Acute Fibrinous and Organizing Pneumonia: One Case Report and Literature Review_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 QinYong ¹ , CuiJin ¹ , ZhuYan ²

1. Department of Respiratory Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210011, China;
2. ;

Corresponding author：

QinYong, Email: qinyong1970822@126.com

Keywords：

Acute fibrinous and organizing pneumonia; Interstitial lung diseases

DOI：

10.7507/1671-6205.2015139

Video：

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Objective To explore the clinical, radiological and pathological characteristics of acute fibrinous and organizing pneumonia (AFOP). Methods A case pathologically diagnosed with AFOP in September 2013 in the Second Affiliated Hospital of Nanjing Medical University was reported, and the related literature was reviewed. Results A 50-year-old woman with fever, chills, cough with sputum and chest pain was admitted to this hospital. The chest CT showed the nodules and patching infiltrates of the right middle lung. The pathological examination revealed the focally exudation of fibrin, lymphocyte infiltration and the presence of foam cells within the alveolar spaces, which is different from other well-known acute lung injures such as diffuse alveolar damage, cryptogenic organizing pneumonitis, and acute eosinophilic pneumonia. Coticosteroid therapy was induced and the patient showed significantly clinical and radiological improvement. Conclusion AFOP has no specific clinical, laboratory tests and radiology features, and it's diagnosis depends on pathological examination. Treatment with coticosteroids is proved to be effective.

Citation： QinYong, CuiJin, ZhuYan. Acute Fibrinous and Organizing Pneumonia: One Case Report and Literature Review. Chinese Journal of Respiratory and Critical Care Medicine, 2015, 14(6): 577-582. doi: 10.7507/1671-6205.2015139 Copy

1.	Beasley MB, Franks TJ, Galvin JR, et al. Acute fibrinous and organizing pneumonia:a histologic pattern of lung injury and possible variant of diffuse alveolar damage. Arch Pathol Lab Med,2002,126:1064-1070.
2.	Hwang DM, Chamberlain DW, Poutanen SM, et al. Pulmonary pathology of severe acute respiratory syndrome in Toronto. Mod Pathol,2005,18:1-10.
3.	Cincotta DR, Sebire NJ, Lim E, et al. Fatal acute fibrinous and organizing pneumonia in an infant:The histopathologic variability of acute respiratory distress syndrome. Pediatr Crit Care Med,2007,8:378-382.
4.	Ryerson CJ, Collard HR. Update on the diagnosis and classification of ILD. Curr Opin Pulm Med,2013,19:453-459.
5.	Balduin R, Giacometti C, Saccarola L, et al. Acute fibrinous and organizing pneumonia in a patient with collagen vascular disease "stigma". Sarcoidosis Vasc Diffuse Lung Dis,2007,24:78-80.
6.	Bhatti S, Hakeem A, Torrealba J, et al. Severe acute fibrinous and organizing pneumonia (AFOP) causing ventilatory failure:successful treatment with mycophenolate mofetil and corticosteroids. Respir Med,2009,103:1764-1767.
7.	Canessa PA, Prattico L, Sivori M,e t al. Acute fibrinous and organizing pneumonia in Whipple's disease. Monaldi Arch Chest Dis,2008,69:186-188.
8.	Damas C, Morais A, Moura CS, et al. Acute fibrinous and organizing pneumonia. Rev Port Pneumol,2006,12:615-620.
9.	Guimarães C,Sanches I, Ferreira C. Acute fibrinous and organising pneumonia. BMJ Case Rep,2012,2012:pii:bcr0120113689.
10.	Hariri L, Unizony S, Stone J, et al. Acute fibrinous and organising pneumonia in systemic lupus erythematosus:a case report and review of the literature. Pathol Int,2010,60:755-759.
11.	Heo JY, Song JY, Noh JY, et al. Acute fibrinous and organizing pneumonia in a patient with HIV infection and Pneumocystis jiroveci pneumonia. Respirology,2010,15:1259-1261.
12.	Kobayashi H, Sugimoto C, Kanoh S, et al. Acute fibrinous and organizing pneumonia:initial presentation as a solitary nodule. J Thorac Imaging,2005,20:291-293.
13.	Lee SM, Park JJ, Sung SH, et al. Acute fibrinous and organizing pneumonia following hematopoietic stem cell transplantation. Korean J Intern Med,2009,24:156-159.
14.	López-Cuenca S, Morales-García S, Martín-Hita A, et al. Severe acute respiratory failure secondary to acute fibrinous and organizing pneumonia requiring mechanical ventilation:a case report and literature review. Respir Care,2012,57:1337-1341.
15.	Otto C, Huzly D, Kemna L, et al. Acute fibrinous and organizing pneumonia associated with influenza A/H1N1 pneumonia after lung transplantation. BMC Pulm Med,2013,13:30.
16.	Prahalad S, Bohnsack JF, Maloney CG, et al. Fatal acute fibrinous and organizing pneumonia in a child with juvenile dermatomyositis. J Pediatr,2005,146:289-291.
17.	Rapaka V, Hussain MA, Niazi M, et al. Severe acute fibrinous and organizing pneumonia causing acute respiratory distress syndrome and shock. J Bronchol Intervent Pulmonol,2011,18:269-273.
18.	Ribera A, Llatjós R, Casanova A, et al. Chlamydia pneumoniae infection associated to acute fibrinous and organizing pneumonia. Enferm Infecc Microbiol Clin,2011,29:631-638.
19.	Santos C, Fradinho F, Catarino A. Acute fibrinous and organizing pneumonia. Rev Port Pneumol,2010,16:607-616.
20.	Tzouvelekis A, Koutsopoulos A, Oikonomou A, et al. Acute fibrinous and organising pneumonia:a case report and review of the literature. J Med Case Rep,2009,3:74.
21.	Valim V, Rocha RH, Couto RB, et al. Acute fibrinous and organizing pneumonia and undifferentiated connective tissue disease. Case Rep Rheumatol,2012,2012:549298.
22.	Vasu T, Cavallazzi R, Hirani A, et al. A 64-year-old male with fever and persistent lung infiltrate. Respir Care,2009,54:1263-1265.
23.	Yokogawa N, Alcid DV. Acute fibrinous and organizing pneumonia as a rare presentation of abacavir hypersensitivity reaction. AIDS,2007,21:2116-2117.
24.	桂贤华,张英为,代静泓,等.急性纤维素性机化性肺炎两例报道及文献复习.中国呼吸与危重监护杂志,2012,11:558-561.
25.	邱玉英,苗立云,蔡后荣,等.急性纤维素性机化性肺炎五例临床和影像及病理分析.中华结核和呼吸杂志,2013,36:425-430.
26.	张捷,方秋红,冯瑞娥,等.急性纤维素性并机化性肺炎一例及文献复习.中华结核和呼吸杂志,2010,33:892-895.
27.	冯安宁,孟凡青.急性纤维素性机化性肺炎的研究进展.临床与实验病理学杂志,2013,29:775-778.
28.	苗立云,代静泓,桂贤华,等.急性纤维蛋白性机化性肺炎的临床病理特征.临床肺科杂志,2010,15:1260-1262.
29.	Chen HJ, Yang JJ, Xu CR, et al. Principles of biopsy in suspected lung cancer:priority still based on invasion in the era of targeted therapy. J Thorac Dis,2013,5:E93-E97.
30.	Ding N, Zha WJ, Ren SN, et al. Invasive examinations in patients with suspected lung cancer:more may be too many. J Thorac Dis,2013,5:E250-E253.
31.	King MA, Pope-Harman A, Allen JN, et al. Acute eosinophilic pneumonia:radiologic and clinical features. Radiology,1997,203:715-719.
32.	King TJ, Mortenson R. Cryptogenic organizing pneumonitis:the North American experience. Chest,1992,102:8s-13s.
33.	Olson J, Colby TV, Elliott CG. Hamman-Rich syndrome revisited. Mayo Clin Proc,1990,65:1538-1548.

1. Beasley MB, Franks TJ, Galvin JR, et al. Acute fibrinous and organizing pneumonia:a histologic pattern of lung injury and possible variant of diffuse alveolar damage. Arch Pathol Lab Med,2002,126:1064-1070.
2. Hwang DM, Chamberlain DW, Poutanen SM, et al. Pulmonary pathology of severe acute respiratory syndrome in Toronto. Mod Pathol,2005,18:1-10.
3. Cincotta DR, Sebire NJ, Lim E, et al. Fatal acute fibrinous and organizing pneumonia in an infant:The histopathologic variability of acute respiratory distress syndrome. Pediatr Crit Care Med,2007,8:378-382.
4. Ryerson CJ, Collard HR. Update on the diagnosis and classification of ILD. Curr Opin Pulm Med,2013,19:453-459.
5. Balduin R, Giacometti C, Saccarola L, et al. Acute fibrinous and organizing pneumonia in a patient with collagen vascular disease "stigma". Sarcoidosis Vasc Diffuse Lung Dis,2007,24:78-80.
6. Bhatti S, Hakeem A, Torrealba J, et al. Severe acute fibrinous and organizing pneumonia (AFOP) causing ventilatory failure:successful treatment with mycophenolate mofetil and corticosteroids. Respir Med,2009,103:1764-1767.
7. Canessa PA, Prattico L, Sivori M,e t al. Acute fibrinous and organizing pneumonia in Whipple's disease. Monaldi Arch Chest Dis,2008,69:186-188.
8. Damas C, Morais A, Moura CS, et al. Acute fibrinous and organizing pneumonia. Rev Port Pneumol,2006,12:615-620.
9. Guimarães C,Sanches I, Ferreira C. Acute fibrinous and organising pneumonia. BMJ Case Rep,2012,2012:pii:bcr0120113689.
10. Hariri L, Unizony S, Stone J, et al. Acute fibrinous and organising pneumonia in systemic lupus erythematosus:a case report and review of the literature. Pathol Int,2010,60:755-759.
11. Heo JY, Song JY, Noh JY, et al. Acute fibrinous and organizing pneumonia in a patient with HIV infection and Pneumocystis jiroveci pneumonia. Respirology,2010,15:1259-1261.
12. Kobayashi H, Sugimoto C, Kanoh S, et al. Acute fibrinous and organizing pneumonia:initial presentation as a solitary nodule. J Thorac Imaging,2005,20:291-293.
13. Lee SM, Park JJ, Sung SH, et al. Acute fibrinous and organizing pneumonia following hematopoietic stem cell transplantation. Korean J Intern Med,2009,24:156-159.
14. López-Cuenca S, Morales-García S, Martín-Hita A, et al. Severe acute respiratory failure secondary to acute fibrinous and organizing pneumonia requiring mechanical ventilation:a case report and literature review. Respir Care,2012,57:1337-1341.
15. Otto C, Huzly D, Kemna L, et al. Acute fibrinous and organizing pneumonia associated with influenza A/H1N1 pneumonia after lung transplantation. BMC Pulm Med,2013,13:30.
16. Prahalad S, Bohnsack JF, Maloney CG, et al. Fatal acute fibrinous and organizing pneumonia in a child with juvenile dermatomyositis. J Pediatr,2005,146:289-291.
17. Rapaka V, Hussain MA, Niazi M, et al. Severe acute fibrinous and organizing pneumonia causing acute respiratory distress syndrome and shock. J Bronchol Intervent Pulmonol,2011,18:269-273.
18. Ribera A, Llatjós R, Casanova A, et al. Chlamydia pneumoniae infection associated to acute fibrinous and organizing pneumonia. Enferm Infecc Microbiol Clin,2011,29:631-638.
19. Santos C, Fradinho F, Catarino A. Acute fibrinous and organizing pneumonia. Rev Port Pneumol,2010,16:607-616.
20. Tzouvelekis A, Koutsopoulos A, Oikonomou A, et al. Acute fibrinous and organising pneumonia:a case report and review of the literature. J Med Case Rep,2009,3:74.
21. Valim V, Rocha RH, Couto RB, et al. Acute fibrinous and organizing pneumonia and undifferentiated connective tissue disease. Case Rep Rheumatol,2012,2012:549298.
22. Vasu T, Cavallazzi R, Hirani A, et al. A 64-year-old male with fever and persistent lung infiltrate. Respir Care,2009,54:1263-1265.
23. Yokogawa N, Alcid DV. Acute fibrinous and organizing pneumonia as a rare presentation of abacavir hypersensitivity reaction. AIDS,2007,21:2116-2117.
24. 桂贤华,张英为,代静泓,等.急性纤维素性机化性肺炎两例报道及文献复习.中国呼吸与危重监护杂志,2012,11:558-561.
25. 邱玉英,苗立云,蔡后荣,等.急性纤维素性机化性肺炎五例临床和影像及病理分析.中华结核和呼吸杂志,2013,36:425-430.
26. 张捷,方秋红,冯瑞娥,等.急性纤维素性并机化性肺炎一例及文献复习.中华结核和呼吸杂志,2010,33:892-895.
27. 冯安宁,孟凡青.急性纤维素性机化性肺炎的研究进展.临床与实验病理学杂志,2013,29:775-778.
28. 苗立云,代静泓,桂贤华,等.急性纤维蛋白性机化性肺炎的临床病理特征.临床肺科杂志,2010,15:1260-1262.
29. Chen HJ, Yang JJ, Xu CR, et al. Principles of biopsy in suspected lung cancer:priority still based on invasion in the era of targeted therapy. J Thorac Dis,2013,5:E93-E97.
30. Ding N, Zha WJ, Ren SN, et al. Invasive examinations in patients with suspected lung cancer:more may be too many. J Thorac Dis,2013,5:E250-E253.
31. King MA, Pope-Harman A, Allen JN, et al. Acute eosinophilic pneumonia:radiologic and clinical features. Radiology,1997,203:715-719.
32. King TJ, Mortenson R. Cryptogenic organizing pneumonitis:the North American experience. Chest,1992,102:8s-13s.
33. Olson J, Colby TV, Elliott CG. Hamman-Rich syndrome revisited. Mayo Clin Proc,1990,65:1538-1548.

Chinese Journal of Respiratory and Critical Care Medicine

Acute Fibrinous and Organizing Pneumonia: One Case Report and Literature Review

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