Dis,2008,46:1412-1422.
20. Maertens J,Buve K,Theunissen K,et al. Galactomannan serves as a surrogate endpoint for outcome of pulmonary invasive aspergillosis in neutropenic hematology patients. Cancer,2009,115:355-362.
21. Nouer SA,Nucci M,Kumar NS,et al. Earlier response assessment in invasive aspergillosis based on the kinetics of serum Aspergillus galactomannan:proposal for a new definition. Clin Infect Dis,2011,53:671-676.
22. Koo S,Bryar JM,Baden LR,et al. Prognostic features of galactomannan antigenemia in galactomannan-positive invasive aspergillosis. J Clin Microbiol,2010,48:1255-1260.
23. Chai LY,Kullberg BJ,Johnson EM,et al. Early serum galactomannan trend as a predictor of outcome of invasive aspergillosis. J Clin Microbiol,2012,50:2330-2336.
24. Ku NS,Han SH,Choi JY,et al. Diagnostic value of the serum galactomannan assay for invasive aspergillosis:it is less useful in non-haematological patients. Scand J Infect Dis,2012,44:600-604.
25. Nihtinen A,Anttila VJ,Richardson M,et al. Invasive Aspergillus infections in allo-SCT recipients:environmental sampling,nasal and oral colonization and galactomannan testing. Bone Marrow Transplant,2010,45:333-338.
26. Kitasato Y,Tao Y,Hoshino T,et al. Comparison of Aspergillus galactomannan antigen testing with a new cut-off index and Aspergillus precipitating antibody testing for the diagnosis of chronic pulmonary aspergillosis. Respirology,2009,14:701-708.
27. Fujiuchi S,Yamamoto Y,Takeda A,et al. Evaluation of galactomannan antigen and beta-D-glucan value for diagnosis of chronic necrotizing pulmomary aspergillosis. Nihon Kokyuki Gakkai Zasshi,2009,47:7-11.
28. Park SY,Lee SO,Choi SH,et al. Serum and bronchoalveolar lavage fluid galactomannan assays in patients with pulmonary aspergilloma. Clin Infect Dis,2011,52:e149-e152.
29. Danpornprasert P,Foongladda S,Tscheikuna J. Impact of bronchoalveolar lavage galactomannan on the outcome of patients at risk for invasive pulmonary aspergillosis. J Med Assoc Thai,2010,93 Suppl 1:S86-S93.
30. Nguyen MH,Leather H,Clancy CJ,et al. Galactomannan testing in bronchoalveolar lavage fluid facilitates the diagnosis of invasive pulmonary aspergillosis in patients with hematologic malignancies and stem cell transplant recipients. Biol Blood Marrow Transplant,2011,17:1043-1050.
31. Clancy CJ,Jaber RA,Leather HL,et al. Bronchoalveolar lavage galactomannan in diagnosis of invasive pulmonary aspergillosis among solid-organ transplant recipients. J Clin Microbiol,2007,45:1759-1765.
32. Paugam A,Baixench MT,Lebuisson A,et al. Diagnosis of invasive pulmonary aspergillosis:value of bronchoalveolar lavage galactomannan for immunocompromised patients. Pathol Biol (Paris),2010,58:100-103.
33. Luong ML,Clancy CJ,Vadnerkar A,et al. Comparison of an Aspergillus real-time polymerase chain reaction assay with galactomannan testing of bronchoalvelolar lavage fluid for the diagnosis of invasive pulmonary aspergillosis in lung transplant recipients. Clin Infect Dis,2011,52:1218-1226.
34. Torelli R,Sanguinetti M,Moody A,et al. Diagnosis of invasive aspergillosis by a commercial real-time PCR assay for Aspergillus DNA in bronchoalveolar lavage fluid samples from high-risk patients compared to a galactomannan enzyme immunoassay. J Clin Microbiol,2011,49:4273-4278.
35. Reinwald M,Spiess B,Heinz WJ,et al. Diagnosing pulmonary aspergillosis in patients with hematological malignancies:a multicenter prospective evaluation of an Aspergillus PCR assay and a galactomannan ELISA in bronchoalveolar lavage samples. Eur J Haematol,2012,89:120-127.
36. Musher B,Fredricks D,Leisenring W,et al. Aspergillus galactomannan enzyme immunoassay and quantitative PCR for diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid. J Clin Microbiol,2004,42:5517-5522.
37. Maertens J,Maertens V,Theunissen K,et al. Bronchoalveolar lavage fluid galactomannan for the diagnosis of invasive pulmonary aspergillosis in patients with hematologic diseases. Clin Infect Dis,2009,49:1688-1693.
38. Bergeron A,Belle A,Sulahian A,et al. Contribution of galactomannan antigen detection in BAL to the diagnosis of invasive pulmonary aspergillosis in patients with hematologic malignancies. Chest,2010,137:410-415.
39. Park SY,Lee SO,Choi SH,et al. Aspergillus galactomannan antigen assay in bronchoalveolar lavage fluid for diagnosis of invasive pulmonary aspergillosis. J Infect,2010,61:492-498.
40. Guo YL,Chen YQ,Wang K,et al. Accuracy of BAL galactomannan in diagnosing invasive aspergillosis:a bivariate metaanalysis and systematic review. Chest,2010,138:817-824.
41. Desai R,Ross LA,Hoffman JA. The role of bronchoalveolar lavage galactomannan in the diagnosis of pediatric invasive aspergillosis. Pediatr Infect Dis J,2009,28:283-286.
42. Acosta J,Catalan M,del Palacio-Peréz-Medel A,et al. A prospective comparison of galactomannan in bronchoalveolar lavage fluid for the diagnosis of pulmonary invasive aspergillosis in medical patients under intensive care:comparison with the diagnostic performance of galactomannan and of (1→3)-β-D-glucan chromogenic assay in serum samples. Clin Microbiol Infect,2011,17:1053-1060.
43. Nguyen MH,Jaber R,Leather HL,et al. Use of bronchoalveolar lavage to detect galactomannan for diagnosis of pulmonary aspergillosis among nonimmunocompromised hosts. J Clin Microbiol,2007,45:2787-2792.
44. Brownback KR,Pitts LR,Simpson SQ. Utility of galactomannan antigen detection in bronchoalveolar lavage fluid in immunocompromised patients. Mycoses,2013,56:552-558.
45. Racil Z,Kocmanova I,Toskova M,et al. Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological diseases-the role of factors affecting assay performance. Int J Infect Dis,2011,15:e874-e881.
46. Fisher CE,Stevens AM,Leisenring W,et al. The serum galactomannan index predicts mortality in hematopoietic stem cell transplant recipients with invasive aspergillosis. Clin Infect Dis,2013,57:1001-1004.

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半乳甘露聚糖实验诊断曲霉病的进展

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